LLPS-Mum-4590
P4hb

▼ OVERVIEW

Status: Unreviewed
Protein Name: Protein disulfide-isomerase
Gene Name: P4hb, Pdia1
Ensembl Gene: ENSMUSG00000025130.11
Ensembl Protein: ENSMUSP00000128796.1
Organism: Mus musculus
Taxa ID: 10090
LLPS Type: Others


▼ PROPERTY


——— Disorder propensity (calculated by IUPred2A)

▼ Classification

Condensates:
CondensateEvidenceOrthologs
Nucleolus, Stress granulePredicted from orthologs(View)

▼ FUNCTION

This multifunctional protein catalyzes the formation, breakage and rearrangement of disulfide bonds. At the cell surface, seems to act as a reductase that cleaves disulfide bonds of proteins attached to the cell. May therefore cause structural modifications of exofacial proteins. Inside the cell, seems to form/rearrange disulfide bonds of nascent proteins. At high concentrations, functions as a chaperone that inhibits aggregation of misfolded proteins. At low concentrations, facilitates aggregation (anti-chaperone activity). May be involved with other chaperones in the structural modification of the TG precursor in hormone biogenesis. Also acts a structural subunit of various enzymes such as prolyl 4-hydroxylase and microsomal triacylglycerol transfer protein MTTP (By similarity). Receptor for LGALS9; the interaction retains P4HB at the cell surface of Th2 T helper cells, increasing disulfide reductase activity at the plasma membrane, altering the plasma membrane redox state and enhancing cell migration (PubMed:21670307).

▼ SEQUENCE

Protein Sequence (FASTA)
1     MLSRALLCLA  LAWAARVGAD  ALEEEDNVLV  LKKSNFEEAL  AAHKYLLVEF  YAPWCGHCKA  60
61    LAPEYAKAAA  KLKAEGSEIR  LAKVDATEES  DLAQQYGVRG  YPTIKFFKNG  DTASPKEYTA  120
121   GREADDIVNW  LKKRTGPAAT  TLSDTAAAES  LVDSSEVTVI  GFFKDVESDS  AKQFLLAAEA  180
181   IDDIPFGITS  NSGVFSKYQL  DKDGVVLFKK  FDEGRNNFEG  EITKEKLLDF  IKHNQLPLVI  240
241   EFTEQTAPKI  FGGEIKTHIL  LFLPKSVSDY  DGKLSSFKRA  AEGFKGKILF  IFIDSDHTDN  300
301   QRILEFFGLK  KEECPAVRLI  TLEEEMTKYK  PESDELTAEK  ITEFCHRFLE  GKIKPHLMSQ  360
361   EVPEDWDKQP  VKVLVGANFE  EVAFDEKKNV  FVEFYAPWCG  HCKQLAPIWD  KLGETYKDHE  420
421   NIIIAKMDST  ANEVEAVKVH  SFPTLKFFPA  SADRTVIDYN  GERTLDGFKK  FLESGGQDGA  480
481   GDDEDLDLEE  ALEPDMEEDD  DQKAVKDEL  509
Nucleotide CDS Sequence (FASTA)
1     ATGCTGAGCC  GTGCTTTGCT  GTGCCTAGCC  CTGGCCTGGG  CGGCTAGGGT  GGGCGCCGAC  60
61    GCCCTGGAGG  AGGAGGACAA  CGTCCTGGTG  TTGAAGAAGA  GCAACTTCGA  GGAGGCGCTG  120
121   GCGGCGCACA  AGTACCTGCT  GGTGGAGTTC  TATGCCCCGT  GGTGTGGCCA  CTGCAAAGCT  180
181   CTGGCTCCCG  AGTATGCCAA  AGCTGCCGCA  AAACTGAAGG  CAGAAGGCTC  TGAGATTCGA  240
241   CTAGCAAAGG  TGGATGCCAC  AGAAGAGTCT  GACCTGGCTC  AGCAGTATGG  TGTCCGTGGC  300
301   TACCCCACAA  TCAAGTTCTT  CAAGAATGGA  GACACAGCCT  CCCCAAAGGA  ATATACAGCT  360
361   GGCAGGGAAG  CTGATGACAT  TGTCAACTGG  CTGAAGAAAC  GCACGGGCCC  AGCAGCTACA  420
421   ACCCTGTCTG  ACACTGCAGC  TGCAGAGTCC  TTGGTGGACT  CAAGCGAAGT  GACGGTCATC  480
481   GGTTTCTTCA  AGGACGTAGA  GTCAGACTCT  GCCAAGCAGT  TCTTGCTGGC  AGCAGAGGCT  540
541   ATTGATGACA  TACCTTTTGG  AATCACGTCC  AACAGTGGTG  TGTTCTCCAA  GTACCAGCTG  600
601   GACAAAGATG  GGGTGGTCCT  CTTTAAGAAG  TTTGATGAAG  GCCGCAACAA  CTTTGAGGGT  660
661   GAGATCACCA  AGGAGAAGCT  TCTAGACTTC  ATCAAGCACA  ATCAGCTGCC  TTTGGTCATC  720
721   GAGTTCACTG  AACAGACAGC  TCCGAAGATT  TTTGGAGGTG  AGATCAAGAC  ACACATTCTG  780
781   CTGTTCCTGC  CCAAGAGTGT  ATCTGACTAT  GACGGCAAGC  TGAGCAGCTT  CAAGAGAGCA  840
841   GCCGAGGGCT  TCAAGGGCAA  GATCCTATTT  ATCTTCATCG  ATAGCGACCA  CACTGATAAC  900
901   CAGCGCATAC  TTGAGTTCTT  TGGCCTGAAG  AAGGAGGAGT  GTCCCGCTGT  GCGGCTTATT  960
961   ACCCTAGAGG  AAGAGATGAC  CAAGTACAAA  CCAGAGTCAG  ATGAGCTGAC  GGCTGAGAAA  1020
1021  ATCACAGAGT  TTTGCCACCG  CTTCTTAGAG  GGCAAGATCA  AGCCCCACCT  GATGAGCCAA  1080
1081  GAAGTGCCTG  AAGACTGGGA  CAAACAGCCG  GTAAAAGTAC  TGGTTGGGGC  GAACTTTGAA  1140
1141  GAGGTCGCTT  TTGATGAGAA  AAAGAACGTG  TTTGTTGAAT  TCTATGCCCC  TTGGTGTGGT  1200
1201  CACTGCAAGC  AGCTAGCCCC  CATTTGGGAT  AAACTGGGAG  AGACATACAA  GGATCATGAG  1260
1261  AATATCATCA  TTGCTAAGAT  GGACTCAACA  GCCAATGAGG  TGGAAGCTGT  CAAAGTACAT  1320
1321  AGCTTTCCCA  CACTGAAGTT  CTTCCCAGCA  AGTGCAGACA  GAACGGTCAT  TGATTACAAC  1380
1381  GGCGAGCGGA  CACTGGACGG  TTTTAAGAAA  TTCTTGGAGA  GTGGTGGCCA  GGATGGAGCA  1440
1441  GGGGACGATG  AGGACCTCGA  CCTAGAAGAA  GCTTTAGAGC  CAGACATGGA  GGAAGACGAC  1500
1501  GATCAGAAAG  CTGTGAAGGA  TGAACTGTAG  1530

▼ KEYWORD

ID
Family
Acetylation
Cell membrane
Chaperone
Complete proteome
Disulfide bond
Endoplasmic reticulum
Isomerase
Membrane
Phosphoprotein
Redox-active center
Reference proteome
Repeat
Signal

▼ GENE ONTOLOGY

ID
Classification
Description
Cellular Component
Endoplasmic reticulum
Cellular Component
Endoplasmic reticulum chaperone complex
Cellular Component
Endoplasmic reticulum lumen
Cellular Component
Endoplasmic reticulum-Golgi intermediate compartment
Cellular Component
External side of plasma membrane
Cellular Component
Melanosome
Cellular Component
Procollagen-proline 4-dioxygenase complex
Molecular Function
Enzyme binding
Molecular Function
Integrin binding
Molecular Function
Peptide disulfide oxidoreductase activity
Molecular Function
Procollagen-proline 4-dioxygenase activity
Molecular Function
Protein disulfide isomerase activity
Molecular Function
Protein heterodimerization activity
Biological Process
Cell redox homeostasis
Biological Process
Cellular response to hypoxia
Biological Process
Cellular response to interleukin-7
Biological Process
Peptidyl-proline hydroxylation to 4-hydroxy-L-proline
Biological Process
Positive regulation of viral entry into host cell
Biological Process
Protein folding
Biological Process
Regulation of oxidative stress-induced intrinsic apoptotic signaling pathway
Biological Process
Response to endoplasmic reticulum stress

▼ KEGG


▼ ORTHOLOGY

DrLLPS IDOrganismIdentityE-valueScore
LLPS-Mea-2928Mesocricetus auratus96.760.0 880
LLPS-Eqc-2618Equus caballus95.820.0 859
LLPS-Mal-4575Mandrillus leucophaeus95.310.0 804
LLPS-Caj-2913Callithrix jacchus95.240.0 874
LLPS-Chs-3047Chlorocebus sabaeus95.160.0 856
LLPS-Hos-0425Homo sapiens94.990.0 862
LLPS-Gog-1522Gorilla gorilla94.980.0 860
LLPS-Ova-1127Ovis aries94.770.0 859
LLPS-Pat-1550Pan troglodytes94.770.0 860
LLPS-Maf-2864Macaca fascicularis94.730.0 855
LLPS-Mam-2186Macaca mulatta94.730.0 855
LLPS-Bot-4725Bos taurus94.590.0 866
LLPS-Rhb-0285Rhinopithecus bieti94.470.0 809
LLPS-Cap-4354Cavia porcellus94.470.0 859
LLPS-Poa-2135Pongo abelii94.360.0 861
LLPS-Ict-0592Ictidomys tridecemlineatus94.250.0 852
LLPS-Caf-3104Canis familiaris93.850.0 844
LLPS-Aim-1235Ailuropoda melanoleuca93.720.0 856
LLPS-Myl-1544Myotis lucifugus93.460.0 846
LLPS-Paa-2508Papio anubis93.440.0 837
LLPS-Fud-4111Fukomys damarensis93.120.0 856
LLPS-Fec-4567Felis catus92.640.0 849
LLPS-Pap-2505Pan paniscus92.460.0 843
LLPS-Nol-1212Nomascus leucogenys92.310.0 835
LLPS-Otg-1292Otolemur garnettii91.990.0 843
LLPS-Dio-3475Dipodomys ordii90.630.0 791
LLPS-Sus-3130Sus scrofa89.450.0 817
LLPS-Loa-4410Loxodonta africana88.690.0 788
LLPS-Sah-2893Sarcophilus harrisii87.770.0 805
LLPS-Gaga-2310Gallus gallus87.320.0 729
LLPS-Mod-3319Monodelphis domestica86.980.0 803
LLPS-Meg-2195Meleagris gallopavo86.910.0 632
LLPS-Fia-1850Ficedula albicollis85.490.0 759
LLPS-Tag-3535Taeniopygia guttata84.330.0 731
LLPS-Cea-0364Cercocebus atys80.740.0 778
LLPS-Man-2688Macaca nemestrina80.740.0 784
LLPS-Xet-3277Xenopus tropicalis79.610.0 727
LLPS-Lac-2418Latimeria chalumnae79.390.0 729
LLPS-Aon-2082Aotus nancymaae78.60.0 746
LLPS-Icp-1514Ictalurus punctatus77.410.0 713
LLPS-Scf-0579Scleropages formosus76.920.0 712
LLPS-Asm-2564Astyanax mexicanus76.540.0 707
LLPS-Xim-3823Xiphophorus maculatus76.430.0 691
LLPS-Pof-1172Poecilia formosa76.320.0 690
LLPS-Leo-2232Lepisosteus oculatus76.090.0 712
LLPS-Orl-3709Oryzias latipes75.880.0 696
LLPS-Dar-3881Danio rerio75.70.0 712
LLPS-Orn-2225Oreochromis niloticus75.490.0 700
LLPS-Scm-1986Scophthalmus maximus74.840.0 686
LLPS-Gaa-3255Gasterosteus aculeatus73.570.0 692
LLPS-Drm-1174Drosophila melanogaster55.418e-173 504
LLPS-Cis-2032Ciona savignyi53.171e-167 491
LLPS-Tut-0916Tursiops truncatus49.463e-147 438
LLPS-Mup-4011Mustela putorius furo48.352e-147 441
LLPS-Tar-3560Takifugu rubripes47.498e-137 414
LLPS-Ten-0114Tetraodon nigroviridis46.72e-129 394
LLPS-Tra-0355Triticum aestivum46.091e-1068.2
LLPS-Orb-1614Oryza barthii45.543e-1272.8
LLPS-Org-1567Oryza glaberrima45.543e-1272.8
LLPS-Cae-1069Caenorhabditis elegans44.784e-125 381
LLPS-Lep-1297Leersia perrieri44.445e-1168.9
LLPS-Orp-1932Oryza punctata44.121e-1067.8
LLPS-Ora-2614Ornithorhynchus anatinus43.936e-1271.6
LLPS-Sei-1275Setaria italica43.286e-1272.0
LLPS-Php-0728Physcomitrella patens42.312e-1376.6
LLPS-Nia-2190Nicotiana attenuata41.272e-94 305
LLPS-Dos-0390Dothistroma septosporum40.911e-1273.9
LLPS-Brr-0516Brassica rapa40.93e-92 300
LLPS-Glm-1544Glycine max40.831e-96 311
LLPS-Sot-0513Solanum tuberosum40.792e-94 304
LLPS-Art-0187Arabidopsis thaliana40.664e-94 305
LLPS-Phv-0005Phaseolus vulgaris40.612e-94 304
LLPS-Brn-3126Brassica napus40.452e-91 297
LLPS-Bro-1332Brassica oleracea40.455e-91 298
LLPS-Sol-1624Solanum lycopersicum40.343e-94 304
LLPS-Dac-2384Daucus carota39.661e-88 290
LLPS-Viv-1994Vitis vinifera39.583e-0860.5
LLPS-Arl-2262Arabidopsis lyrata39.568e-93 301
LLPS-Gor-2380Gossypium raimondii39.432e-90 295
LLPS-Chr-0532Chlamydomonas reinhardtii39.29e-90 291
LLPS-Met-0077Medicago truncatula39.084e-87 286
LLPS-Mua-0100Musa acuminata38.852e-84 275
LLPS-Sem-1146Selaginella moellendorffii38.61e-86 282
LLPS-Hea-0793Helianthus annuus38.515e-88 288
LLPS-Orbr-1041Oryza brachyantha38.188e-90 293
LLPS-Orni-1623Oryza nivara38.015e-84 278
LLPS-Orr-1570Oryza rufipogon38.011e-84 278
LLPS-Usm-1330Ustilago maydis37.974e-78 260
LLPS-Orgl-1400Oryza glumaepatula37.874e-85 280
LLPS-Ori-2409Oryza indica37.774e-88 288
LLPS-Ors-0295Oryza sativa37.774e-88 288
LLPS-Sob-1992Sorghum bicolor37.772e-90 294
LLPS-Mae-1094Manihot esculenta37.641e-81 271
LLPS-Prp-2401Prunus persica37.614e-75 252
LLPS-Zem-0861Zea mays37.551e-88 290
LLPS-Brd-1598Brachypodium distachyon37.182e-71 243
LLPS-Via-1945Vigna angularis37.013e-77 258
LLPS-Scs-0673Sclerotinia sclerotiorum36.922e-1067.0
LLPS-Coc-2170Corchorus capsularis36.882e-75 263
LLPS-Hov-0338Hordeum vulgare36.862e-69 238
LLPS-Vir-2187Vigna radiata36.764e-75 253
LLPS-Tum-1554Tuber melanosporum36.722e-76 256
LLPS-Spr-0369Sporisorium reilianum36.665e-75 252
LLPS-Abg-1354Absidia glauca36.625e-73 247
LLPS-Crn-0781Cryptococcus neoformans36.388e-75 251
LLPS-Orm-0315Oryza meridionalis36.231e-81 271
LLPS-Cus-0849Cucumis sativus36.176e-79 262
LLPS-Zyt-0903Zymoseptoria tritici35.812e-73 248
LLPS-Pyt-1132Pyrenophora teres35.681e-68 236
LLPS-Lem-1488Leptosphaeria maculans35.571e-72 246
LLPS-Pot-2815Populus trichocarpa35.565e-70 238
LLPS-Cog-1011Colletotrichum gloeosporioides35.273e-72 244
LLPS-Cogr-1438Colletotrichum graminicola35.272e-72 245
LLPS-Trr-1154Trichoderma reesei35.138e-72 243
LLPS-Phn-0522Phaeosphaeria nodorum35.065e-69 237
LLPS-Map-0794Magnaporthe poae35.01e-70 241
LLPS-Trv-0226Trichoderma virens34.912e-70 239
LLPS-Ast-0597Aspergillus terreus34.93e-71 242
LLPS-Ved-0376Verticillium dahliae34.832e-69 237
LLPS-Scp-0630Schizosaccharomyces pombe34.784e-1169.3
LLPS-Nef-0239Neosartorya fischeri34.645e-72 244
LLPS-Mao-1287Magnaporthe oryzae34.565e-70 239
LLPS-Asc-0229Aspergillus clavatus34.494e-71 242
LLPS-Pytr-0188Pyrenophora triticirepentis34.484e-69 236
LLPS-Coo-0908Colletotrichum orbiculare34.413e-71 242
LLPS-Asfu-1475Aspergillus fumigatus34.384e-73 247
LLPS-Gag-1519Gaeumannomyces graminis34.359e-70 238
LLPS-Thc-2076Theobroma cacao34.336e-69 238
LLPS-Amt-1963Amborella trichopoda33.923e-71 242
LLPS-Asn-0938Aspergillus nidulans33.693e-69 236
LLPS-Nec-0977Neurospora crassa33.621e-68 234
LLPS-Asni-1295Aspergillus niger33.127e-71 241