LLPS-Mum-1439
Tubb2a

▼ OVERVIEW

Status: Reviewed
Protein Name: Tubulin beta-2A chain
Gene Name: Tubb2a, Tubb2
Ensembl Gene: ENSMUSG00000058672.7
Ensembl Protein: ENSMUSP00000060246.8
Organism: Mus musculus
Taxa ID: 10090
LLPS Type: Client


▼ PROPERTY


——— Disorder propensity (calculated by IUPred2A)

▼ Classification

Condensates:
CondensateDescriptionTissue/CellPMIDs
Postsynaptic density
"...We report the first direct comparison of the proteome of triplicate isolates of mouse and human cortical postsynaptic densities. The mouse postsynaptic density comprised 1556 proteins and the human one 1461."
Mouse cortex23071613

▼ FUNCTION

Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain (By similarity).

▼ CROSS REFERENCE

▼ SEQUENCE

Protein Sequence (FASTA)
1     MREIVHIQAG  QCGNQIGAKF  WEVISDEHGI  DPTGSYHGDS  DLQLERINVY  YNEAAGNKYV  60
61    PRAILVDLEP  GTMDSVRSGP  FGQIFRPDNF  VFGQSGAGNN  WAKGHYTEGA  ELVDSVLDVV  120
121   RKESESCDCL  QGFQLTHSLG  GGTGSGMGTL  LISKIREEYP  DRIMNTFSVM  PSPKVSDTVV  180
181   EPYNATLSVH  QLVENTDETY  SIDNEALYDI  CFRTLKLTTP  TYGDLNHLVS  ATMSGVTTCL  240
241   RFPGQLNADL  RKLAVNMVPF  PRLHFFMPGF  APLTSRGSQQ  YRALTVPELT  QQMFDSKNMM  300
301   AACDPRHGRY  LTVAAIFRGR  MSMKEVDEQM  LNVQNKNSSY  FVEWIPNNVK  TAVCDIPPRG  360
361   LKMSATFIGN  STAIQELFKR  ISEQFTAMFR  RKAFLHWYTG  EGMDEMEFTE  AESNMNDLVS  420
421   EYQQYQDATA  DEQGEFEEEE  GEDEA  445
Nucleotide CDS Sequence (FASTA)
1     ATGCGCGAGA  TCGTGCACAT  CCAGGCGGGC  CAGTGTGGCA  ACCAGATCGG  CGCTAAGTTT  60
61    TGGGAGGTGA  TAAGCGATGA  GCATGGCATC  GACCCCACTG  GCAGTTACCA  TGGCGACAGT  120
121   GACTTGCAGC  TGGAGAGGAT  CAATGTGTAC  TACAATGAAG  CTGCTGGCAA  CAAATATGTA  180
181   CCTCGGGCCA  TCCTAGTGGA  CCTGGAGCCG  GGCACCATGG  ACTCAGTGAG  GTCGGGACCA  240
241   TTCGGCCAGA  TCTTCAGGCC  AGACAACTTT  GTGTTCGGCC  AGAGTGGTGC  AGGAAATAAC  300
301   TGGGCAAAAG  GCCACTACAC  AGAGGGGGCC  GAGCTGGTGG  ACTCTGTCCT  AGATGTGGTG  360
361   AGGAAGGAGT  CTGAAAGCTG  TGACTGTCTC  CAGGGTTTCC  AGCTGACCCA  CTCACTGGGG  420
421   GGAGGCACTG  GCTCAGGCAT  GGGGACCCTG  CTCATCAGCA  AGATCAGAGA  GGAGTACCCA  480
481   GACCGCATCA  TGAACACCTT  CAGCGTCATG  CCCTCACCCA  AGGTCTCTGA  TACTGTGGTG  540
541   GAGCCCTATA  ATGCCACCCT  CTCAGTGCAC  CAGCTGGTAG  AGAACACAGA  TGAAACCTAT  600
601   TCCATTGACA  ATGAGGCTCT  GTATGACATC  TGTTTCCGCA  CCCTGAAGCT  GACCACACCC  660
661   ACCTATGGCG  ATCTCAACCA  CCTGGTGTCA  GCCACCATGA  GTGGAGTGAC  CACCTGCCTG  720
721   CGCTTCCCAG  GCCAGCTGAA  CGCAGACCTG  CGCAAGCTGG  CCGTGAACAT  GGTGCCATTC  780
781   CCACGCCTGC  ACTTCTTCAT  GCCAGGCTTT  GCACCTCTGA  CCAGCCGGGG  CAGCCAGCAG  840
841   TACCGAGCCC  TGACGGTGCC  CGAGCTGACC  CAGCAGATGT  TCGACTCCAA  GAACATGATG  900
901   GCTGCCTGCG  ACCCTCGCCA  TGGCCGCTAC  CTGACCGTGG  CCGCCATTTT  CCGTGGCCGC  960
961   ATGTCCATGA  AGGAGGTGGA  TGAGCAGATG  CTCAACGTGC  AGAACAAGAA  CAGCAGCTAC  1020
1021  TTCGTGGAGT  GGATCCCCAA  CAACGTCAAG  ACGGCCGTGT  GTGACATCCC  TCCTCGTGGC  1080
1081  CTCAAGATGT  CAGCCACCTT  CATTGGCAAC  AGCACTGCCA  TCCAGGAGCT  GTTCAAGCGC  1140
1141  ATCTCGGAGC  AGTTCACTGC  CATGTTCCGG  CGCAAGGCTT  TCCTGCACTG  GTACACGGGT  1200
1201  GAGGGCATGG  ACGAGATGGA  GTTCACCGAG  GCGGAGAGCA  ACATGAATGA  CCTGGTGTCT  1260
1261  GAGTACCAGC  AGTACCAGGA  TGCCACGGCT  GATGAGCAGG  GCGAGTTCGA  GGAGGAGGAG  1320
1321  GGTGAAGATG  AGGCTTGA  1338

▼ KEYWORD

ID
Family
Acetylation
Complete proteome
Cytoplasm
Cytoskeleton
Direct protein sequencing
GTP-binding
Isopeptide bond
Methylation
Microtubule
Nucleotide-binding
Phosphoprotein
Reference proteome
Ubl conjugation

▼ GENE ONTOLOGY

ID
Classification
Description
Cellular Component
Cytoplasm
Cellular Component
Microtubule
Molecular Function
GTP binding
Molecular Function
GTPase activity
Molecular Function
Structural constituent of cytoskeleton
Biological Process
Microtubule cytoskeleton organization
Biological Process
Microtubule-based process
Biological Process
Mitotic cell cycle

▼ KEGG


▼ ORTHOLOGY

DrLLPS IDOrganismIdentityE-valueScore
LLPS-Orc-0778Oryctolagus cuniculus100.00.0 862
LLPS-Hos-0725Homo sapiens100.00.0 862
LLPS-Ict-3890Ictidomys tridecemlineatus100.00.0 862
LLPS-Nol-1668Nomascus leucogenys100.00.0 862
LLPS-Cas-0310Carlito syrichta100.00.0 862
LLPS-Cap-3299Cavia porcellus100.00.0 862
LLPS-Caj-3474Callithrix jacchus100.00.0 862
LLPS-Ora-3257Ornithorhynchus anatinus100.00.0 862
LLPS-Mea-0029Mesocricetus auratus100.00.0 862
LLPS-Ran-3832Rattus norvegicus100.00.0 862
LLPS-Bot-3356Bos taurus100.00.0 862
LLPS-Pes-0306Pelodiscus sinensis99.770.0 860
LLPS-Gog-4560Gorilla gorilla99.770.0 860
LLPS-Sah-2091Sarcophilus harrisii99.770.0 860
LLPS-Cea-0167Cercocebus atys99.770.0 860
LLPS-Sus-2521Sus scrofa99.770.0 860
LLPS-Mal-1974Mandrillus leucophaeus99.770.0 860
LLPS-Eqc-0951Equus caballus99.760.0 822
LLPS-Fud-3783Fukomys damarensis99.760.0 821
LLPS-Fia-0318Ficedula albicollis99.530.0 858
LLPS-Tag-2634Taeniopygia guttata99.530.0 858
LLPS-Gaga-3609Gallus gallus99.530.0 858
LLPS-Chs-1745Chlorocebus sabaeus99.530.0 858
LLPS-Maf-2364Macaca fascicularis99.530.0 858
LLPS-Mup-4432Mustela putorius furo99.530.0 858
LLPS-Aim-3912Ailuropoda melanoleuca99.530.0 858
LLPS-Paa-4095Papio anubis99.530.0 858
LLPS-Ere-0293Erinaceus europaeus99.530.0 853
LLPS-Dio-3707Dipodomys ordii99.530.0 858
LLPS-Tut-2274Tursiops truncatus99.530.0 858
LLPS-Xet-3389Xenopus tropicalis99.070.0 856
LLPS-Myl-4418Myotis lucifugus98.840.0 847
LLPS-Anc-3467Anolis carolinensis98.370.0 851
LLPS-Lac-3032Latimeria chalumnae97.670.0 848
LLPS-Dar-2798Danio rerio97.670.0 847
LLPS-Cis-0796Ciona savignyi97.670.0 848
LLPS-Cii-2095Ciona intestinalis97.670.0 848
LLPS-Man-4381Macaca nemestrina97.660.0 843
LLPS-Fec-0114Felis catus97.660.0 843
LLPS-Mod-3852Monodelphis domestica97.660.0 843
LLPS-Mam-0567Macaca mulatta97.660.0 843
LLPS-Caf-3592Canis familiaris97.660.0 843
LLPS-Loa-2963Loxodonta africana97.440.0 836
LLPS-Scm-0259Scophthalmus maximus97.440.0 847
LLPS-Ten-0400Tetraodon nigroviridis97.440.0 842
LLPS-Icp-0893Ictalurus punctatus97.440.0 847
LLPS-Orn-2508Oreochromis niloticus97.420.0 840
LLPS-Gaa-1346Gasterosteus aculeatus97.420.0 838
LLPS-Pof-2355Poecilia formosa97.210.0 844
LLPS-Asm-3759Astyanax mexicanus97.210.0 847
LLPS-Leo-2361Lepisosteus oculatus97.210.0 847
LLPS-Orl-0208Oryzias latipes97.210.0 843
LLPS-Scf-3711Scleropages formosus97.190.0 842
LLPS-Rhb-0035Rhinopithecus bieti96.970.0 840
LLPS-Pat-3341Pan troglodytes96.970.0 840
LLPS-Urm-3705Ursus maritimus96.970.0 840
LLPS-Poa-2450Pongo abelii96.970.0 840
LLPS-Aon-0745Aotus nancymaae96.970.0 840
LLPS-Ova-2492Ovis aries96.970.0 840
LLPS-Tar-2601Takifugu rubripes96.740.0 843
LLPS-Xim-1769Xiphophorus maculatus96.740.0 843
LLPS-Drm-0325Drosophila melanogaster96.590.0 797
LLPS-Otg-1654Otolemur garnettii96.250.0 833
LLPS-Pap-1145Pan paniscus96.250.0 833
LLPS-Anp-3174Anas platyrhynchos95.780.0 777
LLPS-Cae-1271Caenorhabditis elegans94.880.0 828
LLPS-Chr-0860Chlamydomonas reinhardtii89.530.0 795
LLPS-Php-1447Physcomitrella patens89.070.0 794
LLPS-Orbr-1685Oryza brachyantha88.370.0 782
LLPS-Sem-1389Selaginella moellendorffii88.370.0 791
LLPS-Glm-1038Glycine max87.910.0 779
LLPS-Sei-2030Setaria italica87.910.0 779
LLPS-Sob-2219Sorghum bicolor87.880.0 778