LLPS-Hos-a748
AGPAT5

▼ OVERVIEW

Status: Reviewed
Protein Name: 1-acyl-sn-glycerol-3-phosphate acyltransferase epsilon; 1-acylglycerol-3-phosphate O-acyltransferase 5; 1-AGP acyltransferase 5; 1-AGPAT 5; Lysophosphatidic acid acyltransferase epsilon; LPAAT-epsilon
Gene Name: AGPAT5
Ensembl Gene: ENSG00000155189.11
Ensembl Protein: ENSP00000428152.1
Organism: Homo sapiens
Taxa ID: 9606
LLPS Type: Others


▼ PROPERTY


——— Disorder propensity (calculated by IUPred2A)

▼ Classification

Condensates:
CondensateDescriptionTissue/CellPMIDs
Postsynaptic density
"...We report the first direct comparison of the proteome of triplicate isolates of mouse and human cortical postsynaptic densities. The mouse postsynaptic density comprised 1556 proteins and the human one 1461."
Human cortex23071613

▼ FUNCTION

Converts lysophosphatidic acid (LPA) into phosphatidic acid by incorporating an acyl moiety at the sn-2 position of the glycerol backbone. Acts on LPA containing saturated or unsaturated fatty acids C15:0-C20:4 at the sn-1 position using C18:1-CoA as the acyl donor. Also acts on lysophosphatidylethanolamine using oleoyl-CoA, but not arachidonoyl-CoA, and lysophosphatidylinositol using arachidonoyl-CoA, but not oleoyl-CoA. Activity toward lysophosphatidylglycerol not detectable.

▼ SEQUENCE

Protein Sequence (FASTA)
1     MLLSLVLHTY  SMRYLLPSVV  LLGTAPTYVL  AWGVWRLLSA  FLPARFYQAL  DDRLYCVYQS  60
61    MVLFFFENYT  GVQILLYGDL  PKNKENIIYL  ANHQSTVDWI  VADILAIRQN  ALGHVRYVLK  120
121   EGLKWLPLYG  CYFAQHGGIY  VKRSAKFNEK  EMRNKLQSYV  DAGTPMYLVI  FPEGTRYNPE  180
181   QTKVLSASQA  FAAQRGLAVL  KHVLTPRIKA  THVAFDCMKN  YLDAIYDVTV  VYEGKDDGGQ  240
241   RRESPTMTEF  LCKECPKIHI  HIDRIDKKDV  PEEQEHMRRW  LHERFEIKDK  MLIEFYESPD  300
301   PERRKRFPGK  SVNSKLSIKK  TLPSMLILSG  LTAGMLMTDA  GRKLYVNTWI  YGTLLGCLWV  360
361   TIKA  364
Nucleotide CDS Sequence (FASTA)
1     ATGCTGCTGT  CCCTGGTGCT  CCACACGTAC  TCCATGCGCT  ACCTGCTGCC  CAGCGTCGTG  60
61    CTCCTGGGCA  CGGCGCCCAC  CTACGTGTTG  GCCTGGGGGG  TCTGGCGGCT  GCTCTCCGCC  120
121   TTCCTGCCCG  CCCGCTTCTA  CCAAGCGCTG  GACGACCGGC  TCTACTGCGT  CTACCAGAGC  180
181   ATGGTGCTCT  TCTTCTTCGA  GAATTACACC  GGGGTCCAGA  TATTGCTATA  TGGAGATTTG  240
241   CCAAAAAATA  AAGAAAATAT  AATATATTTA  GCAAATCATC  AAAGCACAGT  TGACTGGATT  300
301   GTTGCTGACA  TCTTGGCCAT  CAGGCAGAAT  GCGCTAGGAC  ATGTGCGCTA  CGTGCTGAAA  360
361   GAAGGGTTAA  AATGGCTGCC  ATTGTATGGG  TGTTACTTTG  CTCAGCATGG  AGGAATCTAT  420
421   GTAAAGCGCA  GTGCCAAATT  TAACGAGAAA  GAGATGCGAA  ACAAGTTGCA  GAGCTACGTG  480
481   GACGCAGGAA  CTCCAATGTA  TCTTGTGATT  TTTCCAGAAG  GTACAAGGTA  TAATCCAGAG  540
541   CAAACAAAAG  TCCTTTCAGC  TAGTCAGGCA  TTTGCTGCCC  AACGTGGCCT  TGCAGTATTA  600
601   AAACATGTGC  TAACACCACG  AATAAAGGCA  ACTCACGTTG  CTTTTGATTG  CATGAAGAAT  660
661   TATTTAGATG  CAATTTATGA  TGTTACGGTG  GTTTATGAAG  GGAAAGACGA  TGGAGGGCAG  720
721   CGAAGAGAGT  CACCGACCAT  GACGGAATTT  CTCTGCAAAG  AATGTCCAAA  AATTCATATT  780
781   CACATTGATC  GTATCGACAA  AAAAGATGTC  CCAGAAGAAC  AAGAACATAT  GAGAAGATGG  840
841   CTGCATGAAC  GTTTCGAAAT  CAAAGATAAG  ATGCTTATAG  AATTTTATGA  GTCACCAGAT  900
901   CCAGAAAGAA  GAAAAAGATT  TCCTGGGAAA  AGTGTTAATT  CCAAATTAAG  TATCAAGAAG  960
961   ACTTTACCAT  CAATGTTGAT  CTTAAGTGGT  TTGACTGCAG  GCATGCTTAT  GACCGATGCT  1020
1021  GGAAGGAAGC  TGTATGTGAA  CACCTGGATA  TATGGAACCC  TACTTGGCTG  CCTGTGGGTT  1080
1081  ACTATTAAAG  CATAG  1095

▼ KEYWORD

ID
Family
Acyltransferase
Complete proteome
Endoplasmic reticulum
Lipid biosynthesis
Lipid metabolism
Membrane
Mitochondrion
Nucleus
Phospholipid biosynthesis
Phospholipid metabolism
Polymorphism
Reference proteome
Transferase
Transmembrane
Transmembrane helix

▼ GENE ONTOLOGY

ID
Classification
Description
Cellular Component
Endoplasmic reticulum membrane
Cellular Component
Integral component of membrane
Cellular Component
Mitochondrial outer membrane
Cellular Component
Mitochondrion
Cellular Component
Nuclear envelope
Molecular Function
1-acylglycerol-3-phosphate O-acyltransferase activity
Molecular Function
Transferase activity, transferring acyl groups
Biological Process
Acylglycerol metabolic process
Biological Process
CDP-diacylglycerol biosynthetic process
Biological Process
Hematopoietic progenitor cell differentiation
Biological Process
Phosphatidic acid biosynthetic process
Biological Process
Phospholipid biosynthetic process
Biological Process
Phospholipid metabolic process

▼ KEGG


▼ ORTHOLOGY

DrLLPS IDOrganismIdentityE-valueScore
LLPS-Pat-a737Pan troglodytes99.730.0758
LLPS-Poa-a724Pongo abelii99.670.0636
LLPS-Gog-a732Gorilla gorilla99.450.0757
LLPS-Rhb-a728Rhinopithecus bieti99.450.0756
LLPS-Pap-a724Pan paniscus99.440.0748
LLPS-Mal-a726Mandrillus leucophaeus99.180.0753
LLPS-Cea-a740Cercocebus atys99.180.0753
LLPS-Mam-a726Macaca mulatta99.180.0753
LLPS-Maf-a735Macaca fascicularis99.180.0753
LLPS-Man-a740Macaca nemestrina97.80.0742
LLPS-Nol-a723Nomascus leucogenys97.250.0731
LLPS-Paa-a738Papio anubis96.150.0719
LLPS-Aon-a740Aotus nancymaae94.770.0726
LLPS-Caj-a729Callithrix jacchus94.490.0723
LLPS-Chs-a724Chlorocebus sabaeus92.410.0692
LLPS-Otg-a726Otolemur garnettii89.010.0697
LLPS-Urm-a670Ursus maritimus88.520.0575
LLPS-Orc-a690Oryctolagus cuniculus87.770.0521
LLPS-Caf-a719Canis familiaris87.670.0548
LLPS-Sus-a737Sus scrofa87.670.0682
LLPS-Aim-a704Ailuropoda melanoleuca87.360.0676
LLPS-Eqc-a736Equus caballus87.120.0659
LLPS-Tut-a390Tursiops truncatus86.990.0542
LLPS-Mup-a713Mustela putorius furo86.60.0533
LLPS-Cas-a637Carlito syrichta86.30.0657
LLPS-Fec-a738Felis catus86.030.0669
LLPS-Ere-a180Erinaceus europaeus86.030.0667
LLPS-Ict-a726Ictidomys tridecemlineatus85.451e-133389
LLPS-Ova-a716Ovis aries84.930.0537
LLPS-Bot-a741Bos taurus84.490.0659
LLPS-Mea-a701Mesocricetus auratus83.010.0647
LLPS-Mum-a737Mus musculus81.920.0640
LLPS-Dio-a709Dipodomys ordii81.11e-169483
LLPS-Ora-a611Ornithorhynchus anatinus80.231e-93293
LLPS-Ran-a729Rattus norvegicus80.00.0622
LLPS-Myl-a686Myotis lucifugus79.821e-58194
LLPS-Sah-a661Sarcophilus harrisii79.41e-115343
LLPS-Loa-a716Loxodonta africana78.530.0609
LLPS-Gaga-a668Gallus gallus77.470.0611
LLPS-Tag-a641Taeniopygia guttata77.20.0613
LLPS-Anp-a599Anas platyrhynchos77.20.0610
LLPS-Fia-a654Ficedula albicollis76.920.0612
LLPS-Mod-a702Monodelphis domestica76.860.0599
LLPS-Meg-a600Meleagris gallopavo76.291e-168481
LLPS-Pes-a630Pelodiscus sinensis76.160.0602
LLPS-Anc-a677Anolis carolinensis72.376e-166475
LLPS-Cap-a733Cavia porcellus71.90.0533
LLPS-Lac-a651Latimeria chalumnae69.780.0535
LLPS-Pof-a649Poecilia formosa69.510.0550
LLPS-Xet-a633Xenopus tropicalis69.130.0549
LLPS-Dar-a645Danio rerio68.870.0551
LLPS-Xim-a652Xiphophorus maculatus68.60.0549
LLPS-Leo-a642Lepisosteus oculatus68.580.0546
LLPS-Asm-a641Astyanax mexicanus68.134e-180513
LLPS-Scf-a623Scleropages formosus67.770.0546
LLPS-Orn-a643Oreochromis niloticus67.40.0535
LLPS-Tar-a611Takifugu rubripes66.940.0523
LLPS-Scm-a621Scophthalmus maximus66.940.0520
LLPS-Icp-a645Ictalurus punctatus66.760.0536
LLPS-Orl-a635Oryzias latipes66.670.0520
LLPS-Ten-a610Tetraodon nigroviridis66.30.0519
LLPS-Gaa-a630Gasterosteus aculeatus66.022e-178509