DrLLPS - Data resource of LLPS

Overview
Property
Classification
Function
Cross Reference
Sequence
GO
Annotation
Orthology
TOP

Disorder▼
- D²P²
- IUPred2A
Domain▼
PTM▼
Variation▼
Mutation▼
- CGAP
Interaction▼
- HINT
- RISE
- RAIN
- Mentha
- PINA
- IID
- iRefIndex
- MIST
Disease▼
Drug▼
Physicochemical▼
- Compute pI/Mw
- AAindex
Function▼
- CORUM
- RaftProt
Proteomics▼
Structure▼
- PDB
Localization▼
- COMPARTMENTS
- NLSdb
Expression▼
Element▼
Methylation▼

LLPS-Mum-1347
Ndufa13

▼ OVERVIEW


Status:	Reviewed
Protein Name:	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13; Cell death regulatory protein GRIM-19; Complex I-B16.6; CI-B16.6; Gene associated with retinoic and interferon-induced mortality 19 protein; GRIM-19; Gene associated with retinoic and IFN-induced mortality 19 protein; NADH-ubiquinone oxidoreductase B16.6 subunit
Gene Name:	Ndufa13, Grim19
Ensembl Gene:	ENSMUSG00000036199.9
Ensembl Protein:	ENSMUSP00000105796.3
Organism:	Mus musculus
Taxa ID:	10090
LLPS Type:	Client

PDB: 6G72 (A, B, C, D, E, F, G, H, I, J, K, L, M, N, O, P, Q, R, S, T, V, W, X, Y, Z, a, b, c, d, e, f, g, h, i, j, k, l, m, n, o, p, q, r, s) More

▼ PROPERTY

——— Disorder propensity (calculated by IUPred2A)

▼ Classification

Condensates:

Condensate	Description	Tissue/Cell	PMIDs
Postsynaptic density	"...We report the first direct comparison of the proteome of triplicate isolates of mouse and human cortical postsynaptic densities. The mouse postsynaptic density comprised 1556 proteins and the human one 1461."	Mouse cortex	23071613

▼ FUNCTION

Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. Involved in the interferon/all-trans-retinoic acid (IFN/RA) induced cell death. This apoptotic activity is inhibited by interaction with viral IRF1. Prevents the transactivation of STAT3 target genes. May play a role in CARD15-mediated innate mucosal responses and serve to regulate intestinal epithelial cell responses to microbes.

▼ CROSS REFERENCE

Database	Nucleotide ID	Protein ID
Ensembl	ENSMUST00000110167.4	ENSMUSP00000105796.3
UniProt		Q9ERS2, NDUAD_MOUSE, Q9DC98, Q9DCA1
GeneBank	BC055435, BC037149, BC034899, AK003012, AK002999, AK012422, AK010517, AF286698	AAH37149.1, AAH55435.1, BAB28227.1, AAH34899.1, BAB22505.1, BAB26999.1, AAG28168.1
RefSeq	NM_023312.2, XM_017312943.1	NP_075801.1, XP_017168432.1
Entrez	67184

▼ SEQUENCE

Protein Sequence (FASTA)
1 MAASKVKQDM PPPGGYGPID YKRNLPRRGL SGYSMFAVGI GALIFGYWRM MRWNQERRRL 60 61 LIEDLEARIA LMPLFQAEKD RRTLQILREN LEEEAIIMKD VPNWKVGESV FHTTRWVPPL 120 121 IGEMYGLRTK EEMSNANFGF TWYT 144
Nucleotide CDS Sequence (FASTA)
1 ATGGCGGCGT CGAAGGTGAA GCAGGACATG CCCCCGCCAG GGGGCTACGG CCCCATCGAC 60 61 TACAAGCGGA ACCTGCCCCG CCGGGGACTG TCGGGGTACA GCATGTTTGC TGTGGGCATC 120 121 GGGGCCTTGA TCTTTGGCTA CTGGAGAATG ATGAGGTGGA ACCAGGAGCG CAGGCGCCTG 180 181 CTGATTGAGG ACTTGGAGGC CAGGATCGCC CTCATGCCGC TCTTCCAGGC AGAGAAGGAC 240 241 CGGAGGACCC TGCAGATTCT CCGGGAAAAC CTGGAGGAGG AAGCCATCAT CATGAAGGAT 300 301 GTGCCCAACT GGAAGGTGGG CGAGTCTGTG TTCCATACCA CACGATGGGT GCCACCCCTC 360 361 ATTGGCGAGA TGTATGGGTT GCGCACCAAG GAGGAGATGA GCAATGCCAA CTTCGGCTTC 420 421 ACCTGGTACA CTTAG 435

▼ KEYWORD

ID	Family
KW-0002	3D-structure
KW-0007	Acetylation
KW-0053	Apoptosis
KW-0181	Complete proteome
KW-0903	Direct protein sequencing
KW-0249	Electron transport
KW-0472	Membrane
KW-0496	Mitochondrion
KW-0999	Mitochondrion inner membrane
KW-0539	Nucleus
KW-1185	Reference proteome
KW-0679	Respiratory chain
KW-0812	Transmembrane
KW-1133	Transmembrane helix
KW-0813	Transport

▼ GENE ONTOLOGY

ID	Classification	Description
GO:0005737	Cellular Component	Cytoplasm
GO:0016021	Cellular Component	Integral component of membrane
GO:0005743	Cellular Component	Mitochondrial inner membrane
GO:0031966	Cellular Component	Mitochondrial membrane
GO:0005746	Cellular Component	Mitochondrial respirasome
GO:0005747	Cellular Component	Mitochondrial respiratory chain complex I
GO:0005739	Cellular Component	Mitochondrion
GO:0005654	Cellular Component	Nucleoplasm
GO:0005634	Cellular Component	Nucleus
GO:0005524	Molecular Function	ATP binding
GO:0008137	Molecular Function	NADH dehydrogenase (ubiquinone) activity
GO:0003954	Molecular Function	NADH dehydrogenase activity
GO:0097190	Biological Process	Apoptotic signaling pathway
GO:0035458	Biological Process	Cellular response to interferon-beta
GO:0071300	Biological Process	Cellular response to retinoic acid
GO:0097191	Biological Process	Extrinsic apoptotic signaling pathway
GO:0032981	Biological Process	Mitochondrial respiratory chain complex I assembly
GO:0030308	Biological Process	Negative regulation of cell growth
GO:2001243	Biological Process	Negative regulation of intrinsic apoptotic signaling pathway
GO:0045892	Biological Process	Negative regulation of transcription, DNA-templated
GO:0043280	Biological Process	Positive regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0045732	Biological Process	Positive regulation of protein catabolic process
GO:0045039	Biological Process	Protein insertion into mitochondrial inner membrane
GO:0072593	Biological Process	Reactive oxygen species metabolic process

▼ KEGG

mmu:67184

▼ ANNOTATION

Disorder
D²P²	IUPred2A

Domain
SMART	Pfam	InterPro	CDD

PTM
EPSD	PLMD	PhosphoSitePlus	dbPTM	PTMcode

Mutation
CGAP

Interaction
HINT	RISE	RAIN	Mentha	PINA
IID	iRefIndex	MIST

Physicochemical
Compute pI/Mw	AAindex

Function
CORUM	RaftProt

Structure
PDB

Localization
COMPARTMENTS	NLSdb

Expression
ArrayExpress	GXD	TISSUES

Element
miRTarBase	miRWalk	RAID	microRNA.org

▼ ORTHOLOGY

DrLLPS ID	Organism	Identity	E-value	Score
LLPS-Ran-2179	Rattus norvegicus	94.44	1e-96	281
LLPS-Mea-1168	Mesocricetus auratus	90.97	2e-94	276
LLPS-Aim-3229	Ailuropoda melanoleuca	90.57	7e-64	202
LLPS-Cas-0546	Carlito syrichta	85.42	2e-89	264
LLPS-Ict-3184	Ictidomys tridecemlineatus	85.42	5e-87	257
LLPS-Caf-0160	Canis familiaris	85.42	5e-89	263
LLPS-Fec-1626	Felis catus	85.42	3e-88	260
LLPS-Myl-0383	Myotis lucifugus	85.42	9e-89	265
LLPS-Sus-4367	Sus scrofa	85.42	6e-89	263
LLPS-Hos-4240	Homo sapiens	85.05	2e-61	192
LLPS-Pap-0354	Pan paniscus	85.05	2e-61	192
LLPS-Nol-3544	Nomascus leucogenys	84.72	2e-87	258
LLPS-Eqc-4013	Equus caballus	84.72	8e-88	259
LLPS-Mod-1023	Monodelphis domestica	84.72	5e-88	260
LLPS-Cap-0083	Cavia porcellus	84.29	4e-84	250
LLPS-Paa-3209	Papio anubis	84.03	9e-87	257
LLPS-Otg-4347	Otolemur garnettii	83.33	3e-85	253
LLPS-Mal-4464	Mandrillus leucophaeus	83.33	3e-87	259
LLPS-Tut-1356	Tursiops truncatus	83.33	9e-85	254
LLPS-Gog-4715	Gorilla gorilla	83.33	2e-86	256
LLPS-Cea-3184	Cercocebus atys	83.33	2e-86	256
LLPS-Pat-2700	Pan troglodytes	83.22	8e-86	254
LLPS-Man-3317	Macaca nemestrina	82.64	8e-86	255
LLPS-Bot-1996	Bos taurus	82.64	8e-86	254
LLPS-Maf-0069	Macaca fascicularis	82.64	4e-86	256
LLPS-Chs-3769	Chlorocebus sabaeus	82.64	7e-86	257
LLPS-Loa-3061	Loxodonta africana	81.12	4e-84	250
LLPS-Fud-0758	Fukomys damarensis	81.12	4e-82	245
LLPS-Caj-2237	Callithrix jacchus	80.56	2e-80	241
LLPS-Aon-3466	Aotus nancymaae	80.56	1e-80	241
LLPS-Sah-3205	Sarcophilus harrisii	80.42	2e-83	249
LLPS-Urm-1124	Ursus maritimus	78.95	5e-62	194
LLPS-Xet-3383	Xenopus tropicalis	77.36	2e-57	181
LLPS-Icp-3944	Ictalurus punctatus	76.22	1e-77	234
LLPS-Dar-4071	Danio rerio	75.61	3e-40	136
LLPS-Leo-0060	Lepisosteus oculatus	75.35	3e-77	234
LLPS-Asm-0933	Astyanax mexicanus	75.0	5e-78	234
LLPS-Ova-2280	Ovis aries	74.07	1e-61	197
LLPS-Orn-0998	Oreochromis niloticus	73.61	2e-76	231
LLPS-Pof-2502	Poecilia formosa	73.61	2e-69	214
LLPS-Gaga-3423	Gallus gallus	72.92	2e-75	228
LLPS-Ten-3730	Tetraodon nigroviridis	72.92	2e-73	223
LLPS-Orl-2387	Oryzias latipes	72.22	6e-75	227
LLPS-Lac-4039	Latimeria chalumnae	71.53	7e-73	221
LLPS-Xim-2191	Xiphophorus maculatus	71.53	3e-69	212
LLPS-Scm-3718	Scophthalmus maximus	70.83	5e-73	222
LLPS-Gaa-3954	Gasterosteus aculeatus	70.83	9e-73	221
LLPS-Tar-0050	Takifugu rubripes	69.23	1e-69	213
LLPS-Pes-2123	Pelodiscus sinensis	66.07	2e-40	138
LLPS-Rhb-0873	Rhinopithecus bieti	66.07	9e-40	137
LLPS-Meg-1042	Meleagris gallopavo	61.9	7e-22	88.6
LLPS-Scf-1875	Scleropages formosus	58.33	2e-55	177
LLPS-Fia-1565	Ficedula albicollis	57.53	4e-52	168
LLPS-Ora-1922	Ornithorhynchus anatinus	53.7	1e-24	96.7
LLPS-Nia-2174	Nicotiana attenuata	53.23	3e-15	71.6
LLPS-Hea-1131	Helianthus annuus	48.72	9e-34	121
LLPS-Mua-2268	Musa acuminata	47.06	2e-31	115
LLPS-Zem-2450	Zea mays	46.22	9e-33	119
LLPS-Sob-0574	Sorghum bicolor	46.22	1e-32	118
LLPS-Lep-0437	Leersia perrieri	46.22	2e-32	118
LLPS-Viv-2213	Vitis vinifera	46.15	1e-31	116
LLPS-Sei-2330	Setaria italica	46.15	2e-32	118
LLPS-Dac-1545	Daucus carota	46.15	2e-31	115
LLPS-Tru-1084	Triticum urartu	45.38	3e-30	117
LLPS-Orbr-2172	Oryza brachyantha	45.38	6e-33	119
LLPS-Orp-2377	Oryza punctata	45.38	7e-31	114
LLPS-Met-1744	Medicago truncatula	45.38	7e-30	111
LLPS-Tra-1389	Triticum aestivum	45.38	1e-31	116
LLPS-Glm-1522	Glycine max	45.38	3e-31	115
LLPS-Coc-2338	Corchorus capsularis	45.3	3e-31	115
LLPS-Pot-2386	Populus trichocarpa	45.3	6e-31	114
LLPS-Hov-1035	Hordeum vulgare	45.3	2e-31	115
LLPS-Brd-1002	Brachypodium distachyon	45.3	2e-31	115
LLPS-Thc-0847	Theobroma cacao	45.3	5e-31	114
LLPS-Miv-1533	Microbotryum violaceum	45.22	2e-26	102
LLPS-Org-1403	Oryza glaberrima	44.54	4e-30	112
LLPS-Orr-1959	Oryza rufipogon	44.54	2e-29	112
LLPS-Orm-1634	Oryza meridionalis	44.54	7e-30	113
LLPS-Amt-0133	Amborella trichopoda	44.54	4e-31	116
LLPS-Ors-2089	Oryza sativa	44.54	4e-30	112
LLPS-Orgl-0564	Oryza glumaepatula	44.54	2e-29	112
LLPS-Orni-1179	Oryza nivara	44.54	2e-29	112
LLPS-Orb-2186	Oryza barthii	44.54	2e-29	112
LLPS-Ori-2321	Oryza indica	44.54	4e-30	112
LLPS-Gor-1222	Gossypium raimondii	44.44	1e-30	113
LLPS-Cus-2014	Cucumis sativus	44.44	3e-30	112
LLPS-Usm-1492	Ustilago maydis	44.17	2e-26	102
LLPS-Asf-1522	Aspergillus flavus	44.0	4e-13	66.6
LLPS-Aso-1437	Aspergillus oryzae	44.0	4e-13	66.6
LLPS-Prp-1477	Prunus persica	43.7	1e-30	113
LLPS-Phv-0654	Phaseolus vulgaris	43.7	7e-29	108
LLPS-Art-2748	Arabidopsis thaliana	43.59	1e-27	105
LLPS-Arl-2965	Arabidopsis lyrata	43.59	1e-27	105
LLPS-Sot-2182	Solanum tuberosum	43.59	1e-28	108
LLPS-Chr-0046	Chlamydomonas reinhardtii	43.1	9e-21	87.8
LLPS-Abg-0079	Absidia glauca	42.98	7e-25	98.2
LLPS-Via-2014	Vigna angularis	42.86	5e-28	106
LLPS-Bro-2205	Brassica oleracea	42.74	3e-27	104
LLPS-Brr-2711	Brassica rapa	42.74	3e-27	104
LLPS-Brn-1655	Brassica napus	42.74	2e-27	105
LLPS-Gas-0120	Galdieria sulphuraria	42.57	3e-21	89.4
LLPS-Mae-0330	Manihot esculenta	42.45	8e-23	93.2
LLPS-Sol-2031	Solanum lycopersicum	42.28	4e-27	104
LLPS-Yal-0570	Yarrowia lipolytica	42.24	1e-19	84.3
LLPS-Pug-1261	Puccinia graminis	41.74	5e-24	95.9
LLPS-Gag-1038	Gaeumannomyces graminis	41.57	4e-14	69.7
LLPS-Spr-1431	Sporisorium reilianum	41.53	2e-24	97.1
LLPS-Cii-2117	Ciona intestinalis	41.46	2e-21	89.4
LLPS-Nef-0282	Neosartorya fischeri	41.33	2e-08	53.1
LLPS-Cym-1091	Cyanidioschyzon merolae	41.28	1e-18	82.4
LLPS-Chc-1075	Chondrus crispus	40.87	1e-22	92.4
LLPS-Php-0667	Physcomitrella patens	40.83	9e-25	98.2
LLPS-Kop-1525	Komagataella pastoris	40.18	2e-17	79.0
LLPS-Vir-2079	Vigna radiata	40.16	2e-25	100
LLPS-Crn-1548	Cryptococcus neoformans	40.0	4e-23	93.6
LLPS-Dos-1115	Dothistroma septosporum	39.56	2e-14	70.1
LLPS-Fuv-1437	Fusarium verticillioides	38.53	1e-12	66.2
LLPS-Tum-1566	Tuber melanosporum	38.1	9e-19	82.0
LLPS-Map-0339	Magnaporthe poae	38.05	2e-15	72.8
LLPS-Lem-1163	Leptosphaeria maculans	37.61	8e-16	73.9
LLPS-Sem-0091	Selaginella moellendorffii	37.61	1e-16	76.6
LLPS-Pytr-1394	Pyrenophora triticirepentis	36.75	1e-14	70.9
LLPS-Pyt-1277	Pyrenophora teres	36.75	9e-15	71.2
LLPS-Ved-0730	Verticillium dahliae	36.28	9e-14	68.6
LLPS-Fus-1445	Fusarium solani	36.28	2e-14	70.5
LLPS-Phn-0791	Phaeosphaeria nodorum	35.96	5e-14	68.9
LLPS-Mao-1638	Magnaporthe oryzae	35.96	3e-14	69.7
LLPS-Zyt-0518	Zymoseptoria tritici	35.71	6e-14	68.9
LLPS-Drm-1852	Drosophila melanogaster	35.43	3e-15	73.2
LLPS-Cogr-1023	Colletotrichum graminicola	35.4	6e-13	66.2
LLPS-Fuo-1526	Fusarium oxysporum	35.4	6e-13	66.2
LLPS-Trr-1305	Trichoderma reesei	35.4	2e-12	64.7
LLPS-Coo-1246	Colletotrichum orbiculare	35.4	7e-13	65.9
LLPS-Trv-0335	Trichoderma virens	34.51	3e-12	63.9
LLPS-Ast-1565	Aspergillus terreus	34.51	1e-12	65.1
LLPS-Asc-0908	Aspergillus clavatus	34.51	2e-09	55.8
LLPS-Osl-1465	Ostreococcus lucimarinus	34.35	1e-18	82.4
LLPS-Asfu-0733	Aspergillus fumigatus	34.21	2e-12	65.1
LLPS-Asni-1389	Aspergillus niger	34.21	4e-07	49.3
LLPS-Beb-1182	Beauveria bassiana	33.91	1e-13	68.2
LLPS-Blg-0164	Blumeria graminis	32.8	9e-14	68.2
LLPS-Cae-0599	Caenorhabditis elegans	32.31	8e-15	72.4
LLPS-Nec-0613	Neurospora crassa	32.14	8e-14	68.6
LLPS-Asn-1432	Aspergillus nidulans	29.91	4e-10	58.2

LLPS-Mum-1347Ndufa13

Protein Sequence

Nucleotide Sequence

LLPS-Mum-1347
Ndufa13