• Disorder▼
  • Domain▼
  • PTM▼
  • Variation▼
  • Mutation▼
  • Interaction▼
  • Disease▼
  • Drug▼
  • Physicochemical▼
  • Function▼
  • Proteomics▼
  • Structure▼
  • Localization▼
  • Expression▼
  • Element▼
  • Methylation▼

LLPS-Bot-4725
P4HB

Integrated Annotations

▼ OVERVIEW

Status: Unreviewed
Protein Name: Protein disulfide-isomerase
Gene Name: P4HB
Ensembl Gene: ENSBTAG00000006045.5
Ensembl Protein: ENSBTAP00000007943.5
Organism: Bos taurus
Taxa ID: 9913
LLPS Type: Others


▼ PROPERTY


——— Disorder propensity (calculated by IUPred2A)

▼ Classification

Condensates:
CondensateEvidenceOrthologs
Nucleolus, Stress granulePredicted from orthologs(View)

▼ SEQUENCE

Protein Sequence (FASTA)
1     MRVQRRRAPD  PPGQSEVGTG  GRARGGRTYK  SRTGGARSRG  LLSWRRQLKR  RVCADMLRRA  60
61    LLCLALTALF  RAGAGAPDEE  DHVLVLHKGN  FDEALAAHKY  LLVEFYAPWC  GHCKALAPEY  120
121   AKAAGKLKAE  GSEIRLAKVD  ATEESDLAQQ  YGVRGYPTIK  FFKNGDTASP  KEYTAGREAD  180
181   DIVNWLKKRT  GPAASTLSDG  AAAEALVESS  EVAVIGFFKD  MESDSAKQFL  LAAEAIDDIP  240
241   FGITSNSDVF  SKYQLDKDGV  VLFKKFDEGR  NNFEGEVTKE  KLLDFIKHNQ  LPLVIEFTEQ  300
301   TAPKIFGGEI  KTHILLFLPK  SVSDYEGKLS  NFKKAAESFK  GKILFIFIDS  DHTDNQRILE  360
361   FFGLKKEECP  AVRLITLEEE  MTKYKPESDE  LTAEKITEFC  HRFLEGKIKP  HLMSQELPDD  420
421   WDKQPVKVLV  GKNFEEVAFD  EKKNVFVEFY  APWCGHCKQL  APIWDKLGET  YKDHENIVIA  480
481   KMDSTANEVE  AVKVHSFPTL  KFFPASADRT  VIDYNGERTL  DGFKKFLESG  GQDGAGDDDD  540
541   LEDLEEAEEP  DLEEDDDQKA  VKDEL  565
Nucleotide CDS Sequence (FASTA)
1     ATGCGAGTGC  AGCGGAGGCG  GGCCCCGGAC  CCCCCAGGCC  AATCGGAGGT  GGGCACGGGC  60
61    GGGCGCGCGC  GCGGCGGCCG  GACTTATAAG  AGCAGGACGG  GCGGCGCGCG  CTCTCGTGGC  120
121   CTGCTGTCCT  GGCGGCGCCA  ACTGAAGCGC  CGCGTCTGTG  CCGACATGCT  GCGCCGCGCT  180
181   CTGCTCTGCC  TGGCCCTGAC  CGCGCTATTC  CGCGCGGGTG  CCGGCGCCCC  CGACGAGGAG  240
241   GACCACGTCC  TGGTGCTCCA  TAAGGGCAAC  TTCGACGAGG  CGCTGGCGGC  CCACAAGTAC  300
301   CTGCTGGTGG  AGTTCTACGC  CCCATGGTGC  GGCCACTGCA  AGGCTCTGGC  CCCGGAGTAT  360
361   GCCAAAGCAG  CTGGGAAGCT  GAAGGCAGAA  GGTTCTGAGA  TCAGACTGGC  CAAGGTGGAT  420
421   GCCACTGAAG  AGTCTGACCT  GGCCCAGCAG  TATGGTGTCC  GAGGCTACCC  CACCATCAAG  480
481   TTCTTCAAGA  ATGGAGACAC  AGCTTCCCCC  AAAGAGTACA  CAGCTGGCCG  AGAAGCGGAT  540
541   GATATCGTGA  ACTGGCTGAA  GAAGCGCACG  GGCCCCGCTG  CCAGCACGCT  GTCCGACGGG  600
601   GCTGCTGCAG  AGGCCTTGGT  GGAGTCCAGT  GAGGTGGCCG  TCATTGGCTT  CTTCAAGGAC  660
661   ATGGAGTCGG  ACTCCGCAAA  GCAGTTCTTG  TTGGCAGCAG  AGGCCATTGA  TGACATCCCC  720
721   TTCGGGATCA  CATCTAACAG  CGATGTGTTC  TCCAAATACC  AGCTGGACAA  GGATGGGGTT  780
781   GTCCTCTTTA  AGAAGTTTGA  CGAAGGCCGG  AACAACTTTG  AGGGGGAGGT  CACCAAAGAA  840
841   AAGCTTCTGG  ACTTCATCAA  GCACAACCAG  TTGCCCCTGG  TCATTGAGTT  CACCGAGCAG  900
901   ACAGCCCCGA  AGATCTTCGG  AGGGGAAATC  AAGACTCACA  TCCTGCTGTT  CCTGCCGAAA  960
961   AGCGTGTCTG  ACTATGAGGG  CAAGCTGAGC  AACTTCAAAA  AAGCGGCTGA  GAGCTTCAAG  1020
1021  GGCAAGATCC  TGTTTATCTT  CATCGACAGC  GACCACACTG  ACAACCAGCG  CATCCTGGAA  1080
1081  TTCTTCGGCC  TAAAGAAAGA  GGAGTGCCCG  GCCGTGCGCC  TCATCACGCT  GGAGGAGGAG  1140
1141  ATGACCAAAT  ATAAGCCAGA  GTCAGATGAG  CTGACGGCAG  AGAAGATCAC  CGAGTTCTGC  1200
1201  CACCGCTTCC  TGGAGGGCAA  GATTAAGCCC  CACCTGATGA  GCCAGGAGCT  GCCTGACGAC  1260
1261  TGGGACAAGC  AGCCTGTCAA  AGTGCTGGTT  GGGAAGAACT  TTGAAGAGGT  TGCTTTTGAT  1320
1321  GAGAAAAAGA  ACGTCTTTGT  AGAGTTCTAT  GCCCCGTGGT  GCGGTCACTG  CAAGCAGCTG  1380
1381  GCCCCCATCT  GGGATAAGCT  GGGAGAGACG  TACAAGGACC  ACGAGAACAT  AGTCATCGCC  1440
1441  AAGATGGACT  CCACGGCCAA  CGAGGTGGAG  GCGGTGAAAG  TGCACAGCTT  CCCCACGCTC  1500
1501  AAGTTCTTCC  CCGCCAGCGC  CGACAGGACG  GTCATCGACT  ACAATGGGGA  GCGGACACTG  1560
1561  GATGGTTTTA  AGAAGTTCCT  GGAGAGTGGT  GGCCAGGATG  GGGCCGGAGA  TGATGACGAT  1620
1621  CTAGAAGATC  TTGAAGAAGC  AGAAGAGCCT  GATCTGGAGG  AAGATGATGA  TCAAAAAGCT  1680
1681  GTGAAAGATG  AACTGTAA  1698

▼ ORTHOLOGY

DrLLPS IDOrganismIdentityE-valueScore
LLPS-Ova-1127Ovis aries99.780.0 905
LLPS-Eqc-2618Equus caballus97.340.0 890
LLPS-Mal-4575Mandrillus leucophaeus96.730.0 826
LLPS-Gog-1522Gorilla gorilla96.330.0 884
LLPS-Chs-3047Chlorocebus sabaeus96.320.0 881
LLPS-Man-2688Macaca nemestrina96.250.0 629
LLPS-Hos-0425Homo sapiens96.140.0 884
LLPS-Poa-2135Pongo abelii96.140.0 885
LLPS-Cea-0364Cercocebus atys95.970.0 625
LLPS-Pat-1550Pan troglodytes95.930.0 883
LLPS-Caj-2913Callithrix jacchus95.740.0 884
LLPS-Rhb-0285Rhinopithecus bieti95.630.0 828
LLPS-Myl-1544Myotis lucifugus95.550.0 877
LLPS-Mam-2186Macaca mulatta95.50.0 876
LLPS-Maf-2864Macaca fascicularis95.50.0 876
LLPS-Mea-2928Mesocricetus auratus95.190.0 853
LLPS-Fec-4567Felis catus95.130.0 879
LLPS-Aim-1235Ailuropoda melanoleuca95.130.0 883
LLPS-Mum-4590Mus musculus94.780.0 856
LLPS-Ict-0592Ictidomys tridecemlineatus94.740.0 863
LLPS-Caf-3104Canis familiaris94.680.0 870
LLPS-Cap-4354Cavia porcellus94.510.0 859
LLPS-Paa-2508Papio anubis94.30.0 863
LLPS-Aon-2082Aotus nancymaae93.920.0 578
LLPS-Fud-4111Fukomys damarensis93.910.0 864
LLPS-Pap-2505Pan paniscus93.760.0 865
LLPS-Nol-1212Nomascus leucogenys93.60.0 858
LLPS-Otg-1292Otolemur garnettii92.70.0 862
LLPS-Loa-4410Loxodonta africana92.510.0 808
LLPS-Dio-3475Dipodomys ordii91.560.0 800
LLPS-Sus-3130Sus scrofa91.210.0 845
LLPS-Sah-2893Sarcophilus harrisii88.160.0 818
LLPS-Mod-3319Monodelphis domestica87.80.0 818
LLPS-Gaga-2310Gallus gallus87.560.0 749
LLPS-Meg-2195Meleagris gallopavo87.470.0 620
LLPS-Fia-1850Ficedula albicollis85.490.0 762
LLPS-Tag-3535Taeniopygia guttata84.560.0 729
LLPS-Xet-3277Xenopus tropicalis80.390.0 740
LLPS-Lac-2418Latimeria chalumnae79.570.0 721
LLPS-Icp-1514Ictalurus punctatus77.970.0 725
LLPS-Leo-2232Lepisosteus oculatus77.310.0 724
LLPS-Asm-2564Astyanax mexicanus76.650.0 718
LLPS-Scf-0579Scleropages formosus76.640.0 719
LLPS-Pof-1172Poecilia formosa76.430.0 701
LLPS-Xim-3823Xiphophorus maculatus76.430.0 704
LLPS-Dar-3881Danio rerio76.210.0 720
LLPS-Orl-3709Oryzias latipes76.210.0 706
LLPS-Orn-2225Oreochromis niloticus75.770.0 710
LLPS-Scm-1986Scophthalmus maximus75.330.0 693
LLPS-Gaa-3255Gasterosteus aculeatus73.790.0 701
LLPS-Drm-1174Drosophila melanogaster56.291e-177 518
LLPS-Cis-2032Ciona savignyi53.631e-173 508
LLPS-Tut-0916Tursiops truncatus49.242e-145 436
LLPS-Mup-4011Mustela putorius furo48.555e-149 447
LLPS-Tar-1297Takifugu rubripes48.186e-21 100
LLPS-Ten-0114Tetraodon nigroviridis46.922e-134 409
LLPS-Cae-1069Caenorhabditis elegans44.236e-127 388
LLPS-Mua-0100Musa acuminata43.592e-0861.2
LLPS-Php-0728Physcomitrella patens42.62e-99 318
LLPS-Nia-2190Nicotiana attenuata41.963e-93 303
LLPS-Sot-0513Solanum tuberosum41.896e-94 305
LLPS-Sol-1624Solanum lycopersicum41.76e-94 305
LLPS-Brr-0516Brassica rapa41.572e-99 320
LLPS-Art-0187Arabidopsis thaliana41.455e-100 322
LLPS-Phv-0005Phaseolus vulgaris41.391e-93 304
LLPS-Glm-1544Glycine max41.393e-95 310
LLPS-Bro-1332Brassica oleracea41.122e-98 318
LLPS-Phn-0522Phaeosphaeria nodorum41.124e-1479.3
LLPS-Brn-3126Brassica napus41.122e-98 318
LLPS-Dos-0390Dothistroma septosporum40.911e-1790.5
LLPS-Gor-2380Gossypium raimondii40.532e-90 296
LLPS-Scp-0630Schizosaccharomyces pombe40.522e-1789.7
LLPS-Orp-1932Oryza punctata40.356e-1685.1
LLPS-Lep-1297Leersia perrieri40.351e-1584.0
LLPS-Arl-2262Arabidopsis lyrata40.353e-98 317
LLPS-Zyt-0903Zymoseptoria tritici40.356e-1685.1
LLPS-Tra-1194Triticum aestivum40.264e-98 317
LLPS-Coc-2170Corchorus capsularis40.01e-1585.1
LLPS-Prp-2401Prunus persica40.05e-0962.8
LLPS-Dac-2384Daucus carota39.963e-87 288
LLPS-Sob-1992Sorghum bicolor39.822e-93 304
LLPS-Viv-1994Vitis vinifera39.584e-1272.8
LLPS-Sei-0575Setaria italica39.439e-93 302
LLPS-Met-0077Medicago truncatula39.433e-85 283
LLPS-Hea-0793Helianthus annuus39.179e-94 305
LLPS-Zem-0861Zea mays39.082e-92 301
LLPS-Orb-0499Oryza barthii38.962e-84 280
LLPS-Orbr-1041Oryza brachyantha38.882e-89 293
LLPS-Chr-0532Chlamydomonas reinhardtii38.81e-91 298
LLPS-Orr-1570Oryza rufipogon38.745e-84 278
LLPS-Orni-1623Oryza nivara38.746e-84 280
LLPS-Orgl-1400Oryza glumaepatula38.61e-84 280
LLPS-Sem-1146Selaginella moellendorffii38.568e-92 297
LLPS-Ors-0295Oryza sativa38.481e-87 288
LLPS-Ori-2409Oryza indica38.481e-87 288
LLPS-Brd-0334Brachypodium distachyon38.071e-85 283
LLPS-Usm-1330Ustilago maydis38.012e-83 275
LLPS-Mae-1094Manihot esculenta37.982e-78 265
LLPS-Crn-0781Cryptococcus neoformans37.376e-78 261
LLPS-Abg-1354Absidia glauca37.095e-77 259
LLPS-Hov-0338Hordeum vulgare37.012e-76 259
LLPS-Orm-0315Oryza meridionalis36.924e-81 271
LLPS-Spr-0369Sporisorium reilianum36.92e-81 271
LLPS-Via-1945Vigna angularis36.522e-80 268
LLPS-Vir-2187Vigna radiata36.113e-78 263
LLPS-Tum-1554Tuber melanosporum36.114e-84 279
LLPS-Org-1567Oryza glaberrima36.024e-73 248
LLPS-Lem-1488Leptosphaeria maculans35.674e-78 262
LLPS-Cus-0849Cucumis sativus35.512e-82 273
LLPS-Cogr-1438Colletotrichum graminicola35.422e-78 262
LLPS-Cog-1011Colletotrichum gloeosporioides35.214e-78 262
LLPS-Map-0794Magnaporthe poae35.083e-76 257
LLPS-Trr-1154Trichoderma reesei35.063e-78 262
LLPS-Fus-1624Fusarium solani35.017e-73 257
LLPS-Pot-2815Populus trichocarpa34.974e-75 253
LLPS-Ved-0376Verticillium dahliae34.96e-76 256
LLPS-Ast-0597Aspergillus terreus34.848e-76 256
LLPS-Asc-0229Aspergillus clavatus34.841e-77 261
LLPS-Trv-0226Trichoderma virens34.641e-76 257
LLPS-Gag-1519Gaeumannomyces graminis34.648e-76 256
LLPS-Mao-1287Magnaporthe oryzae34.471e-74 252
LLPS-Asfu-1475Aspergillus fumigatus34.271e-77 261
LLPS-Fuv-1460Fusarium verticillioides34.214e-73 248
LLPS-Nef-0239Neosartorya fischeri34.23e-76 257
LLPS-Beb-1617Beauveria bassiana34.195e-74 251
LLPS-Coo-0908Colletotrichum orbiculare34.132e-76 257
LLPS-Nec-0977Neurospora crassa34.132e-74 252
LLPS-Pytr-0188Pyrenophora triticirepentis33.92e-72 247
LLPS-Aso-0516Aspergillus oryzae33.71e-72 247
LLPS-Asf-0191Aspergillus flavus33.73e-73 249
LLPS-Asn-0938Aspergillus nidulans33.622e-75 255
LLPS-Amt-1963Amborella trichopoda33.483e-74 251
LLPS-Scs-0673Sclerotinia sclerotiorum33.262e-73 249
LLPS-Asni-1295Aspergillus niger33.056e-77 259