LLPS-Mum-a686
Arfgap2

▼ OVERVIEW

Status: Reviewed
Protein Name: ADP-ribosylation factor GTPase-activating protein 2
Gene Name: Arfgap2, Zfp289, Znf289
Ensembl Gene: ENSMUSG00000027255.14
Ensembl Protein: ENSMUSP00000028691.6
Organism: Mus musculus
Taxa ID: 10090
LLPS Type: Others


▼ PROPERTY


——— Disorder propensity (calculated by IUPred2A)

▼ Classification

Condensates:
CondensateDescriptionTissue/CellPMIDs
Postsynaptic density
"...We report the first direct comparison of the proteome of triplicate isolates of mouse and human cortical postsynaptic densities. The mouse postsynaptic density comprised 1556 proteins and the human one 1461."
Mouse cortex23071613

▼ FUNCTION

GTPase-activating protein (GAP) for ADP ribosylation factor 1 (ARF1). May regulate coatomer-mediated protein transport from the Golgi complex to the endoplasmic reticulum. Hydrolysis of ARF1-bound GTP may lead to dissociation of coatomer from Golgi-derived membranes to allow fusion with target membranes (By similarity).

▼ SEQUENCE

Protein Sequence (FASTA)
1     MAASPSKTEI  QTIFKRLRAI  PTNKACFDCG  AKSPSWASIT  YGVFLCIDCS  GVHRSLGVHL  60
61    SFIRSTELDS  NWSWLQLRCM  QVGGNANATA  FFRQHGCMAN  DANTKYTSRA  AQMYREKIRQ  120
121   LGSAALTRHG  TDLWIDSMNS  APSHSPEKKD  SDFFTEHTQA  PAWDTAATDP  SGTQQPALPS  180
181   ESSSLAQPEQ  GPNTDLLGTS  PQASLESMYL  SAKGPSCTRE  LKSSIIGKKK  PAAAKKGLGA  240
241   KKGLGAQKVS  NQSFTEIERQ  AQVAEKLREQ  QAADAKKQAE  ESMVASMRLA  YQELQIDRKK  300
301   EEKKLQNLEG  KKREQAERLG  MGLVSRSSIS  HSVLSEMQMI  EQETPLSAKS  SRSQLDLFDD  360
361   VGTFASGPPK  YKDNPFSLGE  TFGSRWDSDA  AWGMDRVEEK  EPEVTISSIR  PISERTASRR  420
421   EVETRSSGLE  SSEARQKFAG  AKAISSDMFF  GREVDSEYEA  RSRLQQLSGS  SAISSSDLFG  480
481   NMDGAHGGGT  VSLGNVLPTA  DIAQFKQGVK  SVAGKMAVLA  NGVMNSLQDR  YGSY  534
Nucleotide CDS Sequence (FASTA)
1     ATGGCGGCGA  GCCCGAGCAA  GACCGAAATC  CAGACTATTT  TTAAGAGACT  TCGCGCAATT  60
61    CCCACCAACA  AGGCCTGTTT  CGATTGTGGC  GCCAAGAGTC  CTAGTTGGGC  CAGCATCACT  120
121   TACGGTGTAT  TTTTGTGTAT  TGACTGCTCC  GGAGTGCATC  GCTCCTTGGG  TGTCCATCTC  180
181   AGCTTTATCA  GGTCCACAGA  GTTGGATTCG  AACTGGAGCT  GGTTGCAGCT  GAGGTGTATG  240
241   CAGGTCGGCG  GGAATGCCAA  TGCGACTGCT  TTTTTCCGCC  AACACGGATG  TATGGCCAAT  300
301   GATGCTAACA  CCAAATATAC  GAGCCGAGCT  GCCCAGATGT  ACCGAGAGAA  GATCCGGCAG  360
361   TTAGGGAGTG  CAGCTCTGAC  TAGGCATGGT  ACTGATCTTT  GGATAGACAG  TATGAACAGT  420
421   GCTCCAAGTC  ACTCTCCAGA  GAAGAAAGAC  TCTGATTTCT  TCACAGAACA  TACTCAGGCC  480
481   CCTGCTTGGG  ATACAGCAGC  CACTGATCCT  TCAGGGACTC  AGCAACCAGC  CCTACCTTCA  540
541   GAGAGCAGTA  GCCTGGCACA  ACCTGAACAA  GGCCCTAACA  CTGATCTGCT  CGGAACCTCA  600
601   CCCCAAGCCT  CTCTGGAGTC  CATGTATCTG  TCAGCTAAAG  GGCCCTCTTG  TACCAGAGAA  660
661   CTGAAAAGCT  CCATTATTGG  CAAGAAGAAG  CCAGCAGCCG  CTAAGAAAGG  GCTGGGTGCC  720
721   AAGAAAGGCC  TGGGAGCTCA  GAAGGTGAGC  AACCAGAGCT  TTACTGAGAT  TGAGCGGCAG  780
781   GCCCAGGTGG  CAGAGAAGCT  CCGAGAGCAG  CAGGCAGCTG  ATGCCAAGAA  GCAGGCAGAA  840
841   GAGTCCATGG  TTGCCTCCAT  GCGTCTGGCC  TACCAGGAGC  TCCAGATTGA  TCGCAAGAAG  900
901   GAGGAGAAAA  AGCTCCAGAA  TCTTGAAGGA  AAGAAGCGAG  AGCAGGCTGA  AAGGCTGGGC  960
961   ATGGGCTTGG  TGTCCCGAAG  CTCCATCTCC  CATTCTGTGC  TGTCTGAGAT  GCAGATGATT  1020
1021  GAGCAGGAAA  CCCCGCTGAG  TGCGAAATCT  TCCCGTTCAC  AGCTTGACTT  GTTTGATGAT  1080
1081  GTTGGAACAT  TTGCATCTGG  ACCCCCAAAG  TACAAGGACA  ACCCCTTTTC  CTTGGGAGAA  1140
1141  ACTTTTGGTT  CCCGCTGGGA  TTCAGATGCA  GCCTGGGGTA  TGGACAGGGT  AGAAGAGAAG  1200
1201  GAACCTGAAG  TTACCATCTC  CAGCATCCGG  CCTATTTCAG  AAAGAACTGC  GAGTCGGAGG  1260
1261  GAAGTGGAGA  CTCGGAGCTC  AGGCCTTGAG  TCCAGTGAAG  CACGGCAGAA  GTTTGCAGGA  1320
1321  GCCAAAGCCA  TCTCGTCCGA  CATGTTCTTT  GGTCGTGAGG  TGGATTCTGA  GTATGAAGCT  1380
1381  AGGTCTCGGT  TACAGCAGCT  TTCGGGCAGC  AGTGCCATCA  GCTCTTCAGA  CCTTTTTGGA  1440
1441  AACATGGATG  GAGCTCATGG  AGGAGGAACT  GTATCTCTGG  GGAATGTACT  TCCTACAGCT  1500
1501  GACATTGCCC  AGTTTAAGCA  GGGTGTCAAG  TCTGTGGCTG  GCAAGATGGC  TGTGCTGGCC  1560
1561  AATGGTGTGA  TGAATTCCTT  ACAGGATCGC  TACGGTTCCT  ACTGA  1605

▼ KEYWORD

ID
Family
Acetylation
Alternative splicing
Coiled coil
Complete proteome
Cytoplasm
ER-Golgi transport
Golgi apparatus
GTPase activation
Membrane
Metal-binding
Phosphoprotein
Protein transport
Reference proteome
Transport
Zinc
Zinc-finger

▼ GENE ONTOLOGY

ID
Classification
Description
Cellular Component
Cytosol
Cellular Component
Golgi apparatus
Cellular Component
Golgi membrane
Cellular Component
Plasma membrane
Cellular Component
Trans-Golgi network
Molecular Function
GTPase activator activity
Molecular Function
Metal ion binding
Biological Process
COPI coating of Golgi vesicle
Biological Process
Endoplasmic reticulum to Golgi vesicle-mediated transport
Biological Process
Protein transport
Biological Process
Retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum

▼ KEGG


▼ ORTHOLOGY

DrLLPS IDOrganismIdentityE-valueScore
LLPS-Ran-a677Rattus norvegicus94.760.01039
LLPS-Mea-a644Mesocricetus auratus92.880.0982
LLPS-Sus-a685Sus scrofa91.390.0949
LLPS-Chs-a669Chlorocebus sabaeus91.030.0987
LLPS-Ict-a674Ictidomys tridecemlineatus90.820.0968
LLPS-Eqc-a681Equus caballus90.450.0942
LLPS-Hos-a692Homo sapiens90.090.0931
LLPS-Gog-a676Gorilla gorilla90.090.0931
LLPS-Otg-a675Otolemur garnettii90.070.0929
LLPS-Cap-a680Cavia porcellus90.070.0969
LLPS-Pat-a681Pan troglodytes89.910.0928
LLPS-Poa-a674Pongo abelii89.910.0929
LLPS-Pap-a672Pan paniscus89.720.0922
LLPS-Paa-a682Papio anubis89.530.0943
LLPS-Mal-a670Mandrillus leucophaeus89.350.0942
LLPS-Rhb-a674Rhinopithecus bieti89.350.0942
LLPS-Cea-a686Cercocebus atys89.160.0939
LLPS-Bot-a687Bos taurus89.140.0929
LLPS-Caj-a675Callithrix jacchus88.970.0936
LLPS-Maf-a683Macaca fascicularis88.970.0939
LLPS-Man-a686Macaca nemestrina88.970.0939
LLPS-Mam-a672Macaca mulatta88.970.0939
LLPS-Fud-a659Fukomys damarensis88.760.0915
LLPS-Cas-a589Carlito syrichta88.760.0951
LLPS-Mup-a660Mustela putorius furo88.580.0913
LLPS-Loa-a663Loxodonta africana87.970.0940
LLPS-Tut-a367Tursiops truncatus87.830.0908
LLPS-Orc-a641Oryctolagus cuniculus87.640.0927
LLPS-Fec-a683Felis catus87.450.0900
LLPS-Caf-a666Canis familiaris87.080.0924
LLPS-Aim-a653Ailuropoda melanoleuca86.890.0894
LLPS-Urm-a621Ursus maritimus86.70.0890
LLPS-Dio-a656Dipodomys ordii86.280.0860
LLPS-Nol-a671Nomascus leucogenys84.670.0858
LLPS-Ova-a667Ovis aries82.970.0820
LLPS-Mod-a650Monodelphis domestica82.80.0873
LLPS-Myl-a636Myotis lucifugus82.580.0855
LLPS-Ora-a566Ornithorhynchus anatinus81.340.0863
LLPS-Aon-a685Aotus nancymaae78.70.0812
LLPS-Fia-a603Ficedula albicollis76.940.0807
LLPS-Gaga-a615Gallus gallus76.560.0796
LLPS-Tag-a592Taeniopygia guttata75.140.0775
LLPS-Meg-a552Meleagris gallopavo74.90.0744
LLPS-Anp-a553Anas platyrhynchos74.760.0748
LLPS-Pes-a582Pelodiscus sinensis72.320.0649
LLPS-Sah-a613Sarcophilus harrisii71.030.0671
LLPS-Anc-a626Anolis carolinensis70.650.0753
LLPS-Leo-a594Lepisosteus oculatus70.110.0777
LLPS-Pof-a597Poecilia formosa69.490.0715
LLPS-Xim-a600Xiphophorus maculatus68.060.0691
LLPS-Scf-a573Scleropages formosus67.090.0709
LLPS-Xet-a588Xenopus tropicalis66.730.0694
LLPS-Dar-a596Danio rerio66.550.0731
LLPS-Tar-a562Takifugu rubripes66.240.0709
LLPS-Ten-a561Tetraodon nigroviridis66.190.0712
LLPS-Orn-a591Oreochromis niloticus66.180.0694
LLPS-Icp-a597Ictalurus punctatus65.70.0700
LLPS-Orl-a586Oryzias latipes65.510.0657
LLPS-Scm-a571Scophthalmus maximus64.910.0658
LLPS-Gaa-a578Gasterosteus aculeatus63.130.0688
LLPS-Asm-a591Astyanax mexicanus62.480.0641
LLPS-Sot-a077Solanum tuberosum61.682e-38152
LLPS-Cus-a047Cucumis sativus60.951e-37149
LLPS-Nia-a081Nicotiana attenuata60.758e-38150
LLPS-Coc-a077Corchorus capsularis60.684e-40157
LLPS-Pot-a091Populus trichocarpa60.03e-39154
LLPS-Mae-a094Manihot esculenta59.831e-38152
LLPS-Sem-a064Selaginella moellendorffii59.815e-37140
LLPS-Viv-a080Vitis vinifera59.132e-38152
LLPS-Thc-a081Theobroma cacao58.976e-39154
LLPS-Lac-a604Latimeria chalumnae58.90.0565
LLPS-Mua-a095Musa acuminata58.268e-38150
LLPS-Sol-a082Solanum lycopersicum58.121e-38153
LLPS-Prp-a072Prunus persica57.945e-36145
LLPS-Phv-a084Phaseolus vulgaris57.393e-37149
LLPS-Met-a061Medicago truncatula57.392e-38152
LLPS-Gor-a099Gossypium raimondii57.147e-38150
LLPS-Dac-a048Daucus carota57.146e-38150
LLPS-Glm-a108Glycine max54.22e-38152
LLPS-Brn-a121Brassica napus53.794e-39154
LLPS-Chr-a097Chlamydomonas reinhardtii53.392e-35144
LLPS-Cym-a024Cyanidioschyzon merolae53.151e-31133
LLPS-Sei-a083Setaria italica53.159e-40158
LLPS-Brr-a096Brassica rapa53.032e-38152
LLPS-Bro-a099Brassica oleracea50.341e-38153
LLPS-Scj-a036Schizosaccharomyces japonicus50.06e-38152
LLPS-Osl-a045Ostreococcus lucimarinus50.01e-24110