LLPS-Mum-2770
Dlgap5
▼ OVERVIEW
| Status: | Reviewed |
| Protein Name: | Disks large-associated protein 5 |
| Gene Name: | Dlgap5, Dlg7, Kiaa0008 |
| Ensembl Gene: | ENSMUSG00000037544.14 |
| Ensembl Protein: | ENSMUSP00000040416.3 |
| Organism: | Mus musculus |
| Taxa ID: | 10090 |
| LLPS Type: | Others |
▼ Classification
Condensates:
| Condensate | Description | Tissue/Cell | PMIDs |
|---|---|---|---|
| Spindle apparatus | "...MiCroKiTS 4.0: a database of midbody, centrosome, kinetochore, telomere and spindle." | N/A | 21173113 |
| Centrosome/Spindle pole body | Predicted from orthologs | N/A | (View) |
▼ FUNCTION
| Potential cell cycle regulator that may play a role in carcinogenesis of cancer cells. Mitotic phosphoprotein regulated by the ubiquitin-proteasome pathway. Key regulator of adherens junction integrity and differentiation that may be involved in CDH1-mediated adhesion and signaling in epithelial cells (By similarity). |
▼ CROSS REFERENCE
| Database | Nucleotide ID | Protein ID |
|---|---|---|
| Ensembl | ENSMUST00000043296.9 | ENSMUSP00000040416.3 |
| Ensembl | ENSMUST00000178661.7 | ENSMUSP00000154283.1 |
| Ensembl | ENSMUST00000177822.1 | ENSMUSP00000137382.1 |
| Ensembl | ENSMUST00000111778.3 | ENSMUSP00000107408.3 |
| Ensembl | ENSMUST00000180299.7 | ENSMUSP00000153953.1 |
| UniProt | Q8K4R9, DLGP5_MOUSE, Q6ZQL3, Q80VS7, Q8BUC8, Q8BZ79 | |
| GeneBank | AK129032, BC058087, AK036384, AB076696, BC043924, AK085882 | BAB97377.1, BAC39560.1, BAC29405.1, BAC97842.1, AAH58087.1, AAH43924.1 |
| RefSeq | NM_144553.2 | NP_653136.2 |
| Entrez | 218977 |
▼ SEQUENCE
| Protein Sequence (FASTA) |
|---|
1 MLVSRFASRF RKDSSTEMVR TNLAHRKSLS QKENRHRVYE RNRHFGLKDV NIPLEGRELG 60 61 NIHETSQDLS PEKASSKTRS VKMVLSDQRK QLLQKYKEEK QLQKLKEQRE KAKRGVFKVG 120 121 LYRPAAPGFL VTDQRGAKAE PEKAFPHTGR ITRSKTKEYM EQTKIGSRNV PKATQSDQRQ 180 181 TSEKQPLDRE RKVMQPVLFT SGKGTESAAT QRAKLMARTV SSTTRKPVTR ATNEKGSERM 240 241 RPSGGRPAKK PEGKPDKVIP SKVERDEKHL DSQTRETSEM GPLGVFREVE SLPATAPAQG 300 301 KERKSFAPKH CVFQPPCGLK SYQVAPLSPR SANAFLTPNC DWNQLRPEVF STTTQDKANE 360 361 ILVQQGLESL TDRSKEHVLN QKGASTSDSN HASVKGVPCS EASEGQTSQP PHDVPYFRKI 420 421 LQSETDRLTS HCQEWEGKLD LDIPDEAKGL IRTTVGQTRL LIKERFRQFE GLVDNCEYKR 480 481 GEKETTCTDL DGFWDMVSFQ VDDVNQKFNN LIKLEASGWK DSNNPSKKVL RKKIVPGRTS 540 541 KAKQDDDGRA AARSRLAAIK NAMKGRPQQE VQAHAAAPEN TKEVDKIVFD AGFFRIESPV 600 601 KSFSVLSSER RSQRFGTPLS ASKVVPEGRA AGDLLRQKMP LKKPDPQSSK SEHVDRTFSD 660 661 GLESRCHVED TPCPGEQDSS DIEHDVNKIN VKMDCFSVET NLPLPAGDAN TNQKEAISAV 720 721 EGASSAVTSQ DLLMSNPETN TSSQSNTSQE EAEASQSVLL HKSLTSECHL LEPPGLSCTS 780 781 PCTREETRQP DRSRQFSFGG DLILFSPL 808 |
| Nucleotide CDS Sequence (FASTA) |
1 ATGCTGGTGT CACGTTTTGC CAGTCGGTTT CGGAAAGACT CGAGCACTGA GATGGTTAGA 60 61 ACCAACTTGG CTCATAGAAA GTCTCTGTCT CAGAAGGAGA ACAGACACAG GGTGTATGAG 120 121 CGAAACAGAC ACTTCGGTTT GAAGGACGTC AACATTCCAC TGGAAGGGCG AGAGCTTGGT 180 181 AATATACACG AGACATCGCA AGACCTCTCT CCAGAGAAGG CCAGCTCCAA AACAAGGTCA 240 241 GTAAAAATGG TCCTGAGTGA CCAACGGAAG CAGCTCCTCC AGAAGTACAA GGAAGAAAAA 300 301 CAACTTCAAA AACTGAAAGA ACAGCGAGAG AAAGCCAAAC GTGGAGTGTT CAAAGTGGGT 360 361 CTCTATAGAC CCGCTGCGCC TGGCTTTCTT GTCACAGACC AGAGGGGTGC GAAAGCTGAG 420 421 CCAGAAAAGG CTTTTCCACA TACTGGACGG ATTACAAGAT CAAAGACCAA AGAATATATG 480 481 GAGCAGACTA AGATTGGTAG CAGGAATGTT CCTAAAGCAA CCCAGAGTGA CCAAAGACAA 540 541 ACTTCTGAAA AACAACCATT AGACAGAGAG AGAAAAGTTA TGCAGCCTGT GCTGTTCACG 600 601 TCAGGGAAAG GGACTGAATC AGCGGCTACT CAGAGGGCCA AGCTGATGGC CCGAACAGTG 660 661 TCATCCACTA CAAGAAAGCC AGTCACAAGA GCCACGAATG AGAAAGGATC AGAAAGAATG 720 721 AGACCAAGTG GAGGGAGACC TGCCAAAAAA CCAGAAGGCA AGCCGGACAA GGTTATTCCT 780 781 TCCAAAGTTG AGCGGGACGA AAAGCATTTG GATTCGCAGA CCAGGGAAAC AAGTGAAATG 840 841 GGTCCGCTCG GAGTCTTCCG AGAAGTGGAA AGCTTGCCTG CAACAGCCCC TGCCCAAGGG 900 901 AAGGAAAGGA AGTCCTTTGC CCCCAAGCAC TGTGTCTTCC AGCCCCCGTG TGGTCTGAAG 960 961 AGCTACCAGG TGGCTCCCCT GAGCCCTAGA AGTGCCAACG CTTTCCTGAC ACCCAATTGT 1020 1021 GATTGGAACC AGTTAAGACC AGAAGTTTTT AGCACTACAA CTCAAGACAA AGCAAATGAA 1080 1081 ATCTTGGTAC AGCAAGGATT GGAGTCGCTA ACAGACCGTA GTAAAGAACA TGTCTTAAAT 1140 1141 CAGAAGGGTG CTTCTACTTC AGATTCAAAT CACGCTTCTG TGAAAGGAGT CCCATGCTCT 1200 1201 GAAGCGAGCG AAGGCCAGAC CTCTCAGCCC CCCCACGATG TGCCATACTT CAGAAAAATC 1260 1261 CTCCAATCAG AAACTGACAG GCTGACCTCG CACTGCCAGG AGTGGGAGGG GAAGCTGGAC 1320 1321 CTGGACATCC CTGATGAAGC TAAAGGTCTT ATCCGTACAA CGGTTGGTCA AACAAGACTC 1380 1381 CTTATCAAGG AGAGATTCAG ACAGTTTGAA GGACTGGTGG ACAACTGCGA GTATAAACGG 1440 1441 GGTGAAAAGG AGACGACCTG CACAGATCTG GATGGATTCT GGGATATGGT TAGTTTTCAG 1500 1501 GTCGATGATG TGAACCAGAA ATTCAACAAC CTGATCAAAC TTGAGGCGTC AGGATGGAAA 1560 1561 GACAGCAATA ATCCAAGCAA AAAAGTCCTC CGGAAAAAAA TTGTGCCCGG TAGAACAAGC 1620 1621 AAAGCAAAGC AGGATGACGA CGGACGAGCG GCAGCTAGGA GTCGCCTTGC AGCCATAAAG 1680 1681 AATGCAATGA AAGGCAGGCC ACAGCAGGAA GTGCAGGCCC ACGCAGCAGC TCCGGAGAAC 1740 1741 ACAAAGGAAG TTGACAAAAT AGTGTTTGAT GCTGGGTTTT TCAGAATCGA GAGCCCAGTG 1800 1801 AAGTCATTCT CAGTCCTGTC TTCTGAACGT CGTTCTCAAA GATTTGGAAC ACCTCTGTCT 1860 1861 GCCAGCAAAG TTGTGCCTGA GGGCAGGGCT GCAGGGGACC TTCTGAGACA GAAGATGCCA 1920 1921 CTGAAGAAGC CGGACCCTCA GAGCAGCAAG AGCGAGCATG TTGATCGGAC GTTTTCAGAT 1980 1981 GGTCTTGAAA GCAGGTGCCA CGTAGAAGAC ACCCCCTGTC CTGGAGAGCA AGATTCAAGT 2040 2041 GACATAGAGC ATGATGTAAA TAAAATAAAT GTCAAGATGG ATTGTTTCTC TGTTGAAACG 2100 2101 AATTTGCCTC TTCCTGCTGG TGATGCTAAT ACCAATCAAA AAGAAGCAAT CTCAGCTGTG 2160 2161 GAAGGAGCGA GCTCTGCAGT CACCTCCCAG GATTTGCTGA TGAGCAACCC TGAGACAAAT 2220 2221 ACCTCCTCAC AGAGCAACAC CTCACAAGAA GAAGCTGAGG CGTCGCAGTC AGTACTGTTA 2280 2281 CATAAAAGTC TCACTTCTGA ATGCCACCTT CTTGAACCAC CAGGCCTCAG CTGCACCAGC 2340 2341 CCCTGCACTC GGGAGGAGAC CAGACAGCCA GATCGCAGCA GACAGTTCTC CTTTGGAGGT 2400 2401 GACCTCATTC TCTTCTCACC ACTATGA 2427 |
▼ KEYWORD
▼ GENE ONTOLOGY
ID | Classification | Description |
Cellular Component | Cytosol | |
Cellular Component | Microtubule organizing center | |
Cellular Component | Mitochondrion | |
Cellular Component | Nucleus | |
Cellular Component | Spindle pole centrosome | |
Molecular Function | Phosphoprotein phosphatase activity | |
Biological Process | Cell cycle | |
Biological Process | Signaling |
▼ ANNOTATION
| Mutation | ||||
| CGAP | ||||
| Physicochemical | ||||
| Compute pI/Mw | AAindex | |||
| Function | ||||
| CellMarker | RaftProt | |||
| Localization | ||||
| COMPARTMENTS | ||||
| Expression | ||||
| ArrayExpress | GXD | TISSUES | ||
▼ ORTHOLOGY
| DrLLPS ID | Organism | Identity | E-value | Score |
|---|---|---|---|---|
| LLPS-Ran-0079 | Rattus norvegicus | 75.7 | 0.0 | 1132 |
| LLPS-Dio-3093 | Dipodomys ordii | 71.72 | 2e-39 | 148 |
| LLPS-Eqc-2092 | Equus caballus | 69.47 | 1e-31 | 126 |
| LLPS-Mea-0128 | Mesocricetus auratus | 65.85 | 0.0 | 906 |
| LLPS-Xet-1954 | Xenopus tropicalis | 62.89 | 2e-64 | 237 |
| LLPS-Chs-0747 | Chlorocebus sabaeus | 59.88 | 0.0 | 679 |
| LLPS-Myl-2210 | Myotis lucifugus | 59.24 | 0.0 | 791 |
| LLPS-Fec-1831 | Felis catus | 59.05 | 0.0 | 803 |
| LLPS-Urm-1662 | Ursus maritimus | 58.98 | 0.0 | 822 |
| LLPS-Mup-2420 | Mustela putorius furo | 58.65 | 0.0 | 789 |
| LLPS-Sus-1200 | Sus scrofa | 58.65 | 0.0 | 801 |
| LLPS-Aim-1148 | Ailuropoda melanoleuca | 58.46 | 0.0 | 832 |
| LLPS-Mam-1706 | Macaca mulatta | 57.87 | 0.0 | 783 |
| LLPS-Poa-1749 | Pongo abelii | 57.86 | 0.0 | 756 |
| LLPS-Aon-1743 | Aotus nancymaae | 57.66 | 0.0 | 768 |
| LLPS-Rhb-3232 | Rhinopithecus bieti | 57.62 | 0.0 | 780 |
| LLPS-Ova-0729 | Ovis aries | 57.57 | 0.0 | 792 |
| LLPS-Bot-0844 | Bos taurus | 57.5 | 0.0 | 789 |
| LLPS-Orc-0005 | Oryctolagus cuniculus | 57.26 | 0.0 | 776 |
| LLPS-Gog-0892 | Gorilla gorilla | 56.99 | 0.0 | 780 |
| LLPS-Hos-0587 | Homo sapiens | 56.99 | 0.0 | 781 |
| LLPS-Mal-0720 | Mandrillus leucophaeus | 56.94 | 0.0 | 762 |
| LLPS-Paa-2300 | Papio anubis | 56.71 | 0.0 | 757 |
| LLPS-Cea-1607 | Cercocebus atys | 56.71 | 0.0 | 758 |
| LLPS-Maf-0516 | Macaca fascicularis | 56.71 | 0.0 | 754 |
| LLPS-Man-1801 | Macaca nemestrina | 56.71 | 0.0 | 755 |
| LLPS-Pat-2145 | Pan troglodytes | 56.64 | 0.0 | 778 |
| LLPS-Caj-1866 | Callithrix jacchus | 56.57 | 0.0 | 750 |
| LLPS-Caf-0984 | Canis familiaris | 56.33 | 0.0 | 766 |
| LLPS-Pap-2259 | Pan paniscus | 56.32 | 0.0 | 757 |
| LLPS-Loa-1801 | Loxodonta africana | 56.03 | 0.0 | 721 |
| LLPS-Nol-3577 | Nomascus leucogenys | 55.36 | 0.0 | 719 |
| LLPS-Cas-1789 | Carlito syrichta | 55.27 | 0.0 | 686 |
| LLPS-Otg-3272 | Otolemur garnettii | 54.46 | 0.0 | 720 |
| LLPS-Anp-1081 | Anas platyrhynchos | 54.43 | 8e-21 | 102 |
| LLPS-Fud-0360 | Fukomys damarensis | 51.32 | 0.0 | 638 |
| LLPS-Cap-1862 | Cavia porcellus | 49.05 | 0.0 | 554 |
| LLPS-Chc-0075 | Chondrus crispus | 45.98 | 3e-30 | 124 |
| LLPS-Sah-2147 | Sarcophilus harrisii | 44.76 | 5e-131 | 411 |
| LLPS-Mod-3377 | Monodelphis domestica | 43.7 | 3e-139 | 434 |
| LLPS-Ora-0241 | Ornithorhynchus anatinus | 43.59 | 1e-99 | 329 |
| LLPS-Gaga-0356 | Gallus gallus | 43.59 | 5e-120 | 389 |
| LLPS-Pes-2055 | Pelodiscus sinensis | 43.5 | 2e-92 | 307 |
| LLPS-Tag-1383 | Taeniopygia guttata | 41.03 | 3e-103 | 337 |
| LLPS-Orn-0076 | Oreochromis niloticus | 40.31 | 1e-46 | 183 |
| LLPS-Orl-1052 | Oryzias latipes | 39.88 | 2e-53 | 203 |
| LLPS-Meg-1109 | Meleagris gallopavo | 39.61 | 4e-126 | 401 |
| LLPS-Fia-0284 | Ficedula albicollis | 38.94 | 1e-117 | 383 |
| LLPS-Leo-1841 | Lepisosteus oculatus | 37.54 | 2e-46 | 174 |
| LLPS-Anc-0226 | Anolis carolinensis | 37.04 | 3e-98 | 325 |
| LLPS-Drm-0010 | Drosophila melanogaster | 36.29 | 1e-15 | 85.5 |
| LLPS-Scf-3400 | Scleropages formosus | 35.65 | 1e-16 | 88.6 |
| LLPS-Dar-1456 | Danio rerio | 35.29 | 2e-69 | 252 |
| LLPS-Xim-0360 | Xiphophorus maculatus | 35.14 | 3e-16 | 87.8 |
| LLPS-Ten-0394 | Tetraodon nigroviridis | 35.14 | 3e-15 | 84.3 |
| LLPS-Pof-3083 | Poecilia formosa | 35.14 | 4e-16 | 87.4 |
| LLPS-Icp-1324 | Ictalurus punctatus | 34.28 | 1e-59 | 223 |
| LLPS-Gaa-3887 | Gasterosteus aculeatus | 34.23 | 2e-15 | 85.1 |
| LLPS-Tar-3672 | Takifugu rubripes | 34.23 | 6e-15 | 83.2 |
| LLPS-Scm-0825 | Scophthalmus maximus | 34.23 | 7e-15 | 83.2 |
| LLPS-Lac-2374 | Latimeria chalumnae | 34.0 | 5e-51 | 193 |
| LLPS-Cii-1842 | Ciona intestinalis | 33.97 | 7e-29 | 124 |
| LLPS-Cis-0880 | Ciona savignyi | 33.56 | 7e-29 | 123 |
| LLPS-Asm-3560 | Astyanax mexicanus | 32.48 | 6e-15 | 83.6 |
| LLPS-Ict-1402 | Ictidomys tridecemlineatus | 31.55 | 2e-15 | 84.7 |