• Disorder▼
  • Domain▼
  • PTM▼
  • Variation▼
  • Mutation▼
  • Interaction▼
  • Disease▼
  • Drug▼
  • Physicochemical▼
  • Function▼
  • Proteomics▼
  • Structure▼
  • Localization▼
  • Expression▼
  • Element▼
  • Methylation▼

LLPS-Myl-2053
SRP72

Integrated Annotations

▼ OVERVIEW

Status: Unreviewed
Protein Name: Signal recognition particle subunit SRP72
Gene Name: SRP72
Ensembl Gene: ENSMLUG00000007344.2
Ensembl Protein: ENSMLUP00000006718.2
Organism: Myotis lucifugus
Taxa ID: 59463
LLPS Type: Regulator


▼ PROPERTY


——— Disorder propensity (calculated by IUPred2A)

▼ Classification

Condensates:
CondensateEvidenceOrthologs
Nucleolus, Stress granulePredicted from orthologs(View)

▼ FUNCTION

Signal-recognition-particle assembly has a crucial role in targeting secretory proteins to the rough endoplasmic reticulum membrane.

▼ CROSS REFERENCE

DatabaseNucleotide IDProtein ID
EnsemblENSMLUT00000007361.2ENSMLUP00000006718.2
UniProtG1P936, G1P936_MYOLU
GeneBankAAPE02027690

▼ SEQUENCE

Protein Sequence (FASTA)
1     MASGGGGGAG  GVSVPALWSE  VNRYGQNGDF  TRALKTVNKI  LQVNKDDVTA  LHCKVVCLIQ  60
61    NGSFKEALNI  ISSHTKVLAN  NSLSFEKAYC  EYRLNRIENA  LKTIESANQQ  TDKLKELYGQ  120
121   VLYRLERYDE  CLAVYRDLVR  NSQDDYDEER  KTNLSAVVAA  QSNWEKVVPE  NLGLQEGTHE  180
181   LCYNAACALI  GQGQLSQAMK  ILQKAEVDLC  RRSLSEDSDG  TEEDPQAELA  IIHGQMAYIL  240
241   QLQGRTEEAL  QLYNQIIKLK  PTDVGLLAVI  ANNIITINKD  QNVFDSKKKV  KLTNAEGVEF  300
301   KLSKKQLQAI  EFNKALLAMY  TNQAEQCRKI  SSSLQSQSPE  RLLPVLIQAA  QFCREKQHTK  360
361   AIELLQEFSD  QHPENAAEIK  LTMAQLKISQ  GNISKACLIL  RSIEELKHKP  GMVSALVTMY  420
421   SHEEDIDSAI  EVFTQAIQWY  QKHQPKSPAH  LSLIREAANF  KLKYGRKKEA  ISDLEQLWKQ  480
481   NPKDIHTLAQ  LISAYSLVDP  EKAKALSKHL  PSSDSMSLKV  DVEALENSPG  ATYVRKKGGK  540
541   VAGESQPKEQ  GQGDLKKKKK  KKKGKLPKNY  DPKVTPDPER  WLPMRERSYY  RGRKKGKKKD  600
601   QIGKGTQGAT  AGASSELDAS  KTVSSPPTSP  RPGSAATASA  STSNIIPPRH  QKPAGAPATK  660
661   KKQQQKKKKG  GKGGW  675
Nucleotide CDS Sequence (FASTA)
1     ATGGCGAGCG  GCGGCGGCGG  CGGCGCTGGG  GGGGTTTCGG  TGCCTGCGCT  CTGGAGCGAA  60
61    GTGAACCGTT  ATGGCCAGAA  TGGTGACTTC  ACGCGCGCTC  TCAAGACCGT  CAACAAAATA  120
121   CTGCAGGTCA  ACAAGGATGA  TGTAACTGCC  CTACACTGTA  AAGTGGTATG  CCTTATCCAG  180
181   AATGGGAGTT  TCAAGGAAGC  CTTGAACATC  ATCAGTTCTC  ATACCAAAGT  GTTAGCCAAT  240
241   AACTCTCTTT  CTTTTGAGAA  GGCATATTGC  GAGTATAGGC  TGAACAGAAT  TGAGAATGCC  300
301   TTGAAGACAA  TAGAAAGTGC  CAACCAGCAG  ACAGACAAAC  TAAAGGAGCT  TTATGGACAA  360
361   GTGTTATACC  GGCTAGAACG  CTATGATGAA  TGCTTAGCTG  TGTATAGAGA  TCTCGTCCGA  420
421   AACTCCCAAG  ATGATTATGA  TGAGGAGAGA  AAAACAAACC  TTTCAGCAGT  TGTTGCAGCT  480
481   CAAAGCAATT  GGGAAAAAGT  GGTTCCAGAG  AACTTGGGCC  TCCAAGAAGG  CACACATGAA  540
541   CTCTGCTACA  ATGCTGCATG  TGCACTGATA  GGACAAGGCC  AGCTGAGTCA  GGCAATGAAA  600
601   ATCCTACAAA  AAGCTGAAGT  AGATCTTTGC  CGCCGTTCAT  TATCAGAAGA  TTCTGATGGG  660
661   ACTGAGGAAG  ACCCACAGGC  AGAACTGGCC  ATCATTCACG  GGCAGATGGC  CTATATTCTG  720
721   CAGCTTCAGG  GTCGTACAGA  GGAGGCTCTG  CAACTTTACA  ATCAGATAAT  AAAACTAAAG  780
781   CCAACAGATG  TGGGATTGCT  AGCTGTGATT  GCAAATAACA  TCATTACCAT  TAACAAGGAC  840
841   CAAAATGTCT  TTGACTCCAA  GAAGAAGGTG  AAATTAACCA  ATGCAGAAGG  AGTAGAGTTT  900
901   AAGCTTTCCA  AGAAACAGCT  GCAAGCTATA  GAATTTAACA  AAGCTTTACT  TGCTATGTAC  960
961   ACAAATCAGG  CAGAACAGTG  CCGAAAAATA  TCTTCCAGTT  TACAGTCCCA  AAGCCCTGAG  1020
1021  CGTCTCCTGC  CTGTGTTAAT  CCAAGCTGCA  CAGTTCTGTC  GTGAAAAGCA  GCACACAAAA  1080
1081  GCTATAGAGC  TGCTTCAGGA  ATTTTCAGAT  CAGCATCCAG  AAAATGCAGC  TGAAATTAAG  1140
1141  CTGACCATGG  CACAACTGAA  AATTTCCCAA  GGTAATATTT  CCAAAGCATG  TCTAATCTTG  1200
1201  AGAAGCATAG  AGGAATTAAA  GCATAAACCA  GGCATGGTAT  CTGCATTAGT  GACTATGTAC  1260
1261  AGCCATGAGG  AAGATATTGA  TAGCGCCATT  GAGGTCTTCA  CACAAGCTAT  CCAGTGGTAT  1320
1321  CAAAAACATC  AGCCCAAATC  TCCTGCTCAT  TTGTCCTTGA  TAAGAGAAGC  TGCAAATTTC  1380
1381  AAACTCAAAT  ATGGGCGGAA  GAAGGAAGCA  ATTAGTGACC  TAGAACAGCT  ATGGAAACAA  1440
1441  AATCCAAAAG  ATATTCATAC  CCTGGCGCAG  CTTATTTCTG  CTTACTCACT  TGTAGATCCT  1500
1501  GAGAAAGCAA  AAGCTCTTAG  TAAACACTTG  CCCTCGTCAG  ATAGTATGTC  TCTGAAAGTA  1560
1561  GATGTTGAGG  CTCTTGAAAA  TTCTCCAGGT  GCTACGTATG  TTCGGAAGAA  GGGTGGAAAA  1620
1621  GTTGCTGGAG  AGAGTCAACC  AAAGGAGCAA  GGACAGGGAG  ATTTGAAAAA  GAAGAAGAAA  1680
1681  AAAAAGAAGG  GAAAACTGCC  TAAGAATTAT  GACCCAAAAG  TGACTCCAGA  TCCAGAAAGA  1740
1741  TGGCTACCAA  TGCGGGAACG  GTCTTACTAC  CGGGGAAGGA  AGAAGGGTAA  GAAGAAGGAT  1800
1801  CAGATTGGAA  AAGGGACCCA  GGGAGCAACT  GCAGGAGCTT  CATCTGAACT  GGATGCCAGT  1860
1861  AAAACTGTGA  GCAGCCCACC  CACCTCGCCA  AGACCTGGCA  GTGCAGCAAC  AGCATCTGCA  1920
1921  TCTACAAGTA  ATATCATACC  CCCAAGACAC  CAGAAACCTG  CAGGGGCTCC  AGCAACAAAA  1980
1981  AAGAAACAGC  AACAGAAAAA  GAAGAAAGGT  GGAAAAGGTG  GCTGGTGA  2028

▼ KEYWORD

ID
Family
Coiled coil
Complete proteome
Cytoplasm
Reference proteome
Ribonucleoprotein
Signal recognition particle
TPR repeat

▼ GENE ONTOLOGY

ID
Classification
Description
Cellular Component
Endoplasmic reticulum
Cellular Component
Signal recognition particle, endoplasmic reticulum targeting
Molecular Function
7S RNA binding
Molecular Function
Ribosome binding
Molecular Function
Signal recognition particle binding
Molecular Function
TPR domain binding
Biological Process
Response to drug
Biological Process
SRP-dependent cotranslational protein targeting to membrane

▼ ORTHOLOGY

DrLLPS IDOrganismIdentityE-valueScore
LLPS-Caf-1408Canis familiaris98.140.01141
LLPS-Aim-3002Ailuropoda melanoleuca97.830.01137
LLPS-Cas-2904Carlito syrichta97.830.01144
LLPS-Mup-2210Mustela putorius furo97.670.01133
LLPS-Eqc-3497Equus caballus97.670.01143
LLPS-Urm-2957Ursus maritimus97.520.01134
LLPS-Fec-1098Felis catus97.520.01137
LLPS-Poa-1484Pongo abelii97.360.01137
LLPS-Hos-2276Homo sapiens97.210.01139
LLPS-Pap-2732Pan paniscus97.210.01139
LLPS-Ict-2648Ictidomys tridecemlineatus97.210.01137
LLPS-Pat-1515Pan troglodytes97.190.01110
LLPS-Maf-1868Macaca fascicularis97.050.01135
LLPS-Cea-0335Cercocebus atys97.050.01136
LLPS-Paa-4710Papio anubis97.050.01136
LLPS-Ova-0895Ovis aries97.050.01134
LLPS-Mam-2875Macaca mulatta97.050.01138
LLPS-Man-4622Macaca nemestrina97.020.01108
LLPS-Mea-0184Mesocricetus auratus96.90.01135
LLPS-Gog-4223Gorilla gorilla96.850.01108
LLPS-Bot-2739Bos taurus96.740.01129
LLPS-Otg-1719Otolemur garnettii96.740.01134
LLPS-Loa-0390Loxodonta africana96.740.01129
LLPS-Cap-4396Cavia porcellus96.430.01133
LLPS-Fud-3433Fukomys damarensis96.280.01126
LLPS-Tut-1220Tursiops truncatus96.120.01063
LLPS-Orc-3094Oryctolagus cuniculus96.120.01117
LLPS-Aon-2698Aotus nancymaae95.860.01094
LLPS-Caj-1041Callithrix jacchus95.810.01122
LLPS-Dio-2631Dipodomys ordii95.810.01127
LLPS-Mum-4492Mus musculus95.350.01122
LLPS-Mal-3396Mandrillus leucophaeus94.70.01097
LLPS-Sus-2907Sus scrofa93.80.01077
LLPS-Ran-4751Rattus norvegicus93.640.01098
LLPS-Chs-3223Chlorocebus sabaeus91.470.01035
LLPS-Nol-1907Nomascus leucogenys90.990.01037
LLPS-Rhb-4080Rhinopithecus bieti90.850.01028
LLPS-Sah-2851Sarcophilus harrisii90.050.01004
LLPS-Pes-2895Pelodiscus sinensis85.170.0 981
LLPS-Mod-1508Monodelphis domestica84.940.0 967
LLPS-Anc-3852Anolis carolinensis84.540.0 979
LLPS-Gaga-2590Gallus gallus84.140.01012
LLPS-Fia-0271Ficedula albicollis83.720.01011
LLPS-Tag-1680Taeniopygia guttata83.720.01009
LLPS-Anp-0767Anas platyrhynchos80.930.01001
LLPS-Meg-2173Meleagris gallopavo79.680.0 908
LLPS-Dar-1600Danio rerio78.360.0 795
LLPS-Lac-2966Latimeria chalumnae77.682e-124 376
LLPS-Leo-3942Lepisosteus oculatus76.520.0 915
LLPS-Scf-1996Scleropages formosus76.240.0 911
LLPS-Xet-2155Xenopus tropicalis76.080.0 876
LLPS-Ten-1102Tetraodon nigroviridis75.970.0 903
LLPS-Orn-3749Oreochromis niloticus75.660.0 909
LLPS-Asm-0729Astyanax mexicanus75.620.0 917
LLPS-Pof-2418Poecilia formosa75.580.0 904
LLPS-Xim-3502Xiphophorus maculatus74.810.0 900
LLPS-Icp-3573Ictalurus punctatus74.380.0 899
LLPS-Scm-0665Scophthalmus maximus73.920.0 875
LLPS-Tar-0707Takifugu rubripes73.910.0 889
LLPS-Orl-2132Oryzias latipes73.450.0 887
LLPS-Gaa-3852Gasterosteus aculeatus72.910.0 889
LLPS-Ora-3334Ornithorhynchus anatinus69.750.0 770
LLPS-Cii-1266Ciona intestinalis42.714e-138 428
LLPS-Drm-1853Drosophila melanogaster42.178e-127 397
LLPS-Cis-1161Ciona savignyi40.19e-125 393
LLPS-Sol-0759Solanum lycopersicum34.862e-77 266
LLPS-Gor-1064Gossypium raimondii34.071e-74 259
LLPS-Coc-1875Corchorus capsularis33.783e-75 261
LLPS-Php-2495Physcomitrella patens33.171e-71 252
LLPS-Thc-2336Theobroma cacao32.993e-71 250
LLPS-Dac-1689Daucus carota32.941e-70 248
LLPS-Sot-2250Solanum tuberosum32.883e-58 210
LLPS-Brd-2409Brachypodium distachyon32.727e-63 227
LLPS-Arl-2002Arabidopsis lyrata32.714e-68 241
LLPS-Viv-2110Vitis vinifera32.62e-71 251
LLPS-Glm-2608Glycine max32.484e-76 263
LLPS-Pot-2202Populus trichocarpa32.483e-72 253
LLPS-Hov-0827Hordeum vulgare32.292e-61 223
LLPS-Chr-1089Chlamydomonas reinhardtii32.261e-1688.2
LLPS-Phv-2482Phaseolus vulgaris32.143e-70 247
LLPS-Zem-1133Zea mays32.131e-57 212
LLPS-Cus-0965Cucumis sativus32.082e-67 239
LLPS-Tra-1186Triticum aestivum32.053e-66 236
LLPS-Mua-2003Musa acuminata31.819e-63 227
LLPS-Brn-1507Brassica napus31.741e-66 237
LLPS-Bro-1589Brassica oleracea31.741e-66 237
LLPS-Sob-2107Sorghum bicolor31.724e-61 222
LLPS-Orr-1812Oryza rufipogon31.654e-44 170
LLPS-Mae-1304Manihot esculenta31.623e-69 244
LLPS-Prp-1314Prunus persica31.596e-68 241
LLPS-Sei-2369Setaria italica31.573e-68 242
LLPS-Via-0953Vigna angularis31.423e-61 223
LLPS-Met-2169Medicago truncatula31.417e-67 238
LLPS-Brr-1413Brassica rapa31.45e-66 236
LLPS-Sem-1322Selaginella moellendorffii31.385e-56 207
LLPS-Amt-1872Amborella trichopoda31.257e-60 218
LLPS-Lep-1891Leersia perrieri31.171e-62 226
LLPS-Orp-1121Oryza punctata30.972e-64 231
LLPS-Crn-1168Cryptococcus neoformans30.871e-1273.6
LLPS-Tru-1469Triticum urartu30.842e-35 142
LLPS-Art-2515Arabidopsis thaliana30.828e-65 232
LLPS-Orni-0933Oryza nivara30.813e-63 228
LLPS-Orb-2404Oryza barthii30.813e-63 228
LLPS-Ori-0381Oryza indica30.813e-63 228
LLPS-Orgl-2164Oryza glumaepatula30.813e-63 228
LLPS-Ors-1994Oryza sativa30.814e-63 228
LLPS-Org-2093Oryza glaberrima30.813e-63 228
LLPS-Orbr-1378Oryza brachyantha30.648e-64 229
LLPS-Orm-0192Oryza meridionalis30.645e-62 224
LLPS-Hea-1464Helianthus annuus30.522e-58 214
LLPS-Abg-1381Absidia glauca30.295e-69 244
LLPS-Nia-1979Nicotiana attenuata30.021e-55 206
LLPS-Fus-1306Fusarium solani29.222e-42 167
LLPS-Cae-1770Caenorhabditis elegans28.793e-48 184
LLPS-Vir-1730Vigna radiata28.722e-56 209
LLPS-Fuo-0656Fusarium oxysporum28.284e-50 190
LLPS-Fuv-0633Fusarium verticillioides28.112e-50 191
LLPS-Trr-0811Trichoderma reesei27.233e-38 154
LLPS-Trv-1561Trichoderma virens26.979e-43 167
LLPS-Asf-0690Aspergillus flavus26.687e-32 135
LLPS-Aso-1165Aspergillus oryzae26.687e-32 135
LLPS-Beb-0957Beauveria bassiana26.621e-38 155
LLPS-Blg-1494Blumeria graminis26.331e-25 116
LLPS-Pyt-0742Pyrenophora teres26.293e-28 124
LLPS-Tum-0730Tuber melanosporum26.251e-29 129
LLPS-Asn-1180Aspergillus nidulans26.221e-30 132
LLPS-Ast-1422Aspergillus terreus26.155e-27 120
LLPS-Ved-1021Verticillium dahliae26.081e-25 115
LLPS-Cogr-1289Colletotrichum graminicola25.968e-26 117
LLPS-Asc-1020Aspergillus clavatus25.925e-29 127
LLPS-Pytr-1228Pyrenophora triticirepentis25.791e-31 135
LLPS-Zyt-0607Zymoseptoria tritici25.514e-27 120
LLPS-Lem-1172Leptosphaeria maculans25.492e-25 115
LLPS-Cog-1356Colletotrichum gloeosporioides25.437e-22 104
LLPS-Asni-1478Aspergillus niger25.38e-22 104
LLPS-Coo-0661Colletotrichum orbiculare25.082e-28 125
LLPS-Gas-1283Galdieria sulphuraria24.634e-22 105
LLPS-Nef-1145Neosartorya fischeri24.599e-23 107
LLPS-Nec-1481Neurospora crassa24.551e-33 140
LLPS-Dos-1536Dothistroma septosporum24.332e-25 115
LLPS-Asfu-1160Aspergillus fumigatus24.055e-22 105
LLPS-Phn-1294Phaeosphaeria nodorum23.987e-24 110
LLPS-Gag-1049Gaeumannomyces graminis23.752e-22 106
LLPS-Yal-1104Yarrowia lipolytica23.63e-1273.9
LLPS-Mao-0566Magnaporthe oryzae23.221e-1791.3
LLPS-Chc-0766Chondrus crispus22.464e-2099.4
LLPS-Scc-1392Schizosaccharomyces cryophilus22.344e-0757.4