LLPS-Mum-a737
Agpat5

▼ OVERVIEW

Status: Reviewed
Protein Name: 1-acyl-sn-glycerol-3-phosphate acyltransferase epsilon; 1-acylglycerol-3-phosphate O-acyltransferase 5; 1-AGP acyltransferase 5; 1-AGPAT 5; Lysophosphatidic acid acyltransferase epsilon; LPAAT-epsilon
Gene Name: Agpat5, D8Ertd319e
Ensembl Gene: ENSMUSG00000031467.10
Ensembl Protein: ENSMUSP00000117025.1
Organism: Mus musculus
Taxa ID: 10090
LLPS Type: Others


▼ PROPERTY


——— Disorder propensity (calculated by IUPred2A)

▼ Classification

Condensates:
CondensateDescriptionTissue/CellPMIDs
Postsynaptic density
"...We report the first direct comparison of the proteome of triplicate isolates of mouse and human cortical postsynaptic densities. The mouse postsynaptic density comprised 1556 proteins and the human one 1461."
Mouse cortex23071613

▼ FUNCTION

Converts lysophosphatidic acid (LPA) into phosphatidic acid by incorporating an acyl moiety at the sn-2 position of the glycerol backbone. Acts on LPA containing saturated or unsaturated fatty acids C15:0-C20:4 at the sn-1 position using C18:1-CoA as the acyl donor. Also acts on lysophosphatidylethanolamine using oleoyl-CoA, but not arachidonoyl-CoA, and lysophosphatidylinositol using arachidonoyl-CoA, but not oleoyl-CoA. Activity toward lysophosphatidylglycerol not detectable.

▼ SEQUENCE

Protein Sequence (FASTA)
1     MLLSLVLHTY  SMRYLLPSVL  LLGSAPTYLL  AWTLWRVLSA  LMPARLYQRV  DDRLYCVYQN  60
61    MVLFFFENYT  GVQILLYGDL  PKNKENVIYL  ANHQSTVDWI  VADMLAARQD  ALGHVRYVLK  120
121   DKLKWLPLYG  FYFAQHGGIY  VKRSAKFNDK  EMRSKLQSYV  NAGTPMYLVI  FPEGTRYNAT  180
181   YTKLLSASQA  FAAQRGLAVL  KHVLTPRIKA  THVAFDSMKS  HLDAIYDVTV  VYEGNEKGSG  240
241   KYSNPPSMTE  FLCKQCPKLH  IHFDRIDRNE  VPEEQEHMKK  WLHERFEIKD  RLLIEFYDSP  300
301   DPERRNKFPG  KSVHSRLSVK  KTLPSVLILG  SLTAVMLMTE  SGRKLYMGTW  LYGTLLGCLW  360
361   FVIKA  365
Nucleotide CDS Sequence (FASTA)
1     ATGCTGCTGT  CCCTGGTGCT  CCACACGTAC  TCTATGCGCT  ACCTGCTCCC  CAGCGTCCTG  60
61    TTGCTGGGCT  CGGCGCCCAC  CTACCTGCTG  GCCTGGACGC  TGTGGCGGGT  GCTCTCCGCG  120
121   CTGATGCCCG  CCCGCCTGTA  CCAGCGCGTG  GACGACCGGC  TTTACTGCGT  CTACCAGAAC  180
181   ATGGTGCTCT  TCTTCTTCGA  GAACTACACC  GGGGTCCAGA  TATTGCTATA  TGGAGATTTG  240
241   CCAAAAAATA  AAGAAAATGT  AATATATCTA  GCGAATCATC  AAAGCACAGT  TGACTGGATT  300
301   GTTGCGGACA  TGCTGGCTGC  CAGACAGGAT  GCCCTAGGAC  ATGTGCGCTA  CGTACTGAAA  360
361   GACAAGTTAA  AATGGCTTCC  GCTGTATGGG  TTCTACTTTG  CTCAGCATGG  AGGAATTTAT  420
421   GTAAAACGAA  GTGCCAAATT  TAATGATAAA  GAAATGAGAA  GCAAGCTGCA  GAGCTATGTG  480
481   AACGCAGGAA  CACCGATGTA  TCTTGTGATT  TTCCCAGAGG  GAACAAGGTA  TAATGCAACA  540
541   TACACAAAAC  TCCTTTCAGC  CAGTCAGGCA  TTTGCTGCTC  AGCGGGGCCT  TGCAGTATTA  600
601   AAACACGTAC  TGACACCAAG  AATAAAGGCC  ACTCACGTTG  CTTTTGATTC  TATGAAGAGT  660
661   CATTTAGATG  CAATTTATGA  TGTCACAGTG  GTTTATGAAG  GGAATGAGAA  AGGTTCAGGA  720
721   AAATACTCAA  ATCCACCATC  CATGACTGAG  TTTCTCTGCA  AACAGTGCCC  AAAACTTCAT  780
781   ATTCACTTTG  ATCGTATAGA  CAGAAATGAA  GTTCCAGAGG  AACAAGAACA  CATGAAAAAG  840
841   TGGCTTCATG  AGCGCTTTGA  GATAAAAGAT  AGGTAA  876

▼ KEYWORD

ID
Family
Acyltransferase
Complete proteome
Endoplasmic reticulum
Lipid biosynthesis
Lipid metabolism
Membrane
Mitochondrion
Nucleus
Phospholipid biosynthesis
Phospholipid metabolism
Reference proteome
Transferase
Transmembrane
Transmembrane helix

▼ GENE ONTOLOGY

ID
Classification
Description
Cellular Component
Endoplasmic reticulum membrane
Cellular Component
Integral component of membrane
Cellular Component
Mitochondrion
Cellular Component
Nuclear envelope
Molecular Function
1-acylglycerol-3-phosphate O-acyltransferase activity
Molecular Function
Transferase activity, transferring acyl groups
Biological Process
Acylglycerol metabolic process
Biological Process
CDP-diacylglycerol biosynthetic process
Biological Process
Hematopoietic progenitor cell differentiation
Biological Process
Phospholipid metabolic process

▼ KEGG


▼ ORTHOLOGY

DrLLPS IDOrganismIdentityE-valueScore
LLPS-Mea-a701Mesocricetus auratus95.620.0734
LLPS-Ran-a729Rattus norvegicus95.340.0721
LLPS-Mal-a726Mandrillus leucophaeus82.470.0646
LLPS-Cea-a740Cercocebus atys82.470.0646
LLPS-Mam-a726Macaca mulatta82.470.0646
LLPS-Maf-a735Macaca fascicularis82.470.0646
LLPS-Pat-a737Pan troglodytes82.190.0642
LLPS-Rhb-a728Rhinopithecus bieti82.190.0643
LLPS-Poa-a724Pongo abelii81.970.0537
LLPS-Hos-a748Homo sapiens81.920.0640
LLPS-Pap-a724Pan paniscus81.670.0632
LLPS-Gog-a732Gorilla gorilla81.370.0638
LLPS-Man-a740Macaca nemestrina81.370.0637
LLPS-Otg-a726Otolemur garnettii80.870.0635
LLPS-Paa-a738Papio anubis80.270.0619
LLPS-Caj-a729Callithrix jacchus80.220.0627
LLPS-Aon-a740Aotus nancymaae80.220.0630
LLPS-Orc-a690Oryctolagus cuniculus80.03e-166475
LLPS-Nol-a723Nomascus leucogenys80.00.0616
LLPS-Tut-a390Tursiops truncatus79.794e-175498
LLPS-Sus-a737Sus scrofa79.730.0624
LLPS-Caf-a719Canis familiaris79.454e-176501
LLPS-Urm-a670Ursus maritimus79.340.0522
LLPS-Ere-a180Erinaceus europaeus78.90.0616
LLPS-Cas-a637Carlito syrichta78.690.0602
LLPS-Eqc-a736Equus caballus78.630.0601
LLPS-Aim-a704Ailuropoda melanoleuca77.750.0612
LLPS-Mup-a713Mustela putorius furo77.591e-169484
LLPS-Ova-a716Ovis aries77.45e-173493
LLPS-Fec-a738Felis catus77.260.0605
LLPS-Ora-a611Ornithorhynchus anatinus76.741e-89283
LLPS-Ict-a726Ictidomys tridecemlineatus76.648e-118349
LLPS-Chs-a724Chlorocebus sabaeus76.490.0588
LLPS-Bot-a741Bos taurus76.440.0608
LLPS-Dio-a709Dipodomys ordii76.031e-158455
LLPS-Tag-a641Taeniopygia guttata72.80.0583
LLPS-Anp-a599Anas platyrhynchos72.530.0579
LLPS-Sah-a661Sarcophilus harrisii72.361e-104315
LLPS-Loa-a716Loxodonta africana72.280.0564
LLPS-Fia-a654Ficedula albicollis71.980.0580
LLPS-Gaga-a668Gallus gallus71.980.0579
LLPS-Myl-a686Myotis lucifugus71.932e-51175
LLPS-Meg-a600Meleagris gallopavo71.825e-160460
LLPS-Mod-a702Monodelphis domestica70.560.0553
LLPS-Pes-a630Pelodiscus sinensis70.140.0561
LLPS-Anc-a677Anolis carolinensis68.773e-156451
LLPS-Leo-a642Lepisosteus oculatus66.850.0531
LLPS-Lac-a651Latimeria chalumnae66.767e-179510
LLPS-Cap-a733Cavia porcellus66.763e-174498
LLPS-Asm-a641Astyanax mexicanus65.939e-177505
LLPS-Orn-a643Oreochromis niloticus65.560.0521
LLPS-Icp-a645Ictalurus punctatus65.380.0527
LLPS-Ten-a610Tetraodon nigroviridis65.288e-177505
LLPS-Tar-a611Takifugu rubripes65.288e-178508
LLPS-Orl-a635Oryzias latipes65.01e-178510
LLPS-Scf-a623Scleropages formosus64.740.0525
LLPS-Scm-a621Scophthalmus maximus64.724e-177506
LLPS-Gaa-a630Gasterosteus aculeatus64.441e-172495
LLPS-Dar-a645Danio rerio64.440.0521
LLPS-Xet-a633Xenopus tropicalis63.661e-179512
LLPS-Xim-a652Xiphophorus maculatus63.640.0516
LLPS-Pof-a649Poecilia formosa63.462e-179512