LLPS-Hos-a340
CSPG5
▼ OVERVIEW
| Status: | Unreviewed |
| Protein Name: | Chondroitin sulfate proteoglycan 5; Acidic leucine-rich EGF-like domain-containing brain protein; Neuroglycan C |
| Gene Name: | CSPG5, CALEB, NGC |
| Ensembl Gene: | ENSG00000114646.9 |
| Ensembl Protein: | ENSP00000392096.1 |
| Organism: | Homo sapiens |
| Taxa ID: | 9606 |
| LLPS Type: | Others |
▼ Classification
Condensates:
| Condensate | Evidence | Orthologs |
|---|---|---|
| Postsynaptic density | Predicted from orthologs | (View) |
▼ FUNCTION
| May function as a growth and differentiation factor involved in neuritogenesis. May induce ERBB3 activation. |
▼ CROSS REFERENCE
| Database | Nucleotide ID | Protein ID |
|---|---|---|
| Ensembl | ENST00000456150.5 | ENSP00000392096.1 |
| Ensembl | ENST00000383738.6 | ENSP00000373244.2 |
| Ensembl | ENST00000610462.1 | ENSP00000478923.1 |
| Ensembl | ENST00000264723.8 | ENSP00000264723.4 |
| UniProt | O95196, CSPG5_HUMAN, Q71M39, Q71M40 | |
| GeneBank | AF461089, AC099778, AF461087, AF461088, AC112512, AF059274 | AAQ04776.1, AAQ04774.1, AAC69612.1, AAQ04775.1 |
| RefSeq | NM_001206943.1, NM_001206944.1, NM_006574.3 | NP_001193872.1, NP_001193873.1, NP_006565.2 |
| Entrez | 10675 |
▼ SEQUENCE
| Protein Sequence (FASTA) |
|---|
1 MGRAGGGGPG RGPPPLLLFL GAALVLASGA VPAREAGSAV EAEELVKGSP AWEPPANDTR 60 61 EEAGPPAAGE DEASWTAPGG ELAGPEEVLQ ESAAVTGTAW LEADSPGLGG VTAEAGSGDA 120 121 QALPATLQAP HEVLGQSIMP PAIPEATEAS GPPSPTPGDK LSPASELPKE SPLEVWLNLG 180 181 GSTPDPQGPE LTYPFQGTLE PQPASDIIDI DYFEGLDGEG RGADLGSFPG SPGTSENHPD 240 241 TEGETPSWSL LDLYDDFTPF DESDFYPTTS FYDDLDEEEE EEEDDKDAVG GGDLEDENEL 300 301 LVPTGKPGLG PGTGQPTSRW HAVPPQHTLG SVPGSSIALR PRPGEPGRDL ASSENGTECR 360 361 SGFVRHNGSC RSVCDLFPSY CHNGGQCYLV ENIGAFCRCN TQDYIWHKGM RCESIITDFQ 420 421 VMCVAVGSAA LVLLLLFMMT VFFAKKLYLL KTENTKLRRT NKFRTPSELH NDNFSLSTIA 480 481 EGSHPNVRKL CNTPRTSSPH ARALAHYDNV ICQDDPSAPH KIQEVLKSCL KEEESFNIQN 540 541 SMSPKLEGGK GDQADLDVNC LQNNLT 566 |
| Nucleotide CDS Sequence (FASTA) |
1 ATGGGGCGAG CCGGGGGCGG GGGCCCGGGC CGGGGGCCGC CGCCACTGCT GCTGTTTCTG 60 61 GGGGCCGCGC TGGTCCTGGC CTCTGGGGCC GTGCCGGCGC GTGAGGCGGG CAGCGCGGTT 120 121 GAGGCCGAAG AGCTGGTGAA GGGCAGCCCG GCGTGGGAGC CGCCTGCCAA CGACACGCGG 180 181 GAAGAAGCCG GCCCACCAGC GGCTGGGGAA GATGAGGCGT CGTGGACGGC GCCCGGTGGC 240 241 GAGCTGGCCG GGCCAGAAGA GGTGCTGCAG GAGTCGGCTG CGGTGACCGG CACCGCCTGG 300 301 CTGGAAGCTG ACAGCCCAGG CCTGGGAGGA GTGACCGCAG AGGCGGGCAG CGGCGATGCC 360 361 CAGGCCCTTC CAGCTACGCT CCAGGCTCCC CACGAGGTCC TCGGGCAGTC AATCATGCCC 420 421 CCTGCCATTC CTGAGGCTAC AGAGGCCAGC GGGCCACCCT CCCCCACCCC CGGCGACAAG 480 481 CTGAGCCCAG CTTCTGAACT CCCCAAGGAG AGCCCCTTGG AGGTTTGGCT GAACCTGGGG 540 541 GGCAGCACAC CCGACCCTCA AGGGCCAGAG CTGACTTACC CATTTCAGGG CACCCTGGAG 600 601 CCCCAACCGG CATCAGATAT CATTGACATC GACTACTTCG AAGGACTGGA TGGTGAGGGT 660 661 CGTGGCGCAG ATCTGGGGAG CTTCCCAGGG TCACCAGGAA CCTCAGAGAA CCACCCTGAT 720 721 ACTGAGGGAG AGACCCCTTC CTGGAGCCTG CTTGACTTAT ACGATGATTT CACCCCCTTC 780 781 GATGAATCTG ATTTCTACCC CACCACATCC TTTTATGATG ACTTGGATGA AGAGGAGGAG 840 841 GAAGAGGAGG ATGACAAAGA TGCAGTAGGA GGTGGAGACC TAGAAGATGA AAATGAGCTT 900 901 CTAGTGCCCA CTGGGAAGCC TGGTCTGGGG CCCGGGACAG GCCAGCCCAC CAGTCGGTGG 960 961 CATGCTGTCC CTCCACAGCA CACTCTGGGG TCGGTCCCCG GCAGCAGCAT CGCCCTCAGG 1020 1021 CCCCGCCCAG GAGAGCCAGG CAGGGACTTG GCCTCCAGTG AAAATGGCAC TGAGTGCCGC 1080 1081 AGTGGCTTTG TGCGGCATAA CGGCTCCTGC CGGTCAGTGT GCGACCTCTT CCCAAGTTAC 1140 1141 TGTCACAATG GCGGCCAGTG CTACCTGGTG GAGAACATAG GGGCCTTCTG CAGGTGCAAC 1200 1201 ACGCAGGACT ACATCTGGCA CAAGGGGATG CGCTGCGAGT CCATCATCAC CGACTTCCAG 1260 1261 GTGATGTGCG TGGCCGTGGG CTCGGCTGCC CTCGTCCTGC TCCTGCTCTT CATGATGACG 1320 1321 GTGTTCTTTG CCAAGAAGCT CTACCTGCTC AAGACGGAGA ATACCAAGCT GCGTAGGACC 1380 1381 AACAAATTCC GGACCCCATC TGAGCTCCAC AATGATAACT TCTCCCTCTC CACCATTGCC 1440 1441 GAGGGCTCTC ACCCAAATGA TGATCCTAGT GCTCCCCACA AAATCCAGGA GGTTCTCAAG 1500 1501 TCCTGCCTGA AAGAGGAGGA GTCATTTAAC ATCCAGAACT CCATGTCGCC CAAACTTGAG 1560 1561 GGTGGCAAAG GTGACCAGGC TGACTTGGAT GTGAACTGTC TTCAGAATAA TTTAACCTAA 1620 |
▼ KEYWORD
ID | Family |
Alternative splicing | |
Cell membrane | |
Complete proteome | |
Developmental protein | |
Differentiation | |
Disulfide bond | |
EGF-like domain | |
Endoplasmic reticulum | |
Glycoprotein | |
Golgi apparatus | |
Growth regulation | |
Membrane | |
Neurogenesis | |
Phosphoprotein | |
Polymorphism | |
Proteoglycan | |
Reference proteome | |
Signal | |
Transmembrane | |
Transmembrane helix
|
▼ GENE ONTOLOGY
ID | Classification | Description |
Cellular Component | Cell surface | |
Cellular Component | Endoplasmic reticulum membrane | |
Cellular Component | Extracellular region | |
Cellular Component | GABA-ergic synapse | |
Cellular Component | Glutamatergic synapse | |
Cellular Component | Golgi apparatus | |
Cellular Component | Golgi lumen | |
Cellular Component | Golgi membrane | |
Cellular Component | Golgi-associated vesicle membrane | |
Cellular Component | Integral component of membrane | |
Cellular Component | Integral component of plasma membrane | |
Cellular Component | Integral component of postsynaptic membrane | |
Cellular Component | Lysosomal lumen | |
Cellular Component | Membrane | |
Molecular Function | Growth factor activity | |
Biological Process | Chondroitin sulfate biosynthetic process | |
Biological Process | Chondroitin sulfate catabolic process | |
Biological Process | Cytoskeleton organization | |
Biological Process | Dermatan sulfate biosynthetic process | |
Biological Process | Glial cell projection elongation | |
Biological Process | Intracellular transport | |
Biological Process | Nervous system development | |
Biological Process | Positive regulation of substrate adhesion-dependent cell spreading | |
Biological Process | Regulation of growth | |
Biological Process | Regulation of synaptic vesicle exocytosis | |
Biological Process | Trans-synaptic signaling, modulating synaptic transmission |
▼ ANNOTATION
| Disorder | ||||
| IUPred2A | ||||
| Disease | ||||
| OMIM | DisGeNET | ActiveDriverDB | ||
| Drug | ||||
| CTD | ||||
| Physicochemical | ||||
| Compute pI/Mw | AAindex | |||
| Function | ||||
| CellMarker | ||||
| Localization | ||||
| COMPARTMENTS | ||||
| Methylation | ||||
| TCGA | ICGC | COSMIC | MethyCancer | |
▼ ORTHOLOGY
| DrLLPS ID | Organism | Identity | E-value | Score |
|---|---|---|---|---|
| LLPS-Pat-a332 | Pan troglodytes | 99.47 | 0.0 | 1145 |
| LLPS-Gog-a331 | Gorilla gorilla | 98.62 | 0.0 | 1011 |
| LLPS-Cea-a336 | Cercocebus atys | 97.0 | 0.0 | 1113 |
| LLPS-Chs-a332 | Chlorocebus sabaeus | 97.0 | 0.0 | 1114 |
| LLPS-Mam-a332 | Macaca mulatta | 97.0 | 0.0 | 1055 |
| LLPS-Mal-a326 | Mandrillus leucophaeus | 96.71 | 0.0 | 965 |
| LLPS-Paa-a335 | Papio anubis | 96.64 | 0.0 | 1110 |
| LLPS-Rhb-a328 | Rhinopithecus bieti | 96.26 | 0.0 | 1090 |
| LLPS-Man-a335 | Macaca nemestrina | 95.58 | 0.0 | 1089 |
| LLPS-Aon-a340 | Aotus nancymaae | 95.57 | 0.0 | 1026 |
| LLPS-Pap-a331 | Pan paniscus | 95.1 | 0.0 | 1086 |
| LLPS-Nol-a330 | Nomascus leucogenys | 91.95 | 0.0 | 654 |
| LLPS-Maf-a336 | Macaca fascicularis | 91.93 | 0.0 | 981 |
| LLPS-Caj-a332 | Callithrix jacchus | 91.47 | 0.0 | 952 |
| LLPS-Otg-a337 | Otolemur garnettii | 90.56 | 0.0 | 951 |
| LLPS-Aim-a325 | Ailuropoda melanoleuca | 89.46 | 0.0 | 932 |
| LLPS-Cas-a306 | Carlito syrichta | 88.37 | 0.0 | 900 |
| LLPS-Fec-a336 | Felis catus | 87.55 | 0.0 | 890 |
| LLPS-Ict-a333 | Ictidomys tridecemlineatus | 87.52 | 0.0 | 947 |
| LLPS-Mup-a332 | Mustela putorius furo | 87.15 | 0.0 | 718 |
| LLPS-Mea-a311 | Mesocricetus auratus | 87.01 | 0.0 | 915 |
| LLPS-Ran-a336 | Rattus norvegicus | 86.79 | 0.0 | 938 |
| LLPS-Mum-a340 | Mus musculus | 85.77 | 0.0 | 837 |
| LLPS-Eqc-a341 | Equus caballus | 84.37 | 0.0 | 850 |
| LLPS-Loa-a327 | Loxodonta africana | 83.9 | 0.0 | 899 |
| LLPS-Bot-a340 | Bos taurus | 82.94 | 0.0 | 851 |
| LLPS-Orc-a323 | Oryctolagus cuniculus | 82.48 | 0.0 | 860 |
| LLPS-Fud-a329 | Fukomys damarensis | 82.44 | 0.0 | 872 |
| LLPS-Urm-a308 | Ursus maritimus | 81.99 | 0.0 | 798 |
| LLPS-Sus-a338 | Sus scrofa | 81.78 | 0.0 | 822 |
| LLPS-Dio-a328 | Dipodomys ordii | 80.36 | 0.0 | 847 |
| LLPS-Ova-a329 | Ovis aries | 79.1 | 0.0 | 795 |
| LLPS-Cap-a334 | Cavia porcellus | 78.6 | 0.0 | 802 |
| LLPS-Myl-a320 | Myotis lucifugus | 76.54 | 2e-77 | 249 |
| LLPS-Pes-a297 | Pelodiscus sinensis | 69.66 | 5e-56 | 192 |
| LLPS-Fia-a291 | Ficedula albicollis | 68.64 | 3e-69 | 228 |
| LLPS-Gaga-a300 | Gallus gallus | 66.37 | 9e-75 | 261 |
| LLPS-Mod-a320 | Monodelphis domestica | 66.3 | 0.0 | 670 |
| LLPS-Meg-a279 | Meleagris gallopavo | 63.1 | 1e-45 | 164 |
| LLPS-Sah-a313 | Sarcophilus harrisii | 63.06 | 0.0 | 600 |
| LLPS-Asm-a292 | Astyanax mexicanus | 54.98 | 8e-79 | 263 |
| LLPS-Icp-a300 | Ictalurus punctatus | 54.25 | 5e-69 | 239 |