LLPS-Art-2948
At1g57610
▼ OVERVIEW
| Status: | Unreviewed |
| Protein Name: | Calcium uniporter protein 5, mitochondrial |
| Gene Name: | At1g57610, T8L23.8 |
| Ensembl Gene: | AT1G57610 |
| Ensembl Protein: | AT1G57610.2 |
| Organism: | Arabidopsis thaliana |
| Taxa ID: | 3702 |
| LLPS Type: | Others |
▼ Classification
Condensates:
| Condensate | Evidence | Orthologs |
|---|---|---|
| Mitochondrial RNA granule | Predicted from orthologs | (View) |
▼ FUNCTION
| Mitochondrial inner membrane calcium uniporter that mediates calcium uptake into mitochondria. Constitutes a pore-forming and calcium-conducting subunit. Mitochondrial calcium homeostasis plays key roles in cellular physiology and regulates cell bioenergetics, cytoplasmic calcium signals and activation of cell death pathways. |
▼ CROSS REFERENCE
| Database | Nucleotide ID | Protein ID |
|---|---|---|
| Ensembl | AT1G57610.2 | AT1G57610.2 |
| Ensembl | AT1G57610.3 | AT1G57610.3 |
| Ensembl | AT1G57610.4 | AT1G57610.4 |
| Ensembl | AT1G57610.1 | AT1G57610.1 |
| UniProt | Q8VYR0, MCU5_ARATH, Q9FVU1 | |
| GeneBank | CP002684, AC079733, AY070082 | AAL49777.1, AEE33441.1, AAG50752.1, AEE33442.1 |
| RefSeq | NM_104558.4, NM_202314.3 | NP_176074.2, NP_974043.1 |
▼ SEQUENCE
| Protein Sequence (FASTA) |
|---|
1 MWSVMGLVRR TAMSSTVNKA SPVRSLLGGF RCLNVESKEE DEKKDMTVLE AKKLMRLVNV 60 61 EDMKKKLIGM GDKEMVTYTT LIEASQGLGI ARSLDEAHAF ARVLDDAGVI LIFRDKVYLH 120 121 PHKVVDLIRK AVPLGLNPDD ELIREEFDKM RSMKEEIDVL AHQQVRKILW GGLGYSVVQI 180 181 GIFVRLTFWE FSWDVMEPIT FFTTATGIIV GYAYFLMTSR DPTYQDFMKR LFLSRQRKLL 240 241 KSHKFDAERF KELENKWKIT SCSSSSCHAN ASIRNRVGVD LDLEDSLQSH HRD 293 |
| Nucleotide CDS Sequence (FASTA) |
1 ATGTGGTCGG TGATGGGTTT AGTGAGACGT ACGGCTATGT CCTCCACCGT GAATAAAGCT 60 61 TCTCCGGTTA GGTCTTTGCT TGGTGGGTTT AGATGTCTCA ACGTTGAGTC TAAGGAAGAA 120 121 GATGAGAAAA AGGATATGAC TGTGTTAGAA GCTAAGAAGT TAATGAGATT AGTGAATGTT 180 181 GAAGATATGA AGAAGAAGCT TATTGGTATG GGTGATAAAG AAATGGTTAC TTACACTACA 240 241 CTTATTGAAG CATCTCAAGG TTTAGGTATC GCTAGATCTC TTGATGAAGC TCATGCTTTT 300 301 GCTCGTGTTC TTGATGATGC TGGTGTTATT TTGATCTTTC GTGATAAAGT CTATCTTCAT 360 361 CCTCATAAGG TGGTGGATTT GATTAGAAAG GCAGTGCCTT TAGGTTTGAA TCCAGATGAT 420 421 GAGTTGATTA GAGAAGAGTT TGATAAGATG AGAAGTATGA AGGAAGAGAT TGATGTGTTA 480 481 GCTCATCAAC AAGTGAGGAA GATTCTATGG GGTGGTCTTG GTTACTCAGT GGTTCAAATT 540 541 GGAATCTTTG TTAGGCTAAC TTTTTGGGAG TTTTCTTGGG ATGTGATGGA ACCAATAACG 600 601 TTTTTCACTA CAGCTACTGG GATTATTGCA GAGGAAGTTG CTTAA 645 |
▼ KEYWORD
ID | Family |
Alternative splicing | |
Calcium | |
Calcium channel | |
Calcium transport | |
Complete proteome | |
Ion channel | |
Ion transport | |
Membrane | |
Mitochondrion | |
Mitochondrion inner membrane | |
Reference proteome | |
Transit peptide | |
Transmembrane | |
Transmembrane helix | |
Transport
|
▼ GENE ONTOLOGY
ID | Classification | Description |
Cellular Component | Integral component of membrane | |
Cellular Component | Mitochondrial inner membrane | |
Molecular Function | Calcium channel activity | |
Molecular Function | Uniporter activity | |
Biological Process | Mitochondrial calcium ion homeostasis |
▼ ORTHOLOGY
| DrLLPS ID | Organism | Identity | E-value | Score |
|---|---|---|---|---|
| LLPS-Arl-2733 | Arabidopsis lyrata | 94.12 | 0.0 | 544 |
| LLPS-Bro-2992 | Brassica oleracea | 69.59 | 2e-142 | 410 |
| LLPS-Brn-0604 | Brassica napus | 69.59 | 2e-142 | 410 |
| LLPS-Brr-2285 | Brassica rapa | 69.36 | 1e-138 | 401 |
| LLPS-Gor-2539 | Gossypium raimondii | 67.49 | 2e-114 | 340 |
| LLPS-Coc-1666 | Corchorus capsularis | 66.53 | 2e-113 | 337 |
| LLPS-Thc-0227 | Theobroma cacao | 65.87 | 9e-114 | 338 |
| LLPS-Lep-1764 | Leersia perrieri | 65.61 | 7e-75 | 233 |
| LLPS-Viv-1953 | Vitis vinifera | 65.26 | 4e-98 | 297 |
| LLPS-Mua-0490 | Musa acuminata | 64.95 | 2e-97 | 296 |
| LLPS-Amt-2345 | Amborella trichopoda | 64.35 | 3e-97 | 296 |
| LLPS-Orbr-2281 | Oryza brachyantha | 64.33 | 3e-73 | 229 |
| LLPS-Orp-1846 | Oryza punctata | 63.5 | 5e-61 | 198 |
| LLPS-Phv-1422 | Phaseolus vulgaris | 62.99 | 2e-108 | 325 |
| LLPS-Tru-1914 | Triticum urartu | 62.96 | 1e-72 | 229 |
| LLPS-Met-2552 | Medicago truncatula | 62.7 | 3e-105 | 317 |
| LLPS-Orni-1073 | Oryza nivara | 62.32 | 7e-60 | 194 |
| LLPS-Cus-0955 | Cucumis sativus | 61.54 | 5e-109 | 327 |
| LLPS-Pot-1468 | Populus trichocarpa | 60.82 | 3e-100 | 304 |
| LLPS-Vir-1404 | Vigna radiata | 60.82 | 4e-79 | 246 |
| LLPS-Sei-2047 | Setaria italica | 59.26 | 2e-89 | 275 |
| LLPS-Via-1677 | Vigna angularis | 57.89 | 3e-89 | 276 |
| LLPS-Hov-0707 | Hordeum vulgare | 57.84 | 2e-79 | 247 |
| LLPS-Brd-0941 | Brachypodium distachyon | 57.8 | 8e-87 | 269 |
| LLPS-Orr-2120 | Oryza rufipogon | 57.42 | 4e-84 | 261 |
| LLPS-Orm-1615 | Oryza meridionalis | 57.42 | 4e-84 | 261 |
| LLPS-Ors-2105 | Oryza sativa | 57.42 | 4e-84 | 261 |
| LLPS-Ori-1656 | Oryza indica | 57.42 | 4e-84 | 261 |
| LLPS-Orb-1344 | Oryza barthii | 57.42 | 4e-84 | 261 |
| LLPS-Nia-0083 | Nicotiana attenuata | 57.26 | 2e-95 | 290 |
| LLPS-Org-1177 | Oryza glaberrima | 57.08 | 4e-78 | 246 |
| LLPS-Orgl-0988 | Oryza glumaepatula | 57.08 | 4e-78 | 246 |
| LLPS-Sob-1715 | Sorghum bicolor | 56.86 | 4e-74 | 233 |
| LLPS-Zem-1215 | Zea mays | 54.26 | 1e-77 | 245 |
| LLPS-Prp-1583 | Prunus persica | 53.06 | 1e-98 | 300 |
| LLPS-Hea-2669 | Helianthus annuus | 52.96 | 1e-101 | 306 |
| LLPS-Tra-0960 | Triticum aestivum | 51.78 | 2e-88 | 272 |
| LLPS-Sol-2363 | Solanum lycopersicum | 50.16 | 3e-97 | 295 |
| LLPS-Sem-1996 | Selaginella moellendorffii | 46.92 | 1e-52 | 177 |
| LLPS-Ora-1282 | Ornithorhynchus anatinus | 43.59 | 2e-15 | 78.2 |
| LLPS-Gog-2705 | Gorilla gorilla | 41.0 | 9e-20 | 90.9 |
| LLPS-Php-2428 | Physcomitrella patens | 39.62 | 2e-59 | 200 |
| LLPS-Mae-0674 | Manihot esculenta | 38.97 | 3e-46 | 165 |
| LLPS-Xet-1755 | Xenopus tropicalis | 38.33 | 5e-22 | 97.8 |
| LLPS-Sah-3978 | Sarcophilus harrisii | 38.26 | 2e-21 | 95.9 |
| LLPS-Pes-1770 | Pelodiscus sinensis | 38.1 | 4e-22 | 98.2 |
| LLPS-Ova-4068 | Ovis aries | 38.1 | 7e-22 | 97.4 |
| LLPS-Sot-0262 | Solanum tuberosum | 37.8 | 7e-48 | 169 |
| LLPS-Anc-3179 | Anolis carolinensis | 37.39 | 1e-20 | 94.0 |
| LLPS-Scm-3598 | Scophthalmus maximus | 37.39 | 1e-20 | 94.4 |
| LLPS-Mod-1750 | Monodelphis domestica | 37.39 | 3e-21 | 95.5 |
| LLPS-Scf-1182 | Scleropages formosus | 37.39 | 2e-21 | 96.3 |
| LLPS-Ict-4592 | Ictidomys tridecemlineatus | 37.3 | 1e-21 | 96.3 |
| LLPS-Nol-3902 | Nomascus leucogenys | 37.3 | 2e-21 | 96.3 |
| LLPS-Gaga-2665 | Gallus gallus | 37.3 | 6e-22 | 97.8 |
| LLPS-Cas-1342 | Carlito syrichta | 37.3 | 2e-21 | 96.3 |
| LLPS-Mam-3563 | Macaca mulatta | 37.3 | 2e-21 | 96.3 |
| LLPS-Eqc-0259 | Equus caballus | 37.3 | 3e-21 | 95.9 |
| LLPS-Poa-2277 | Pongo abelii | 37.3 | 1e-21 | 96.7 |
| LLPS-Caf-1860 | Canis familiaris | 37.3 | 2e-21 | 96.3 |
| LLPS-Rhb-4716 | Rhinopithecus bieti | 37.3 | 2e-21 | 96.3 |
| LLPS-Fia-0132 | Ficedula albicollis | 37.3 | 7e-22 | 97.4 |
| LLPS-Orc-1170 | Oryctolagus cuniculus | 37.3 | 2e-21 | 96.3 |
| LLPS-Anp-3272 | Anas platyrhynchos | 37.3 | 7e-22 | 97.1 |
| LLPS-Loa-3948 | Loxodonta africana | 37.3 | 1e-21 | 96.7 |
| LLPS-Man-2655 | Macaca nemestrina | 37.3 | 2e-21 | 96.3 |
| LLPS-Pat-2327 | Pan troglodytes | 37.3 | 2e-21 | 96.3 |
| LLPS-Urm-3498 | Ursus maritimus | 37.3 | 1e-21 | 96.3 |
| LLPS-Pap-3738 | Pan paniscus | 37.3 | 1e-21 | 96.3 |
| LLPS-Hos-2060 | Homo sapiens | 37.3 | 2e-21 | 96.3 |
| LLPS-Meg-1912 | Meleagris gallopavo | 37.3 | 6e-22 | 97.4 |
| LLPS-Mup-0542 | Mustela putorius furo | 37.3 | 2e-21 | 96.3 |
| LLPS-Aim-1721 | Ailuropoda melanoleuca | 37.3 | 1e-21 | 96.3 |
| LLPS-Mal-2056 | Mandrillus leucophaeus | 37.3 | 2e-21 | 96.3 |
| LLPS-Paa-4289 | Papio anubis | 37.3 | 2e-21 | 96.3 |
| LLPS-Bot-3534 | Bos taurus | 37.3 | 2e-21 | 96.3 |
| LLPS-Caj-0896 | Callithrix jacchus | 37.3 | 2e-21 | 96.3 |
| LLPS-Cea-4499 | Cercocebus atys | 37.3 | 2e-21 | 96.3 |
| LLPS-Aon-0279 | Aotus nancymaae | 37.3 | 2e-21 | 96.3 |
| LLPS-Sus-0720 | Sus scrofa | 37.3 | 2e-21 | 96.3 |
| LLPS-Chs-3757 | Chlorocebus sabaeus | 37.3 | 2e-21 | 96.3 |
| LLPS-Maf-4298 | Macaca fascicularis | 37.3 | 2e-21 | 96.3 |
| LLPS-Drm-0701 | Drosophila melanogaster | 37.07 | 4e-18 | 88.2 |
| LLPS-Ten-3108 | Tetraodon nigroviridis | 36.52 | 9e-19 | 87.8 |
| LLPS-Orn-2249 | Oreochromis niloticus | 36.52 | 1e-20 | 94.4 |
| LLPS-Myl-2927 | Myotis lucifugus | 36.52 | 1e-20 | 93.2 |
| LLPS-Asm-3241 | Astyanax mexicanus | 36.52 | 7e-21 | 94.0 |
| LLPS-Leo-0324 | Lepisosteus oculatus | 36.52 | 1e-20 | 94.4 |
| LLPS-Tag-2668 | Taeniopygia guttata | 36.51 | 2e-21 | 95.9 |
| LLPS-Cap-4492 | Cavia porcellus | 36.51 | 4e-21 | 95.5 |
| LLPS-Otg-4745 | Otolemur garnettii | 36.51 | 5e-21 | 94.4 |
| LLPS-Fec-1648 | Felis catus | 36.51 | 5e-21 | 95.1 |
| LLPS-Ran-3526 | Rattus norvegicus | 36.51 | 2e-21 | 96.3 |
| LLPS-Fud-3683 | Fukomys damarensis | 36.51 | 3e-21 | 95.9 |
| LLPS-Mea-1153 | Mesocricetus auratus | 36.51 | 2e-21 | 96.3 |
| LLPS-Cii-1801 | Ciona intestinalis | 36.13 | 4e-23 | 101 |
| LLPS-Dar-1453 | Danio rerio | 35.71 | 2e-20 | 93.6 |
| LLPS-Cis-0594 | Ciona savignyi | 35.71 | 3e-20 | 92.4 |
| LLPS-Mum-3787 | Mus musculus | 35.71 | 6e-21 | 94.7 |
| LLPS-Pof-3130 | Poecilia formosa | 35.65 | 2e-20 | 93.2 |
| LLPS-Gaa-3965 | Gasterosteus aculeatus | 35.65 | 4e-20 | 92.4 |
| LLPS-Tar-2366 | Takifugu rubripes | 35.65 | 2e-20 | 94.0 |
| LLPS-Xim-2969 | Xiphophorus maculatus | 35.65 | 6e-20 | 93.2 |
| LLPS-Icp-0155 | Ictalurus punctatus | 35.65 | 8e-20 | 92.8 |
| LLPS-Orl-3925 | Oryzias latipes | 35.65 | 2e-20 | 92.8 |
| LLPS-Glm-0538 | Glycine max | 34.96 | 3e-39 | 145 |
| LLPS-Lac-3464 | Latimeria chalumnae | 34.78 | 2e-20 | 92.8 |
| LLPS-Dac-2376 | Daucus carota | 32.19 | 3e-38 | 143 |
| LLPS-Osl-0689 | Ostreococcus lucimarinus | 30.81 | 6e-20 | 92.0 |
| LLPS-Chr-1683 | Chlamydomonas reinhardtii | 30.77 | 4e-19 | 88.6 |
| LLPS-Cae-2033 | Caenorhabditis elegans | 30.22 | 7e-16 | 80.1 |