• Disorder▼
  • Domain▼
  • PTM▼
  • Variation▼
  • Mutation▼
  • Interaction▼
  • Disease▼
  • Drug▼
  • Physicochemical▼
  • Function▼
  • Proteomics▼
  • Structure▼
  • Localization▼
  • Expression▼
  • Element▼
  • Methylation▼

LLPS-Man-4622

Integrated Annotations

▼ OVERVIEW

Status: Unreviewed
Protein Name: Signal recognition particle subunit SRP72
Ensembl Gene: ENSMNEG00000038065.1
Ensembl Protein: ENSMNEP00000029306.1
Organism: Macaca nemestrina
Taxa ID: 9545
LLPS Type: LLPS regulator


▼ PROPERTY


——— Disorder propensity (calculated by IUPred2A)

▼ Classification

Condensates:
CondensateEvidenceOrthologs
Nucleolus, Stress granulePredicted from orthologs(View)

▼ FUNCTION

Signal-recognition-particle assembly has a crucial role in targeting secretory proteins to the rough endoplasmic reticulum membrane.

▼ SEQUENCE

Protein Sequence (FASTA)
1     MASSGSGGVS  VPALWSEVNR  YGQNGDFTRA  LKTVNKILQI  NKDDVTALHC  KVVCLIQNGS  60
61    FKEALNVINT  HTKVLANNSL  SFEKAYCEYR  LNRIENALKT  IESANQQTDK  LKELYGQVLY  120
121   RLERYDECLA  VYRDLVRNSQ  DDYDEERKTN  LSAVVAAQSN  WEKVVPENLG  LQEGTHELCY  180
181   NTACALIGQG  QLNQAMKILQ  KAEDLCRRSL  SEDTDGTEED  PQAELAIIHG  QMAYILQLQG  240
241   RTEEALQLYN  QIIKLKPTDV  GLLAVIANNI  ITINKDQNVF  DSKKKVKLTN  AEGVEFKLSK  300
301   KQLQAIEFNK  ALLAMYTNQA  EQCRKISASL  QSQSPEHLLP  VLIQAAQLCR  EKQHTKAIEL  360
361   LQEFSDQHPE  NAAEIKLTMA  QLKISQGNIS  KACLILRSIE  ELKHKPGMVS  ALVTMYSHEE  420
421   DIDSAIEVFA  LAIQWYQNHQ  PKSPAHLSLI  REAANFKLKY  GRKKEAISDL  QQLWKQNPKD  480
481   IHTLAQLISA  YSLVDPEKAK  ALSKHLPSSD  SMSLKVDVEA  LENSPGATYI  RKKGGKVTGD  540
541   SQPKEQGQGD  LKKKKKKKKG  KLPKNYDPKV  TPDPERWLPM  RERSYYRGRK  KGKKKDQIGK  600
601   GTQGATAGAS  SELDASKTVS  SPPTSPRPGS  AATVSASTKT  ATEKEERWKR  WLVMRIFLLQ  660
661   AVFKLVSVTL  GI  672
Nucleotide CDS Sequence (FASTA)
1     ATGGCGAGTA  GCGGCAGTGG  GGGGGTGTCA  GTGCCTGCGC  TGTGGAGTGA  AGTGAACCGG  60
61    TATGGCCAGA  ACGGCGACTT  CACGCGCGCT  CTGAAGACCG  TCAATAAGAT  ACTACAGATC  120
121   AACAAAGATG  ACGTAACTGC  CCTGCATTGT  AAAGTGGTAT  GCCTTATCCA  GAATGGAAGT  180
181   TTCAAGGAAG  CTTTGAATGT  CATCAATACT  CACACCAAAG  TGTTAGCCAA  TAACTCTCTC  240
241   TCCTTTGAAA  AGGCATATTG  CGAGTACAGG  CTGAACAGAA  TTGAGAATGC  CTTGAAGACA  300
301   ATAGAAAGTG  CTAACCAGCA  GACAGACAAA  CTGAAGGAGC  TTTATGGACA  AGTGTTATAC  360
361   CGTTTGGAAC  GCTATGATGA  ATGCTTAGCG  GTATATAGAG  ATCTTGTCCG  AAACTCTCAA  420
421   GATGATTATG  ATGAGGAGAG  GAAAACAAAC  CTTTCAGCAG  TTGTTGCAGC  TCAAAGCAAT  480
481   TGGGAAAAAG  TGGTTCCAGA  GAACTTGGGC  CTCCAAGAAG  GCACACATGA  GCTGTGCTAC  540
541   AACACTGCGT  GTGCACTAAT  AGGCCAAGGC  CAGCTGAACC  AGGCCATGAA  AATCCTGCAA  600
601   AAGGCTGAAG  ATCTTTGTCG  CCGTTCTTTA  TCAGAAGACA  CTGATGGGAC  TGAGGAAGAC  660
661   CCACAGGCAG  AACTGGCCAT  CATTCATGGT  CAGATGGCCT  ATATTCTGCA  GCTTCAGGGT  720
721   CGAACAGAGG  AGGCTTTGCA  ACTTTACAAT  CAAATAATAA  AACTAAAACC  AACAGATGTG  780
781   GGATTACTAG  CTGTAATTGC  AAATAACATC  ATTACCATTA  ACAAGGACCA  AAATGTCTTT  840
841   GACTCCAAGA  AGAAAGTGAA  ATTAACCAAT  GCGGAAGGAG  TAGAGTTTAA  ACTGTCCAAG  900
901   AAACAACTAC  AAGCTATAGA  ATTTAACAAA  GCTTTACTTG  CTATGTACAC  AAACCAGGCT  960
961   GAACAATGCC  GCAAAATATC  TGCCAGTTTA  CAGTCCCAAA  GTCCCGAGCA  TCTCTTACCT  1020
1021  GTGTTAATCC  AAGCTGCCCA  GCTCTGCCGT  GAAAAGCAGC  ACACAAAAGC  AATAGAGCTG  1080
1081  CTTCAGGAAT  TTTCAGATCA  GCATCCAGAA  AATGCGGCTG  AAATTAAGCT  GACCATGGCA  1140
1141  CAGTTGAAAA  TTTCTCAAGG  TAATATTTCT  AAAGCATGTC  TAATATTAAG  AAGCATAGAG  1200
1201  GAGTTAAAGC  ATAAACCAGG  CATGGTGTCT  GCATTAGTTA  CCATGTACAG  CCATGAAGAA  1260
1261  GATATTGATA  GTGCCATTGA  GGTCTTCGCA  CTAGCTATCC  AGTGGTATCA  AAACCATCAG  1320
1321  CCCAAATCTC  CTGCTCATTT  GTCCTTGATA  AGAGAAGCTG  CAAACTTCAA  ACTCAAATAT  1380
1381  GGGCGGAAGA  AGGAGGCAAT  TAGTGACCTA  CAACAGCTAT  GGAAACAAAA  TCCGAAAGAT  1440
1441  ATTCACACCC  TGGCACAGCT  AATTTCTGCT  TACTCACTTG  TAGATCCAGA  GAAAGCCAAA  1500
1501  GCTCTTAGTA  AACACTTGCC  ATCGTCAGAT  AGTATGTCTC  TAAAAGTAGA  TGTTGAGGCT  1560
1561  CTTGAAAATT  CTCCTGGTGC  TACGTACATT  CGGAAGAAGG  GTGGAAAAGT  TACTGGAGAT  1620
1621  AGTCAACCAA  AGGAACAAGG  ACAGGGAGAT  TTGAAAAAGA  AGAAAAAGAA  AAAGAAGGGA  1680
1681  AAATTGCCTA  AGAATTATGA  CCCAAAAGTT  ACCCCAGATC  CAGAAAGATG  GCTGCCAATG  1740
1741  CGAGAACGTT  CTTACTACCG  GGGAAGAAAG  AAGGGTAAAA  AGAAGGATCA  GATTGGAAAA  1800
1801  GGGACCCAGG  GAGCAACTGC  AGGAGCTTCA  TCTGAACTGG  ATGCCAGTAA  AACTGTGAGC  1860
1861  AGCCCACCCA  CCTCCCCAAG  ACCTGGCAGT  GCTGCAACAG  TATCTGCCTC  TACAAGTAAC  1920
1921  ATCATACCCC  CAAGACACCA  GAAACCTGCA  GGGGCTCCAG  CAACAAAAAA  GAAACAGCAA  1980
1981  CAGAAAAAGA  AGAAAGGTGG  AAAAGGTGGC  TGGTGA  2016

▼ KEYWORD

ID
Family
Coiled coil
Complete proteome
Cytoplasm
Reference proteome
Ribonucleoprotein
Signal recognition particle
TPR repeat

▼ GENE ONTOLOGY

ID
Classification
Description
Cellular Component
Signal recognition particle, endoplasmic reticulum targeting
Molecular Function
7S RNA binding
Biological Process
SRP-dependent cotranslational protein targeting to membrane

▼ ORTHOLOGY

DrLLPS IDOrganismIdentityE-valueScore
LLPS-Maf-1868Macaca fascicularis100.00.01173
LLPS-Mam-2875Macaca mulatta100.00.01175
LLPS-Paa-4710Papio anubis99.840.01172
LLPS-Cea-0335Cercocebus atys99.840.01172
LLPS-Pat-1515Pan troglodytes99.40.01228
LLPS-Poa-1484Pongo abelii99.360.01166
LLPS-Hos-2276Homo sapiens99.360.01166
LLPS-Pap-2732Pan paniscus99.360.01166
LLPS-Gog-4223Gorilla gorilla99.110.01226
LLPS-Cas-2904Carlito syrichta98.710.01157
LLPS-Caf-1408Canis familiaris98.570.01156
LLPS-Ict-2648Ictidomys tridecemlineatus98.410.01156
LLPS-Fec-1098Felis catus98.380.01151
LLPS-Mup-2210Mustela putorius furo98.220.01146
LLPS-Mea-0184Mesocricetus auratus98.220.01150
LLPS-Aim-3002Ailuropoda melanoleuca98.090.01152
LLPS-Cap-4396Cavia porcellus98.090.01155
LLPS-Otg-1719Otolemur garnettii97.930.01149
LLPS-Mal-3396Mandrillus leucophaeus97.770.01224
LLPS-Eqc-3497Equus caballus97.770.01149
LLPS-Urm-2957Ursus maritimus97.770.01147
LLPS-Ova-0895Ovis aries97.620.01148
LLPS-Orc-3094Oryctolagus cuniculus97.460.01140
LLPS-Bot-2739Bos taurus97.30.01144
LLPS-Loa-0390Loxodonta africana97.30.01143
LLPS-Aon-2698Aotus nancymaae97.170.01200
LLPS-Fud-3433Fukomys damarensis97.140.01145
LLPS-Caj-1041Callithrix jacchus97.140.01142
LLPS-Tut-1220Tursiops truncatus97.130.01081
LLPS-Myl-2053Myotis lucifugus97.090.01138
LLPS-Dio-2631Dipodomys ordii96.930.01144
LLPS-Mum-4492Mus musculus96.50.01135
LLPS-Ran-4751Rattus norvegicus94.590.01112
LLPS-Sus-2907Sus scrofa94.50.01095
LLPS-Chs-3223Chlorocebus sabaeus93.160.01070
LLPS-Rhb-4080Rhinopithecus bieti92.690.01059
LLPS-Nol-1907Nomascus leucogenys92.530.01060
LLPS-Sah-2851Sarcophilus harrisii90.270.01015
LLPS-Pes-2895Pelodiscus sinensis87.650.0 999
LLPS-Gaga-2590Gallus gallus87.50.01033
LLPS-Tag-1680Taeniopygia guttata87.060.01030
LLPS-Fia-0271Ficedula albicollis87.060.01030
LLPS-Anc-3852Anolis carolinensis86.430.0 996
LLPS-Mod-1508Monodelphis domestica85.740.0 985
LLPS-Anp-0767Anas platyrhynchos84.140.01021
LLPS-Meg-2173Meleagris gallopavo82.80.0 927
LLPS-Scf-1996Scleropages formosus79.90.0 936
LLPS-Leo-3942Lepisosteus oculatus79.870.0 941
LLPS-Asm-0729Astyanax mexicanus79.090.0 942
LLPS-Ten-1102Tetraodon nigroviridis78.610.0 930
LLPS-Pof-2418Poecilia formosa78.610.0 934
LLPS-Xet-2155Xenopus tropicalis78.450.0 894
LLPS-Orn-3749Oreochromis niloticus78.280.0 933
LLPS-Dar-1600Danio rerio78.180.0 825
LLPS-Lac-2966Latimeria chalumnae78.113e-126 381
LLPS-Icp-3573Ictalurus punctatus77.960.0 924
LLPS-Xim-3502Xiphophorus maculatus77.80.0 930
LLPS-Tar-0707Takifugu rubripes76.990.0 914
LLPS-Orl-2132Oryzias latipes76.570.0 889
LLPS-Scm-0665Scophthalmus maximus76.260.0 891
LLPS-Gaa-3852Gasterosteus aculeatus75.490.0 908
LLPS-Ora-3334Ornithorhynchus anatinus71.010.0 781
LLPS-Cii-1266Ciona intestinalis40.979e-139 429
LLPS-Cis-1161Ciona savignyi40.752e-129 405
LLPS-Drm-1853Drosophila melanogaster40.514e-128 400
LLPS-Sol-0759Solanum lycopersicum34.182e-78 270
LLPS-Dac-1689Daucus carota33.737e-72 251
LLPS-Gor-1064Gossypium raimondii33.621e-75 262
LLPS-Coc-1875Corchorus capsularis33.58e-76 263
LLPS-Arl-2002Arabidopsis lyrata33.335e-71 249
LLPS-Viv-2110Vitis vinifera33.166e-75 260
LLPS-Sot-2250Solanum tuberosum33.032e-60 216
LLPS-Chr-1089Chlamydomonas reinhardtii32.794e-1892.8
LLPS-Thc-2336Theobroma cacao32.713e-72 253
LLPS-Php-2495Physcomitrella patens32.551e-70 249
LLPS-Brn-1507Brassica napus32.481e-69 245
LLPS-Bro-1589Brassica oleracea32.481e-69 245
LLPS-Glm-2608Glycine max32.373e-78 269
LLPS-Brd-2409Brachypodium distachyon32.274e-61 222
LLPS-Phv-2482Phaseolus vulgaris32.22e-72 253
LLPS-Cus-0965Cucumis sativus32.146e-70 246
LLPS-Brr-1413Brassica rapa32.141e-68 243
LLPS-Art-2515Arabidopsis thaliana32.056e-69 243
LLPS-Mae-1304Manihot esculenta32.039e-72 251
LLPS-Pot-2202Populus trichocarpa32.023e-73 255
LLPS-Mua-2003Musa acuminata31.866e-64 230
LLPS-Hov-0827Hordeum vulgare31.72e-60 220
LLPS-Zem-1133Zea mays31.664e-56 208
LLPS-Amt-1872Amborella trichopoda31.535e-63 227
LLPS-Orr-1812Oryza rufipogon31.484e-44 170
LLPS-Via-0953Vigna angularis31.471e-63 230
LLPS-Sei-2369Setaria italica31.44e-67 239
LLPS-Prp-1314Prunus persica31.355e-69 244
LLPS-Tra-1186Triticum aestivum31.328e-65 232
LLPS-Sob-2107Sorghum bicolor31.261e-59 218
LLPS-Lep-1891Leersia perrieri31.142e-61 223
LLPS-Met-2169Medicago truncatula31.013e-68 241
LLPS-Orbr-1378Oryza brachyantha30.988e-63 227
LLPS-Orgl-2164Oryza glumaepatula30.687e-63 227
LLPS-Orni-0933Oryza nivara30.685e-63 227
LLPS-Orb-2404Oryza barthii30.685e-63 227
LLPS-Ori-0381Oryza indica30.685e-63 227
LLPS-Org-2093Oryza glaberrima30.685e-63 227
LLPS-Ors-1994Oryza sativa30.687e-63 227
LLPS-Orp-1121Oryza punctata30.684e-64 230
LLPS-Orm-0192Oryza meridionalis30.517e-62 224
LLPS-Sem-1322Selaginella moellendorffii30.43e-56 208
LLPS-Nia-1979Nicotiana attenuata30.341e-55 206
LLPS-Tru-1469Triticum urartu30.31e-34 140
LLPS-Hea-1464Helianthus annuus30.247e-59 216
LLPS-Crn-1168Cryptococcus neoformans29.938e-1373.9
LLPS-Abg-1381Absidia glauca29.561e-68 243
LLPS-Fus-1306Fusarium solani29.094e-42 166
LLPS-Vir-1730Vigna radiata28.728e-58 213
LLPS-Cae-1770Caenorhabditis elegans28.714e-51 192
LLPS-Yal-1104Yarrowia lipolytica28.268e-1375.5
LLPS-Fuv-0633Fusarium verticillioides28.161e-50 191
LLPS-Fuo-0656Fusarium oxysporum28.165e-50 189
LLPS-Ast-1422Aspergillus terreus27.183e-27 121
LLPS-Asn-1180Aspergillus nidulans27.159e-32 135
LLPS-Trr-0811Trichoderma reesei27.157e-38 153
LLPS-Blg-1494Blumeria graminis26.942e-27 122
LLPS-Asf-0690Aspergillus flavus26.894e-32 136
LLPS-Aso-1165Aspergillus oryzae26.894e-32 136
LLPS-Tum-0730Tuber melanosporum26.591e-29 129
LLPS-Trv-1561Trichoderma virens26.552e-41 164
LLPS-Pyt-0742Pyrenophora teres26.331e-28 125
LLPS-Beb-0957Beauveria bassiana26.26e-38 153
LLPS-Pytr-1228Pyrenophora triticirepentis26.176e-32 135
LLPS-Lem-1172Leptosphaeria maculans26.033e-27 121
LLPS-Ved-1021Verticillium dahliae26.01e-26 118
LLPS-Asc-1020Aspergillus clavatus25.921e-28 125
LLPS-Cogr-1289Colletotrichum graminicola25.687e-25 114
LLPS-Zyt-0607Zymoseptoria tritici25.211e-27 122
LLPS-Nef-1145Neosartorya fischeri25.044e-22 105
LLPS-Cog-1356Colletotrichum gloeosporioides24.969e-21 100
LLPS-Scj-1087Schizosaccharomyces japonicus24.824e-1067.0
LLPS-Coo-0661Colletotrichum orbiculare24.795e-27 120
LLPS-Asni-1478Aspergillus niger24.752e-23 109
LLPS-Phn-1294Phaeosphaeria nodorum24.585e-24 111
LLPS-Dos-1536Dothistroma septosporum24.542e-26 119
LLPS-Gas-1283Galdieria sulphuraria24.51e-22 107
LLPS-Nec-1481Neurospora crassa24.267e-33 139
LLPS-Asfu-1160Aspergillus fumigatus24.141e-21 103
LLPS-Gag-1049Gaeumannomyces graminis23.626e-23 108
LLPS-Asg-0191Ashbya gossypii22.672e-0964.7
LLPS-Chc-0766Chondrus crispus22.462e-20 100
LLPS-Kop-1160Komagataella pastoris22.382e-0655.1
LLPS-Mao-0566Magnaporthe oryzae22.321e-1791.3