LLPS-Mod-2792
DLAT
Integrated Annotations
▼ OVERVIEW
| Status: | Unreviewed |
| Protein Name: | Acetyltransferase component of pyruvate dehydrogenase complex |
| Gene Name: | DLAT |
| Ensembl Gene: | ENSMODG00000014415.3 |
| Ensembl Protein: | ENSMODP00000018020.3 |
| Organism: | Monodelphis domestica |
| Taxa ID: | 13616 |
| LLPS Type: | LLPS regulator |
▼ Classification
Condensates:
| Condensate | Evidence | Orthologs |
|---|---|---|
| Nucleolus, Stress granule, Postsynaptic density | Predicted from orthologs | (View) |
▼ FUNCTION
| The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). |
▼ CROSS REFERENCE
| Database | Nucleotide ID | Protein ID |
|---|---|---|
| Ensembl | ENSMODT00000018352.3 | ENSMODP00000018020.3 |
| UniProt | F7BHC0, F7BHC0_MONDO |
▼ SEQUENCE
| Protein Sequence (FASTA) |
|---|
1 MWRVCARQAR RARALRAWGP CSASGAVPRV PFLLLQVLGA PGRRWYSLPP HQKVPLPSLS 60 61 PTMQAGTIAR WEKKEGEKIN EGDLIAEVET DKATVGFESL EECYLAKIIV PEGTRDVPVG 120 121 AVICITVEKM EDVDAFKNYT LDSTAATTPQ VSTAPPSAPV ASSPSLQAPG SSYPPHLQVL 180 181 LPALSPTMTM GTVQRWEKKV GEKLNEGDLL AEIETDKATI GFEVQEEGYL AKILIPEGTR 240 241 DVPLGTPLCI IVEKEADIPA FADYRQTGVT DIKPQATPST SPPIAAVPPT PLSTPTAPSA 300 301 SHPAMPTGAK GRVFASPLAK KLAAEKGIDL KQVRGTGPDG RITKKDIESF VPSKATPALP 360 361 PTAAMPAPAP GVAAVPTGIF TDIPISNIRR VIAQRLMQSK QTIPHYYLSI DVNMGEVLEV 420 421 RKELNTILAG GSKISVNDFI IKASAMACLK VPEANSSWMD TVIRQNHVVD ISVAVSTPSG 480 481 LITPIVFNAH IKGLESIAND VVSLATKARE GKLQPHEFQG GTFTISNLGM FGIKNFSAII 540 541 NPPQACILAV GASENRLVPA DNEKGFDVAS MMSVTLSCDH RVVDGAVGAQ WLAEFKKYLE 600 601 KPITMIL 607 |
| Nucleotide CDS Sequence (FASTA) |
1 ATGTGGCGAG TGTGTGCACG GCAGGCTCGC AGGGCTAGAG CATTGCGGGC CTGGGGTCCT 60 61 TGCTCCGCCT CCGGGGCCGT GCCACGGGTG CCTTTCCTGC TGCTGCAGGT CTTGGGGGCT 120 121 CCTGGACGAC GCTGGTACAG TCTTCCTCCA CACCAGAAGG TTCCTTTGCC TTCTCTTTCC 180 181 CCTACAATGC AGGCAGGGAC CATTGCCCGC TGGGAGAAAA AGGAAGGGGA AAAGATCAAT 240 241 GAGGGTGACC TTATAGCTGA AGTTGAAACA GATAAAGCTA CTGTTGGATT TGAGAGCCTA 300 301 GAAGAGTGCT ACCTGGCTAA AATAATTGTT CCTGAAGGTA CCAGAGATGT TCCAGTTGGA 360 361 GCAGTCATCT GTATTACTGT TGAAAAAATG GAGGATGTGG ATGCATTTAA AAATTATACC 420 421 CTGGATTCCA CAGCAGCAAC CACTCCCCAA GTTTCTACAG CTCCTCCCTC TGCTCCTGTG 480 481 GCTTCATCAC CTTCTCTCCA GGCTCCAGGG AGCTCATATC CTCCTCATTT GCAAGTCCTG 540 541 CTTCCTGCCC TCTCTCCCAC TATGACTATG GGCACAGTTC AGAGGTGGGA GAAGAAGGTG 600 601 GGTGAGAAAT TGAATGAAGG AGACTTGCTG GCTGAGATAG AAACTGACAA AGCCACAATA 660 661 GGTTTTGAAG TACAAGAGGA AGGATATCTG GCAAAAATTC TTATCCCTGA AGGCACGAGA 720 721 GATGTCCCTC TAGGAACTCC ACTCTGTATC ATTGTAGAAA AAGAAGCAGA TATTCCTGCA 780 781 TTTGCTGACT ATAGGCAGAC CGGAGTAACT GATATAAAAC CCCAAGCAAC ACCATCCACC 840 841 TCACCCCCGA TTGCTGCTGT TCCTCCTACA CCCCTATCTA CACCCACTGC ACCTTCAGCC 900 901 TCCCATCCAG CTATGCCTAC TGGTGCAAAA GGAAGAGTAT TTGCAAGTCC TCTTGCAAAG 960 961 AAATTGGCAG CAGAGAAAGG AATTGACCTT AAACAAGTGA GAGGAACCGG GCCAGATGGT 1020 1021 AGAATCACCA AGAAAGATAT CGAATCTTTT GTGCCTTCAA AGGCTACTCC TGCTCTTCCT 1080 1081 CCAACAGCGG CCATGCCTGC ACCAGCTCCA GGAGTAGCAG CAGTTCCTAC TGGCATTTTT 1140 1141 ACAGATATCC CAATCAGCAA TATTCGTAGA GTTATTGCCC AGCGTTTAAT GCAGTCCAAG 1200 1201 CAAACAATAC CTCATTATTA CCTTTCCATA GATGTAAACA TGGGAGAAGT TTTAGAAGTA 1260 1261 CGGAAAGAAC TCAACACAAT ATTGGCAGGA GGCAGTAAAA TTTCTGTCAA TGACTTTATC 1320 1321 ATTAAAGCTT CAGCTATGGC ATGTTTGAAA GTACCTGAAG CAAATTCTTC TTGGATGGAT 1380 1381 ACAGTTATAA GGCAAAATCA TGTTGTTGAT ATTAGTGTTG CCGTCAGTAC TCCTTCTGGA 1440 1441 CTCATTACAC CTATTGTATT TAATGCACAT ATAAAAGGAC TGGAATCCAT TGCTAATGAT 1500 1501 GTAGTTTCTT TAGCAACCAA AGCTCGAGAG GGTAAACTTC AGCCACATGA ATTTCAGGGT 1560 1561 GGTACTTTTA CCATCTCCAA TTTAGGTATG TTTGGGATTA AGAATTTCTC TGCCATTATT 1620 1621 AACCCACCTC AGGCATGTAT TTTGGCAGTT GGTGCTTCAG AGAATAGACT GGTTCCAGCA 1680 1681 GATAATGAAA AAGGATTTGA TGTAGCCAGC ATGATGTCTG TTACACTCAG CTGTGACCAT 1740 1741 CGGGTCGTGG ATGGAGCAGT TGGAGCTCAG TGGCTTGCTG AGTTCAAAAA ATACCTTGAA 1800 1801 AAGCCTATCA CTATGATATT ATAA 1824 |
▼ KEYWORD
▼ GENE ONTOLOGY
ID | Classification | Description |
Cellular Component | Mitochondrial matrix | |
Cellular Component | Pyruvate dehydrogenase complex | |
Molecular Function | Dihydrolipoyllysine-residue acetyltransferase activity | |
Molecular Function | Identical protein binding | |
Molecular Function | Pyruvate dehydrogenase (NAD+) activity |
▼ ORTHOLOGY
| DrLLPS ID | Organism | Identity | E-value | Score |
|---|---|---|---|---|
| LLPS-Sah-0056 | Sarcophilus harrisii | 89.19 | 0.0 | 881 |
| LLPS-Mup-2620 | Mustela putorius furo | 84.92 | 0.0 | 865 |
| LLPS-Rhb-0569 | Rhinopithecus bieti | 83.95 | 0.0 | 885 |
| LLPS-Orc-4017 | Oryctolagus cuniculus | 83.93 | 0.0 | 887 |
| LLPS-Maf-3073 | Macaca fascicularis | 83.78 | 0.0 | 884 |
| LLPS-Chs-3595 | Chlorocebus sabaeus | 83.78 | 0.0 | 881 |
| LLPS-Cea-0854 | Cercocebus atys | 83.78 | 0.0 | 884 |
| LLPS-Paa-0723 | Papio anubis | 83.78 | 0.0 | 884 |
| LLPS-Mal-2892 | Mandrillus leucophaeus | 83.78 | 0.0 | 884 |
| LLPS-Man-1865 | Macaca nemestrina | 83.78 | 0.0 | 884 |
| LLPS-Mam-1987 | Macaca mulatta | 83.78 | 0.0 | 884 |
| LLPS-Myl-0448 | Myotis lucifugus | 83.65 | 0.0 | 873 |
| LLPS-Cap-2228 | Cavia porcellus | 83.47 | 0.0 | 875 |
| LLPS-Otg-3730 | Otolemur garnettii | 83.45 | 0.0 | 883 |
| LLPS-Aim-4260 | Ailuropoda melanoleuca | 83.42 | 0.0 | 862 |
| LLPS-Urm-0368 | Ursus maritimus | 83.42 | 0.0 | 861 |
| LLPS-Bot-2105 | Bos taurus | 83.28 | 0.0 | 878 |
| LLPS-Ova-2176 | Ovis aries | 83.28 | 0.0 | 876 |
| LLPS-Aon-2872 | Aotus nancymaae | 83.11 | 0.0 | 877 |
| LLPS-Poa-0744 | Pongo abelii | 83.11 | 0.0 | 894 |
| LLPS-Caf-2485 | Canis familiaris | 83.01 | 0.0 | 874 |
| LLPS-Hos-0703 | Homo sapiens | 82.94 | 0.0 | 894 |
| LLPS-Pat-2657 | Pan troglodytes | 82.94 | 0.0 | 892 |
| LLPS-Pap-3009 | Pan paniscus | 82.77 | 0.0 | 886 |
| LLPS-Gog-0338 | Gorilla gorilla | 82.6 | 0.0 | 891 |
| LLPS-Caj-2321 | Callithrix jacchus | 82.6 | 0.0 | 879 |
| LLPS-Cas-1428 | Carlito syrichta | 82.6 | 0.0 | 880 |
| LLPS-Nol-1965 | Nomascus leucogenys | 82.6 | 0.0 | 894 |
| LLPS-Ict-2922 | Ictidomys tridecemlineatus | 82.52 | 0.0 | 859 |
| LLPS-Eqc-4725 | Equus caballus | 82.26 | 0.0 | 877 |
| LLPS-Fud-0003 | Fukomys damarensis | 82.15 | 0.0 | 892 |
| LLPS-Fec-1097 | Felis catus | 82.09 | 0.0 | 879 |
| LLPS-Sus-2741 | Sus scrofa | 81.98 | 0.0 | 879 |
| LLPS-Loa-1453 | Loxodonta africana | 81.26 | 0.0 | 882 |
| LLPS-Dio-2508 | Dipodomys ordii | 79.05 | 0.0 | 872 |
| LLPS-Ran-4342 | Rattus norvegicus | 79.01 | 0.0 | 856 |
| LLPS-Mum-3507 | Mus musculus | 78.85 | 0.0 | 862 |
| LLPS-Ora-0018 | Ornithorhynchus anatinus | 78.48 | 0.0 | 769 |
| LLPS-Fia-0093 | Ficedula albicollis | 78.3 | 0.0 | 793 |
| LLPS-Gaga-0229 | Gallus gallus | 77.39 | 0.0 | 819 |
| LLPS-Meg-0233 | Meleagris gallopavo | 76.5 | 0.0 | 754 |
| LLPS-Tag-2532 | Taeniopygia guttata | 76.17 | 0.0 | 804 |
| LLPS-Xet-0307 | Xenopus tropicalis | 75.78 | 0.0 | 795 |
| LLPS-Anc-1891 | Anolis carolinensis | 75.04 | 0.0 | 810 |
| LLPS-Leo-1798 | Lepisosteus oculatus | 74.82 | 0.0 | 790 |
| LLPS-Dar-2098 | Danio rerio | 74.56 | 0.0 | 791 |
| LLPS-Tar-0382 | Takifugu rubripes | 74.12 | 0.0 | 778 |
| LLPS-Pes-1605 | Pelodiscus sinensis | 74.12 | 0.0 | 789 |
| LLPS-Lac-2360 | Latimeria chalumnae | 73.99 | 0.0 | 813 |
| LLPS-Orn-0575 | Oreochromis niloticus | 73.69 | 0.0 | 789 |
| LLPS-Asm-0656 | Astyanax mexicanus | 73.51 | 0.0 | 783 |
| LLPS-Anp-0143 | Anas platyrhynchos | 73.36 | 0.0 | 817 |
| LLPS-Tut-1457 | Tursiops truncatus | 73.14 | 0.0 | 730 |
| LLPS-Mea-3042 | Mesocricetus auratus | 72.97 | 0.0 | 778 |
| LLPS-Pof-3830 | Poecilia formosa | 72.71 | 0.0 | 779 |
| LLPS-Icp-3397 | Ictalurus punctatus | 72.4 | 0.0 | 781 |
| LLPS-Xim-0616 | Xiphophorus maculatus | 71.62 | 0.0 | 776 |
| LLPS-Gaa-1406 | Gasterosteus aculeatus | 71.09 | 0.0 | 789 |
| LLPS-Ten-1120 | Tetraodon nigroviridis | 70.99 | 0.0 | 788 |
| LLPS-Scm-0387 | Scophthalmus maximus | 68.83 | 0.0 | 764 |
| LLPS-Orl-0936 | Oryzias latipes | 68.75 | 0.0 | 600 |
| LLPS-Art-1966 | Arabidopsis thaliana | 60.22 | 4e-27 | 119 |
| LLPS-Bro-0056 | Brassica oleracea | 60.22 | 2e-27 | 120 |
| LLPS-Via-2341 | Vigna angularis | 59.52 | 7e-23 | 105 |
| LLPS-Arl-2409 | Arabidopsis lyrata | 59.14 | 1e-26 | 118 |
| LLPS-Gor-1235 | Gossypium raimondii | 59.14 | 2e-27 | 120 |
| LLPS-Hea-0562 | Helianthus annuus | 58.7 | 3e-26 | 117 |
| LLPS-Brr-1982 | Brassica rapa | 58.51 | 1e-25 | 115 |
| LLPS-Viv-1300 | Vitis vinifera | 58.42 | 1e-26 | 118 |
| LLPS-Lep-0368 | Leersia perrieri | 58.33 | 2e-22 | 104 |
| LLPS-Vir-1343 | Vigna radiata | 58.24 | 2e-26 | 117 |
| LLPS-Pot-0493 | Populus trichocarpa | 58.06 | 5e-26 | 116 |
| LLPS-Hov-0064 | Hordeum vulgare | 57.61 | 2e-27 | 120 |
| LLPS-Orp-1625 | Oryza punctata | 57.61 | 2e-25 | 115 |
| LLPS-Drm-1228 | Drosophila melanogaster | 57.43 | 3e-30 | 128 |
| LLPS-Orb-2058 | Oryza barthii | 56.52 | 3e-25 | 114 |
| LLPS-Ori-1991 | Oryza indica | 56.52 | 2e-25 | 114 |
| LLPS-Orni-1048 | Oryza nivara | 56.52 | 4e-25 | 114 |
| LLPS-Tra-1361 | Triticum aestivum | 56.52 | 2e-26 | 117 |
| LLPS-Ors-1661 | Oryza sativa | 56.52 | 3e-25 | 114 |
| LLPS-Orbr-1402 | Oryza brachyantha | 56.52 | 1e-25 | 115 |
| LLPS-Orm-0462 | Oryza meridionalis | 56.52 | 7e-25 | 114 |
| LLPS-Orr-2307 | Oryza rufipogon | 56.52 | 3e-25 | 114 |
| LLPS-Org-1339 | Oryza glaberrima | 56.52 | 3e-25 | 114 |
| LLPS-Zem-2419 | Zea mays | 56.52 | 2e-24 | 112 |
| LLPS-Tru-0561 | Triticum urartu | 56.52 | 3e-26 | 117 |
| LLPS-Cus-1013 | Cucumis sativus | 56.25 | 4e-27 | 119 |
| LLPS-Thc-0694 | Theobroma cacao | 55.88 | 5e-27 | 119 |
| LLPS-Cae-0584 | Caenorhabditis elegans | 55.88 | 3e-30 | 128 |
| LLPS-Met-1016 | Medicago truncatula | 55.56 | 2e-26 | 117 |
| LLPS-Cis-1861 | Ciona savignyi | 55.5 | 0.0 | 582 |
| LLPS-Orgl-1486 | Oryza glumaepatula | 55.43 | 4e-24 | 110 |
| LLPS-Brd-1351 | Brachypodium distachyon | 55.43 | 3e-26 | 117 |
| LLPS-Nia-0696 | Nicotiana attenuata | 55.34 | 2e-26 | 117 |
| LLPS-Cii-1673 | Ciona intestinalis | 55.1 | 7e-148 | 444 |
| LLPS-Cym-0420 | Cyanidioschyzon merolae | 54.35 | 3e-24 | 112 |
| LLPS-Glm-2523 | Glycine max | 54.13 | 1e-25 | 115 |
| LLPS-Mae-1416 | Manihot esculenta | 53.98 | 1e-26 | 118 |
| LLPS-Coc-0405 | Corchorus capsularis | 53.92 | 2e-26 | 117 |
| LLPS-Dos-1234 | Dothistroma septosporum | 53.68 | 3e-25 | 113 |
| LLPS-Nec-0030 | Neurospora crassa | 53.54 | 5e-23 | 106 |
| LLPS-Amt-1575 | Amborella trichopoda | 52.88 | 1e-25 | 115 |
| LLPS-Prp-1740 | Prunus persica | 52.85 | 1e-27 | 121 |
| LLPS-Brn-0777 | Brassica napus | 52.83 | 3e-24 | 111 |
| LLPS-Sei-1293 | Setaria italica | 52.73 | 3e-26 | 117 |
| LLPS-Phv-1341 | Phaseolus vulgaris | 52.5 | 2e-26 | 117 |
| LLPS-Sem-2379 | Selaginella moellendorffii | 52.44 | 5e-19 | 95.1 |
| LLPS-Mua-1294 | Musa acuminata | 52.43 | 1e-24 | 112 |
| LLPS-Osl-1241 | Ostreococcus lucimarinus | 52.38 | 5e-20 | 96.7 |
| LLPS-Sob-0329 | Sorghum bicolor | 52.29 | 1e-25 | 115 |
| LLPS-Asg-0958 | Ashbya gossypii | 52.0 | 5e-25 | 112 |
| LLPS-Yal-1441 | Yarrowia lipolytica | 51.95 | 2e-18 | 92.4 |
| LLPS-Mao-0912 | Magnaporthe oryzae | 51.52 | 4e-22 | 103 |
| LLPS-Ved-1080 | Verticillium dahliae | 51.06 | 5e-24 | 109 |
| LLPS-Gas-0743 | Galdieria sulphuraria | 51.04 | 3e-23 | 107 |
| LLPS-Usm-0388 | Ustilago maydis | 50.96 | 1e-93 | 304 |
| LLPS-Dac-2052 | Daucus carota | 50.65 | 6e-16 | 85.9 |
| LLPS-Chc-0087 | Chondrus crispus | 50.58 | 4e-126 | 385 |
| LLPS-Scs-0541 | Sclerotinia sclerotiorum | 50.53 | 6e-20 | 97.4 |
| LLPS-Abg-0102 | Absidia glauca | 50.0 | 1e-22 | 105 |
| LLPS-Gag-0935 | Gaeumannomyces graminis | 49.49 | 9e-22 | 102 |
| LLPS-Mel-0407 | Melampsora laricipopulina | 49.4 | 4e-16 | 85.5 |
| LLPS-Scf-0599 | Scleropages formosus | 49.4 | 1e-15 | 84.3 |
| LLPS-Ere-0803 | Erinaceus europaeus | 49.34 | 3e-60 | 214 |
| LLPS-Pug-0558 | Puccinia graminis | 49.32 | 8e-14 | 78.2 |
| LLPS-Sol-0120 | Solanum lycopersicum | 49.21 | 9e-28 | 121 |
| LLPS-Cog-0978 | Colletotrichum gloeosporioides | 48.98 | 3e-20 | 98.2 |
| LLPS-Scj-0922 | Schizosaccharomyces japonicus | 48.94 | 7e-21 | 100 |
| LLPS-Put-0577 | Puccinia triticina | 48.19 | 2e-15 | 83.2 |
| LLPS-Scp-0790 | Schizosaccharomyces pombe | 48.06 | 1e-129 | 396 |
| LLPS-Sot-0414 | Solanum tuberosum | 48.03 | 5e-27 | 119 |
| LLPS-Map-0219 | Magnaporthe poae | 48.0 | 5e-22 | 103 |
| LLPS-Blg-0419 | Blumeria graminis | 47.92 | 5e-20 | 97.4 |
| LLPS-Asni-0920 | Aspergillus niger | 47.52 | 6e-20 | 98.2 |
| LLPS-Sac-0020 | Saccharomyces cerevisiae | 47.46 | 1e-24 | 112 |
| LLPS-Scc-0720 | Schizosaccharomyces cryophilus | 47.39 | 5e-129 | 395 |
| LLPS-Php-0987 | Physcomitrella patens | 47.13 | 1e-19 | 97.1 |
| LLPS-Trr-0662 | Trichoderma reesei | 47.13 | 7e-17 | 87.4 |
| LLPS-Fus-0693 | Fusarium solani | 47.0 | 3e-22 | 104 |
| LLPS-Cogr-0311 | Colletotrichum graminicola | 46.94 | 4e-21 | 100 |
| LLPS-Tum-1186 | Tuber melanosporum | 46.77 | 1e-111 | 347 |
| LLPS-Miv-0579 | Microbotryum violaceum | 46.74 | 1e-14 | 81.3 |
| LLPS-Asc-1453 | Aspergillus clavatus | 46.08 | 6e-20 | 98.6 |
| LLPS-Asn-0165 | Aspergillus nidulans | 46.08 | 2e-20 | 99.0 |
| LLPS-Nef-0566 | Neosartorya fischeri | 46.08 | 5e-20 | 97.4 |
| LLPS-Asfu-0875 | Aspergillus fumigatus | 46.08 | 5e-20 | 97.4 |
| LLPS-Trv-0872 | Trichoderma virens | 46.0 | 1e-20 | 99.4 |
| LLPS-Fuo-0567 | Fusarium oxysporum | 46.0 | 2e-22 | 104 |
| LLPS-Kop-0446 | Komagataella pastoris | 45.71 | 1e-20 | 99.4 |
| LLPS-Spr-0639 | Sporisorium reilianum | 45.56 | 5e-120 | 372 |
| LLPS-Crn-0599 | Cryptococcus neoformans | 45.54 | 2e-121 | 375 |
| LLPS-Ast-0654 | Aspergillus terreus | 45.1 | 2e-19 | 95.9 |
| LLPS-Pytr-0518 | Pyrenophora triticirepentis | 45.1 | 3e-19 | 95.1 |
| LLPS-Fuv-1056 | Fusarium verticillioides | 45.0 | 3e-21 | 101 |
| LLPS-Beb-1506 | Beauveria bassiana | 45.0 | 7e-21 | 99.8 |
| LLPS-Chr-0005 | Chlamydomonas reinhardtii | 44.7 | 1e-139 | 427 |
| LLPS-Pyt-0382 | Pyrenophora teres | 44.12 | 4e-19 | 94.7 |
| LLPS-Aso-0283 | Aspergillus oryzae | 44.12 | 3e-19 | 95.1 |
| LLPS-Asf-0598 | Aspergillus flavus | 44.12 | 3e-19 | 95.5 |
| LLPS-Coo-1514 | Colletotrichum orbiculare | 39.57 | 6e-101 | 322 |
| LLPS-Phn-0985 | Phaeosphaeria nodorum | 38.66 | 2e-12 | 73.9 |
| LLPS-Lem-0909 | Leptosphaeria maculans | 34.48 | 5e-29 | 124 |
| LLPS-Zyt-1350 | Zymoseptoria tritici | 34.48 | 3e-30 | 127 |