LLPS-Mum-0306
Nup93

▼ OVERVIEW

Status: Reviewed
Protein Name: Nuclear pore complex protein Nup93; 93 kDa nucleoporin; CBP-interacting protein 4; Nucleoporin Nup93
Gene Name: Nup93, Cip4, Kiaa0095
Ensembl Gene: ENSMUSG00000032939.14
Ensembl Protein: ENSMUSP00000105174.1
Organism: Mus musculus
Taxa ID: 10090
LLPS Type: Others


▼ PROPERTY


——— Disorder propensity (calculated by IUPred2A)

▼ Classification

Condensates:
CondensateDescriptionTissue/CellPMIDs
NucleolusPredicted from orthologsN/A(View)

▼ FUNCTION

Plays a role in the nuclear pore complex (NPC) assembly and/or maintenance. May anchor nucleoporins, but not NUP153 and TPR, to the NPC (By similarity). During renal development, regulates podocyte migration and proliferation through SMAD4 signaling (By similarity) (PubMed:26878725).

▼ SEQUENCE

Protein Sequence (FASTA)
1     MDTEGFGELL  QQAEQLAAET  EGISELPHVE  RNLQEIQQAG  ERLRSRTLTR  TSQETADVKA  60
61    SVLLGSRGLD  ISHISQRLES  LSAATTFEPL  EPVKDTDIQG  FLKNEKDNAL  LSAIEESRKR  120
121   TFGMAEEYHR  ESMLVEWEQV  KQRILHTLLA  SGEDALDFTQ  ESEPSYIGDV  NPPGRSSLDS  180
181   IEMAYARQIY  IYNEKIVSGH  LQPNLVDLCA  SVAELDDKSI  SDMWAMVKQM  TDVVLTPATD  240
241   ALKSRSSVEV  RMDFVKQALG  YLEQSYKNYT  LVTVFGNLHQ  AQLGGVPGTY  QLVRSFLNIK  300
301   LPAPSPGLQD  GEVEGHPVWA  LIYYCMRCGD  LLAASQVVSR  AQHQLGEFKT  WFQEYMNSKD  360
361   RRLSPATENK  LRLHYRRALR  NNTDPYKRAV  YCIIGRCDIT  DNQSEVADKT  EDYLWLKLNQ  420
421   VCFDDDGTSS  PQDRLTLSQF  QKQLLEDYGE  SHFTVNQQPF  LYFQVLFLTA  QFEAAIAFLF  480
481   RMERLRCHAV  HVALVLFELK  LLLKSSGQSA  QLLSHEPGDP  PCMRRLNFVR  LLMLYTRKFE  540
541   STDPREALQY  FYFLRDEKDS  QGENMFLRCV  SELVIESREF  DMILGKLEND  GSRKPGVIDK  600
601   FTSDTKPIIN  KVASVAENKG  LFEEAAKLYD  LAKNADKVLE  LMNKLLSPVV  PQISAPQSNK  660
661   ERLKNMALSI  AERYRAQGIS  ANKFVDSTFY  LLLDLITFFD  EYHSGHIDRA  FDIIDRLKLV  720
721   PLNQESVEER  VAAFRNFSDE  IRHNLSEVLL  ATMNILFTQF  KRLKGTSPSS  ATRPQRVIED  780
781   RDSQLRSQAR  ALITFAGMIP  YRTSGDTNAR  LVQMEVLMN  819
Nucleotide CDS Sequence (FASTA)
1     ATGGATACTG  AGGGGTTTGG  TGAGCTCCTT  CAGCAAGCTG  AACAGCTTGC  TGCTGAGACT  60
61    GAAGGCATCT  CTGAGCTTCC  ACATGTAGAA  CGAAATTTAC  AGGAGATCCA  GCAAGCTGGT  120
121   GAGCGCCTGC  GTTCCCGTAC  CCTCACACGC  ACATCCCAGG  AGACAGCAGA  TGTCAAGGCA  180
181   TCAGTTCTTC  TCGGGTCAAG  GGGACTTGAC  ATATCCCATA  TCTCCCAGAG  ACTGGAGAGT  240
241   CTGAGCGCAG  CCACCACTTT  TGAACCTCTC  GAGCCTGTGA  AGGACACGGA  CATTCAGGGC  300
301   TTCCTGAAGA  ATGAGAAAGA  TAATGCCTTG  TTGTCTGCTA  TTGAAGAGTC  CCGGAAGAGG  360
361   ACCTTTGGCA  TGGCTGAGGA  GTATCATCGA  GAATCAATGC  TGGTCGAGTG  GGAACAAGTG  420
421   AAACAAAGGA  TTCTGCACAC  ACTGCTGGCG  TCGGGAGAGG  ATGCCCTTGA  CTTCACCCAA  480
481   GAAAGTGAGC  CGAGTTACAT  CGGTGATGTG  AATCCCCCTG  GGCGAAGCTC  TCTGGATAGC  540
541   ATTGAGATGG  CCTATGCCCG  GCAGATCTAT  ATCTATAACG  AGAAGATTGT  GAGTGGACAC  600
601   CTACAGCCTA  ACCTGGTGGA  CCTGTGTGCC  TCTGTCGCAG  AGCTGGATGA  CAAGAGCATT  660
661   TCTGACATGT  GGGCCATGGT  AAAACAAATG  ACAGATGTGG  TGCTGACACC  AGCAACTGAC  720
721   GCCCTGAAGA  GCCGGAGCAG  TGTGGAAGTG  CGTATGGACT  TTGTCAAGCA  AGCCTTGGGA  780
781   TATCTTGAGC  AGAGTTATAA  GAATTACACC  CTTGTGACTG  TCTTCGGAAA  TCTGCATCAG  840
841   GCACAGCTGG  GCGGTGTGCC  TGGGACTTAC  CAGCTGGTTC  GGAGTTTCCT  AAACATTAAA  900
901   CTGCCAGCTC  CTTCACCAGG  ACTTCAGGAT  GGAGAGGTAG  AAGGCCATCC  TGTCTGGGCA  960
961   TTAATTTATT  ACTGCATGCG  CTGTGGAGAC  CTGCTTGCCG  CATCACAAGT  CGTCAGTCGA  1020
1021  GCCCAGCACC  AGCTTGGGGA  ATTTAAAACT  TGGTTCCAGG  AGTACATGAA  CAGCAAGGAT  1080
1081  AGAAGATTGT  CTCCAGCTAC  AGAAAACAAA  CTCCGACTTC  ACTACCGCAG  AGCCCTCAGG  1140
1141  AACAACACAG  ACCCCTACAA  GAGAGCTGTG  TACTGTATTA  TTGGGAGATG  CGATATCACC  1200
1201  GACAATCAGA  GTGAAGTAGC  CGACAAGACT  GAGGACTACC  TATGGTTAAA  ATTGAACCAG  1260
1261  GTGTGTTTTG  ATGATGACGG  CACCAGCTCA  CCACAAGACA  GGCTCACTCT  CTCACAGTTC  1320
1321  CAGAAGCAGC  TGCTAGAAGA  CTATGGCGAG  TCCCACTTCA  CGGTGAACCA  GCAGCCCTTC  1380
1381  CTCTACTTTC  AAGTGCTGTT  CCTGACTGCA  CAGTTTGAAG  CTGCCATTGC  CTTCCTCTTC  1440
1441  CGCATGGAGC  GGCTGCGCTG  CCATGCTGTC  CATGTGGCCC  TGGTGCTGTT  TGAGCTAAAG  1500
1501  CTGCTTTTAA  AGTCCTCTGG  ACAGAGTGCT  CAACTCCTCA  GCCACGAGCC  TGGCGACCCT  1560
1561  CCCTGCATGC  GACGGCTGAA  CTTTGTGCGT  CTGCTCATGC  TCTACACCCG  CAAGTTTGAG  1620
1621  TCCACGGACC  CAAGAGAAGC  CCTCCAGTAC  TTTTACTTCC  TCAGGGATGA  GAAAGACAGT  1680
1681  CAAGGAGAAA  ACATGTTTCT  GCGCTGTGTG  AGCGAGCTTG  TGATAGAAAG  TCGAGAGTTT  1740
1741  GATATGATTC  TTGGAAAACT  AGAGAACGAT  GGAAGTAGAA  AGCCTGGAGT  TATAGATAAG  1800
1801  TTTACCAGTG  ACACAAAGCC  TATTATCAAC  AAAGTTGCTT  CGGTGGCAGA  AAACAAAGGA  1860
1861  CTGTTTGAAG  AGGCAGCGAA  GCTTTATGAC  CTTGCTAAGA  ATGCTGACAA  GGTGCTGGAG  1920
1921  CTGATGAACA  AGCTGCTAAG  CCCTGTTGTC  CCACAGATCA  GCGCCCCACA  GTCTAACAAA  1980
1981  GAAAGGCTGA  AGAACATGGC  CCTCTCCATT  GCGGAGAGGT  ACAGAGCTCA  GGGAATAAGT  2040
2041  GCAAATAAGT  TTGTGGACTC  TACATTCTAT  CTCCTCTTGG  ACCTGATCAC  CTTTTTTGAC  2100
2101  GAGTATCACA  GTGGTCATAT  TGACAGAGCC  TTTGATATTA  TTGACCGCTT  GAAGCTGGTG  2160
2161  CCTCTGAATC  AGGAGAGTGT  GGAAGAAAGG  GTGGCTGCCT  TCAGAAACTT  CAGTGATGAA  2220
2221  ATCAGACACA  ACCTCTCAGA  AGTTCTTCTC  GCCACCATGA  ACATCCTGTT  CACACAGTTT  2280
2281  AAGAGGCTCA  AAGGAACAAG  TCCATCTTCA  GCAACCAGGC  CCCAGCGAGT  CATTGAAGAC  2340
2341  CGTGACTCTC  AACTCCGAAG  TCAAGCCAGA  GCCCTGATTA  CCTTTGCTGG  GATGATACCG  2400
2401  TACCGGACGT  CGGGGGACAC  TAATGCCAGG  CTGGTGCAGA  TGGAGGTCCT  CATGAATTAA  2460

▼ KEYWORD

ID
Family
Alternative splicing
Complete proteome
Membrane
mRNA transport
Nuclear pore complex
Nucleus
Phosphoprotein
Protein transport
Reference proteome
Translocation
Transport

▼ GENE ONTOLOGY

ID
Classification
Description
Cellular Component
Nuclear envelope
Cellular Component
Nuclear membrane
Cellular Component
Nuclear periphery
Cellular Component
Nuclear pore
Molecular Function
Structural constituent of nuclear pore
Biological Process
Nuclear envelope organization
Biological Process
Nuclear pore complex assembly
Biological Process
Poly(A)+ mRNA export from nucleus
Biological Process
Positive regulation of SMAD protein signal transduction
Biological Process
Protein import into nucleus
Biological Process
Renal system development
Biological Process
SMAD protein signal transduction

▼ KEGG


▼ ORTHOLOGY

DrLLPS IDOrganismIdentityE-valueScore
LLPS-Ran-0156Rattus norvegicus99.510.01618
LLPS-Dio-1166Dipodomys ordii98.410.01602
LLPS-Orc-1849Oryctolagus cuniculus98.410.01599
LLPS-Ict-1537Ictidomys tridecemlineatus98.290.01600
LLPS-Otg-3010Otolemur garnettii98.290.01601
LLPS-Bot-1227Bos taurus98.050.01598
LLPS-Sus-0147Sus scrofa98.050.01594
LLPS-Aim-1846Ailuropoda melanoleuca97.920.01595
LLPS-Paa-3341Papio anubis97.830.01509
LLPS-Maf-2963Macaca fascicularis97.830.01511
LLPS-Man-3833Macaca nemestrina97.830.01511
LLPS-Rhb-2976Rhinopithecus bieti97.830.01510
LLPS-Mup-2770Mustela putorius furo97.80.01593
LLPS-Ova-2345Ovis aries97.80.01596
LLPS-Chs-1472Chlorocebus sabaeus97.80.01583
LLPS-Poa-4085Pongo abelii97.80.01586
LLPS-Urm-0434Ursus maritimus97.80.01593
LLPS-Mal-2654Mandrillus leucophaeus97.710.01509
LLPS-Cea-4223Cercocebus atys97.710.01508
LLPS-Gog-0441Gorilla gorilla97.710.01509
LLPS-Pat-3202Pan troglodytes97.710.01509
LLPS-Pap-1879Pan paniscus97.710.01509
LLPS-Caf-1533Canis familiaris97.680.01589
LLPS-Nol-4579Nomascus leucogenys97.680.01580
LLPS-Loa-0833Loxodonta africana97.680.01595
LLPS-Hos-3612Homo sapiens97.580.01508
LLPS-Myl-2089Myotis lucifugus97.440.01587
LLPS-Cas-0333Carlito syrichta97.070.01511
LLPS-Fec-0216Felis catus96.50.01520
LLPS-Eqc-3510Equus caballus96.10.01367
LLPS-Mam-2198Macaca mulatta95.930.01471
LLPS-Caj-2866Callithrix jacchus95.690.01466
LLPS-Aon-4237Aotus nancymaae95.670.01464
LLPS-Mod-0087Monodelphis domestica95.480.01560
LLPS-Sah-0347Sarcophilus harrisii95.260.01558
LLPS-Cap-1640Cavia porcellus94.870.01553
LLPS-Fud-2804Fukomys damarensis94.630.01546
LLPS-Mea-3213Mesocricetus auratus94.260.01519
LLPS-Ora-0981Ornithorhynchus anatinus93.930.01454
LLPS-Pes-1582Pelodiscus sinensis92.310.01509
LLPS-Gaga-1716Gallus gallus92.060.01502
LLPS-Meg-1940Meleagris gallopavo92.060.01499
LLPS-Anp-1421Anas platyrhynchos91.960.01429
LLPS-Fia-0290Ficedula albicollis90.840.01492
LLPS-Tag-2819Taeniopygia guttata90.720.01489
LLPS-Leo-2202Lepisosteus oculatus83.70.01384
LLPS-Dar-0300Danio rerio83.540.01384
LLPS-Icp-2451Ictalurus punctatus83.170.01379
LLPS-Asm-2554Astyanax mexicanus83.170.01386
LLPS-Orl-2946Oryzias latipes82.80.01375
LLPS-Anc-0558Anolis carolinensis82.80.01192
LLPS-Ten-2502Tetraodon nigroviridis82.480.01367
LLPS-Scm-0361Scophthalmus maximus82.320.01375
LLPS-Gaa-0089Gasterosteus aculeatus82.20.01369
LLPS-Orn-1088Oreochromis niloticus82.070.01377
LLPS-Lac-1604Latimeria chalumnae81.910.01230
LLPS-Scf-1172Scleropages formosus81.710.01296
LLPS-Pof-2756Poecilia formosa80.00.01335
LLPS-Xim-2581Xiphophorus maculatus79.880.01318
LLPS-Xet-0126Xenopus tropicalis79.680.01279
LLPS-Tar-0008Takifugu rubripes75.530.01079
LLPS-Cii-1028Ciona intestinalis47.050.0 706
LLPS-Cis-1239Ciona savignyi43.41e-107 343
LLPS-Drm-0885Drosophila melanogaster36.222e-144 452
LLPS-Put-0536Puccinia triticina32.221e-0863.2
LLPS-Tum-0116Tuber melanosporum29.512e-0758.9
LLPS-Cae-1381Caenorhabditis elegans28.161e-58 218
LLPS-Cym-1047Cyanidioschyzon merolae27.668e-0653.9
LLPS-Miv-0952Microbotryum violaceum27.191e-75 270
LLPS-Asg-0193Ashbya gossypii26.812e-62 231
LLPS-Trr-1591Trichoderma reesei26.734e-31 135
LLPS-Scp-0388Schizosaccharomyces pombe26.67e-38 156
LLPS-Usm-1147Ustilago maydis26.527e-70 253
LLPS-Scj-0773Schizosaccharomyces japonicus26.442e-42 170
LLPS-Pug-0308Puccinia graminis26.317e-72 260
LLPS-Mel-0549Melampsora laricipopulina26.192e-64 237
LLPS-Spr-0332Sporisorium reilianum26.177e-71 256
LLPS-Asf-1533Aspergillus flavus25.987e-41 166
LLPS-Blg-0166Blumeria graminis25.931e-26 121
LLPS-Cogr-1275Colletotrichum graminicola25.558e-38 157
LLPS-Mao-0571Magnaporthe oryzae25.513e-30 132
LLPS-Met-1708Medicago truncatula25.496e-2099.4
LLPS-Map-0478Magnaporthe poae25.45e-28 125
LLPS-Asfu-0007Aspergillus fumigatus25.352e-37 155
LLPS-Yal-1376Yarrowia lipolytica25.256e-59 220
LLPS-Aso-0874Aspergillus oryzae25.24e-45 179
LLPS-Asn-0776Aspergillus nidulans25.116e-37 154
LLPS-Gas-0030Galdieria sulphuraria25.041e-37 155
LLPS-Asc-0117Aspergillus clavatus25.02e-38 158
LLPS-Nia-2131Nicotiana attenuata24.948e-1066.6
LLPS-Coo-0862Colletotrichum orbiculare24.826e-36 150
LLPS-Crn-1090Cryptococcus neoformans24.795e-52 200
LLPS-Zyt-0096Zymoseptoria tritici24.694e-31 135
LLPS-Beb-0702Beauveria bassiana24.569e-34 144
LLPS-Asni-0632Aspergillus niger24.516e-46 182
LLPS-Sac-1197Saccharomyces cerevisiae24.487e-52 198
LLPS-Ved-0656Verticillium dahliae24.414e-34 145
LLPS-Sot-1585Solanum tuberosum24.383e-1790.9
LLPS-Amt-1401Amborella trichopoda24.363e-1997.4
LLPS-Orni-1885Oryza nivara24.289e-0757.0
LLPS-Pyt-1101Pyrenophora teres24.254e-34 145
LLPS-Pytr-0369Pyrenophora triticirepentis24.257e-32 138
LLPS-Ast-0817Aspergillus terreus24.164e-44 176
LLPS-Hea-0305Helianthus annuus24.145e-1893.6
LLPS-Chc-0103Chondrus crispus24.112e-29 127
LLPS-Pot-2591Populus trichocarpa24.07e-2099.4
LLPS-Phv-1441Phaseolus vulgaris23.998e-1995.9
LLPS-Scs-0251Sclerotinia sclerotiorum23.897e-29 128
LLPS-Trv-1337Trichoderma virens23.746e-31 135
LLPS-Fus-0499Fusarium solani23.724e-32 139
LLPS-Fuv-0438Fusarium verticillioides23.711e-33 143
LLPS-Fuo-0894Fusarium oxysporum23.712e-33 142
LLPS-Lem-1456Leptosphaeria maculans23.74e-28 125
LLPS-Mae-1278Manihot esculenta23.662e-1688.2
LLPS-Nef-1305Neosartorya fischeri23.566e-40 163
LLPS-Nec-1134Neurospora crassa23.217e-34 144
LLPS-Thc-1859Theobroma cacao23.076e-2099.8
LLPS-Sol-0451Solanum lycopersicum23.051e-1895.1
LLPS-Viv-1419Vitis vinifera22.974e-1893.6
LLPS-Arl-0121Arabidopsis lyrata22.863e-20 100
LLPS-Dos-0452Dothistroma septosporum22.72e-26 120
LLPS-Glm-1692Glycine max22.622e-1998.2
LLPS-Coc-0685Corchorus capsularis22.544e-1893.6
LLPS-Art-0801Arabidopsis thaliana22.462e-21 103
LLPS-Php-0656Physcomitrella patens22.445e-24 112
LLPS-Scc-0630Schizosaccharomyces cryophilus22.331e-35 149
LLPS-Brn-1630Brassica napus22.31e-1998.2
LLPS-Gag-0325Gaeumannomyces graminis22.241e-29 130
LLPS-Sem-0313Selaginella moellendorffii22.194e-1687.0
LLPS-Gor-0945Gossypium raimondii22.155e-1377.0
LLPS-Via-0951Vigna angularis22.131e-21 104
LLPS-Bro-0487Brassica oleracea22.136e-1893.2
LLPS-Brr-1440Brassica rapa22.11e-1895.5
LLPS-Dac-0360Daucus carota22.064e-1997.1
LLPS-Abg-1093Absidia glauca22.05e-38 157
LLPS-Vir-0809Vigna radiata22.09e-22 105
LLPS-Kop-0398Komagataella pastoris21.934e-45 179
LLPS-Lep-0159Leersia perrieri21.881e-1585.9
LLPS-Cus-0006Cucumis sativus21.771e-1895.1
LLPS-Mua-1357Musa acuminata21.764e-23 109
LLPS-Prp-0155Prunus persica21.613e-1687.8
LLPS-Phn-1531Phaeosphaeria nodorum21.577e-24 112
LLPS-Sei-1049Setaria italica21.52e-1997.8
LLPS-Hov-0164Hordeum vulgare21.261e-1379.3
LLPS-Orgl-0935Oryza glumaepatula21.253e-1584.7
LLPS-Zem-1370Zea mays21.162e-1688.6
LLPS-Sob-1717Sorghum bicolor21.163e-1584.7
LLPS-Orbr-0273Oryza brachyantha21.155e-1584.0
LLPS-Tra-2276Triticum aestivum21.143e-1480.9
LLPS-Brd-0418Brachypodium distachyon20.988e-1892.8
LLPS-Ori-0929Oryza indica20.898e-1686.3
LLPS-Orb-1758Oryza barthii20.892e-1585.1
LLPS-Orr-1680Oryza rufipogon20.891e-1585.9
LLPS-Org-1543Oryza glaberrima20.892e-1585.1
LLPS-Ors-1459Oryza sativa20.891e-1585.9