LLPS-Mum-0458
Ppp1r8

▼ OVERVIEW

Status: Reviewed
Protein Name: Nuclear inhibitor of protein phosphatase 1
Gene Name: Ppp1r8, Nipp1
Ensembl Gene: ENSMUSG00000028882.13
Ensembl Protein: ENSMUSP00000030702.7
Organism: Mus musculus
Taxa ID: 10090
LLPS Type: Others
PDB: 2JPE (A) More


▼ PROPERTY


——— Disorder propensity (calculated by IUPred2A)

▼ Classification

Condensates:
CondensateDescriptionTissue/CellPMIDs
Stress granulePredicted from orthologsN/A(View)

▼ FUNCTION

Inhibitor subunit of the major nuclear protein phosphatase-1 (PP-1). It has RNA-binding activity but does not cleave RNA and may target PP-1 to RNA-associated substrates. May also be involved in pre-mRNA splicing. Binds DNA and might act as a transcriptional repressor. Essential for cell proliferation and early embryonic development.

▼ SEQUENCE

Protein Sequence (FASTA)
1     MAAAVNSGSS  LPLFDCPTWA  GKPPPGLHLD  VVKGDKLIEK  LIIDEKKYYL  FGRNPDLCDF  60
61    TIDHQSCSRV  HAALVYHKHL  KRVFLIDLNS  THGTFLGHIR  LEPHKPQQIP  IDSTVSFGAS  120
121   TRAYTLREKP  QTLPSAVKGD  EKMGGEDDEL  KGLLGLPEEE  TELDNLTEFN  TAHNKRISTL  180
181   TIEEGNLDIQ  RPKRKRKNSR  VTFSEDDEII  NPEDVDPSVG  RFRNMVQTAV  VPVKKKRMEG  240
241   SGSLGLEESG  SRRMQNFAFS  GGLYGGLPPT  HSETGSQPHG  IHGTALIGGL  PMPYPNLAPD  300
301   VDLTPVVPSA  VAINPTPNPA  VYNPEAVNEP  KKKKYAKEAW  PGKKPTPSLL  I  351
Nucleotide CDS Sequence (FASTA)
1     ATGGCGGCAG  CCGTGAACTC  CGGCTCCAGC  CTCCCGCTGT  TCGACTGCCC  GACTTGGGCA  60
61    GGTAAACCAC  CACCTGGCTT  ACATCTGGAT  GTGGTGAAAG  GAGACAAGCT  AATTGAGAAG  120
121   CTGATTATTG  ATGAGAAAAA  GTATTACTTA  TTTGGGAGGA  ACCCCGATCT  GTGTGACTTC  180
181   ACTATCGACC  ACCAGTCATG  CTCTCGAGTC  CACGCAGCGC  TGGTGTACCA  CAAACACCTG  240
241   AAGAGAGTTT  TCTTGATAGA  CCTCAACAGC  ACACATGGCA  CTTTCTTGGG  TCACATTCGG  300
301   CTGGAACCTC  ACAAGCCTCA  ACAGATTCCC  ATCGATTCTA  CGGTCTCATT  TGGCGCGTCC  360
361   ACGAGGGCAT  ACACTCTGCG  AGAGAAGCCT  CAGACATTGC  CATCGGCTGT  GAAAGGAGAT  420
421   GAGAAGATGG  GCGGAGAGGA  TGATGAACTC  AAGGGCTTGT  TGGGACTTCC  CGAAGAGGAG  480
481   ACCGAGCTGG  ATAACCTGAC  AGAGTTCAAC  ACTGCCCACA  ACAAGCGGAT  TTCAACCCTC  540
541   ACTATTGAGG  AGGGGAACCT  GGACATCCAG  AGACCAAAGA  GGAAGAGGAA  GAACTCAAGG  600
601   GTGACCTTCA  GTGAGGATGA  CGAGATCATC  AACCCAGAGG  ACGTGGATCC  GTCTGTTGGT  660
661   CGGTTCCGGA  ACATGGTGCA  GACAGCAGTG  GTTCCAGTCA  AGAAGAAGCG  GATGGAGGGC  720
721   TCTGGCTCTC  TGGGCCTGGA  GGAGTCGGGG  AGCAGGCGCA  TGCAGAACTT  TGCCTTCAGT  780
781   GGAGGACTAT  ATGGGGGCCT  GCCCCCCACA  CACAGTGAAA  CGGGCTCCCA  GCCGCATGGC  840
841   ATTCATGGGA  CAGCGCTCAT  TGGTGGCTTG  CCCATGCCAT  ACCCGAACCT  CGCCCCTGAT  900
901   GTGGACTTGA  CTCCTGTTGT  GCCATCAGCA  GTGGCCATAA  ATCCCACACC  AAACCCTGCA  960
961   GTCTATAACC  CTGAGGCTGT  GAATGAACCC  AAGAAGAAGA  AATACGCGAA  GGAGGCTTGG  1020
1021  CCGGGCAAGA  AGCCCACACC  TTCCTTACTG  ATTTGA  1056

▼ KEYWORD

ID
Family
3D-structure
Complete proteome
Developmental protein
DNA-binding
mRNA processing
mRNA splicing
Nucleus
Phosphoprotein
Protein phosphatase inhibitor
Reference proteome
Repressor
RNA-binding
Spliceosome
Transcription
Transcription regulation

▼ GENE ONTOLOGY

ID
Classification
Description
Cellular Component
Nuclear speck
Cellular Component
Nucleoplasm
Cellular Component
Nucleus
Cellular Component
Spliceosomal complex
Molecular Function
DNA binding
Molecular Function
MRNA binding
Molecular Function
Protein phosphatase regulator activity
Molecular Function
Protein serine/threonine phosphatase inhibitor activity
Biological Process
Cell population proliferation
Biological Process
MRNA processing
Biological Process
Multicellular organism development
Biological Process
Negative regulation of protein dephosphorylation
Biological Process
Production of miRNAs involved in gene silencing by miRNA
Biological Process
RNA splicing

▼ KEGG


▼ ORTHOLOGY

DrLLPS IDOrganismIdentityE-valueScore
LLPS-Ran-1209Rattus norvegicus99.150.0 600
LLPS-Mea-1834Mesocricetus auratus98.580.0 602
LLPS-Paa-2858Papio anubis98.010.0 596
LLPS-Mal-0309Mandrillus leucophaeus98.010.0 596
LLPS-Ova-3700Ovis aries98.010.0 596
LLPS-Aim-0453Ailuropoda melanoleuca98.010.0 596
LLPS-Mup-3469Mustela putorius furo98.010.0 596
LLPS-Dio-1318Dipodomys ordii98.010.0 597
LLPS-Bot-1834Bos taurus98.010.0 596
LLPS-Gog-2064Gorilla gorilla98.010.0 596
LLPS-Caj-3445Callithrix jacchus98.010.0 596
LLPS-Maf-2335Macaca fascicularis98.010.0 596
LLPS-Chs-3065Chlorocebus sabaeus98.010.0 596
LLPS-Aon-1114Aotus nancymaae98.010.0 596
LLPS-Ict-1478Ictidomys tridecemlineatus98.010.0 598
LLPS-Nol-3188Nomascus leucogenys98.010.0 596
LLPS-Caf-2454Canis familiaris98.010.0 596
LLPS-Urm-0014Ursus maritimus98.010.0 596
LLPS-Pat-0760Pan troglodytes98.010.0 596
LLPS-Hos-0769Homo sapiens98.010.0 596
LLPS-Fec-1889Felis catus98.010.0 596
LLPS-Man-3513Macaca nemestrina98.010.0 596
LLPS-Ere-0618Erinaceus europaeus97.720.0 594
LLPS-Tut-0137Tursiops truncatus97.720.0 595
LLPS-Fud-1651Fukomys damarensis97.720.0 593
LLPS-Sus-4098Sus scrofa97.720.0 595
LLPS-Cas-1390Carlito syrichta97.720.0 595
LLPS-Mam-2145Macaca mulatta97.720.0 589
LLPS-Rhb-4752Rhinopithecus bieti97.720.0 589
LLPS-Ora-0023Ornithorhynchus anatinus97.475e-128 375
LLPS-Myl-3402Myotis lucifugus97.450.0 588
LLPS-Poa-1733Pongo abelii97.440.0 591
LLPS-Eqc-0343Equus caballus97.440.0 591
LLPS-Orc-4126Oryctolagus cuniculus97.440.0 593
LLPS-Otg-3689Otolemur garnettii97.150.0 593
LLPS-Loa-1562Loxodonta africana96.590.0 583
LLPS-Sah-2094Sarcophilus harrisii96.580.0 590
LLPS-Mod-2645Monodelphis domestica96.580.0 590
LLPS-Cap-4183Cavia porcellus95.710.0 581
LLPS-Pes-1455Pelodiscus sinensis93.070.0 518
LLPS-Cea-0165Cercocebus atys92.920.0 549
LLPS-Pap-0109Pan paniscus92.590.0 552
LLPS-Gaga-3338Gallus gallus92.310.0 556
LLPS-Fia-3200Ficedula albicollis90.20.0 540
LLPS-Meg-1412Meleagris gallopavo90.170.0 546
LLPS-Anc-0619Anolis carolinensis89.770.0 541
LLPS-Anp-0786Anas platyrhynchos89.740.0 553
LLPS-Tag-0255Taeniopygia guttata87.051e-175 498
LLPS-Xet-0733Xenopus tropicalis82.953e-175 498
LLPS-Ten-0370Tetraodon nigroviridis80.477e-93 283
LLPS-Scf-1949Scleropages formosus77.439e-146 423
LLPS-Asm-0867Astyanax mexicanus77.366e-145 421
LLPS-Dar-2661Danio rerio76.343e-152 439
LLPS-Icp-4086Ictalurus punctatus76.04e-149 432
LLPS-Tar-1413Takifugu rubripes75.072e-148 430
LLPS-Leo-0069Lepisosteus oculatus74.299e-154 444
LLPS-Orl-3622Oryzias latipes73.943e-130 385
LLPS-Orn-3105Oreochromis niloticus72.521e-151 438
LLPS-Scm-1842Scophthalmus maximus72.221e-141 412
LLPS-Xim-1955Xiphophorus maculatus72.167e-137 402
LLPS-Pof-0209Poecilia formosa71.233e-144 419
LLPS-Gaa-2818Gasterosteus aculeatus70.455e-149 431
LLPS-Lac-3318Latimeria chalumnae65.87e-133 390
LLPS-Cii-1111Ciona intestinalis48.691e-78 250
LLPS-Drm-0272Drosophila melanogaster45.772e-72 236
LLPS-Php-1582Physcomitrella patens44.253e-1786.7
LLPS-Art-2935Arabidopsis thaliana43.334e-1888.2
LLPS-Arl-0919Arabidopsis lyrata42.51e-1787.8
LLPS-Sob-0519Sorghum bicolor42.372e-1889.4
LLPS-Sei-1183Setaria italica41.532e-1787.0
LLPS-Dac-1333Daucus carota41.229e-1990.5
LLPS-Amt-0891Amborella trichopoda41.032e-1683.6
LLPS-Brr-0530Brassica rapa40.943e-1889.0
LLPS-Orp-1868Oryza punctata40.52e-1684.0
LLPS-Viv-2065Vitis vinifera40.174e-1889.0
LLPS-Brn-1916Brassica napus40.152e-1889.0
LLPS-Bro-0130Brassica oleracea40.152e-1889.0
LLPS-Sot-0876Solanum tuberosum40.03e-1786.3
LLPS-Sol-2346Solanum lycopersicum40.03e-1786.3
LLPS-Met-1005Medicago truncatula39.691e-1890.5
LLPS-Zem-0427Zea mays39.691e-1890.5
LLPS-Orgl-1441Oryza glumaepatula39.682e-1786.7
LLPS-Mua-0438Musa acuminata39.682e-1889.0
LLPS-Orni-0142Oryza nivara39.682e-1786.7
LLPS-Orb-0759Oryza barthii39.682e-1786.7
LLPS-Ori-1391Oryza indica39.682e-1786.7
LLPS-Org-2019Oryza glaberrima39.682e-1786.7
LLPS-Orr-1336Oryza rufipogon39.682e-1786.7
LLPS-Ors-0815Oryza sativa39.682e-1786.7
LLPS-Lep-0611Leersia perrieri39.372e-1787.4
LLPS-Nia-1198Nicotiana attenuata39.232e-1786.7
LLPS-Glm-0516Glycine max38.935e-1991.3
LLPS-Brd-1003Brachypodium distachyon38.891e-1787.0
LLPS-Orbr-0485Oryza brachyantha38.845e-1682.8
LLPS-Tra-1346Triticum aestivum38.37e-1888.2
LLPS-Cae-0556Caenorhabditis elegans38.222e-47 169
LLPS-Vir-1331Vigna radiata38.173e-1888.6
LLPS-Via-0413Vigna angularis38.172e-1889.7
LLPS-Cus-0693Cucumis sativus38.12e-1684.0
LLPS-Pot-0516Populus trichocarpa38.12e-1786.7
LLPS-Coc-1883Corchorus capsularis36.927e-1887.8
LLPS-Gor-0148Gossypium raimondii36.766e-1785.1
LLPS-Chr-0154Chlamydomonas reinhardtii35.651e-1170.5
LLPS-Hea-0081Helianthus annuus35.01e-0963.5
LLPS-Tru-1883Triticum urartu34.846e-1682.4
LLPS-Phv-2515Phaseolus vulgaris34.116e-1270.9
LLPS-Thc-1240Theobroma cacao32.565e-1168.2
LLPS-Prp-2437Prunus persica32.561e-1067.0
LLPS-Crn-1561Cryptococcus neoformans32.262e-0962.0
LLPS-Abg-1290Absidia glauca32.095e-1063.2
LLPS-Usm-0632Ustilago maydis31.168e-0857.4
LLPS-Hov-0090Hordeum vulgare28.578e-1887.8
LLPS-Mae-0656Manihot esculenta27.974e-1785.9