DrLLPS - Data resource of LLPS

LLPS-Hos-0857
CSTB

▼ OVERVIEW


Status:	Reviewed
Protein Name:	Cystatin-B; CPI-B; Liver thiol proteinase inhibitor; Stefin-B
Gene Name:	CSTB, CST6, STFB
Ensembl Gene:	ENSG00000160213.7
Ensembl Protein:	ENSP00000291568.5
Organism:	Homo sapiens
Taxa ID:	9606
LLPS Type:	Others

PDB: 1STF (E, I) More

▼ PROPERTY

——— Disorder propensity (calculated by IUPred2A)

▼ Classification

Condensates:

Condensate	Description	Tissue/Cell	PMIDs
Stress granule	"...A list of candidate SG proteins identified by mass spectrometry in NPCs, including statistical analysis."	Neural progenitor cells	29373831
Stress granule	"...Together, our APEX and IF screening approaches identified 260 SG proteins, including ~150 candidates that had not previously been associated with SGs."	HEK293T cells	29373831

▼ FUNCTION

This is an intracellular thiol proteinase inhibitor. Tightly binding reversible inhibitor of cathepsins L, H and B.

▼ CROSS REFERENCE

Database	Nucleotide ID	Protein ID
Ensembl	ENST00000291568.6	ENSP00000291568.5
Ensembl	ENST00000640406.1	ENSP00000492672.1
Ensembl	ENST00000639959.1	ENSP00000492123.1
UniProt		P04080, CYTB_HUMAN
GeneBank	AF208234, L03558, BC010532, BC003370, U46692, AP001752	AAA99014.1, AAA35727.1, AAF44059.1, BAA95541.1, AAH03370.1, AAH10532.1
RefSeq	NM_000100.3	NP_000091.1
Entrez	1476

▼ SEQUENCE

Protein Sequence (FASTA)
1 MMCGAPSATQ PATAETQHIA DQVRSQLEEK ENKKFPVFKA VSFKSQVVAG TNYFIKVHVG 60 61 DEDFVHLRVF QSLPHENKPL TLSNYQTNKA KHDELTYF 98
Nucleotide CDS Sequence (FASTA)
1 ATGATGTGCG GGGCGCCCTC CGCCACGCAG CCGGCCACCG CCGAGACCCA GCACATCGCC 60 61 GACCAGGTGA GGTCCCAGCT TGAAGAGAAA GAAAACAAGA AGTTCCCTGT GTTTAAGGCC 120 121 GTGTCATTCA AGAGCCAGGT GGTCGCGGGG ACAAACTACT TCATCAAGGT GCACGTCGGC 180 181 GACGAGGACT TCGTACACCT GCGAGTGTTC CAATCTCTCC CTCATGAAAA CAAGCCCTTG 240 241 ACCTTATCTA ACTACCAGAC CAACAAAGCC AAGCATGATG AGCTGACCTA TTTCTGA 297

▼ KEYWORD

ID	Family
KW-0002	3D-structure
KW-0007	Acetylation
KW-0181	Complete proteome
KW-0963	Cytoplasm
KW-0903	Direct protein sequencing
KW-0225	Disease mutation
KW-0887	Epilepsy
KW-0539	Nucleus
KW-0646	Protease inhibitor
KW-1185	Reference proteome
KW-0789	Thiol protease inhibitor

▼ GENE ONTOLOGY

ID	Classification	Description
GO:0062023	Cellular Component	Collagen-containing extracellular matrix
GO:0005737	Cellular Component	Cytoplasm
GO:0005829	Cellular Component	Cytosol
GO:0070062	Cellular Component	Extracellular exosome
GO:0005576	Cellular Component	Extracellular region
GO:0005615	Cellular Component	Extracellular space
GO:1904813	Cellular Component	Ficolin-1-rich granule lumen
GO:0005730	Cellular Component	Nucleolus
GO:0034774	Cellular Component	Secretory granule lumen
GO:1904724	Cellular Component	Tertiary granule lumen
GO:0004869	Molecular Function	Cysteine-type endopeptidase inhibitor activity
GO:0004866	Molecular Function	Endopeptidase inhibitor activity
GO:0002020	Molecular Function	Protease binding
GO:0003723	Molecular Function	RNA binding
GO:0008344	Biological Process	Adult locomotory behavior
GO:0010466	Biological Process	Negative regulation of peptidase activity
GO:0045861	Biological Process	Negative regulation of proteolysis
GO:0043312	Biological Process	Neutrophil degranulation

▼ KEGG

hsa:1476

▼ ANNOTATION

Disorder
D²P²	IUPred2A	MobiDB

Domain
AmyPro	SMART	Pfam	InterPro	CDD
PROSITE	Gene3D

PTM
EPSD	PLMD	PhosphoSitePlus	dbPTM	HPRD
BioGRID	mUbiSiDa	PTMcode

Variation
dbSNP	VarCards

Mutation
TCGA	ICGC	CGAP	IntOGen	BioMuta

Interaction
HINT	InWeb_IM	RISE	RAIN	Mentha
PINA	IID	iRefIndex	MIST	DifferentialNET
RNAct

Disease
PancanQTL	OMIM	DisGeNET	ActiveDriverDB

Drug
DrugBank	CTD

Physicochemical
Compute pI/Mw	AAindex

Function
CellMarker	RaftProt

Proteomics
THPA	HPM

Structure
PDB	MMDB

Localization
COMPARTMENTS	NLSdb

Expression
TCGA	ICGC	COSMIC	GEO	ArrayExpress
TissGDB	TISSUES	BioXpress	THPA

Element
UTRdb	circBase	CircNet	miRTarBase	miRWalk
miRcode	RAID	microRNA.org

Methylation
TCGA	ICGC	MethyCancer

▼ ORTHOLOGY

DrLLPS ID	Organism	Identity	E-value	Score
LLPS-Poa-1546	Pongo abelii	100.0	5e-68	206
LLPS-Pat-4316	Pan troglodytes	98.98	2e-67	204
LLPS-Mam-1050	Macaca mulatta	94.9	2e-64	196
LLPS-Rhb-2596	Rhinopithecus bieti	94.9	2e-64	196
LLPS-Paa-2553	Papio anubis	94.9	2e-64	196
LLPS-Maf-3638	Macaca fascicularis	94.9	2e-64	196
LLPS-Chs-3447	Chlorocebus sabaeus	94.9	2e-64	196
LLPS-Cea-3404	Cercocebus atys	94.9	2e-64	196
LLPS-Man-2593	Macaca nemestrina	93.88	1e-63	194
LLPS-Caj-3239	Callithrix jacchus	93.88	2e-64	196
LLPS-Mal-0034	Mandrillus leucophaeus	92.86	9e-63	192
LLPS-Aon-3455	Aotus nancymaae	92.86	8e-64	195
LLPS-Otg-3441	Otolemur garnettii	87.76	2e-59	184
LLPS-Eqc-2079	Equus caballus	86.73	5e-60	185
LLPS-Loa-2472	Loxodonta africana	86.73	8e-59	182
LLPS-Sus-4704	Sus scrofa	84.69	1e-56	177
LLPS-Gog-2917	Gorilla gorilla	84.54	6e-51	162
LLPS-Pap-4561	Pan paniscus	83.51	8e-51	162
LLPS-Ict-0735	Ictidomys tridecemlineatus	82.89	9e-39	130
LLPS-Orc-2412	Oryctolagus cuniculus	81.82	8e-41	135
LLPS-Nol-3205	Nomascus leucogenys	81.44	1e-48	156
LLPS-Mup-3651	Mustela putorius furo	80.52	1e-39	133
LLPS-Cas-1500	Carlito syrichta	79.59	6e-55	172
LLPS-Mea-0638	Mesocricetus auratus	79.38	2e-52	166
LLPS-Caf-4022	Canis familiaris	79.22	6e-39	131
LLPS-Bot-1979	Bos taurus	78.57	2e-53	170
LLPS-Ran-4824	Rattus norvegicus	78.57	7e-52	164
LLPS-Mum-3335	Mus musculus	78.57	3e-52	165
LLPS-Sah-3921	Sarcophilus harrisii	77.55	9e-54	169
LLPS-Aim-0136	Ailuropoda melanoleuca	76.62	2e-38	129
LLPS-Tut-0339	Tursiops truncatus	76.53	1e-49	159
LLPS-Fec-2201	Felis catus	76.04	1e-47	155
LLPS-Mod-4316	Monodelphis domestica	75.51	4e-49	158
LLPS-Myl-4467	Myotis lucifugus	75.51	4e-50	160
LLPS-Dio-2264	Dipodomys ordii	73.68	3e-35	121
LLPS-Cap-2487	Cavia porcellus	73.47	1e-50	161
LLPS-Ova-3546	Ovis aries	72.45	2e-48	155
LLPS-Fia-0385	Ficedula albicollis	72.37	5e-34	119
LLPS-Tag-2223	Taeniopygia guttata	71.74	1e-42	140
LLPS-Fud-4273	Fukomys damarensis	71.05	1e-34	120
LLPS-Ora-3526	Ornithorhynchus anatinus	70.97	1e-41	144
LLPS-Gaga-3792	Gallus gallus	69.39	1e-46	151
LLPS-Meg-1980	Meleagris gallopavo	69.39	2e-46	150
LLPS-Pes-3494	Pelodiscus sinensis	68.37	1e-45	149
LLPS-Anc-2234	Anolis carolinensis	63.27	1e-41	138
LLPS-Leo-2095	Lepisosteus oculatus	60.2	3e-39	132
LLPS-Icp-2039	Ictalurus punctatus	56.12	2e-32	115
LLPS-Dar-0419	Danio rerio	55.1	5e-35	121
LLPS-Asm-2864	Astyanax mexicanus	50.0	1e-30	110
LLPS-Scf-0432	Scleropages formosus	49.37	3e-20	85.1
LLPS-Pof-3622	Poecilia formosa	48.98	9e-30	108
LLPS-Xim-0505	Xiphophorus maculatus	47.47	2e-27	102
LLPS-Gaa-2164	Gasterosteus aculeatus	46.39	8e-24	92.8
LLPS-Orl-1897	Oryzias latipes	46.39	9e-27	100
LLPS-Orn-3594	Oreochromis niloticus	45.36	6e-26	98.6
LLPS-Ten-1468	Tetraodon nigroviridis	43.88	4e-23	91.3
LLPS-Scm-2839	Scophthalmus maximus	43.3	3e-23	92.4
LLPS-Xet-2527	Xenopus tropicalis	41.24	3e-19	81.3
LLPS-Tar-2795	Takifugu rubripes	41.24	5e-23	90.9

LLPS-Hos-0857CSTB

Protein Sequence

Nucleotide Sequence

LLPS-Hos-0857
CSTB