DrLLPS - Data resource of LLPS

Overview
Property
Classification
Function
Cross Reference
Sequence
GO
Additional
Orthology
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LLPS-Bot-1996
NDUFA13

Integrated Annotations

▼ OVERVIEW


Status:	Unreviewed
Protein Name:	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13; Cell death regulatory protein GRIM-19; Complex I-B16.6; CI-B16.6; Gene associated with retinoic-interferon-induced mortality 19 protein; GRIM-19; NADH-ubiquinone oxidoreductase B16.6 subunit
Gene Name:	NDUFA13, GRIM19
Ensembl Gene:	ENSBTAG00000007812.6
Ensembl Protein:	ENSBTAP00000010276.5
Organism:	Bos taurus
Taxa ID:	9913
LLPS Type:	Others

PDB: 5LC5 (A, B, C, D, E, F, G, H, I, J, K, L, M, N, O, P, Q, R, S, T, U, V, W, X, Y, Z, a, b, c, d, e, f, g, h, i, j, k, l, m, n, o, p, q, r, s) More

▼ PROPERTY

——— Disorder propensity (calculated by IUPred2A)

▼ Classification

Condensates:

Condensate	Evidence	Orthologs
Nucleolus, Postsynaptic density	Predicted from orthologs	(View)

Organism	DrLLPS ID	UniProt ID	LLPS type	Condensate	Identity	E-value	Score
Mus musculus	LLPS-Mum-1347	Q9ERS2	Client	Nucleolus, Postsynaptic density	82.64	8e-86	254

▼ FUNCTION

Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. Involved in the interferon/all-trans-retinoic acid (IFN/RA) induced cell death. This apoptotic activity is inhibited by interaction with viral IRF1. Prevents the transactivation of STAT3 target genes. May play a role in CARD15-mediated innate mucosal responses and serve to regulate intestinal epithelial cell responses to microbes.

▼ CROSS REFERENCE

Database	Nucleotide ID	Protein ID
Ensembl	ENSBTAT00000010276.6	ENSBTAP00000010276.5
UniProt		Q95KV7, NDUAD_BOVIN, Q3T0G4
GeneBank	AJ316011, BC102406	AAI02407.1, CAC87049.1
RefSeq	NM_176672.2	NP_788845.1

▼ SEQUENCE

Protein Sequence (FASTA)
1 MAASKVKQDM PPVGGYGPID YKRNLPRRGL SGYSMFAVGI GALLFGYWSM MKWNRERRRL 60 61 QIEDFEARIA LMPLLQAEKD RRVLQMLREN LEEEATVMKD VPGWKVGESV FHTTRWVTPM 120 121 MGELYGLRAS EEVLSATYGF IWYT 144
Nucleotide CDS Sequence (FASTA)
1 ATGGCGGCGT CGAAGGTGAA GCAGGACATG CCCCCGGTGG GGGGCTACGG CCCTATCGAC 60 61 TACAAGCGGA ACCTTCCGCG TCGGGGACTG TCGGGCTACA GCATGTTCGC CGTGGGCATT 120 121 GGGGCCTTGC TGTTCGGGTA CTGGAGCATG ATGAAGTGGA ACCGCGAACG CAGGCGTCTA 180 181 CAGATCGAGG ACTTCGAGGC CCGCATCGCG CTGATGCCTC TGTTACAGGC AGAGAAGGAC 240 241 CGGAGGGTTC TCCAGATGCT TCGGGAGAAC TTGGAGGAGG AGGCAACTGT CATGAAGGAT 300 301 GTGCCGGGCT GGAAGGTGGG TGAGTCCGTG TTCCACACCA CGCGCTGGGT GACTCCCATG 360 361 ATGGGCGAGC TCTACGGGCT GCGAGCAAGC GAGGAGGTTC TCAGCGCCAC CTATGGGTTC 420 421 ATATGGTACA CGTAG 435

▼ KEYWORD

ID	Family
KW-0002	3D-structure
KW-0007	Acetylation
KW-0053	Apoptosis
KW-0181	Complete proteome
KW-0903	Direct protein sequencing
KW-0249	Electron transport
KW-0472	Membrane
KW-0496	Mitochondrion
KW-0999	Mitochondrion inner membrane
KW-0539	Nucleus
KW-1185	Reference proteome
KW-0679	Respiratory chain
KW-0812	Transmembrane
KW-1133	Transmembrane helix
KW-0813	Transport

▼ GENE ONTOLOGY

ID	Classification	Description
GO:0005737	Cellular Component	Cytoplasm
GO:0016021	Cellular Component	Integral component of membrane
GO:0005746	Cellular Component	Mitochondrial respirasome
GO:0005747	Cellular Component	Mitochondrial respiratory chain complex I
GO:0005739	Cellular Component	Mitochondrion
GO:0005654	Cellular Component	Nucleoplasm
GO:0008137	Molecular Function	NADH dehydrogenase (ubiquinone) activity
GO:0097190	Biological Process	Apoptotic signaling pathway
GO:0035458	Biological Process	Cellular response to interferon-beta
GO:0071300	Biological Process	Cellular response to retinoic acid
GO:0097191	Biological Process	Extrinsic apoptotic signaling pathway
GO:0032981	Biological Process	Mitochondrial respiratory chain complex I assembly
GO:0030308	Biological Process	Negative regulation of cell growth
GO:2001243	Biological Process	Negative regulation of intrinsic apoptotic signaling pathway
GO:0045892	Biological Process	Negative regulation of transcription, DNA-templated
GO:0043280	Biological Process	Positive regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0045732	Biological Process	Positive regulation of protein catabolic process
GO:0045039	Biological Process	Protein insertion into mitochondrial inner membrane
GO:0072593	Biological Process	Reactive oxygen species metabolic process

▼ KEGG

bta:338084

▼ ORTHOLOGY

DrLLPS ID	Organism	Identity	E-value	Score
LLPS-Ova-2280	Ovis aries	98.1	1e-68	215
LLPS-Aim-3229	Ailuropoda melanoleuca	94.34	3e-66	208
LLPS-Sus-4367	Sus scrofa	93.75	1e-96	283
LLPS-Eqc-4013	Equus caballus	93.75	5e-97	283
LLPS-Tut-1356	Tursiops truncatus	92.36	2e-94	279
LLPS-Caf-0160	Canis familiaris	92.36	1e-95	280
LLPS-Fec-1626	Felis catus	90.97	4e-94	275
LLPS-Urm-1124	Ursus maritimus	89.47	3e-70	215
LLPS-Myl-0383	Myotis lucifugus	88.19	1e-91	272
LLPS-Pap-0354	Pan paniscus	86.92	4e-63	197
LLPS-Hos-4240	Homo sapiens	86.92	4e-63	197
LLPS-Cas-0546	Carlito syrichta	86.81	8e-91	267
LLPS-Fud-0758	Fukomys damarensis	85.31	3e-87	258
LLPS-Ict-3184	Ictidomys tridecemlineatus	84.72	2e-87	258
LLPS-Loa-3061	Loxodonta africana	84.62	3e-86	255
LLPS-Mea-1168	Mesocricetus auratus	84.03	3e-86	255
LLPS-Gog-4715	Gorilla gorilla	83.33	1e-87	260
LLPS-Nol-3544	Nomascus leucogenys	83.33	2e-87	258
LLPS-Pat-2700	Pan troglodytes	83.22	4e-87	258
LLPS-Cap-0083	Cavia porcellus	82.86	5e-84	249
LLPS-Mum-1347	Mus musculus	82.64	8e-86	254
LLPS-Paa-3209	Papio anubis	82.64	4e-86	256
LLPS-Chs-3769	Chlorocebus sabaeus	81.94	3e-85	256
LLPS-Cea-3184	Cercocebus atys	81.94	9e-86	255
LLPS-Ran-2179	Rattus norvegicus	81.94	6e-84	249
LLPS-Mal-4464	Mandrillus leucophaeus	81.94	1e-85	254
LLPS-Mod-1023	Monodelphis domestica	81.94	2e-84	251
LLPS-Man-3317	Macaca nemestrina	81.94	2e-85	254
LLPS-Caj-2237	Callithrix jacchus	81.25	8e-84	249
LLPS-Maf-0069	Macaca fascicularis	81.25	4e-85	253
LLPS-Aon-3466	Aotus nancymaae	81.25	6e-84	249
LLPS-Otg-4347	Otolemur garnettii	79.86	1e-82	247
LLPS-Sah-3205	Sarcophilus harrisii	79.72	3e-81	243
LLPS-Icp-3944	Ictalurus punctatus	77.62	8e-80	239
LLPS-Xet-3383	Xenopus tropicalis	77.36	3e-58	182
LLPS-Leo-0060	Lepisosteus oculatus	76.76	2e-76	232
LLPS-Asm-0933	Astyanax mexicanus	75.0	9e-78	234
LLPS-Dar-4071	Danio rerio	74.39	1e-39	134
LLPS-Orn-0998	Oreochromis niloticus	74.31	6e-78	234
LLPS-Orl-2387	Oryzias latipes	73.61	7e-76	229
LLPS-Scm-3718	Scophthalmus maximus	73.61	1e-74	226
LLPS-Ten-3730	Tetraodon nigroviridis	73.61	4e-74	224
LLPS-Gaa-3954	Gasterosteus aculeatus	72.92	2e-75	228
LLPS-Lac-4039	Latimeria chalumnae	72.92	2e-74	225
LLPS-Gaga-3423	Gallus gallus	70.83	5e-72	219
LLPS-Tar-0050	Takifugu rubripes	70.63	2e-71	218
LLPS-Pof-2502	Poecilia formosa	70.14	3e-66	206
LLPS-Xim-2191	Xiphophorus maculatus	68.06	1e-67	208
LLPS-Pes-2123	Pelodiscus sinensis	67.27	8e-41	139
LLPS-Rhb-0873	Rhinopithecus bieti	66.96	3e-40	138
LLPS-Scf-1875	Scleropages formosus	59.03	7e-56	178
LLPS-Fia-1565	Ficedula albicollis	58.22	3e-52	169
LLPS-Meg-1042	Meleagris gallopavo	56.45	3e-19	81.6
LLPS-Ora-1922	Ornithorhynchus anatinus	53.77	3e-24	95.5
LLPS-Nia-2174	Nicotiana attenuata	52.24	3e-17	76.6
LLPS-Mua-2268	Musa acuminata	47.9	6e-33	119
LLPS-Hea-1131	Helianthus annuus	47.86	4e-34	122
LLPS-Pot-2386	Populus trichocarpa	47.86	9e-33	119
LLPS-Coc-2338	Corchorus capsularis	47.86	5e-33	119
LLPS-Glm-1522	Glycine max	47.06	1e-32	119
LLPS-Met-1744	Medicago truncatula	47.06	2e-31	115
LLPS-Thc-0847	Theobroma cacao	47.01	2e-32	118
LLPS-Dac-1545	Daucus carota	47.01	5e-33	119
LLPS-Cus-2014	Cucumis sativus	47.01	8e-32	116
LLPS-Viv-2213	Vitis vinifera	47.01	8e-33	119
LLPS-Gor-1222	Gossypium raimondii	47.01	2e-32	118
LLPS-Lep-0437	Leersia perrieri	46.22	2e-32	118
LLPS-Orbr-2172	Oryza brachyantha	46.22	3e-32	117
LLPS-Sob-0574	Sorghum bicolor	46.22	2e-32	118
LLPS-Zem-2450	Zea mays	46.22	1e-32	119
LLPS-Sei-2330	Setaria italica	46.15	2e-32	118
LLPS-Tra-1389	Triticum aestivum	45.38	1e-31	116
LLPS-Phv-0654	Phaseolus vulgaris	45.38	2e-30	112
LLPS-Hov-1035	Hordeum vulgare	45.3	2e-31	115
LLPS-Brd-1002	Brachypodium distachyon	45.3	2e-31	115
LLPS-Arl-2965	Arabidopsis lyrata	45.3	7e-29	108
LLPS-Art-2748	Arabidopsis thaliana	45.3	9e-29	108
LLPS-Via-2014	Vigna angularis	44.54	2e-29	110
LLPS-Amt-0133	Amborella trichopoda	44.54	4e-32	119
LLPS-Orp-2377	Oryza punctata	44.54	9e-30	111
LLPS-Prp-1477	Prunus persica	44.54	1e-30	113
LLPS-Brn-1655	Brassica napus	44.44	3e-28	107
LLPS-Brr-2711	Brassica rapa	44.44	2e-28	107
LLPS-Bro-2205	Brassica oleracea	44.44	2e-28	107
LLPS-Abg-0079	Absidia glauca	44.35	1e-25	100
LLPS-Miv-1533	Microbotryum violaceum	44.35	2e-27	105
LLPS-Orni-1179	Oryza nivara	43.7	2e-28	109
LLPS-Orb-2186	Oryza barthii	43.7	2e-28	109
LLPS-Ori-2321	Oryza indica	43.7	5e-29	109
LLPS-Orgl-0564	Oryza glumaepatula	43.7	2e-28	109
LLPS-Ors-2089	Oryza sativa	43.7	5e-29	109
LLPS-Org-1403	Oryza glaberrima	43.7	5e-29	109
LLPS-Orm-1634	Oryza meridionalis	43.7	8e-29	110
LLPS-Orr-1959	Oryza rufipogon	43.7	2e-28	109
LLPS-Sot-2182	Solanum tuberosum	43.59	1e-29	110
LLPS-Mae-0330	Manihot esculenta	43.4	4e-25	99.4
LLPS-Usm-1492	Ustilago maydis	43.33	8e-28	105
LLPS-Asni-1389	Aspergillus niger	43.24	2e-07	50.1
LLPS-Tru-1084	Triticum urartu	42.65	2e-30	117
LLPS-Tum-1566	Tuber melanosporum	42.61	4e-23	93.6
LLPS-Chc-1075	Chondrus crispus	42.61	6e-24	96.3
LLPS-Pug-1261	Puccinia graminis	42.34	9e-25	97.8
LLPS-Chr-0046	Chlamydomonas reinhardtii	42.24	2e-20	87.0
LLPS-Php-0667	Physcomitrella patens	42.02	7e-25	98.6
LLPS-Vir-2079	Vigna radiata	41.73	5e-27	104
LLPS-Dos-1115	Dothistroma septosporum	41.57	1e-14	70.9
LLPS-Sol-2031	Solanum lycopersicum	41.46	1e-27	105
LLPS-Pyt-1277	Pyrenophora teres	41.38	2e-16	75.9
LLPS-Pytr-1394	Pyrenophora triticirepentis	41.38	5e-17	77.0
LLPS-Cii-2117	Ciona intestinalis	41.27	2e-20	86.7
LLPS-Gag-1038	Gaeumannomyces graminis	40.87	1e-16	76.3
LLPS-Kop-1525	Komagataella pastoris	40.87	3e-20	86.3
LLPS-Spr-1431	Sporisorium reilianum	40.68	3e-25	99.0
LLPS-Yal-0570	Yarrowia lipolytica	40.52	9e-21	87.4
LLPS-Sem-0091	Selaginella moellendorffii	40.38	3e-19	84.0
LLPS-Cym-1091	Cyanidioschyzon merolae	40.37	3e-16	75.9
LLPS-Mao-1638	Magnaporthe oryzae	40.35	2e-16	75.5
LLPS-Gas-0120	Galdieria sulphuraria	40.0	1e-21	90.5
LLPS-Zyt-0518	Zymoseptoria tritici	40.0	4e-15	72.0
LLPS-Map-0339	Magnaporthe poae	39.82	3e-17	77.8
LLPS-Asf-1522	Aspergillus flavus	39.82	5e-16	74.7
LLPS-Aso-1437	Aspergillus oryzae	39.82	5e-16	74.7
LLPS-Ved-0730	Verticillium dahliae	39.82	2e-16	75.9
LLPS-Phn-0791	Phaeosphaeria nodorum	39.82	2e-15	73.2
LLPS-Fuv-1437	Fusarium verticillioides	39.45	4e-13	67.4
LLPS-Lem-1163	Leptosphaeria maculans	39.32	2e-16	75.5
LLPS-Coo-1246	Colletotrichum orbiculare	38.94	1e-15	73.2
LLPS-Cogr-1023	Colletotrichum graminicola	38.94	1e-15	73.6
LLPS-Crn-1548	Cryptococcus neoformans	38.74	1e-21	89.4
LLPS-Asfu-0733	Aspergillus fumigatus	38.6	2e-14	70.5
LLPS-Asc-0908	Aspergillus clavatus	38.05	3e-11	61.2
LLPS-Fus-1445	Fusarium solani	38.05	7e-16	74.3
LLPS-Ast-1565	Aspergillus terreus	38.05	2e-14	70.1
LLPS-Trr-1305	Trichoderma reesei	37.17	5e-14	68.9
LLPS-Fuo-1526	Fusarium oxysporum	37.17	1e-14	70.9
LLPS-Drm-1852	Drosophila melanogaster	37.01	5e-18	80.9
LLPS-Osl-1465	Ostreococcus lucimarinus	36.84	2e-18	81.6
LLPS-Blg-0164	Blumeria graminis	36.61	6e-15	71.6
LLPS-Nef-0282	Neosartorya fischeri	36.28	7e-10	57.4
LLPS-Trv-0335	Trichoderma virens	36.28	1e-13	68.2
LLPS-Beb-1182	Beauveria bassiana	35.65	4e-15	72.0
LLPS-Cae-0599	Caenorhabditis elegans	33.08	3e-17	78.6
LLPS-Nec-0613	Neurospora crassa	33.04	1e-15	73.2
LLPS-Asn-1432	Aspergillus nidulans	31.9	2e-11	62.4

LLPS-Bot-1996NDUFA13

Protein Sequence

Nucleotide Sequence

LLPS-Bot-1996
NDUFA13