LLPS-Mum-a340
Cspg5

▼ OVERVIEW

Status: Reviewed
Protein Name: Chondroitin sulfate proteoglycan 5; Acidic leucine-rich EGF-like domain-containing brain protein; Neuroglycan C
Gene Name: Cspg5, Caleb, Ngc
Ensembl Gene: ENSMUSG00000032482.9
Ensembl Protein: ENSMUSP00000035058.5
Organism: Mus musculus
Taxa ID: 10090
LLPS Type: Others


▼ PROPERTY


——— Disorder propensity (calculated by IUPred2A)

▼ Classification

Condensates:
CondensateDescriptionTissue/CellPMIDs
Postsynaptic density
"...We report the first direct comparison of the proteome of triplicate isolates of mouse and human cortical postsynaptic densities. The mouse postsynaptic density comprised 1556 proteins and the human one 1461."
Mouse cortex23071613

▼ FUNCTION

May function as a growth and differentiation factor involved in neuritogenesis. May induce ERBB3 activation.

▼ SEQUENCE

Protein Sequence (FASTA)
1     MGRAGGGGPD  WGPPPVLLLL  GVTLVLTAGA  VPARETGSAI  EAEELVRSSL  AWESRANDTR  60
61    EEAGLPAAGE  DETSWTERGS  EMAAVGPGVG  PEEALEASAA  VTGTAWLEAD  GPGLGGVTAE  120
121   AGSGDAQTLP  ATLQAPDEAL  GSSTMPPAIP  EATETSGPPS  PAVHDKPSVG  PELPKEIPLE  180
181   VRLNLGGSTP  EPTFPLQGTL  ETQPASDIID  IDYFEGLDSE  GRGADMGSFP  GSPGTSENHP  240
241   DTEGETPSWS  LLDLYDDFTP  FDESDFYPTT  SFYDDLEEEE  EEEEDKDTVG  GGDLEDENDL  300
301   LLPSQKPGVG  PGTGQPTNRW  HAVPPQHTLG  MVPGSSISLR  PRPGDPGKDL  ASGENGTECR  360
361   VGFVRHNGSC  RSVCDLFPSY  CHNGGQCYLV  ENIGAFCRCN  TQDYIWHKGM  RCESIITDFQ  420
421   VMCVAVGSAA  LVLLLLFMMT  VFFAKKLYLL  KTENTKLRRT  NKFRTPSELH  NDNFSLSTIA  480
481   EGSHPNVRKF  CDTPRVSSPH  ARALAHYDNI  VCQVTYLPHI  SPFACLCPCL  PLPPCPLALS  540
541   QSRQSPNSFE  DQLRATQWCR  ERCIDSLTV  569
Nucleotide CDS Sequence (FASTA)
1     ATGGGCCGAG  CTGGAGGCGG  GGGCCCGGAC  TGGGGGCCGC  CGCCAGTGCT  GCTGCTTCTG  60
61    GGGGTCACGC  TGGTGCTCAC  CGCTGGGGCC  GTACCGGCAC  GGGAAACAGG  CAGTGCGATC  120
121   GAGGCTGAAG  AGCTGGTGAG  GAGCAGCCTG  GCATGGGAGT  CGCGTGCCAA  TGACACGCGG  180
181   GAGGAAGCCG  GCCTGCCAGC  AGCTGGGGAA  GATGAGACCT  CGTGGACAGA  GCGGGGCAGT  240
241   GAGATGGCTG  CGGTGGGCCC  TGGGGTCGGG  CCAGAGGAGG  CACTAGAGGC  ATCGGCTGCA  300
301   GTGACTGGCA  CTGCCTGGCT  AGAGGCAGAT  GGCCCAGGCC  TGGGTGGAGT  GACTGCAGAG  360
361   GCTGGCAGTG  GCGACGCCCA  GACCCTTCCA  GCTACGCTCC  AGGCTCCTGA  TGAGGCCCTT  420
421   GGGTCATCTA  CAATGCCCCC  TGCCATCCCT  GAGGCTACTG  AAACCAGTGG  ACCTCCCTCC  480
481   CCTGCTGTCC  ATGATAAGCC  TAGTGTAGGC  CCTGAACTCC  CTAAAGAGAT  CCCCTTGGAG  540
541   GTTCGGCTGA  ACCTGGGAGG  CAGCACACCA  GAGCCCACTT  TTCCCCTTCA  GGGCACTCTC  600
601   GAGACCCAAC  CAGCCTCAGA  TATAATTGAC  ATTGATTACT  TTGAAGGATT  GGATAGTGAG  660
661   GGTCGTGGTG  CAGACATGGG  CAGCTTCCCG  GGGTCACCAG  GAACCTCAGA  AAATCACCCT  720
721   GATACCGAAG  GAGAGACCCC  TTCCTGGAGC  CTGCTTGATT  TGTATGATGA  CTTCACCCCT  780
781   TTTGATGAGT  CTGATTTCTA  CCCCACCACA  TCCTTCTATG  ATGATTTGGA  AGAGGAGGAA  840
841   GAAGAGGAGG  AGGATAAGGA  TACAGTAGGA  GGTGGAGACC  TGGAAGATGA  AAACGACCTT  900
901   CTCCTGCCCT  CTCAAAAGCC  TGGTGTGGGG  CCTGGGACAG  GACAGCCCAC  CAACCGGTGG  960
961   CATGCTGTTC  CCCCACAGCA  TACTCTGGGG  ATGGTACCTG  GCAGCAGCAT  CTCTCTTAGG  1020
1021  CCCCGCCCCG  GAGATCCAGG  CAAGGACCTG  GCCTCAGGAG  AAAATGGCAC  AGAGTGCCGA  1080
1081  GTTGGCTTCG  TCAGGCACAA  TGGCTCCTGC  CGGTCAGTCT  GTGACCTCTT  TCCGAGTTAC  1140
1141  TGTCACAACG  GCGGCCAGTG  CTACCTGGTG  GAGAACATAG  GGGCTTTCTG  CAGGTGTAAC  1200
1201  ACCCAGGACT  ACATCTGGCA  CAAGGGGATG  CGCTGTGAGT  CCATCATCAC  GGACTTCCAG  1260
1261  GTGATGTGCG  TGGCCGTTGG  CTCGGCTGCT  CTCGTGCTTC  TCCTCCTGTT  CATGATGACT  1320
1321  GTGTTCTTTG  CCAAGAAGCT  CTATCTGCTC  AAGACTGAGA  ATACCAAGCT  GCGGAGGACC  1380
1381  AATAAATTCC  GGACCCCATC  TGAGCTCCAC  AACGACAACT  TCTCCCTCTC  CACCATTGCC  1440
1441  GAGGGCTCTC  ATCCAAATGT  AAGGAAATTT  TGCGACACTC  CCCGTGTCTC  CTCCCCCCAT  1500
1501  GCCCGTGCCT  TGGCTCACTA  TGATAACATT  GTCTGTCAGG  ACGACCCCAG  CGCTCCCCAC  1560
1561  AAAATCCAGG  ACCCTCTCAA  GTCCCGCCTG  AAGGAGGAAG  AGTCCTTTAA  CATCCAGAAC  1620
1621  TCCATGTCAC  CCAAACTTGA  GGGTGGCAAA  GGTGACCAGG  ATGACTTGGG  GGTGAACTGT  1680
1681  CTGCAGAATA  ACCTAACCTG  A  1701

▼ KEYWORD

ID
Family
Alternative splicing
Cell membrane
Complete proteome
Developmental protein
Differentiation
Disulfide bond
EGF-like domain
Endoplasmic reticulum
Glycoprotein
Golgi apparatus
Growth regulation
Membrane
Neurogenesis
Phosphoprotein
Proteoglycan
Reference proteome
Signal
Transmembrane
Transmembrane helix

▼ GENE ONTOLOGY

ID
Classification
Description
Cellular Component
Cell surface
Cellular Component
Endoplasmic reticulum membrane
Cellular Component
GABA-ergic synapse
Cellular Component
Glutamatergic synapse
Cellular Component
Golgi apparatus
Cellular Component
Golgi membrane
Cellular Component
Golgi-associated vesicle membrane
Cellular Component
Integral component of postsynaptic membrane
Biological Process
Cytoskeleton organization
Biological Process
Glial cell projection elongation
Biological Process
Modulation of chemical synaptic transmission
Biological Process
Positive regulation of substrate adhesion-dependent cell spreading
Biological Process
Regulation of growth
Biological Process
Regulation of synaptic vesicle exocytosis
Biological Process
Trans-synaptic signaling, modulating synaptic transmission

▼ KEGG


▼ ORTHOLOGY

DrLLPS IDOrganismIdentityE-valueScore
LLPS-Ran-a336Rattus norvegicus94.110.0914
LLPS-Nol-a330Nomascus leucogenys93.281e-172501
LLPS-Mea-a311Mesocricetus auratus90.520.0849
LLPS-Meg-a279Meleagris gallopavo88.769e-37140
LLPS-Mup-a332Mustela putorius furo87.610.0598
LLPS-Ict-a333Ictidomys tridecemlineatus87.530.0862
LLPS-Mal-a326Mandrillus leucophaeus86.080.0728
LLPS-Myl-a320Myotis lucifugus85.844e-49175
LLPS-Pap-a331Pan paniscus85.390.0811
LLPS-Gog-a331Gorilla gorilla84.750.0751
LLPS-Aim-a325Ailuropoda melanoleuca84.740.0795
LLPS-Caj-a332Callithrix jacchus84.730.0762
LLPS-Pat-a332Pan troglodytes84.720.0835
LLPS-Hos-a340Homo sapiens84.720.0831
LLPS-Cas-a306Carlito syrichta84.530.0746
LLPS-Aon-a340Aotus nancymaae84.410.0821
LLPS-Eqc-a341Equus caballus84.350.0752
LLPS-Rhb-a328Rhinopithecus bieti84.210.0813
LLPS-Maf-a336Macaca fascicularis84.10.0741
LLPS-Mam-a332Macaca mulatta83.980.0794
LLPS-Man-a335Macaca nemestrina83.950.0794
LLPS-Chs-a332Chlorocebus sabaeus83.940.0802
LLPS-Cea-a336Cercocebus atys83.940.0802
LLPS-Otg-a337Otolemur garnettii83.880.0796
LLPS-Bot-a340Bos taurus83.830.0739
LLPS-Paa-a335Papio anubis83.540.0800
LLPS-Fia-a291Ficedula albicollis82.521e-48173
LLPS-Gaga-a300Gallus gallus82.319e-63228
LLPS-Sus-a338Sus scrofa81.340.0709
LLPS-Fec-a336Felis catus81.210.0741
LLPS-Pes-a297Pelodiscus sinensis81.011e-30122
LLPS-Fud-a329Fukomys damarensis80.530.0761
LLPS-Ova-a329Ovis aries80.470.0680
LLPS-Dio-a328Dipodomys ordii80.240.0748
LLPS-Loa-a327Loxodonta africana79.140.0781
LLPS-Cap-a334Cavia porcellus78.570.0692
LLPS-Urm-a308Ursus maritimus76.520.0652
LLPS-Orc-a323Oryctolagus cuniculus76.450.0716
LLPS-Sah-a313Sarcophilus harrisii64.045e-177519
LLPS-Icp-a300Ictalurus punctatus61.383e-55202
LLPS-Mod-a320Monodelphis domestica61.130.0566
LLPS-Gaa-a1023Gasterosteus aculeatus55.423e-52192
LLPS-Asm-a292Astyanax mexicanus54.736e-70239