LLPS-Mum-4381
Psma3

▼ OVERVIEW

Status: Unreviewed
Protein Name: Proteasome subunit alpha type-3; Macropain subunit C8; Multicatalytic endopeptidase complex subunit C8; Proteasome component C8; Proteasome subunit K
Gene Name: Psma3
Ensembl Gene: ENSMUSG00000060073.9
Ensembl Protein: ENSMUSP00000125739.1
Organism: Mus musculus
Taxa ID: 10090
LLPS Type: Others
PDB: 3UNH (A, B, C, D, E, F, G, H, I, J, K, L, M, N) More


▼ PROPERTY


——— Disorder propensity (calculated by IUPred2A)

▼ Classification

Condensates:
CondensateEvidenceOrthologs
Nuclear specklePredicted from orthologs(View)

▼ FUNCTION

Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP-dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing proteins whose functions are no longer required. Associated with the PA200 or PA28, the 20S proteasome mediates ubiquitin-independent protein degradation. This type of proteolysis is required in several pathways including spermatogenesis (20S-PA200 complex) or generation of a subset of MHC class I-presented antigenic peptides (20S-PA28 complex). Binds to the C-terminus of CDKN1A and thereby mediates its degradation. Negatively regulates the membrane trafficking of the cell-surface thromboxane A2 receptor (TBXA2R) isoform 2.

▼ SEQUENCE

Protein Sequence (FASTA)
1     MSSIGTGYDL  SASTFSPDGR  VFQVEYAMKA  VENSSTAIGI  RCKDGVVFGV  EKLVLSKLYE  60
61    EGSNKRLFNV  DRHVGMAVAG  LLADARSLAD  IAREEASNFR  SNFGYNIPLK  HLADRVAMYV  120
121   HAYTLYSAVR  PFGCSFMLGS  YSANDGAQLY  MIDPSGVSYG  YWGCAIGKAR  QAAKTEIEKL  180
181   QMKEMTCRDV  VKEVAKIIYI  VHDEVKDKAF  ELELSWVGEL  TKGRHEIVPK  DIREEAEKYA  240
241   KESLKEEDES  DDDNM  255
Nucleotide CDS Sequence (FASTA)
1     ATGAGCTCCA  TCGGCACTGG  GTATGACTTG  TCAGCCTCTA  CGTTCTCTCC  TGATGGAAGA  60
61    GTTTTCCAAG  TTGAATATGC  CATGAAGGCT  GTGGAAAACA  GTAGCTATTG  GGATCAGATG  120
121   TAA  123

▼ KEYWORD

ID
Family
3D-structure
Acetylation
Complete proteome
Cytoplasm
Direct protein sequencing
Hydrolase
Nucleus
Phosphoprotein
Protease
Proteasome
Reference proteome
Threonine protease

▼ GENE ONTOLOGY

ID
Classification
Description
Cellular Component
Cytoplasm
Cellular Component
Cytosol
Cellular Component
Nucleoplasm
Cellular Component
Nucleus
Cellular Component
Proteasome complex
Cellular Component
Proteasome core complex
Cellular Component
Proteasome core complex, alpha-subunit complex
Cellular Component
Synapse
Molecular Function
Endopeptidase activity
Molecular Function
Threonine-type endopeptidase activity
Molecular Function
Ubiquitin protein ligase binding
Biological Process
Proteasomal protein catabolic process
Biological Process
Proteasomal ubiquitin-independent protein catabolic process
Biological Process
Proteasome-mediated ubiquitin-dependent protein catabolic process
Biological Process
Regulation of endopeptidase activity

▼ KEGG


▼ ORTHOLOGY

DrLLPS IDOrganismIdentityE-valueScore
LLPS-Mea-0109Mesocricetus auratus100.04e-119 345
LLPS-Ict-4659Ictidomys tridecemlineatus99.585e-177 494
LLPS-Cap-4336Cavia porcellus99.585e-177 494
LLPS-Loa-3282Loxodonta africana99.585e-177 494
LLPS-Fud-3260Fukomys damarensis99.584e-177 495
LLPS-Cas-1034Carlito syrichta99.179e-177 494
LLPS-Orc-4013Oryctolagus cuniculus99.174e-175 493
LLPS-Otg-0879Otolemur garnettii99.179e-177 494
LLPS-Fec-3203Felis catus99.175e-177 495
LLPS-Urm-0817Ursus maritimus99.171e-176 494
LLPS-Aim-2237Ailuropoda melanoleuca99.171e-176 494
LLPS-Ran-3447Rattus norvegicus99.177e-177 494
LLPS-Sus-2460Sus scrofa99.171e-176 494
LLPS-Nol-4628Nomascus leucogenys98.755e-176 492
LLPS-Eqc-4570Equus caballus98.756e-176 492
LLPS-Poa-2480Pongo abelii98.755e-176 492
LLPS-Caf-1219Canis familiaris98.752e-176 493
LLPS-Man-1021Macaca nemestrina98.755e-176 492
LLPS-Pat-4143Pan troglodytes98.755e-176 492
LLPS-Pap-3978Pan paniscus98.755e-176 492
LLPS-Hos-1142Homo sapiens98.755e-176 492
LLPS-Mup-3672Mustela putorius furo98.754e-176 493
LLPS-Myl-1429Myotis lucifugus98.754e-176 493
LLPS-Ova-4460Ovis aries98.756e-176 492
LLPS-Mal-3069Mandrillus leucophaeus98.755e-176 492
LLPS-Paa-4098Papio anubis98.755e-176 492
LLPS-Caj-1352Callithrix jacchus98.755e-176 492
LLPS-Gog-3512Gorilla gorilla98.755e-176 492
LLPS-Cea-1081Cercocebus atys98.755e-176 492
LLPS-Chs-2972Chlorocebus sabaeus98.755e-176 492
LLPS-Maf-4075Macaca fascicularis98.755e-176 492
LLPS-Mam-0285Macaca mulatta98.711e-170 479
LLPS-Mod-0955Monodelphis domestica98.334e-175 490
LLPS-Bot-4114Bos taurus98.331e-175 491
LLPS-Sah-2592Sarcophilus harrisii98.332e-175 491
LLPS-Aon-0926Aotus nancymaae98.332e-175 491
LLPS-Rhb-3574Rhinopithecus bieti97.932e-173 486
LLPS-Pes-2392Pelodiscus sinensis97.53e-174 488
LLPS-Tag-2237Taeniopygia guttata96.772e-167 470
LLPS-Fia-3501Ficedula albicollis96.675e-173 484
LLPS-Anp-0609Anas platyrhynchos96.574e-166 467
LLPS-Gaga-1561Gallus gallus96.083e-172 483
LLPS-Anc-2538Anolis carolinensis95.692e-172 483
LLPS-Meg-2906Meleagris gallopavo92.341e-158 448
LLPS-Leo-3785Lepisosteus oculatus92.085e-167 469
LLPS-Scf-1841Scleropages formosus91.671e-166 469
LLPS-Lac-0146Latimeria chalumnae91.342e-163 461
LLPS-Xet-0178Xenopus tropicalis90.981e-165 466
LLPS-Icp-3907Ictalurus punctatus90.838e-166 466
LLPS-Orn-3329Oreochromis niloticus90.05e-165 464
LLPS-Dio-4368Dipodomys ordii90.01e-153 435
LLPS-Asm-0454Astyanax mexicanus90.09e-165 464
LLPS-Dar-2957Danio rerio89.583e-164 462
LLPS-Pof-2203Poecilia formosa89.33e-163 460
LLPS-Orl-3822Oryzias latipes89.171e-163 461
LLPS-Tar-1809Takifugu rubripes88.753e-162 459
LLPS-Gaa-3011Gasterosteus aculeatus85.833e-159 450
LLPS-Ten-3806Tetraodon nigroviridis85.665e-155 439
LLPS-Xim-4147Xiphophorus maculatus85.423e-153 436
LLPS-Scm-3188Scophthalmus maximus85.143e-94 281
LLPS-Cii-2248Ciona intestinalis69.172e-122 356
LLPS-Cis-1910Ciona savignyi67.921e-120 352
LLPS-Phv-1199Phaseolus vulgaris65.59e-102 303
LLPS-Via-2356Vigna angularis65.093e-102 305
LLPS-Glm-2455Glycine max65.079e-101 301
LLPS-Nia-0544Nicotiana attenuata64.946e-104 309
LLPS-Viv-1547Vitis vinifera64.942e-103 308
LLPS-Cus-2156Cucumis sativus64.942e-103 308
LLPS-Coc-0281Corchorus capsularis64.666e-105 311
LLPS-Pot-2194Populus trichocarpa64.581e-107 318
LLPS-Met-2020Medicago truncatula64.583e-105 312
LLPS-Sot-0151Solanum tuberosum64.51e-101 303
LLPS-Gor-0250Gossypium raimondii64.292e-105 313
LLPS-Dac-1069Daucus carota64.229e-103 306
LLPS-Mae-1189Manihot esculenta64.171e-105 313
LLPS-Lep-1311Leersia perrieri64.14e-103 307
LLPS-Tru-1561Triticum urartu63.791e-101 303
LLPS-Brd-0608Brachypodium distachyon63.791e-102 306
LLPS-Tra-1275Triticum aestivum63.794e-102 304
LLPS-Sei-1463Setaria italica63.793e-102 305
LLPS-Sem-1758Selaginella moellendorffii63.795e-100 299
LLPS-Sol-2254Solanum lycopersicum63.792e-101 302
LLPS-Hea-2161Helianthus annuus63.761e-100 301
LLPS-Thc-1878Theobroma cacao63.753e-106 315
LLPS-Orbr-0193Oryza brachyantha63.682e-102 305
LLPS-Mua-2261Musa acuminata63.369e-101 301
LLPS-Amt-1443Amborella trichopoda63.254e-102 304
LLPS-Prp-1465Prunus persica62.932e-101 302
LLPS-Sob-0872Sorghum bicolor62.937e-101 301
LLPS-Hov-0437Hordeum vulgare62.933e-101 302
LLPS-Php-2512Physcomitrella patens62.938e-101 301
LLPS-Org-2121Oryza glaberrima62.875e-103 306
LLPS-Orr-2347Oryza rufipogon62.875e-103 306
LLPS-Orp-1745Oryza punctata62.875e-103 306
LLPS-Ors-2133Oryza sativa62.875e-103 306
LLPS-Orgl-2173Oryza glumaepatula62.875e-103 306
LLPS-Orni-1212Oryza nivara62.873e-102 307
LLPS-Ori-1343Oryza indica62.875e-103 306
LLPS-Orb-2264Oryza barthii62.555e-100 302
LLPS-Orm-1800Oryza meridionalis62.456e-102 304
LLPS-Mel-1182Melampsora laricipopulina62.232e-100 300
LLPS-Bro-1282Brassica oleracea62.085e-104 309
LLPS-Art-2127Arabidopsis thaliana62.082e-102 309
LLPS-Brr-2527Brassica rapa62.084e-104 310
LLPS-Brn-1070Brassica napus62.084e-104 310
LLPS-Zem-0015Zea mays61.292e-102 305
LLPS-Arl-0788Arabidopsis lyrata61.252e-102 305
LLPS-Drm-2187Drosophila melanogaster59.666e-97 291
LLPS-Usm-1526Ustilago maydis58.93e-95 287
LLPS-Spr-0889Sporisorium reilianum58.052e-95 287
LLPS-Abg-0268Absidia glauca57.686e-91 284
LLPS-Pug-1068Puccinia graminis57.564e-94 284
LLPS-Asni-1591Aspergillus niger57.21e-93 284
LLPS-Miv-1100Microbotryum violaceum56.633e-97 292
LLPS-Put-0597Puccinia triticina55.743e-91 277
LLPS-Vir-2044Vigna radiata54.476e-74 233
LLPS-Chr-1682Chlamydomonas reinhardtii54.178e-87 265
LLPS-Asg-1168Ashbya gossypii54.13e-85 263
LLPS-Tum-1347Tuber melanosporum53.971e-87 269
LLPS-Kop-0320Komagataella pastoris53.533e-87 266
LLPS-Yal-1150Yarrowia lipolytica53.534e-87 266
LLPS-Dos-0198Dothistroma septosporum53.281e-89 274
LLPS-Crn-1355Cryptococcus neoformans53.161e-85 263
LLPS-Scj-0520Schizosaccharomyces japonicus52.927e-82 253
LLPS-Asf-0692Aspergillus flavus52.774e-90 275
LLPS-Aso-1463Aspergillus oryzae52.774e-90 275
LLPS-Chc-0202Chondrus crispus52.442e-82 254
LLPS-Sac-1579Saccharomyces cerevisiae52.055e-81 252
LLPS-Asc-1621Aspergillus clavatus52.038e-92 280
LLPS-Asn-0868Aspergillus nidulans51.661e-90 276
LLPS-Cogr-1086Colletotrichum graminicola51.293e-90 276
LLPS-Zyt-1426Zymoseptoria tritici51.093e-87 268
LLPS-Lem-0901Leptosphaeria maculans50.941e-84 263
LLPS-Pytr-1468Pyrenophora triticirepentis50.558e-89 272
LLPS-Cog-1008Colletotrichum gloeosporioides50.552e-88 273
LLPS-Gag-1367Gaeumannomyces graminis50.551e-86 266
LLPS-Osl-1396Ostreococcus lucimarinus50.421e-76 239
LLPS-Scc-1091Schizosaccharomyces cryophilus50.427e-81 250
LLPS-Phn-1263Phaeosphaeria nodorum50.382e-85 263
LLPS-Trv-0953Trichoderma virens50.377e-86 265
LLPS-Nef-0582Neosartorya fischeri50.25e-78 244
LLPS-Pyt-1393Pyrenophora teres50.188e-88 270
LLPS-Coo-1336Colletotrichum orbiculare50.183e-89 273
LLPS-Scp-1208Schizosaccharomyces pombe50.08e-81 250
LLPS-Mao-1358Magnaporthe oryzae49.452e-85 263
LLPS-Asfu-0774Aspergillus fumigatus49.48e-78 243
LLPS-Nec-1424Neurospora crassa49.273e-88 270
LLPS-Trr-1569Trichoderma reesei49.263e-84 260
LLPS-Gas-1033Galdieria sulphuraria49.181e-80 251
LLPS-Cae-1915Caenorhabditis elegans49.173e-77 241
LLPS-Fus-0371Fusarium solani48.894e-83 257
LLPS-Fuo-0641Fusarium oxysporum48.889e-83 256
LLPS-Fuv-0723Fusarium verticillioides48.881e-82 256
LLPS-Ast-1132Aspergillus terreus48.788e-86 265
LLPS-Cym-0990Cyanidioschyzon merolae48.037e-75 235
LLPS-Ved-0181Verticillium dahliae47.783e-80 250
LLPS-Beb-0973Beauveria bassiana47.433e-80 250
LLPS-Blg-1273Blumeria graminis46.133e-76 239