LLPS-Mum-4889
Timm23
▼ OVERVIEW
| Status: | Unreviewed |
| Protein Name: | Mitochondrial import inner membrane translocase subunit Tim23 |
| Gene Name: | Timm23, Tim23 |
| Ensembl Gene: | ENSMUSG00000013701.13 |
| Ensembl Protein: | ENSMUSP00000126977.1 |
| Organism: | Mus musculus |
| Taxa ID: | 10090 |
| LLPS Type: | Client |
▼ Classification
Condensates:
| Condensate | Evidence | Orthologs |
|---|---|---|
| Nucleolus | Predicted from orthologs | (View) |
▼ FUNCTION
| Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane. |
▼ CROSS REFERENCE
| Database | Nucleotide ID | Protein ID |
|---|---|---|
| Ensembl | ENSMUST00000170331.7 | ENSMUSP00000126977.1 |
| Ensembl | ENSMUST00000013845.12 | ENSMUSP00000013845.6 |
| Ensembl | ENSMUST00000163379.1 | ENSMUSP00000129688.1 |
| Ensembl | ENSMUST00000226683.1 | ENSMUSP00000154804.1 |
| UniProt | Q9WTQ8, TIM23_MOUSE | |
| GeneBank | AB021122 | BAA78407.1 |
| Entrez | 53600 |
▼ SEQUENCE
| Protein Sequence (FASTA) |
|---|
1 MEGGGGSSNK STSGLAGFFG AGGAGYSNAD LAGVPLTGMN PLSPYLNVDP RYLVQDTDEF 60 61 ILPTGANKTR GRFELAFFTI GGCCMTGAAF GAMNGLRLGL KETQSMAWSK PRNVQILNMV 120 121 TRQGALWANT LGSLALLYSA FGVIIEKTRG AEDDLNTVAA GTMTGMLYKC TGGLRGIARG 180 181 GLAGLTLTSL YALYNNWEHM KGSLLQQSL 209 |
| Nucleotide CDS Sequence (FASTA) |
1 ATGGAAGGTG GCGGAGGAAG TAGCAACAAA TCCACCAGCG GGTTAGCTGG CTTCTTCGGA 60 61 GCCGGAGGAG CGGGTTACTC GAACGCTGAT TTGGCCGGCG TCCCGCTGAC TGGTATGAAC 120 121 CCCCTGTCTC CTTATTTAAA TGTGGATCCA CGCTATCTCG TTCAGGATAC TGATGAATTT 180 181 ATTTTGCCAA CTGGAGCTAA TAAAACCCGA GGCAGATTTG AACTAGCTTT CTTTACCATT 240 241 GGAGGATGTT GCATGACAGG GGCCGCATTC GGGGCAATGA ACGGTCTTCG TTTAGGATTG 300 301 AAGGAAACCC AGAGCATGGC CTGGTCCAAA CCAAGAAATG TACAGATTTT GAATATGGTG 360 361 ACTAGGCAAG GAGCACTTTG GGCTAATACT CTAGGCTCCC TGGCTTTGCT CTATAGTGCT 420 421 TTTGGTGTTA TCATTGAGAA AACACGGGGT GCAGAAGATG ACCTCAACAC AGTAGCAGCT 480 481 GGAACCATGA CCGGGATGTT GTATAAATGT ACAGGTGGTC TTCGAGGAAT AGCACGCGGT 540 541 GGCCTGGCAG GACTGACACT CACCAGTCTC TATGCACTGT ATAACAACTG GGAGCACATG 600 601 AAAGGTTCCC TGCTCCAACA GTCACTCTGA 630 |
▼ KEYWORD
▼ GENE ONTOLOGY
ID | Classification | Description |
Cellular Component | Integral component of mitochondrial inner membrane | |
Cellular Component | Mitochondrial inner membrane | |
Cellular Component | Mitochondrial intermembrane space | |
Cellular Component | Mitochondrion | |
Cellular Component | TIM23 mitochondrial import inner membrane translocase complex | |
Molecular Function | Enzyme binding | |
Molecular Function | P-P-bond-hydrolysis-driven protein transmembrane transporter activity | |
Molecular Function | Protein transmembrane transporter activity | |
Biological Process | Protein import into mitochondrial matrix |
▼ ANNOTATION
| Mutation | ||||
| CGAP | ||||
| Physicochemical | ||||
| Compute pI/Mw | AAindex | |||
| Function | ||||
| RaftProt | ||||
| Element | ||||
| miRWalk | RAID | microRNA.org | ||
▼ ORTHOLOGY
| DrLLPS ID | Organism | Identity | E-value | Score |
|---|---|---|---|---|
| LLPS-Poa-3605 | Pongo abelii | 98.62 | 6e-101 | 296 |
| LLPS-Mal-1050 | Mandrillus leucophaeus | 98.62 | 7e-101 | 296 |
| LLPS-Rhb-4788 | Rhinopithecus bieti | 98.37 | 2e-109 | 319 |
| LLPS-Hos-2308 | Homo sapiens | 98.37 | 3e-109 | 319 |
| LLPS-Pat-2435 | Pan troglodytes | 98.37 | 3e-109 | 319 |
| LLPS-Mam-3508 | Macaca mulatta | 98.37 | 3e-109 | 319 |
| LLPS-Cea-1369 | Cercocebus atys | 98.37 | 3e-109 | 319 |
| LLPS-Chs-2966 | Chlorocebus sabaeus | 98.37 | 3e-109 | 319 |
| LLPS-Maf-4335 | Macaca fascicularis | 98.37 | 3e-109 | 319 |
| LLPS-Myl-1400 | Myotis lucifugus | 98.37 | 2e-109 | 319 |
| LLPS-Paa-2485 | Papio anubis | 98.37 | 3e-109 | 319 |
| LLPS-Ran-4051 | Rattus norvegicus | 98.37 | 2e-109 | 320 |
| LLPS-Caf-4332 | Canis familiaris | 97.93 | 2e-100 | 296 |
| LLPS-Man-4260 | Macaca nemestrina | 97.83 | 5e-109 | 318 |
| LLPS-Nol-2846 | Nomascus leucogenys | 97.83 | 1e-108 | 318 |
| LLPS-Sus-3777 | Sus scrofa | 97.83 | 1e-108 | 318 |
| LLPS-Ova-3174 | Ovis aries | 97.83 | 2e-109 | 319 |
| LLPS-Mea-3030 | Mesocricetus auratus | 97.73 | 2e-103 | 304 |
| LLPS-Tut-0798 | Tursiops truncatus | 97.69 | 3e-101 | 297 |
| LLPS-Orc-1759 | Oryctolagus cuniculus | 97.28 | 1e-108 | 318 |
| LLPS-Fec-3090 | Felis catus | 97.28 | 9e-109 | 318 |
| LLPS-Urm-1497 | Ursus maritimus | 97.28 | 7e-109 | 318 |
| LLPS-Eqc-2622 | Equus caballus | 97.28 | 4e-109 | 319 |
| LLPS-Fud-2120 | Fukomys damarensis | 97.28 | 1e-108 | 317 |
| LLPS-Aim-0635 | Ailuropoda melanoleuca | 97.28 | 7e-109 | 318 |
| LLPS-Bot-4828 | Bos taurus | 97.28 | 7e-109 | 318 |
| LLPS-Ict-1039 | Ictidomys tridecemlineatus | 96.74 | 3e-107 | 314 |
| LLPS-Cas-3333 | Carlito syrichta | 96.74 | 3e-108 | 317 |
| LLPS-Cap-0720 | Cavia porcellus | 96.74 | 5e-108 | 316 |
| LLPS-Mup-2307 | Mustela putorius furo | 96.74 | 2e-108 | 317 |
| LLPS-Dio-3107 | Dipodomys ordii | 96.74 | 4e-108 | 316 |
| LLPS-Ora-3002 | Ornithorhynchus anatinus | 94.81 | 5e-91 | 270 |
| LLPS-Fia-3443 | Ficedula albicollis | 94.78 | 2e-89 | 266 |
| LLPS-Caj-1166 | Callithrix jacchus | 94.27 | 1e-105 | 310 |
| LLPS-Aon-1302 | Aotus nancymaae | 94.27 | 1e-105 | 310 |
| LLPS-Loa-3572 | Loxodonta africana | 94.25 | 4e-98 | 289 |
| LLPS-Tag-3093 | Taeniopygia guttata | 94.03 | 3e-89 | 266 |
| LLPS-Mod-3007 | Monodelphis domestica | 94.02 | 2e-106 | 312 |
| LLPS-Gog-4299 | Gorilla gorilla | 93.02 | 7e-81 | 245 |
| LLPS-Anc-3230 | Anolis carolinensis | 92.93 | 2e-103 | 305 |
| LLPS-Anp-2494 | Anas platyrhynchos | 92.65 | 2e-89 | 267 |
| LLPS-Pes-0844 | Pelodiscus sinensis | 92.39 | 1e-103 | 307 |
| LLPS-Sah-3468 | Sarcophilus harrisii | 91.95 | 1e-97 | 288 |
| LLPS-Gaga-3083 | Gallus gallus | 91.3 | 3e-103 | 303 |
| LLPS-Lac-2193 | Latimeria chalumnae | 86.41 | 1e-96 | 286 |
| LLPS-Leo-1882 | Lepisosteus oculatus | 85.33 | 2e-95 | 284 |
| LLPS-Orn-3499 | Oreochromis niloticus | 84.27 | 1e-93 | 280 |
| LLPS-Scf-2863 | Scleropages formosus | 84.18 | 4e-92 | 275 |
| LLPS-Icp-3083 | Ictalurus punctatus | 83.15 | 9e-92 | 275 |
| LLPS-Dar-3632 | Danio rerio | 82.49 | 4e-90 | 270 |
| LLPS-Scm-2225 | Scophthalmus maximus | 82.02 | 6e-91 | 273 |
| LLPS-Asm-2061 | Astyanax mexicanus | 82.02 | 8e-91 | 272 |
| LLPS-Gaa-0645 | Gasterosteus aculeatus | 82.02 | 2e-89 | 269 |
| LLPS-Tar-4020 | Takifugu rubripes | 82.02 | 8e-92 | 275 |
| LLPS-Xim-2689 | Xiphophorus maculatus | 82.02 | 6e-92 | 275 |
| LLPS-Pof-4199 | Poecilia formosa | 81.46 | 9e-92 | 275 |
| LLPS-Ten-2579 | Tetraodon nigroviridis | 81.46 | 7e-90 | 270 |
| LLPS-Xet-2736 | Xenopus tropicalis | 81.18 | 2e-87 | 263 |
| LLPS-Orl-3919 | Oryzias latipes | 80.34 | 7e-90 | 270 |
| LLPS-Otg-4604 | Otolemur garnettii | 65.76 | 2e-69 | 216 |
| LLPS-Drm-1673 | Drosophila melanogaster | 53.08 | 2e-35 | 130 |
| LLPS-Mel-1519 | Melampsora laricipopulina | 43.64 | 7e-08 | 55.1 |
| LLPS-Put-0941 | Puccinia triticina | 42.42 | 3e-09 | 59.3 |
| LLPS-Miv-0474 | Microbotryum violaceum | 42.11 | 9e-07 | 52.4 |
| LLPS-Pug-1268 | Puccinia graminis | 38.64 | 2e-09 | 59.3 |
| LLPS-Cii-1845 | Ciona intestinalis | 37.5 | 4e-19 | 86.7 |
| LLPS-Cus-0324 | Cucumis sativus | 36.92 | 3e-11 | 63.5 |
| LLPS-Dac-0142 | Daucus carota | 36.46 | 7e-08 | 53.9 |
| LLPS-Org-1046 | Oryza glaberrima | 36.08 | 1e-06 | 50.8 |
| LLPS-Orb-2299 | Oryza barthii | 36.08 | 1e-06 | 50.8 |
| LLPS-Cis-2067 | Ciona savignyi | 35.94 | 2e-18 | 84.7 |
| LLPS-Map-0558 | Magnaporthe poae | 35.71 | 7e-08 | 54.7 |
| LLPS-Mao-1578 | Magnaporthe oryzae | 35.71 | 2e-07 | 53.5 |
| LLPS-Gag-0700 | Gaeumannomyces graminis | 35.71 | 2e-07 | 53.5 |
| LLPS-Glm-2990 | Glycine max | 35.33 | 8e-12 | 65.1 |
| LLPS-Scc-1515 | Schizosaccharomyces cryophilus | 35.07 | 2e-10 | 61.6 |
| LLPS-Scp-0298 | Schizosaccharomyces pombe | 35.07 | 1e-10 | 62.4 |
| LLPS-Fus-1532 | Fusarium solani | 33.59 | 3e-09 | 58.5 |
| LLPS-Scj-1239 | Schizosaccharomyces japonicus | 33.58 | 2e-12 | 67.4 |
| LLPS-Cog-0532 | Colletotrichum gloeosporioides | 33.33 | 6e-06 | 49.3 |
| LLPS-Fuo-0530 | Fusarium oxysporum | 33.33 | 3e-09 | 58.5 |
| LLPS-Fuv-1595 | Fusarium verticillioides | 33.33 | 3e-09 | 58.5 |
| LLPS-Asf-1108 | Aspergillus flavus | 33.33 | 8e-10 | 59.7 |
| LLPS-Aso-0107 | Aspergillus oryzae | 33.33 | 9e-10 | 59.7 |
| LLPS-Beb-0821 | Beauveria bassiana | 33.09 | 3e-09 | 58.5 |
| LLPS-Usm-0148 | Ustilago maydis | 33.03 | 7e-08 | 55.1 |
| LLPS-Met-2346 | Medicago truncatula | 32.79 | 3e-09 | 57.8 |
| LLPS-Orm-1668 | Oryza meridionalis | 32.64 | 4e-06 | 50.4 |
| LLPS-Spr-0493 | Sporisorium reilianum | 32.11 | 1e-07 | 54.3 |
| LLPS-Ved-0504 | Verticillium dahliae | 31.88 | 2e-08 | 56.6 |
| LLPS-Asfu-1123 | Aspergillus fumigatus | 31.62 | 2e-09 | 58.5 |
| LLPS-Vir-1607 | Vigna radiata | 31.47 | 2e-08 | 55.5 |
| LLPS-Via-1201 | Vigna angularis | 31.47 | 3e-07 | 52.0 |
| LLPS-Blg-1332 | Blumeria graminis | 31.37 | 3e-07 | 53.1 |
| LLPS-Asn-0826 | Aspergillus nidulans | 31.16 | 1e-09 | 59.3 |
| LLPS-Phv-2228 | Phaseolus vulgaris | 31.13 | 7e-08 | 54.3 |
| LLPS-Amt-0370 | Amborella trichopoda | 30.88 | 6e-07 | 51.6 |
| LLPS-Cae-1959 | Caenorhabditis elegans | 30.83 | 4e-14 | 72.4 |
| LLPS-Nef-1356 | Neosartorya fischeri | 30.66 | 3e-09 | 58.2 |
| LLPS-Cogr-1088 | Colletotrichum graminicola | 30.66 | 5e-09 | 58.2 |
| LLPS-Asni-1509 | Aspergillus niger | 30.66 | 2e-08 | 56.6 |
| LLPS-Coo-1090 | Colletotrichum orbiculare | 30.66 | 3e-08 | 55.8 |
| LLPS-Asc-0677 | Aspergillus clavatus | 30.66 | 2e-09 | 58.9 |
| LLPS-Dos-1504 | Dothistroma septosporum | 30.43 | 1e-07 | 54.3 |
| LLPS-Phn-1153 | Phaeosphaeria nodorum | 30.39 | 1e-06 | 51.2 |
| LLPS-Zyt-1361 | Zymoseptoria tritici | 30.33 | 1e-07 | 54.3 |
| LLPS-Trv-0950 | Trichoderma virens | 30.25 | 3e-07 | 53.1 |
| LLPS-Trr-1175 | Trichoderma reesei | 29.41 | 6e-07 | 52.4 |
| LLPS-Ast-0746 | Aspergillus terreus | 29.41 | 4e-09 | 57.8 |
| LLPS-Asg-0731 | Ashbya gossypii | 29.2 | 2e-08 | 57.0 |
| LLPS-Nec-1103 | Neurospora crassa | 29.2 | 5e-07 | 52.8 |
| LLPS-Abg-1113 | Absidia glauca | 29.13 | 2e-08 | 56.6 |
| LLPS-Lem-1217 | Leptosphaeria maculans | 28.67 | 1e-06 | 51.6 |
| LLPS-Sac-1332 | Saccharomyces cerevisiae | 26.47 | 1e-07 | 54.3 |