LLPS-Mum-3787
Mcu

▼ OVERVIEW

Status: Reviewed
Protein Name: Calcium uniporter protein, mitochondrial
Gene Name: Mcu
Ensembl Gene: ENSMUSG00000009647.13
Ensembl Protein: ENSMUSP00000020312.6
Organism: Mus musculus
Taxa ID: 10090
LLPS Type: Others


▼ PROPERTY


——— Disorder propensity (calculated by IUPred2A)

▼ Classification

Condensates:
CondensateDescriptionTissue/CellPMIDs
Postsynaptic density
"...We report the first direct comparison of the proteome of triplicate isolates of mouse and human cortical postsynaptic densities. The mouse postsynaptic density comprised 1556 proteins and the human one 1461."
Mouse cortex23071613
Mitochondrial RNA granulePredicted from orthologsN/A(View)

▼ FUNCTION

Mitochondrial inner membrane calcium uniporter that mediates calcium uptake into mitochondria (PubMed:21685886, PubMed:23900286, PubMed:24212091). Constitutes the pore-forming and calcium-conducting subunit of the uniporter complex (uniplex) (By similarity). Activity is regulated by MICU1 and MICU2 (By similarity). At low Ca(2+) levels MCU activity is down-regulated by MICU1 and MICU2; at higher Ca(2+) levels MICU1 increases MCU activity (By similarity). Mitochondrial calcium homeostasis plays key roles in cellular physiology and regulates cell bioenergetics, cytoplasmic calcium signals and activation of cell death pathways (By similarity). Involved in buffering the amplitude of systolic calcium rises in cardiomyocytes (By similarity). While dispensable for baseline homeostatic cardiac function, acts as a key regulator of short-term mitochondrial calcium loading underlying a 'fight-or-flight' response during acute stress: acts by mediating a rapid increase of mitochondrial calcium in pacemaker cells (PubMed:26119742, PubMed:26119731, PubMed:25603276). Participates in mitochondrial permeability transition during ischemia-reperfusion injury (PubMed:26119731). Regulates glucose-dependent insulin secretion in pancreatic beta-cells by regulating mitochondrial calcium uptake (By similarity). Mitochondrial calcium uptake in skeletal muscle cells is involved in muscle size in adults (PubMed:25732818). Regulates synaptic vesicle endocytosis kinetics in central nerve terminal (PubMed:26644474). Involved in antigen processing and presentation (PubMed:25251370).

▼ SEQUENCE

Protein Sequence (FASTA)
1     MAAAAGRSLL  LLLCSRGGGG  GAGGCGALTA  GCFPGLGVSR  HRPHQQHRTA  HQRPASWQSV  60
61    GAAYCSTVVP  SDDVTVVYQN  GLPVISVRLP  SRRERCQFTL  KPISDSVGVF  LRQLQEEDRG  120
121   IDRVAIYSPD  GVRVAASTGI  DLLLLDDFKL  VINDLTYHVR  PPKRDLLSHE  DAATLNDVKT  180
181   LVQQLYTTLC  IEQHQLNKER  ELVERLEDLK  QQLAPLEKVR  IEISRKAEKR  TTLVLWGGLA  240
241   YMATQFGILA  RLTWWEYSWD  IMEPVTYFIT  YGSAMAMYAY  FVMTRQEYVY  PEARDRQYLL  300
301   FFHKGAKKSR  FDLEKYNQLK  DAIAQAEMDL  KRLRDPLQVH  LPLRQIGEKE  350
Nucleotide CDS Sequence (FASTA)
1     ATGGCGGCCG  CCGCAGGTAG  ATCGCTCCTG  CTGCTGCTCT  GCTCCCGGGG  CGGCGGCGGG  60
61    GGCGCCGGCG  GCTGCGGAGC  GCTGACTGCC  GGCTGCTTTC  CCGGGCTGGG  CGTCAGCCGC  120
121   CACCGGCCGC  ACCAGCAGCA  CCGGACGGCA  CACCAGAGGC  CGGCTTCCTG  GCAGAGCGTG  180
181   GGAGCCGCAT  ATTGCAGTAC  GGTTGTGCCC  TCTGATGACG  TGACGGTGGT  TTACCAAAAT  240
241   GGATTACCGG  TGATATCTGT  GAGGCTACCC  TCTCGACGCG  AGCGCTGCCA  ATTCACACTC  300
301   AAGCCTATCT  CTGACTCAGT  CGGCGTGTTT  TTACGACAAC  TGCAAGAGGA  GGATCGGGGA  360
361   ATCGACCGGG  TCGCCATCTA  CTCACCAGAT  GGCGTTCGAG  TCGCTGCCTC  CACGGGGATA  420
421   GACCTCCTGC  TCCTCGATGA  CTTTAAGCTT  GTCATTAATG  ACTTAACATA  CCACGTACGG  480
481   CCACCAAAGA  GAGACCTCCT  AAGCCATGAA  GATGCAGCGA  CGCTGAACGA  CGTGAAGACC  540
541   CTGGTCCAGC  AGCTGTACAC  CACACTGTGC  ATTGAGCAGC  ATCAGCTTAA  CAAAGAGCGG  600
601   GAGCTCGTGG  AGAGGTTAGA  GGACCTCAAG  CAGCAGCTGG  CCCCCCTGGA  GAAGGTACGA  660
661   ATTGAAATTA  GCAGAAAAGC  AGAGAAGAGG  ACCACTCTGG  TGCTGTGGGG  AGGCCTGGCC  720
721   TACATGGCCA  CCCAGTTTGG  CATTCTGGCC  CGGCTCACCT  GGTGGGAGTA  CTCGTGGGAC  780
781   ATCATGGAGC  CCGTCACCTA  CTTCATCACG  TACGGAAGCG  CCATGGCCAT  GTATGCGTAT  840
841   TTTGTAATGA  CGCGCCAGGA  ATATGTTTAT  CCAGAAGCCA  GAGACAGACA  ATACTTATTA  900
901   TTTTTCCATA  AAGGAGCCAA  AAAGTCACGT  TTCGACCTAG  AGAAATACAA  TCAGCTCAAG  960
961   GATGCAATTG  CTCAGGCAGA  AATGGATCTT  AAGAGACTGA  GAGACCCATT  ACAAGTACAC  1020
1021  CTGCCCCTCC  GACAGATCGG  AGAAAAGGAA  TGA  1053

▼ KEYWORD

ID
Family
Acetylation
Alternative splicing
Calcium
Calcium channel
Calcium transport
Coiled coil
Complete proteome
Ion channel
Ion transport
Membrane
Mitochondrion
Mitochondrion inner membrane
Phosphoprotein
Reference proteome
Transit peptide
Transmembrane
Transmembrane helix
Transport

▼ GENE ONTOLOGY

ID
Classification
Description
Cellular Component
Calcium channel complex
Cellular Component
Integral component of mitochondrial inner membrane
Cellular Component
Mitochondrial inner membrane
Cellular Component
Mitochondrion
Cellular Component
Uniplex complex
Molecular Function
Calcium channel activity
Molecular Function
Identical protein binding
Molecular Function
Uniporter activity
Biological Process
Calcium import into the mitochondrion
Biological Process
Calcium-mediated signaling
Biological Process
Glucose homeostasis
Biological Process
Mitochondrial calcium ion homeostasis
Biological Process
Mitochondrial calcium ion transmembrane transport
Biological Process
Positive regulation of insulin secretion
Biological Process
Positive regulation of mitochondrial calcium ion concentration
Biological Process
Protein complex oligomerization

▼ KEGG


▼ ORTHOLOGY

DrLLPS IDOrganismIdentityE-valueScore
LLPS-Ran-3526Rattus norvegicus98.750.0 612
LLPS-Otg-4745Otolemur garnettii97.80.0 538
LLPS-Mea-1153Mesocricetus auratus97.490.0 605
LLPS-Myl-2927Myotis lucifugus97.440.0 535
LLPS-Pap-3738Pan paniscus97.010.0 562
LLPS-Dio-3008Dipodomys ordii96.921e-34 134
LLPS-Aim-1721Ailuropoda melanoleuca96.350.0 560
LLPS-Fud-3683Fukomys damarensis96.350.0 559
LLPS-Urm-3498Ursus maritimus96.330.0 556
LLPS-Hos-2060Homo sapiens96.240.0 596
LLPS-Pat-2327Pan troglodytes96.240.0 596
LLPS-Ict-4592Ictidomys tridecemlineatus96.010.0 558
LLPS-Mal-2056Mandrillus leucophaeus96.010.0 560
LLPS-Fec-1648Felis catus95.960.0 601
LLPS-Poa-2277Pongo abelii95.920.0 594
LLPS-Nol-3902Nomascus leucogenys95.920.0 592
LLPS-Mup-0542Mustela putorius furo95.920.0 595
LLPS-Mam-3563Macaca mulatta95.340.0 599
LLPS-Man-2655Macaca nemestrina95.340.0 599
LLPS-Cea-4499Cercocebus atys95.340.0 599
LLPS-Maf-4298Macaca fascicularis95.340.0 599
LLPS-Caf-1860Canis familiaris95.30.0 591
LLPS-Cas-1342Carlito syrichta95.30.0 592
LLPS-Rhb-4716Rhinopithecus bieti95.30.0 593
LLPS-Chs-3757Chlorocebus sabaeus95.080.0 561
LLPS-Paa-4289Papio anubis95.030.0 596
LLPS-Caj-0896Callithrix jacchus95.030.0 595
LLPS-Sus-0720Sus scrofa95.00.0 571
LLPS-Bot-3534Bos taurus94.980.0 588
LLPS-Ova-4068Ovis aries94.980.0 588
LLPS-Eqc-0259Equus caballus94.950.0 546
LLPS-Loa-3948Loxodonta africana94.720.0 572
LLPS-Orc-1170Oryctolagus cuniculus94.670.0 585
LLPS-Cap-4492Cavia porcellus94.410.0 585
LLPS-Aon-0279Aotus nancymaae94.360.0 585
LLPS-Sah-3978Sarcophilus harrisii91.670.0 533
LLPS-Mod-1750Monodelphis domestica91.330.0 538
LLPS-Gaga-2665Gallus gallus88.740.0 524
LLPS-Meg-1912Meleagris gallopavo88.70.0 521
LLPS-Pes-1770Pelodiscus sinensis88.410.0 514
LLPS-Anc-3179Anolis carolinensis88.40.0 532
LLPS-Anp-3272Anas platyrhynchos88.370.0 520
LLPS-Tag-2668Taeniopygia guttata87.710.0 516
LLPS-Fia-0132Ficedula albicollis87.382e-180 511
LLPS-Gaa-3965Gasterosteus aculeatus82.266e-159 457
LLPS-Lac-3464Latimeria chalumnae82.053e-168 478
LLPS-Orn-2249Oreochromis niloticus81.784e-154 445
LLPS-Orl-3925Oryzias latipes81.785e-154 443
LLPS-Xim-2969Xiphophorus maculatus81.44e-153 446
LLPS-Tar-2366Takifugu rubripes81.47e-153 442
LLPS-Gog-2705Gorilla gorilla81.024e-144 417
LLPS-Ten-3108Tetraodon nigroviridis81.015e-152 436
LLPS-Pof-3130Poecilia formosa80.772e-151 438
LLPS-Dar-1453Danio rerio80.675e-163 468
LLPS-Scm-3598Scophthalmus maximus80.625e-154 445
LLPS-Asm-3241Astyanax mexicanus79.369e-127 372
LLPS-Xet-1755Xenopus tropicalis78.334e-176 500
LLPS-Ora-1282Ornithorhynchus anatinus78.073e-149 430
LLPS-Leo-0324Lepisosteus oculatus69.722e-170 487
LLPS-Scf-1182Scleropages formosus67.911e-158 457
LLPS-Icp-0155Ictalurus punctatus66.572e-161 467
LLPS-Cii-1801Ciona intestinalis59.622e-116 347
LLPS-Cis-0594Ciona savignyi56.447e-105 316
LLPS-Drm-0701Drosophila melanogaster50.578e-94 294
LLPS-Cae-2033Caenorhabditis elegans42.752e-77 248
LLPS-Hov-0707Hordeum vulgare38.793e-2092.0
LLPS-Orbr-2281Oryza brachyantha38.745e-2295.9
LLPS-Lep-1764Leersia perrieri38.743e-2193.6
LLPS-Dac-2376Daucus carota38.62e-1682.8
LLPS-Tru-1914Triticum urartu37.936e-2090.9
LLPS-Hea-2669Helianthus annuus37.933e-1785.1
LLPS-Pot-1468Populus trichocarpa37.847e-1784.0
LLPS-Orp-1846Oryza punctata37.848e-2192.8
LLPS-Tra-0960Triticum aestivum37.844e-1989.7
LLPS-Brn-0604Brassica napus37.844e-2092.8
LLPS-Bro-2992Brassica oleracea37.174e-2092.8
LLPS-Brr-2285Brassica rapa37.176e-2092.0
LLPS-Mua-0490Musa acuminata37.078e-1886.3
LLPS-Sot-0262Solanum tuberosum36.612e-1682.8
LLPS-Orr-2120Oryza rufipogon36.096e-2297.8
LLPS-Orm-1615Oryza meridionalis36.095e-2298.2
LLPS-Ors-2105Oryza sativa36.096e-2297.8
LLPS-Orb-1344Oryza barthii36.096e-2297.8
LLPS-Ori-1656Oryza indica36.096e-2297.8
LLPS-Orni-1073Oryza nivara36.092e-2296.7
LLPS-Viv-1953Vitis vinifera36.048e-1886.3
LLPS-Art-2948Arabidopsis thaliana35.717e-2194.7
LLPS-Arl-2733Arabidopsis lyrata35.712e-2196.3
LLPS-Met-2552Medicago truncatula35.713e-1888.2
LLPS-Zem-1215Zea mays35.612e-1990.9
LLPS-Sob-1715Sorghum bicolor35.616e-2091.3
LLPS-Vir-1404Vigna radiata35.482e-1784.0
LLPS-Php-2428Physcomitrella patens35.435e-1682.0
LLPS-Org-1177Oryza glaberrima35.141e-1785.5
LLPS-Mae-0674Manihot esculenta35.146e-1681.6
LLPS-Nia-0083Nicotiana attenuata35.141e-1580.1
LLPS-Orgl-0988Oryza glumaepatula35.141e-1785.5
LLPS-Cus-0955Cucumis sativus35.143e-1579.7
LLPS-Brd-0941Brachypodium distachyon35.145e-1989.7
LLPS-Phv-1422Phaseolus vulgaris34.828e-1784.0
LLPS-Gor-2539Gossypium raimondii34.515e-1784.0
LLPS-Sol-2363Solanum lycopersicum34.518e-1680.9
LLPS-Glm-0538Glycine max34.42e-1888.2
LLPS-Via-1677Vigna angularis34.153e-1682.4
LLPS-Coc-1666Corchorus capsularis33.931e-1580.5
LLPS-Sei-2047Setaria italica33.831e-2094.0
LLPS-Sem-1996Selaginella moellendorffii33.675e-1268.6
LLPS-Prp-1583Prunus persica33.645e-1681.6
LLPS-Amt-2345Amborella trichopoda32.565e-1681.6
LLPS-Thc-0227Theobroma cacao31.391e-1580.1
LLPS-Chr-1683Chlamydomonas reinhardtii30.512e-1064.3
LLPS-Osl-0689Ostreococcus lucimarinus28.745e-0961.2