• Disorder▼
  • Domain▼
  • PTM▼
  • Variation▼
  • Mutation▼
  • Interaction▼
  • Disease▼
  • Drug▼
  • Physicochemical▼
  • Function▼
  • Proteomics▼
  • Structure▼
  • Localization▼
  • Expression▼
  • Element▼
  • Methylation▼

LLPS-Mod-1223
COPB1

Integrated Annotations

▼ OVERVIEW

Status: Unreviewed
Protein Name: Coatomer subunit beta; Beta-coat protein
Gene Name: COPB1
Ensembl Gene: ENSMODG00000007335.2
Ensembl Protein: ENSMODP00000009098.1
Organism: Monodelphis domestica
Taxa ID: 13616
LLPS Type: Others


▼ PROPERTY


——— Disorder propensity (calculated by IUPred2A)

▼ Classification

Condensates:
CondensateEvidenceOrthologs
Nucleolus, Stress granulePredicted from orthologs(View)

▼ FUNCTION

The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins.

▼ CROSS REFERENCE

▼ SEQUENCE

Protein Sequence (FASTA)
1     MTAAENVCYT  LINVPMDSEP  PSEIILKNDL  EKGDVKSKTE  ALKKVIIMIL  NGEKLPGLLM  60
61    TIIRFVLPLQ  DHTIKKLLLV  FWEIVPKTTP  DGRLLHEMIL  VCDAYRKDLQ  HPNEFIRGST  120
121   LRFLCKLKEA  ELLEPLMPAI  RACLEHRHSY  VRRNAVLAIY  TIYRNFEHLI  PDAPELIHDF  180
181   LVNEKDASCK  RNAFMMLIHA  DQDRALDYLS  TCIDQVQTFG  DILQLVIVEL  IYKVCHANPS  240
241   ERARFIRCIY  NLLQSSSPAV  KYEAAGTLVT  LSSAPTAIKA  AAQCYIDLII  KESDNNVKLI  300
301   VLDRLIELKE  HPAHERVLQD  LVMDILRVLS  TPDLEVRKKT  LQLALDLVSS  RNVEELVIVL  360
361   KKEVIKTNNV  SEHEDTDKYR  QLLVRTLHSC  SVRFPDMAAN  VIPVLMEFLS  DNNEAAAADV  420
421   LEFVREAIQR  FDNLRLLIVE  KMLEVFHAIK  SVKIYRGALW  ILGEYCSTKE  DIQSVMTEVR  480
481   RSLGEIPIVE  SEIKKEAGEL  KPEEEINVGP  VQKLVTEMGT  YATQSALSSS  RPTKKEEDRP  540
541   PLRAFLLDGD  FFVAASLATT  LTKIALRYVA  LVQEKKKQNS  FIAEAMLLMA  TILHLGKSSL  600
601   PKKPITDDDV  DRISLCLKVL  SECSPLMNDI  FNKECRQSLS  HMLSAKLEEE  KLSQKKESEK  660
661   RNVTVQPDDP  ISFMQLTAKN  EINCKEDQFQ  LSLLAAMGNT  QRKEAADPLA  SKLNKVTQLT  720
721   GFSDPVYAEA  YVHVNQYDIV  LDVLVVNQTS  DTLQNCTLEL  ATLGDLKLVE  KPSPLTLAPH  780
781   DFANIKANVK  VASTENGIIF  GNIVYDVSGA  ASDRNCVVLS  DIHIDIMDYI  QPASCTDAEF  840
841   RQMWAEFEWE  NKVTVNTNII  DLNEYLHHIL  KSTNMKCLTP  EKALSGYCGF  MAANLYARSI  900
901   FGEDALANVS  IEKPIHLGPE  APVTGHIRIR  AKSQGMALSL  GDKINLSQKK  TNV  953
Nucleotide CDS Sequence (FASTA)
1     ATGACTGCTG  CAGAAAATGT  ATGCTATACG  TTAATTAACG  TACCAATGGA  TTCAGAACCA  60
61    CCATCTGAAA  TTATCTTAAA  AAATGACCTT  GAAAAGGGAG  ATGTGAAGTC  AAAGACTGAG  120
121   GCTTTGAAGA  AAGTGATCAT  TATGATCCTG  AATGGTGAAA  AGCTTCCTGG  ACTTCTGATG  180
181   ACCATAATTC  GTTTTGTGCT  GCCTCTCCAG  GATCACACCA  TCAAAAAATT  ACTCTTGGTA  240
241   TTTTGGGAAA  TTGTTCCCAA  AACAACCCCA  GATGGTAGAC  TTTTGCATGA  GATGATCCTT  300
301   GTGTGTGATG  CTTATCGAAA  GGATCTTCAG  CACCCCAATG  AGTTCATTCG  GGGCTCTACT  360
361   CTTCGTTTTC  TTTGCAAACT  GAAAGAAGCA  GAATTACTGG  AGCCTCTGAT  GCCAGCTATC  420
421   CGGGCCTGCC  TGGAGCATCG  ACACAGCTAT  GTCCGAAGGA  ATGCTGTTTT  GGCCATATAC  480
481   ACCATCTACA  GGAATTTTGA  ACATCTTATA  CCTGATGCTC  CTGAACTCAT  CCATGATTTC  540
541   CTGGTTAATG  AGAAAGATGC  AAGTTGTAAA  AGAAATGCAT  TTATGATGCT  GATCCATGCT  600
601   GACCAGGATC  GAGCTTTGGA  TTACCTAAGT  ACTTGCATTG  ATCAAGTTCA  AACATTTGGG  660
661   GACATTCTTC  AGTTGGTCAT  TGTTGAACTA  ATTTATAAGG  TGTGCCATGC  AAATCCATCA  720
721   GAAAGAGCTC  GTTTTATTCG  TTGCATCTAT  AATTTATTGC  AGTCATCTAG  CCCTGCAGTA  780
781   AAATATGAAG  CTGCAGGCAC  CTTGGTTACC  CTCTCTAGTG  CCCCAACAGC  AATCAAGGCT  840
841   GCTGCTCAGT  GTTACATTGA  CTTAATTATT  AAAGAGAGTG  ACAACAATGT  AAAGCTCATT  900
901   GTCCTGGATC  GCTTGATAGA  GCTGAAAGAG  CATCCTGCTC  ATGAGCGAGT  GCTCCAGGAT  960
961   CTGGTTATGG  ACATCTTGAG  AGTACTGAGT  ACCCCAGATT  TAGAAGTGCG  CAAGAAAACT  1020
1021  CTCCAATTAG  CACTGGACCT  TGTGTCTTCC  AGAAATGTCG  AAGAGCTTGT  GATCGTCCTG  1080
1081  AAGAAGGAAG  TGATTAAAAC  CAATAATGTG  TCAGAGCATG  AAGATACTGA  CAAATACAGG  1140
1141  CAGCTCCTTG  TCCGCACATT  GCACTCTTGC  TCTGTTCGGT  TTCCAGATAT  GGCTGCGAAC  1200
1201  GTCATTCCGG  TGCTAATGGA  GTTTCTCAGT  GACAACAATG  AAGCAGCAGC  TGCTGATGTC  1260
1261  TTAGAGTTTG  TCCGGGAAGC  TATCCAGCGA  TTTGATAATC  TCCGTCTGCT  TATTGTTGAG  1320
1321  AAAATGCTTG  AAGTCTTTCA  TGCTATTAAG  TCTGTCAAAA  TTTACCGAGG  AGCACTGTGG  1380
1381  ATTCTGGGGG  AGTATTGTAG  CACCAAAGAA  GACATACAGA  GTGTTATGAC  TGAGGTCCGC  1440
1441  AGGTCCCTGG  GAGAGATCCC  AATTGTGGAA  TCAGAAATAA  AGAAAGAAGC  TGGTGAATTA  1500
1501  AAACCCGAAG  AAGAAATCAA  TGTGGGACCA  GTTCAGAAAC  TGGTAACTGA  AATGGGTACC  1560
1561  TATGCTACAC  AGAGTGCCCT  CAGCAGTTCC  AGACCAACTA  AAAAGGAGGA  AGACAGGCCT  1620
1621  CCACTTCGAG  CATTTCTCCT  TGATGGGGAC  TTCTTTGTCG  CAGCATCTCT  TGCCACAACT  1680
1681  CTAACCAAGA  TTGCCTTGCG  TTATGTGGCC  CTAGTTCAGG  AGAAGAAGAA  GCAAAATTCT  1740
1741  TTCATTGCTG  AAGCTATGCT  GCTCATGGCC  ACTATTCTTC  ATTTGGGCAA  ATCCTCCCTT  1800
1801  CCCAAGAAGC  CAATTACAGA  TGATGATGTG  GACCGTATCT  CCCTGTGCCT  CAAGGTCTTG  1860
1861  TCTGAATGTT  CACCTTTAAT  GAATGACATT  TTCAATAAAG  AGTGCAGACA  GTCCCTTTCT  1920
1921  CACATGCTGT  CTGCTAAACT  GGAAGAAGAG  AAGCTCTCAC  AGAAGAAAGA  GTCTGAAAAG  1980
1981  AGGAATGTGA  CTGTCCAGCC  TGATGACCCC  ATTTCCTTCA  TGCAACTCAC  TGCCAAAAAT  2040
2041  GAAATCAACT  GTAAAGAAGA  CCAGTTTCAG  CTGAGCCTGC  TGGCAGCTAT  GGGAAACACA  2100
2101  CAGAGGAAGG  AAGCAGCTGA  CCCTCTAGCA  TCAAAACTTA  ACAAGGTGAC  CCAGCTGACA  2160
2161  GGTTTCTCAG  ATCCTGTCTA  TGCAGAAGCT  TACGTTCATG  TCAACCAATA  TGATATCGTT  2220
2221  CTGGATGTAC  TTGTTGTAAA  CCAGACCAGT  GATACTCTGC  AGAACTGCAC  TTTAGAACTA  2280
2281  GCCACACTAG  GGGACCTAAA  ACTTGTGGAA  AAACCTTCTC  CTTTGACCCT  TGCACCTCAT  2340
2341  GATTTTGCAA  ATATTAAGGC  TAATGTTAAA  GTAGCTTCAA  CAGAAAATGG  AATCATTTTT  2400
2401  GGTAATATAG  TATATGATGT  GTCTGGAGCA  GCAAGCGACA  GAAACTGTGT  GGTCCTCAGT  2460
2461  GACATTCACA  TTGACATCAT  GGACTACATC  CAACCTGCTT  CTTGCACCGA  TGCTGAGTTC  2520
2521  CGTCAGATGT  GGGCAGAATT  TGAGTGGGAA  AACAAAGTGA  CAGTTAACAC  AAATATAATT  2580
2581  GATTTAAATG  AATACTTACA  TCATATACTA  AAGTCAACCA  ATATGAAATG  TCTCACTCCA  2640
2641  GAGAAGGCCC  TTTCTGGATA  CTGTGGATTT  ATGGCTGCCA  ACCTCTATGC  CCGTTCCATA  2700
2701  TTTGGAGAGG  ACGCACTTGC  GAATGTCAGT  ATTGAAAAGC  CAATTCATCT  TGGACCAGAA  2760
2761  GCCCCAGTTA  CTGGCCACAT  ACGAATTCGT  GCAAAGAGTC  AGGGAATGGC  CCTGAGCCTT  2820
2821  GGAGATAAGA  TCAATCTGTC  TCAAAAGAAA  ACTAATGTAT  AA  2862

▼ KEYWORD

ID
Family
Complete proteome
Cytoplasm
Cytoplasmic vesicle
ER-Golgi transport
Golgi apparatus
Membrane
Protein transport
Reference proteome
Transport

▼ GENE ONTOLOGY

ID
Classification
Description
Cellular Component
COPI vesicle coat
Cellular Component
Cytosol
Cellular Component
Golgi membrane
Molecular Function
Structural molecule activity
Biological Process
Endoplasmic reticulum to Golgi vesicle-mediated transport
Biological Process
Intra-Golgi vesicle-mediated transport
Biological Process
Intracellular protein transport

▼ KEGG


▼ ORTHOLOGY

DrLLPS IDOrganismIdentityE-valueScore
LLPS-Sah-2401Sarcophilus harrisii99.790.01886
LLPS-Loa-0928Loxodonta africana98.740.01872
LLPS-Mup-1185Mustela putorius furo98.530.01867
LLPS-Urm-1075Ursus maritimus98.530.01867
LLPS-Sus-1571Sus scrofa98.430.01866
LLPS-Caf-0457Canis familiaris98.430.01864
LLPS-Rhb-1181Rhinopithecus bieti98.340.01773
LLPS-Paa-1295Papio anubis98.320.01865
LLPS-Myl-0968Myotis lucifugus98.320.01865
LLPS-Caj-2193Callithrix jacchus98.320.01865
LLPS-Cea-2771Cercocebus atys98.320.01865
LLPS-Aon-1386Aotus nancymaae98.320.01865
LLPS-Maf-0769Macaca fascicularis98.320.01865
LLPS-Chs-1088Chlorocebus sabaeus98.320.01865
LLPS-Nol-3476Nomascus leucogenys98.320.01865
LLPS-Mam-0593Macaca mulatta98.320.01865
LLPS-Man-0081Macaca nemestrina98.320.01865
LLPS-Fec-1204Felis catus98.320.01863
LLPS-Dio-1813Dipodomys ordii98.220.01863
LLPS-Cas-1835Carlito syrichta98.220.01860
LLPS-Gaga-2161Gallus gallus98.220.01859
LLPS-Poa-3158Pongo abelii98.220.01860
LLPS-Otg-0153Otolemur garnettii98.220.01861
LLPS-Hos-0878Homo sapiens98.220.01864
LLPS-Bot-3719Bos taurus98.110.01860
LLPS-Gog-2908Gorilla gorilla98.110.01861
LLPS-Orc-3659Oryctolagus cuniculus98.110.01861
LLPS-Pap-1335Pan paniscus98.110.01862
LLPS-Ict-2430Ictidomys tridecemlineatus98.070.01818
LLPS-Aim-0390Ailuropoda melanoleuca98.010.01859
LLPS-Mea-1084Mesocricetus auratus98.010.01860
LLPS-Pat-2825Pan troglodytes98.010.01858
LLPS-Meg-1794Meleagris gallopavo98.010.01855
LLPS-Mum-3123Mus musculus97.90.01858
LLPS-Anc-0415Anolis carolinensis97.90.01853
LLPS-Fia-0098Ficedula albicollis97.90.01855
LLPS-Ran-1991Rattus norvegicus97.80.01856
LLPS-Ora-2089Ornithorhynchus anatinus97.80.01855
LLPS-Pes-1104Pelodiscus sinensis97.70.01852
LLPS-Tag-2074Taeniopygia guttata97.690.01848
LLPS-Cap-0222Cavia porcellus97.480.01844
LLPS-Fud-2757Fukomys damarensis97.380.01847
LLPS-Anp-1857Anas platyrhynchos97.190.01845
LLPS-Ova-0366Ovis aries97.070.01840
LLPS-Tut-0032Tursiops truncatus97.060.01830
LLPS-Mal-2957Mandrillus leucophaeus95.80.01791
LLPS-Lac-3204Latimeria chalumnae95.170.01816
LLPS-Eqc-0909Equus caballus95.030.01844
LLPS-Leo-0719Lepisosteus oculatus94.850.01811
LLPS-Xet-3513Xenopus tropicalis94.80.01807
LLPS-Orn-0687Oreochromis niloticus94.330.01804
LLPS-Pof-1486Poecilia formosa94.330.01807
LLPS-Xim-2337Xiphophorus maculatus94.230.01804
LLPS-Orl-0331Oryzias latipes94.120.01799
LLPS-Icp-0536Ictalurus punctatus94.110.01791
LLPS-Scm-1566Scophthalmus maximus94.020.01803
LLPS-Tar-1398Takifugu rubripes93.910.01798
LLPS-Ten-1413Tetraodon nigroviridis93.810.01796
LLPS-Dar-3626Danio rerio93.690.01787
LLPS-Gaa-1396Gasterosteus aculeatus93.610.01786
LLPS-Scf-1946Scleropages formosus93.170.01783
LLPS-Asm-3294Astyanax mexicanus92.980.01763
LLPS-Cii-1062Ciona intestinalis71.750.01388
LLPS-Cis-1132Ciona savignyi71.290.01384
LLPS-Drm-1511Drosophila melanogaster67.220.01281
LLPS-Cae-1070Caenorhabditis elegans60.190.01108
LLPS-Abg-1806Absidia glauca51.488e-123 408
LLPS-Cus-1529Cucumis sativus51.280.0 904
LLPS-Pug-1048Puccinia graminis50.970.0 936
LLPS-Coc-1850Corchorus capsularis50.910.0 873
LLPS-Mae-1490Manihot esculenta50.910.0 881
LLPS-Sot-1926Solanum tuberosum50.690.0 872
LLPS-Miv-0088Microbotryum violaceum50.610.0 917
LLPS-Glm-0817Glycine max50.530.0 890
LLPS-Sol-2470Solanum lycopersicum50.480.0 872
LLPS-Hea-1605Helianthus annuus50.370.0 879
LLPS-Gor-0668Gossypium raimondii50.370.0 875
LLPS-Pot-2741Populus trichocarpa50.320.0 869
LLPS-Thc-0384Theobroma cacao50.270.0 875
LLPS-Mel-0325Melampsora laricipopulina50.260.0 921
LLPS-Php-0965Physcomitrella patens50.260.0 901
LLPS-Vir-1137Vigna radiata50.210.0 885
LLPS-Met-1340Medicago truncatula50.210.0 887
LLPS-Phv-0892Phaseolus vulgaris50.210.0 885
LLPS-Amt-0271Amborella trichopoda50.160.0 890
LLPS-Viv-2307Vitis vinifera50.160.0 871
LLPS-Spr-0760Sporisorium reilianum50.10.0 907
LLPS-Hov-1370Hordeum vulgare49.950.0 834
LLPS-Dac-0641Daucus carota49.950.0 870
LLPS-Prp-0951Prunus persica49.890.0 876
LLPS-Brd-0152Brachypodium distachyon49.840.0 831
LLPS-Tra-2826Triticum aestivum49.840.0 834
LLPS-Lep-1659Leersia perrieri49.840.0 829
LLPS-Sob-1179Sorghum bicolor49.840.0 829
LLPS-Orbr-1266Oryza brachyantha49.730.0 830
LLPS-Nia-0289Nicotiana attenuata49.680.0 865
LLPS-Orgl-0817Oryza glumaepatula49.630.0 825
LLPS-Orni-0945Oryza nivara49.630.0 826
LLPS-Orb-1358Oryza barthii49.630.0 825
LLPS-Org-0790Oryza glaberrima49.630.0 826
LLPS-Orm-0616Oryza meridionalis49.630.0 824
LLPS-Usm-1210Ustilago maydis49.60.0 923
LLPS-Brn-1792Brassica napus49.570.0 867
LLPS-Via-2110Vigna angularis49.550.0 822
LLPS-Ori-1192Oryza indica49.520.0 823
LLPS-Orr-0058Oryza rufipogon49.520.0 825
LLPS-Orp-1832Oryza punctata49.520.0 827
LLPS-Ors-1802Oryza sativa49.520.0 825
LLPS-Bro-1153Brassica oleracea49.470.0 869
LLPS-Sem-0922Selaginella moellendorffii49.280.0 870
LLPS-Sei-0585Setaria italica49.20.0 827
LLPS-Brr-2351Brassica rapa49.150.0 868
LLPS-Art-2215Arabidopsis thaliana49.090.0 865
LLPS-Zem-2465Zea mays48.940.0 820
LLPS-Arl-0020Arabidopsis lyrata48.720.0 857
LLPS-Tru-1252Triticum urartu48.470.0 798
LLPS-Scs-0004Sclerotinia sclerotiorum48.320.0 885
LLPS-Chr-1100Chlamydomonas reinhardtii48.240.0 840
LLPS-Crn-0591Cryptococcus neoformans48.020.0 874
LLPS-Zyt-0063Zymoseptoria tritici47.870.0 884
LLPS-Map-0631Magnaporthe poae47.870.0 869
LLPS-Gag-1037Gaeumannomyces graminis47.790.0 869
LLPS-Nef-1195Neosartorya fischeri47.630.0 878
LLPS-Dos-0900Dothistroma septosporum47.610.0 879
LLPS-Osl-0744Ostreococcus lucimarinus47.590.0 818
LLPS-Pytr-1037Pyrenophora triticirepentis47.580.0 851
LLPS-Aso-1288Aspergillus oryzae47.530.0 872
LLPS-Lem-1356Leptosphaeria maculans47.530.0 855
LLPS-Asfu-0364Aspergillus fumigatus47.530.0 876
LLPS-Pyt-0296Pyrenophora teres47.480.0 851
LLPS-Trv-0587Trichoderma virens47.420.0 866
LLPS-Asn-0703Aspergillus nidulans47.360.0 872
LLPS-Trr-0135Trichoderma reesei47.320.0 859
LLPS-Ast-0655Aspergillus terreus47.320.0 866
LLPS-Asni-0411Aspergillus niger47.210.0 868
LLPS-Mao-0580Magnaporthe oryzae47.090.0 860
LLPS-Blg-0221Blumeria graminis47.080.0 891
LLPS-Tum-0194Tuber melanosporum47.050.0 871
LLPS-Cogr-1084Colletotrichum graminicola47.050.0 850
LLPS-Cog-0339Colletotrichum gloeosporioides47.050.0 849
LLPS-Nec-0099Neurospora crassa47.030.0 871
LLPS-Ved-0427Verticillium dahliae47.00.0 843
LLPS-Mua-2005Musa acuminata46.980.0 836
LLPS-Fus-0827Fusarium solani46.850.0 842
LLPS-Asc-1293Aspergillus clavatus46.790.0 846
LLPS-Fuo-1159Fusarium oxysporum46.690.0 840
LLPS-Fuv-0955Fusarium verticillioides46.580.0 837
LLPS-Beb-0236Beauveria bassiana46.580.0 852
LLPS-Coo-0688Colletotrichum orbiculare46.410.0 845
LLPS-Chc-0026Chondrus crispus46.110.0 823
LLPS-Asf-1398Aspergillus flavus46.060.0 856
LLPS-Yal-1010Yarrowia lipolytica44.920.0 812
LLPS-Put-0553Puccinia triticina44.560.0 814
LLPS-Phn-0357Phaeosphaeria nodorum43.940.0 770
LLPS-Gas-1344Galdieria sulphuraria43.730.0 773
LLPS-Kop-1021Komagataella pastoris43.440.0 782
LLPS-Sac-0174Saccharomyces cerevisiae42.710.0 746
LLPS-Scj-0220Schizosaccharomyces japonicus42.130.0 699
LLPS-Scc-0763Schizosaccharomyces cryophilus42.090.0 751
LLPS-Asg-1236Ashbya gossypii42.080.0 715
LLPS-Scp-0723Schizosaccharomyces pombe41.90.0 732
LLPS-Cym-1103Cyanidioschyzon merolae37.040.0 602