LLPS-Hos-0587
DLGAP5
▼ OVERVIEW
| Status: | Unreviewed |
| Protein Name: | Disks large-associated protein 5 |
| Gene Name: | DLGAP5, DLG7, KIAA0008 |
| Ensembl Gene: | ENSG00000126787.12 |
| Ensembl Protein: | ENSP00000451747.1 |
| Organism: | Homo sapiens |
| Taxa ID: | 9606 |
| LLPS Type: | Others |
▼ Classification
Condensates:
| Condensate | Evidence | Orthologs |
|---|---|---|
| Chromatin, Centrosome/Spindle pole body, Spindle apparatus | Predicted from orthologs | (View) |
▼ FUNCTION
| Potential cell cycle regulator that may play a role in carcinogenesis of cancer cells. Mitotic phosphoprotein regulated by the ubiquitin-proteasome pathway. Key regulator of adherens junction integrity and differentiation that may be involved in CDH1-mediated adhesion and signaling in epithelial cells. |
▼ CROSS REFERENCE
| Database | Nucleotide ID | Protein ID |
|---|---|---|
| Ensembl | ENST00000557645.5 | ENSP00000451747.1 |
| Ensembl | ENST00000395425.6 | ENSP00000378815.2 |
| Ensembl | ENST00000554067.1 | ENSP00000452168.1 |
| Ensembl | ENST00000247191.6 | ENSP00000247191.2 |
| UniProt | Q15398, DLGP5_HUMAN, A8MTM6, B4DRM8, Q86T11, Q8NG58 | |
| GeneBank | BT007344, AB076695, AL139316, BC010658, D13633, AK299338, BC016276, BX248255, CH471061 | AAH10658.2, CAD62583.1, BAB97376.1, AAP36008.1, AAH16276.2, BAA02797.3, BAG61340.1, EAW80664.1 |
| RefSeq | NM_001146015.1, NM_014750.4, XM_017021840.1 | NP_001139487.1, NP_055565.3, XP_016877329.1 |
| Entrez | 9787 |
▼ SEQUENCE
| Protein Sequence (FASTA) |
|---|
1 MSSSHFASRH RKDISTEMIR TKIAHRKSLS QKENRHKEYE RNRHFGLKDV NIPTLEGRIL 60 61 VELDETSQGL VPEKTNVKPR AMKTILGDQR KQMLQKYKEE KQLQKLKEQR EKAKRGIFKV 120 121 GRYRPDMPCF LLSNQNAVKA EPKKAIPSSV RITRSKAKDQ MEQTKIDNES DVRAIRPGPR 180 181 QTSEKKVSDK EKKVVQPVMP TSLRMTRSAT QAAKQVPRTV SSTTARKPVT RAANENEPEG 240 241 KVPSKGRPAK NVETKPDKGI SCKVDSEENT LNSQTNATSG MNPDGVLSKM ENLPEINTAK 300 301 IKGKNSFAPK DFMFQPLDGL KTYQVTPMTP RSANAFLTPS YTWTPLKTEV DESQATKEIL 360 361 AQKCKTYSTK TIQQDSNKLP CPLGPLTVWH EEHVLNKNEA TTKNLNGLPI KEVPSLERNE 420 421 GRIAQPHHGV PYFRNILQSE TEKLTSHCFE WDRKLELDIP DDAKDLIRTA VGQTRLLMKE 480 481 RFKQFEGLVD DCEYKRGIKE TTCTDLDGFW DMVSFQIEDV IHKFNNLIKL EESGWQVNNN 540 541 MNHNMNKNVF RKKVVSGIAS KPKQDDAGRI AARNRLAAIK NAMRERIRQE ECAETAVSVI 600 601 PKEVDKIVFD AGFFRVESPV KLFSGLSVSS EGPSQRLGTP KSVNKAVSQS RNEMGIPQQT 660 661 TSPENAGPQN TKSEHVKKTL FLSIPESRSS IEDAQCPGLP DLIEENHVVN KTDLKVDCLS 720 721 SERMSLPLLA GGVADDINTN KKEGISDVVE GMELNSSITS QDVLMSSPEK NTASQNSILE 780 781 EGETKISQSE LFDNKSLTTE CHLLDSPGLN CSNPFTQLER RHQEHARHIS FGGNLITFSP 840 841 LQPGEF 846 |
| Nucleotide CDS Sequence (FASTA) |
1 ATGTCTTCAT CACATTTTGC CAGTCGACAC AGGAAGGATA TAAGTACTGA AATGATTAGA 60 61 ACTAAAATTG CTCATAGGAA ATCACTGTCT CAGAAAGAAA ATAGACATAA GGAATACGAA 120 121 CGAAATAGAC ACTTTGGTTT GAAAGATGTA AACATTCCAA CCTTGGAAGG TAGAATTCTT 180 181 GTTGAATTAG ATGAGACATC TCAAGGGCTT GTTCCAGAAA AGACCAATGT TAAGCCAAGG 240 241 GCAATGAAAA CTATTCTAGG TGATCAACGA AAACAGATGC TCCAAAAATA CAAAGAAGAA 300 301 AAGCAACTTC AAAAATTGAA AGAGCAGAGA GAGAAAGCTA AACGAGGAAT ATTTAAAGTG 360 361 GGTCGTTATA GACCTGATAT GCCTTGTTTT CTTTTATCAA ACCAGAATGC TGTGAAAGCT 420 421 GAGCCAAAAA AGGCTATTCC ATCTTCTGTA CGGATTACAA GGTCAAAGGC CAAAGACCAA 480 481 ATGGAGCAGA CTAAGATTGA TAACGAGAGT GATGTTCGAG CAATCCGACC TGGTCCAAGA 540 541 CAAACTTCTG AAAAGAAAGT GTCAGACAAA GAGAAAAAAG TTGTGCAGCC TGTAATGCCC 600 601 ACGTCGTTGA GAATGACTCG ATCAGCTACT CAAGCAGCAA AGCAGGTTCC CAGAACAGTC 660 661 TCATCTACCA CAGCAAGAAA GCCAGTCACA AGAGCTGCTA ATGAAAACGA ACCAGAAGGA 720 721 AAGGTGCCAA GTAAAGGAAG ACCTGCCAAA AATGTAGAAA CAAAACCCGA CAAGGGTATT 780 781 TCTTGTAAAG TCGATAGTGA AGAAAATACT TTGAATTCAC AAACTAATGC AACAAGTGGA 840 841 ATGAATCCAG ATGGAGTCTT ATCAAAAATG GAAAACTTAC CTGAGATAAA TACTGCAAAA 900 901 ATAAAAGGGA AGAATTCCTT TGCACCTAAG GATTTTATGT TTCAGCCACT GGATGGTCTG 960 961 AAGACCTATC AAGTAACACC TATGACTCCC AGAAGTGCCA ATGCTTTTTT GACACCCAGT 1020 1021 TACACCTGGA CTCCTTTAAA AACAGAAGTT GATGAGTCTC AAGCAACAAA AGAAATTTTG 1080 1081 GCACAAAAAT GTAAAACTTA CTCTACCAAG ACAATACAGC AAGATTCAAA TAAATTGCCA 1140 1141 TGTCCTTTGG GTCCTCTAAC TGTTTGGCAT GAAGAACATG TTTTAAATAA AAATGAAGCT 1200 1201 ACTACTAAAA ATTTAAATGG CCTTCCAATA AAAGAAGTCC CATCACTTGA AAGAAATGAA 1260 1261 GGTCGAATTG CTCAGCCCCA CCATGGTGTG CCATATTTCA GAAATATCCT CCAGTCAGAA 1320 1321 ACTGAGAAAT TAACTTCACA TTGCTTCGAG TGGGACAGGA AACTTGAATT GGACATTCCA 1380 1381 GATGATGCTA AAGATCTTAT TCGCACAGCA GTTGGTCAAA CAAGACTCCT TATGAAGGAA 1440 1441 AGGTTTAAAC AGTTTGAAGG ACTGGTTGAT GATTGTGAAT ATAAACGAGG TATAAAGGAG 1500 1501 ACTACCTGTA CAGATCTGGA TGGATTTTGG GATATGGTTA GTTTTCAGAT AGAAGATGTA 1560 1561 ATCCACAAAT TCAACAATCT GATCAAACTT GAGGAATCTG GGTGGCAAGT CAATAATAAT 1620 1621 ATGAATCATA ATATGAACAA AAATGTCTTT AGGAAAAAAG TTGTCTCAGG TATAGCAAGT 1680 1681 AAACCAAAAC AGGATGATGC TGGAAGAATT GCAGCGAGAA ATCGCCTAGC TGCCATAAAA 1740 1741 AATGCAATGA GAGAGAGAAT TAGGCAGGAA GAATGTGCTG AAACAGCAGT TTCTGTGATA 1800 1801 CCAAAGGAAG TTGATAAAAT AGTGTTCGAT GCTGGATTTT TCAGAGTTGA AAGTCCTGTT 1860 1861 AAATTATTCT CAGGACTTTC TGTCTCTTCT GAAGGCCCTT CTCAAAGACT TGGAACACCT 1920 1921 AAGTCTGTCA ACAAAGCTGT ATCTCAGAGT AGAAATGAGA TGGGCATTCC ACAACAAACT 1980 1981 ACATCACCAG AAAATGCCGG TCCTCAGAAT ACGAAAAGTG AACATGTGAA GAAGACTTTG 2040 2041 TTTTTGAGTA TTCCTGAAAG CAGGAGCAGC ATAGAAGATG CTCAGTGTCC TGGATTACCA 2100 2101 GATTTAATTG AAGAAAATCA TGTTGTAAAT AAGACAGACT TGAAGGTGGA TTGTTTATCC 2160 2161 AGTGAGAGAA TGAGTTTGCC TCTTCTTGCT GGTGGAGTAG CAGATGATAT TAATACTAAC 2220 2221 AAAAAAGAAG GAATTTCAGA TGTTGTGGAA GGAATGGAAC TGAATTCTTC AATTACATCA 2280 2281 CAGGATGTTT TGATGAGTAG CCCTGAAAAA AATACAGCTT CACAAAATAG CATCTTAGAA 2340 2341 GAAGGGGAAA CTAAAATTTC TCAGTCAGAA CTATTTGATA ATAAAAGTCT CACTACTGAA 2400 2401 TGCCACCTTC TTGATTCACC AGGTCTAAAC TGCAGTAATC CATTTACTCA GCTGGAGAGG 2460 2461 AGACATCAAG AACATGCCAG ACACATTTCT TTTGGTGGTA ACCTGATTAC TTTTTCACCT 2520 2521 CTACAACCAG GAGAATTTTG A 2541 |
▼ KEYWORD
▼ GENE ONTOLOGY
ID | Classification | Description |
Cellular Component | Cytosol | |
Cellular Component | Microtubule organizing center | |
Cellular Component | Mitochondrion | |
Cellular Component | Nucleus | |
Cellular Component | Spindle pole centrosome | |
Molecular Function | Phosphoprotein phosphatase activity | |
Biological Process | Cell population proliferation | |
Biological Process | Mitotic chromosome movement towards spindle pole | |
Biological Process | Positive regulation of mitotic metaphase/anaphase transition | |
Biological Process | Positive regulation of transcription of Notch receptor target |
▼ ANNOTATION
| Drug | ||||
| CTD | ||||
| Physicochemical | ||||
| Compute pI/Mw | AAindex | |||
| Function | ||||
| CellMarker | ||||
| Localization | ||||
| COMPARTMENTS | ||||
| Methylation | ||||
| TCGA | ICGC | COSMIC | MethyCancer | |
▼ ORTHOLOGY
| DrLLPS ID | Organism | Identity | E-value | Score |
|---|---|---|---|---|
| LLPS-Chc-0075 | Chondrus crispus | 100.0 | 1e-131 | 398 |
| LLPS-Pat-2145 | Pan troglodytes | 98.35 | 0.0 | 1611 |
| LLPS-Gog-0892 | Gorilla gorilla | 97.75 | 0.0 | 1602 |
| LLPS-Pap-2259 | Pan paniscus | 96.58 | 0.0 | 1574 |
| LLPS-Poa-1749 | Pongo abelii | 96.53 | 0.0 | 1501 |
| LLPS-Mam-1706 | Macaca mulatta | 93.76 | 0.0 | 1510 |
| LLPS-Chs-0747 | Chlorocebus sabaeus | 93.62 | 0.0 | 1221 |
| LLPS-Rhb-3232 | Rhinopithecus bieti | 92.65 | 0.0 | 1491 |
| LLPS-Paa-2300 | Papio anubis | 92.25 | 0.0 | 1488 |
| LLPS-Maf-0516 | Macaca fascicularis | 92.14 | 0.0 | 1484 |
| LLPS-Cea-1607 | Cercocebus atys | 92.14 | 0.0 | 1488 |
| LLPS-Man-1801 | Macaca nemestrina | 92.14 | 0.0 | 1486 |
| LLPS-Mal-0720 | Mandrillus leucophaeus | 92.02 | 0.0 | 1485 |
| LLPS-Nol-3577 | Nomascus leucogenys | 89.98 | 0.0 | 1425 |
| LLPS-Aon-1743 | Aotus nancymaae | 87.89 | 0.0 | 1409 |
| LLPS-Caj-1866 | Callithrix jacchus | 86.76 | 0.0 | 1412 |
| LLPS-Aim-1148 | Ailuropoda melanoleuca | 79.39 | 0.0 | 1278 |
| LLPS-Dio-3093 | Dipodomys ordii | 79.31 | 7e-55 | 191 |
| LLPS-Fec-1831 | Felis catus | 78.58 | 0.0 | 1245 |
| LLPS-Urm-1662 | Ursus maritimus | 78.22 | 0.0 | 1253 |
| LLPS-Myl-2210 | Myotis lucifugus | 77.87 | 0.0 | 1190 |
| LLPS-Bot-0844 | Bos taurus | 77.16 | 0.0 | 1231 |
| LLPS-Mup-2420 | Mustela putorius furo | 77.12 | 0.0 | 1224 |
| LLPS-Ova-0729 | Ovis aries | 76.42 | 0.0 | 1224 |
| LLPS-Sus-1200 | Sus scrofa | 75.88 | 0.0 | 1178 |
| LLPS-Eqc-2092 | Equus caballus | 75.57 | 2e-44 | 162 |
| LLPS-Caf-0984 | Canis familiaris | 74.82 | 0.0 | 1179 |
| LLPS-Loa-1801 | Loxodonta africana | 74.09 | 0.0 | 1134 |
| LLPS-Orc-0005 | Oryctolagus cuniculus | 73.85 | 0.0 | 1160 |
| LLPS-Otg-3272 | Otolemur garnettii | 72.87 | 0.0 | 1133 |
| LLPS-Cas-1789 | Carlito syrichta | 72.65 | 0.0 | 1068 |
| LLPS-Xet-1954 | Xenopus tropicalis | 63.04 | 4e-12 | 74.3 |
| LLPS-Fud-0360 | Fukomys damarensis | 61.67 | 0.0 | 904 |
| LLPS-Cap-1862 | Cavia porcellus | 58.93 | 0.0 | 811 |
| LLPS-Mum-2770 | Mus musculus | 58.18 | 0.0 | 778 |
| LLPS-Ran-0079 | Rattus norvegicus | 55.06 | 0.0 | 752 |
| LLPS-Mea-0128 | Mesocricetus auratus | 53.32 | 0.0 | 721 |
| LLPS-Ora-0241 | Ornithorhynchus anatinus | 49.46 | 3e-144 | 447 |
| LLPS-Mod-3377 | Monodelphis domestica | 48.5 | 8e-172 | 520 |
| LLPS-Sah-2147 | Sarcophilus harrisii | 47.53 | 7e-155 | 474 |
| LLPS-Anp-1081 | Anas platyrhynchos | 47.46 | 1e-89 | 305 |
| LLPS-Ten-0082 | Tetraodon nigroviridis | 46.33 | 2e-42 | 168 |
| LLPS-Pes-2055 | Pelodiscus sinensis | 46.32 | 8e-118 | 375 |
| LLPS-Meg-1109 | Meleagris gallopavo | 43.69 | 2e-144 | 450 |
| LLPS-Icp-1324 | Ictalurus punctatus | 42.53 | 6e-39 | 160 |
| LLPS-Orn-0076 | Oreochromis niloticus | 41.95 | 1e-42 | 171 |
| LLPS-Fia-0284 | Ficedula albicollis | 41.14 | 8e-138 | 437 |
| LLPS-Anc-0226 | Anolis carolinensis | 40.34 | 7e-117 | 376 |
| LLPS-Tag-1383 | Taeniopygia guttata | 40.2 | 6e-94 | 313 |
| LLPS-Gaga-0356 | Gallus gallus | 38.98 | 2e-140 | 444 |
| LLPS-Orl-1052 | Oryzias latipes | 37.64 | 5e-48 | 187 |
| LLPS-Xim-0923 | Xiphophorus maculatus | 36.45 | 1e-14 | 82.4 |
| LLPS-Pof-1046 | Poecilia formosa | 35.51 | 9e-13 | 76.6 |
| LLPS-Leo-1841 | Lepisosteus oculatus | 35.13 | 2e-44 | 169 |
| LLPS-Scf-3400 | Scleropages formosus | 34.91 | 6e-13 | 76.6 |
| LLPS-Dar-4136 | Danio rerio | 34.58 | 1e-13 | 79.3 |
| LLPS-Cis-0880 | Ciona savignyi | 34.5 | 6e-24 | 108 |
| LLPS-Cii-1842 | Ciona intestinalis | 34.22 | 2e-24 | 110 |
| LLPS-Lac-2374 | Latimeria chalumnae | 33.49 | 2e-54 | 204 |
| LLPS-Scm-0825 | Scophthalmus maximus | 33.33 | 4e-12 | 74.3 |
| LLPS-Asm-3560 | Astyanax mexicanus | 32.08 | 7e-12 | 73.6 |
| LLPS-Tar-1153 | Takifugu rubripes | 30.94 | 1e-57 | 216 |
| LLPS-Gaa-0247 | Gasterosteus aculeatus | 30.75 | 9e-53 | 201 |
| LLPS-Ict-1402 | Ictidomys tridecemlineatus | 29.05 | 5e-13 | 77.4 |
| LLPS-Drm-0010 | Drosophila melanogaster | 28.31 | 1e-13 | 79.3 |