LLPS-Mum-3335
Cstb

▼ OVERVIEW


Status: Unreviewed
Protein Name: Cystatin-B; Stefin-B
Gene Name: Cstb, Cst6, Stfb
Ensembl Gene: ENSMUSG00000005054.7
Ensembl Protein: ENSMUSP00000005185.6
Organism: Mus musculus
Taxa ID: 10090
LLPS Type: Others


▼ PROPERTY



——— Disorder propensity (calculated by IUPred2A)

▼ Classification


Condensates:
CondensateEvidenceOrthologs
Stress granulePredicted from orthologs(View)

▼ FUNCTION


This is an intracellular thiol proteinase inhibitor.

▼ SEQUENCE


Protein Sequence (FASTA)
1     MMCGAPSATM  PATAETQEVA  DQVKSQLESK  ENQKFDVFKA  ISFKRQIVAG  TNLFIKVDVG  60
61    GDKCVHLRVF  QPLPHENKPL  TLSSYQTNKE  RHDELSYF  98
Nucleotide CDS Sequence (FASTA)
1     ATGATGTGTG  GCGCGCCATC  TGCCACAATG  CCAGCCACGG  CCGAGACGCA  GGAGGTCGCC  60
61    GACCAGGTGA  AGTCCCAGCT  TGAATCGAAA  GAAAATCAGA  AGTTTGATGT  CTTTAAAGCC  120
121   ATATCCTTCA  AGAGACAGAT  AGTGGCTGGC  ACCAACCTCT  TCATCAAGGT  TGATGTTGGT  180
181   GGAGATAAAT  GCGTGCACTT  GAGGGTGTTT  CAACCCCTCC  CCCATGAAAA  CAAGCCTTTG  240
241   ACCCTGTCTT  CCTATCAGAC  CAACAAAGAA  AGGCACGATG  AGCTCTCCTA  CTTCTGA  297

▼ KEYWORD


ID
Family
Acetylation
Complete proteome
Cytoplasm
Protease inhibitor
Reference proteome
Thiol protease inhibitor

▼ GENE ONTOLOGY


ID
Classification
Description
Cellular Component
Collagen-containing extracellular matrix
Cellular Component
Cytoplasm
Cellular Component
Cytosol
Cellular Component
Extracellular space
Cellular Component
Nucleolus
Cellular Component
Nucleus
Molecular Function
Cysteine-type endopeptidase inhibitor activity
Molecular Function
Endopeptidase inhibitor activity
Molecular Function
Protease binding
Biological Process
Adult locomotory behavior
Biological Process
Negative regulation of peptidase activity
Biological Process
Negative regulation of proteolysis

▼ KEGG



▼ ORTHOLOGY


DrLLPS IDOrganismIdentityE-valueScore
LLPS-Ran-4824Rattus norvegicus85.714e-60 185
LLPS-Mea-0638Mesocricetus auratus79.381e-52 166
LLPS-Pat-4316Pan troglodytes78.571e-52 166
LLPS-Hos-0857Homo sapiens78.573e-52 165
LLPS-Poa-1546Pongo abelii78.573e-52 165
LLPS-Aon-3455Aotus nancymaae78.573e-52 166
LLPS-Rhb-2596Rhinopithecus bieti77.553e-51 163
LLPS-Mam-1050Macaca mulatta77.553e-51 163
LLPS-Maf-3638Macaca fascicularis77.553e-51 163
LLPS-Paa-2553Papio anubis77.553e-51 163
LLPS-Eqc-2079Equus caballus76.533e-51 163
LLPS-Chs-3447Chlorocebus sabaeus76.538e-51 162
LLPS-Cea-3404Cercocebus atys76.537e-51 162
LLPS-Sus-4704Sus scrofa76.539e-50 159
LLPS-Caj-3239Callithrix jacchus76.533e-51 162
LLPS-Man-2593Macaca nemestrina75.511e-49 159
LLPS-Loa-2472Loxodonta africana75.514e-50 160
LLPS-Otg-3441Otolemur garnettii75.519e-50 159
LLPS-Ict-0735Ictidomys tridecemlineatus75.01e-36 125
LLPS-Mal-0034Mandrillus leucophaeus74.493e-49 158
LLPS-Cas-1500Carlito syrichta73.475e-48 154
LLPS-Orc-2412Oryctolagus cuniculus72.731e-35 122
LLPS-Bot-1979Bos taurus71.434e-45 149
LLPS-Cap-2487Cavia porcellus70.413e-48 155
LLPS-Fec-2201Felis catus70.331e-40 137
LLPS-Sah-3921Sarcophilus harrisii69.398e-46 149
LLPS-Caf-4022Canis familiaris68.832e-33 117
LLPS-Aim-0136Ailuropoda melanoleuca68.832e-33 117
LLPS-Dio-2264Dipodomys ordii68.423e-33 116
LLPS-Mup-3651Mustela putorius furo67.539e-33 115
LLPS-Mod-4316Monodelphis domestica67.358e-42 140
LLPS-Tut-0339Tursiops truncatus66.332e-41 138
LLPS-Nol-3205Nomascus leucogenys65.983e-37 127
LLPS-Ora-3526Ornithorhynchus anatinus65.594e-35 127
LLPS-Pap-4561Pan paniscus64.954e-37 127
LLPS-Fia-0385Ficedula albicollis64.473e-29 107
LLPS-Myl-4467Myotis lucifugus64.291e-40 136
LLPS-Gog-2917Gorilla gorilla63.922e-36 125
LLPS-Ova-3546Ovis aries63.278e-40 134
LLPS-Tag-2223Taeniopygia guttata63.045e-37 126
LLPS-Meg-1980Meleagris gallopavo62.243e-41 137
LLPS-Gaga-3792Gallus gallus62.245e-41 137
LLPS-Fud-4273Fukomys damarensis61.842e-27 101
LLPS-Pes-3494Pelodiscus sinensis60.23e-39 132
LLPS-Anc-2234Anolis carolinensis59.181e-37 129
LLPS-Leo-2095Lepisosteus oculatus53.063e-32 114
LLPS-Dar-0419Danio rerio50.02e-28 104
LLPS-Icp-2039Ictalurus punctatus50.08e-28 104
LLPS-Asm-2864Astyanax mexicanus46.942e-27 102
LLPS-Scf-0432Scleropages formosus46.844e-1879.7
LLPS-Orl-1897Oryzias latipes45.367e-2390.5
LLPS-Gaa-2164Gasterosteus aculeatus44.338e-2287.8
LLPS-Pof-3622Poecilia formosa43.887e-2595.5
LLPS-Xim-0505Xiphophorus maculatus43.432e-2289.7
LLPS-Orn-3594Oreochromis niloticus41.242e-1981.6
LLPS-Ten-1468Tetraodon nigroviridis40.825e-1980.5
LLPS-Tar-2795Takifugu rubripes40.211e-2084.7
LLPS-Scm-2839Scophthalmus maximus39.188e-1878.2
LLPS-Xet-2527Xenopus tropicalis36.085e-1570.1