DrLLPS - Data resource of LLPS

LLPS-Myl-2008
GAR1

Integrated Annotations

▼ OVERVIEW


Status:	Unreviewed
Protein Name:	H/ACA ribonucleoprotein complex subunit
Gene Name:	GAR1
Ensembl Gene:	ENSMLUG00000003776.2
Ensembl Protein:	ENSMLUP00000003438.2
Organism:	Myotis lucifugus
Taxa ID:	59463
LLPS Type:	LLPS regulator

▼ PROPERTY

——— Disorder propensity (calculated by IUPred2A)

▼ Classification

Condensates:

Condensate	Evidence	Orthologs
Cajal body, Nucleolus, P-body	Predicted from orthologs	(View)

Organism	DrLLPS ID	UniProt ID	LLPS type	Condensate	Identity	E-value	Score
Caenorhabditis elegans	LLPS-Cae-0262	Q9TYK1	Regulator	P-body	60.20	3e-32	123
Saccharomyces cerevisiae	LLPS-Sac-0322	P28007	Client	Nucleolus	56.84	7e-31	118
Mus musculus	LLPS-Mum-0304	Q9CY66	Client	Cajal body, Nucleolus	94.50	5e-56	184
Arabidopsis thaliana	LLPS-Art-0214	Q8VZT0	Client	Nucleolus	55.34	3e-32	122
Homo sapiens	LLPS-Hos-0993	Q9NY12	Client	Nucleolus	98.17	1e-58	191

▼ FUNCTION

Required for ribosome biogenesis. Part of a complex which catalyzes pseudouridylation of rRNA. This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Pseudouridine ("psi") residues may serve to stabilize the conformation of rRNAs.

▼ CROSS REFERENCE

Database	Nucleotide ID	Protein ID
Ensembl	ENSMLUT00000003773.2	ENSMLUP00000003438.2
UniProt		G1P0X7, G1P0X7_MYOLU
GeneBank	AAPE02042573, AAPE02042575, AAPE02042574
RefSeq	XM_006101370.2, XM_014466702.1, XM_014466703.1, XM_014466704.1, XM_014466705.1	XP_006101432.1, XP_014322188.1, XP_014322189.1, XP_014322190.1, XP_014322191.1

▼ SEQUENCE

Protein Sequence (FASTA)
1 MSFRGGGRGG FNRGGGGGGF GRGGGSNNHF RGGGGGNFRG GGGGNFRGGG RGGFGRGGGR 60 61 GGFNKGQDQG PPEQVVVLGE FLHPCEDDIV CKCTTDENKV PYFNAPVYLE NKEQIGKVDE 120 121 IFGQLRDFYF SVKLSENMKA SSFKKLQKFY IDPYKLLPLQ RFLPRPPGEK GPPRGGGRGG 180 181 RGGGRGGGGG RGGRGGGFRG GRGGGRGGGF RGGRGGGGFR GRGH 224
Nucleotide CDS Sequence (FASTA)
1 ATGTCTTTCC GCGGCGGAGG TCGTGGAGGC TTTAACCGAG GCGGTGGAGG CGGCGGCTTC 60 61 GGTCGCGGCG GCGGCAGCAA CAACCACTTC CGAGGCGGAG GGGGCGGCAA TTTTCGCGGC 120 121 GGCGGCGGCG GCAATTTCCG AGGCGGCGGC AGAGGCGGAT TCGGACGCGG GGGTGGGCGC 180 181 GGCGGCTTTA ACAAAGGCCA GGACCAAGGA CCCCCAGAAC AAGTCGTTGT ATTAGGAGAG 240 241 TTCCTGCATC CCTGTGAAGA TGACATAGTT TGTAAATGTA CCACAGATGA AAATAAGGTG 300 301 CCTTATTTTA ATGCTCCAGT TTATTTAGAA AACAAAGAAC AGATTGGAAA AGTGGATGAA 360 361 ATATTTGGAC AACTTAGAGA TTTTTATTTT TCAGTTAAAT TGTCAGAAAA CATGAAGGCA 420 421 TCTTCCTTTA AAAAGCTACA GAAGTTTTAT ATAGACCCAT ATAAGCTGTT GCCACTGCAG 480 481 AGGTTTTTGC CTAGACCTCC AGGTGAAAAG GGACCTCCAA GAGGTGGTGG CAGGGGTGGT 540 541 CGAGGAGGAG GAAGAGGTGG TGGAGGTGGC AGAGGCGGTA GAGGAGGTGG TTTTAGAGGT 600 601 GGAAGAGGAG GAGGTAGAGG TGGAGGCTTC AGAGGAGGAA GAGGAGGGGG TGGTTTCAGA 660 661 GGGAGAGGAC ATTAA 675

▼ KEYWORD

ID	Family
KW-0181	Complete proteome
KW-0539	Nucleus
KW-1185	Reference proteome
KW-0687	Ribonucleoprotein
KW-0690	Ribosome biogenesis
KW-0694	RNA-binding
KW-0698	rRNA processing

▼ GENE ONTOLOGY

ID	Classification	Description
GO:0031429	Cellular Component	Box H/ACA snoRNP complex
GO:0090661	Cellular Component	Box H/ACA telomerase RNP complex
GO:0001650	Cellular Component	Fibrillar center
GO:0000784	Cellular Component	Nuclear chromosome, telomeric region
GO:0034513	Molecular Function	Box H/ACA snoRNA binding
GO:0070034	Molecular Function	Telomerase RNA binding
GO:0001522	Biological Process	Pseudouridine synthesis
GO:0006364	Biological Process	RRNA processing
GO:0007004	Biological Process	Telomere maintenance via telomerase

▼ ORTHOLOGY

DrLLPS ID	Organism	Identity	E-value	Score
LLPS-Fud-1212	Fukomys damarensis	100.0	4e-19	83.6
LLPS-Ova-0130	Ovis aries	99.08	1e-59	193
LLPS-Bot-0535	Bos taurus	99.08	2e-59	192
LLPS-Sus-1588	Sus scrofa	99.08	2e-59	192
LLPS-Cap-0038	Cavia porcellus	99.08	1e-59	193
LLPS-Paa-0185	Papio anubis	98.17	5e-59	192
LLPS-Mal-0479	Mandrillus leucophaeus	98.17	5e-59	192
LLPS-Mup-2108	Mustela putorius furo	98.17	1e-58	191
LLPS-Caj-0836	Callithrix jacchus	98.17	9e-59	192
LLPS-Aon-0671	Aotus nancymaae	98.17	1e-58	192
LLPS-Cea-0044	Cercocebus atys	98.17	5e-59	192
LLPS-Maf-0107	Macaca fascicularis	98.17	5e-59	192
LLPS-Nol-2378	Nomascus leucogenys	98.17	5e-59	192
LLPS-Cas-0103	Carlito syrichta	98.17	6e-59	191
LLPS-Mam-0794	Macaca mulatta	98.17	5e-59	192
LLPS-Poa-1576	Pongo abelii	98.17	6e-59	192
LLPS-Eqc-1327	Equus caballus	98.17	2e-58	190
LLPS-Orc-0540	Oryctolagus cuniculus	98.17	2e-59	192
LLPS-Man-2023	Macaca nemestrina	98.17	5e-59	192
LLPS-Pat-2019	Pan troglodytes	98.17	5e-59	192
LLPS-Pap-0854	Pan paniscus	98.17	6e-59	192
LLPS-Urm-0908	Ursus maritimus	98.17	6e-59	191
LLPS-Hos-0993	Homo sapiens	98.17	6e-59	192
LLPS-Fec-1611	Felis catus	98.17	6e-59	191
LLPS-Rhb-1349	Rhinopithecus bieti	98.13	1e-57	188
LLPS-Chs-0786	Chlorocebus sabaeus	98.11	1e-56	185
LLPS-Aim-1460	Ailuropoda melanoleuca	97.25	1e-57	188
LLPS-Gog-1744	Gorilla gorilla	97.25	1e-58	191
LLPS-Otg-1612	Otolemur garnettii	97.25	1e-58	191
LLPS-Ora-0612	Ornithorhynchus anatinus	96.23	5e-55	182
LLPS-Ran-0527	Rattus norvegicus	95.41	1e-56	186
LLPS-Dio-1055	Dipodomys ordii	95.41	8e-57	186
LLPS-Ict-0232	Ictidomys tridecemlineatus	95.41	2e-57	188
LLPS-Mea-0789	Mesocricetus auratus	94.5	3e-56	185
LLPS-Mum-0304	Mus musculus	94.5	3e-56	185
LLPS-Orl-1606	Oryzias latipes	94.39	8e-54	180
LLPS-Orn-1633	Oreochromis niloticus	94.39	7e-54	179
LLPS-Sah-2218	Sarcophilus harrisii	94.34	3e-53	177
LLPS-Caf-0515	Canis familiaris	94.32	4e-51	172
LLPS-Mod-1590	Monodelphis domestica	93.52	1e-53	179
LLPS-Xim-2899	Xiphophorus maculatus	93.46	4e-54	180
LLPS-Leo-1293	Lepisosteus oculatus	93.46	3e-53	177
LLPS-Ten-0831	Tetraodon nigroviridis	93.27	1e-51	172
LLPS-Pof-0845	Poecilia formosa	92.52	3e-53	177
LLPS-Pes-2295	Pelodiscus sinensis	92.45	5e-53	176
LLPS-Dar-3049	Danio rerio	91.59	7e-52	174
LLPS-Scm-0886	Scophthalmus maximus	91.59	5e-52	174
LLPS-Anc-1705	Anolis carolinensis	91.51	3e-52	174
LLPS-Fia-2344	Ficedula albicollis	91.51	6e-52	174
LLPS-Tag-0537	Taeniopygia guttata	90.91	3e-47	159
LLPS-Scf-2343	Scleropages formosus	90.83	6e-51	171
LLPS-Tar-1404	Takifugu rubripes	90.65	2e-51	172
LLPS-Icp-0106	Ictalurus punctatus	89.91	7e-53	176
LLPS-Xet-0627	Xenopus tropicalis	89.62	2e-51	172
LLPS-Gaga-1660	Gallus gallus	89.62	3e-51	172
LLPS-Meg-0407	Meleagris gallopavo	89.62	3e-51	172
LLPS-Asm-0336	Astyanax mexicanus	88.79	2e-50	170
LLPS-Anp-0226	Anas platyrhynchos	88.68	1e-50	169
LLPS-Lac-1202	Latimeria chalumnae	87.74	2e-48	162
LLPS-Cis-0301	Ciona savignyi	64.71	5e-32	121
LLPS-Cii-1559	Ciona intestinalis	64.71	1e-31	120
LLPS-Sei-0010	Setaria italica	59.09	1e-26	107
LLPS-Brd-0356	Brachypodium distachyon	59.09	3e-26	106
LLPS-Cae-0262	Caenorhabditis elegans	59.09	2e-26	107
LLPS-Yal-0169	Yarrowia lipolytica	59.04	2e-25	103
LLPS-Orbr-0216	Oryza brachyantha	58.43	5e-27	107
LLPS-Abg-0905	Absidia glauca	58.14	4e-25	103
LLPS-Drm-0267	Drosophila melanogaster	57.95	1e-27	110
LLPS-Zem-0589	Zea mays	57.95	1e-26	107
LLPS-Coc-0780	Corchorus capsularis	57.95	5e-26	105
LLPS-Tru-1052	Triticum urartu	57.69	1e-21	92.4
LLPS-Hov-0806	Hordeum vulgare	57.47	6e-25	102
LLPS-Amt-0555	Amborella trichopoda	57.47	2e-26	105
LLPS-Chr-0453	Chlamydomonas reinhardtii	57.3	9e-26	105
LLPS-Tra-1311	Triticum aestivum	57.3	3e-26	105
LLPS-Php-1358	Physcomitrella patens	56.82	1e-25	104
LLPS-Sob-0578	Sorghum bicolor	56.82	2e-25	103
LLPS-Orp-0463	Oryza punctata	56.82	3e-25	103
LLPS-Orgl-0662	Oryza glumaepatula	56.76	6e-20	87.4
LLPS-Orb-0223	Oryza barthii	56.76	6e-20	87.4
LLPS-Sac-0322	Saccharomyces cerevisiae	56.63	3e-26	106
LLPS-Thc-1004	Theobroma cacao	56.32	5e-25	102
LLPS-Scc-0027	Schizosaccharomyces cryophilus	56.1	3e-23	97.8
LLPS-Via-0125	Vigna angularis	55.93	9e-14	72.4
LLPS-Lep-0475	Leersia perrieri	55.68	4e-25	103
LLPS-Orni-0279	Oryza nivara	55.68	5e-25	102
LLPS-Mua-0281	Musa acuminata	55.68	2e-25	103
LLPS-Hea-0571	Helianthus annuus	55.68	2e-25	103
LLPS-Ori-0056	Oryza indica	55.68	5e-25	102
LLPS-Orr-0504	Oryza rufipogon	55.68	5e-25	102
LLPS-Orm-0779	Oryza meridionalis	55.68	5e-25	102
LLPS-Nia-0209	Nicotiana attenuata	55.68	8e-26	104
LLPS-Ors-0481	Oryza sativa	55.68	5e-25	102
LLPS-Tum-0252	Tuber melanosporum	55.56	3e-23	98.6
LLPS-Put-0331	Puccinia triticina	55.56	1e-12	68.6
LLPS-Vir-0382	Vigna radiata	55.41	1e-19	87.0
LLPS-Asg-1120	Ashbya gossypii	55.29	2e-23	99.0
LLPS-Cus-0135	Cucumis sativus	55.17	7e-25	102
LLPS-Kop-0226	Komagataella pastoris	55.17	5e-25	102
LLPS-Mae-1587	Manihot esculenta	55.17	5e-25	102
LLPS-Gor-1452	Gossypium raimondii	55.17	1e-23	99.0
LLPS-Prp-1094	Prunus persica	55.06	7e-25	102
LLPS-Scj-0051	Schizosaccharomyces japonicus	54.88	9e-22	94.0
LLPS-Org-0562	Oryza glaberrima	54.88	2e-21	92.8
LLPS-Scp-1063	Schizosaccharomyces pombe	54.76	2e-23	98.2
LLPS-Sot-0693	Solanum tuberosum	54.55	4e-25	102
LLPS-Pot-0096	Populus trichocarpa	54.55	2e-25	103
LLPS-Met-0079	Medicago truncatula	54.02	5e-24	100
LLPS-Phv-1081	Phaseolus vulgaris	54.02	5e-24	100
LLPS-Viv-0783	Vitis vinifera	54.02	1e-24	101
LLPS-Brn-2184	Brassica napus	53.93	6e-26	105
LLPS-Glm-1219	Glycine max	53.93	3e-25	103
LLPS-Bro-0704	Brassica oleracea	53.93	5e-26	105
LLPS-Brr-0406	Brassica rapa	53.93	6e-26	105
LLPS-Sol-0028	Solanum lycopersicum	53.85	7e-21	90.5
LLPS-Arl-0724	Arabidopsis lyrata	53.41	4e-24	100
LLPS-Art-0214	Arabidopsis thaliana	53.41	1e-24	102
LLPS-Scs-0492	Sclerotinia sclerotiorum	52.94	6e-23	97.4
LLPS-Dos-1145	Dothistroma septosporum	52.94	4e-21	92.4
LLPS-Spr-0358	Sporisorium reilianum	52.94	2e-22	96.7
LLPS-Lem-0587	Leptosphaeria maculans	52.44	3e-20	90.1
LLPS-Crn-0635	Cryptococcus neoformans	52.33	5e-23	97.4
LLPS-Zyt-0995	Zymoseptoria tritici	51.76	2e-20	90.5
LLPS-Usm-0909	Ustilago maydis	51.76	9e-22	94.7
LLPS-Phn-0460	Phaeosphaeria nodorum	51.35	1e-16	79.3
LLPS-Ast-0417	Aspergillus terreus	51.35	2e-17	81.6
LLPS-Asc-0332	Aspergillus clavatus	51.22	2e-20	90.5
LLPS-Nef-0359	Neosartorya fischeri	51.22	1e-20	91.3
LLPS-Gas-0182	Galdieria sulphuraria	51.19	4e-21	92.4
LLPS-Blg-0351	Blumeria graminis	51.19	6e-23	97.4
LLPS-Pytr-0167	Pyrenophora triticirepentis	51.16	1e-21	94.0
LLPS-Asf-0887	Aspergillus flavus	50.6	3e-20	90.5
LLPS-Gag-0485	Gaeumannomyces graminis	50.59	2e-20	90.9
LLPS-Ved-0894	Verticillium dahliae	50.59	4e-21	92.4
LLPS-Aso-1120	Aspergillus oryzae	50.0	8e-17	80.9
LLPS-Pyt-0153	Pyrenophora teres	50.0	2e-21	93.2
LLPS-Asn-0019	Aspergillus nidulans	49.41	1e-20	90.9
LLPS-Asni-0197	Aspergillus niger	49.41	2e-20	90.1
LLPS-Pug-0483	Puccinia graminis	49.4	7e-21	92.0
LLPS-Map-0769	Magnaporthe poae	48.84	3e-21	93.2
LLPS-Sem-0263	Selaginella moellendorffii	48.84	5e-21	91.7
LLPS-Mel-0381	Melampsora laricipopulina	48.81	1e-20	91.3
LLPS-Trv-0046	Trichoderma virens	48.31	1e-21	94.0
LLPS-Trr-0940	Trichoderma reesei	48.31	1e-21	94.0
LLPS-Beb-0952	Beauveria bassiana	47.73	3e-19	87.0
LLPS-Mao-0800	Magnaporthe oryzae	47.62	7e-20	89.0
LLPS-Miv-0421	Microbotryum violaceum	46.43	6e-18	83.6
LLPS-Coo-0114	Colletotrichum orbiculare	46.07	2e-20	90.1
LLPS-Cogr-0518	Colletotrichum graminicola	46.07	1e-20	91.3
LLPS-Cog-0053	Colletotrichum gloeosporioides	46.07	1e-20	90.9
LLPS-Nec-0159	Neurospora crassa	45.88	1e-15	76.6
LLPS-Fuv-0152	Fusarium verticillioides	44.94	2e-20	90.5
LLPS-Fuo-0698	Fusarium oxysporum	44.94	2e-20	90.5
LLPS-Fus-0642	Fusarium solani	44.94	2e-20	90.5
LLPS-Cym-0134	Cyanidioschyzon merolae	44.44	9e-15	73.9
LLPS-Asfu-0085	Aspergillus fumigatus	38.1	2e-09	58.9

LLPS-Myl-2008GAR1

Protein Sequence

Nucleotide Sequence

LLPS-Myl-2008
GAR1