LLPS-Cae-1070
copb-1

▼ OVERVIEW

Status: Unreviewed
Protein Name: Coatomer subunit beta; Beta-coat protein
Gene Name: copb-1, CELE_Y25C1A.5, Y25C1A.5
Ensembl Gene: WBGene00021292
Ensembl Protein: Y25C1A.5.2
Organism: Caenorhabditis elegans
Taxa ID: 6239
LLPS Type: Others


▼ PROPERTY


——— Disorder propensity (calculated by IUPred2A)

▼ Classification

Condensates:
CondensateEvidenceOrthologs
Nucleolus, Stress granulePredicted from orthologs(View)

▼ FUNCTION

The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins.

▼ CROSS REFERENCE

DatabaseNucleotide IDProtein ID
EnsemblY25C1A.5.2Y25C1A.5.2
EnsemblY25C1A.5.1Y25C1A.5.1
UniProtQ9TYL9, Q9TYL9_CAEEL
GeneBankBX284602CCD61981.1
RefSeqNM_062040.6NP_494441.1
Entrez173656

▼ SEQUENCE

Protein Sequence (FASTA)
1     MSSGEQPCYT  LIHVPSDAEL  PSEAQLKEKF  EKGGDKERIE  ALKKLIYMIL  NGEKTSQSML  60
61    MYVIRFCLPS  NEHTLKKVLL  IFWECVPKTD  SNGKLLHEMI  LVCDAYRKDL  QHPNEFVRGS  120
121   TLRFLCKLRE  PELLEPLMPA  IRACLEHRHS  YVRRNAVCAI  FTIYKNFEFL  IPDAPELVTE  180
181   YLEQEQDASC  KRNAFMMLLH  VDQARALDYL  SGCIDQVGSF  GDILQLVIVE  LIYKVCHNNP  240
241   NEASRFIRCV  YNLLQSSSPA  VRYEAAGTLV  TLSNVPAAVK  AAASAYIDLI  VKESDNNVKL  300
301   IVLDRLVALR  GSSSNEKILQ  GLVMDILRVL  SSPGLEVRKK  TLSLALDLVS  SRNVEDMVMF  360
361   LKKEINKTAT  ESNDENGKYR  QELVKTLHAA  TIKFPDVAST  IVPVLMEFLS  DTNEKASSYV  420
421   LQFVREAVHK  LPNLKNAILG  ALREGIPFIQ  SPTIFMSALW  ILATYCEADG  ALDVLKLVKN  480
481   SLGELPLVDS  ELSGQEEQKP  EEQQPEQQQK  QKPKVTADGT  YATQTALSST  VTTSKKNEKP  540
541   PLRRFLLDGE  FFLGASLATV  LTKLAQQFTE  LNGAASERAN  RFRAECMLIL  SSIIHLAKSG  600
601   LCIVHQQVNE  DDLDRMGATI  KILAQGIPGL  DEQYGDDCKK  SLELMLGAKS  ISRLDVTTEK  660
661   MASTTAAGYR  SKDFVEIDKT  INFTQLSARS  NQQGENLFDL  SLSQALGTAP  KAQKFDFSSS  720
721   KLGKVIQLAG  FSDPIYAEAY  VNVNQYDIVL  DVLIVNQTSD  TLQNVSLELA  TVGDLKLVDK  780
781   PTPVTLAPND  FSNIKATVKV  ASTENGVIFS  TISYDVTGST  SDRNCVYLQD  IKIDIMDYIV  840
841   PGNVTDTEFR  TMWSDFEWEN  KVNVMTPIRD  LRDFLNHLST  STNMKVLTGD  AAIEGDCGFL  900
901   AANLCAHSIF  GEDALANVSV  EKALPMDDSS  PIVGHIRIRA  KSQGMCLTLG  DKLSSAMRSR  960
961   RDGQPIAAPS  A  971
Nucleotide CDS Sequence (FASTA)
1     ATGAGCTCCG  GAGAGCAACC  ATGCTACACA  CTCATCCACG  TGCCCAGTGA  CGCTGAGCTC  60
61    CCATCAGAAG  CTCAATTGAA  GGAAAAATTC  GAGAAAGGAG  GCGATAAAGA  GCGAATTGAG  120
121   GCGCTCAAAA  AGCTCATTTA  CATGATTTTA  AACGGAGAAA  AAACGTCGCA  GAGCATGCTA  180
181   ATGTACGTCA  TCCGCTTCTG  TCTTCCATCC  AATGAGCACA  CCCTTAAAAA  AGTGCTCTTG  240
241   ATCTTCTGGG  AATGTGTTCC  GAAGACGGAT  TCCAATGGAA  AGCTGCTCCA  CGAGATGATT  300
301   CTGGTGTGCG  ATGCCTACCG  AAAAGACCTT  CAACACCCGA  ATGAGTTCGT  TCGCGGTTCG  360
361   ACCCTTCGGT  TTTTGTGCAA  ACTCCGTGAG  CCCGAGCTTC  TCGAGCCGCT  TATGCCGGCG  420
421   ATTAGAGCTT  GTTTGGAGCA  TCGGCACTCG  TATGTTCGTC  GTAACGCTGT  CTGCGCGATT  480
481   TTCACTATTT  ATAAAAACTT  TGAATTCCTG  ATCCCAGACG  CACCGGAGCT  CGTCACAGAA  540
541   TACCTTGAAC  AGGAGCAAGA  TGCTTCGTGC  AAGCGTAACG  CTTTTATGAT  GCTCCTTCAC  600
601   GTAGATCAAG  CTCGTGCTCT  TGACTATTTA  TCGGGATGTA  TCGATCAAGT  CGGATCTTTT  660
661   GGAGATATAT  TGCAGCTCGT  TATTGTTGAA  CTCATTTATA  AGGTTTGCCA  CAATAATCCA  720
721   AACGAGGCTT  CCCGATTCAT  CAGATGTGTC  TACAATCTTC  TTCAGTCATC  ATCACCAGCC  780
781   GTTAGATACG  AAGCCGCCGG  CACCCTCGTC  ACCCTCTCCA  ACGTACCAGC  CGCCGTGAAG  840
841   GCCGCCGCCA  GTGCCTACAT  CGACCTGATA  GTCAAAGAGT  CGGATAACAA  TGTGAAGCTC  900
901   ATCGTTCTCG  ACCGGCTTGT  GGCTCTTCGC  GGCTCGTCGA  GCAACGAAAA  GATTCTCCAA  960
961   GGACTTGTCA  TGGATATTCT  TCGTGTGCTC  AGCTCGCCGG  GCCTAGAAGT  TCGCAAAAAA  1020
1021  ACGCTGAGCC  TGGCGTTGGA  TTTGGTTTCA  AGCCGAAATG  TCGAGGATAT  GGTGATGTTT  1080
1081  TTGAAGAAGG  AAATCAATAA  AACCGCCACC  GAATCCAACG  ATGAAAATGG  AAAATATCGG  1140
1141  CAGGAGCTTG  TCAAGACGCT  TCACGCGGCG  ACTATCAAGT  TTCCAGACGT  TGCTTCAACT  1200
1201  ATTGTTCCAG  TGCTCATGGA  GTTCCTATCA  GACACCAATG  AAAAAGCCTC  CTCATATGTG  1260
1261  CTCCAATTCG  TTCGTGAAGC  TGTTCATAAG  CTTCCTAACC  TGAAAAACGC  GATCCTTGGA  1320
1321  GCTCTCCGTG  AAGGTATTCC  GTTCATCCAA  TCGCCTACGA  TCTTCATGTC  AGCCCTCTGG  1380
1381  ATCCTTGCGA  CGTACTGTGA  AGCCGATGGA  GCTCTGGATG  TGCTCAAGCT  TGTTAAGAAC  1440
1441  TCTCTTGGAG  AGCTTCCACT  TGTGGATAGT  GAGCTCTCTG  GGCAGGAAGA  GCAAAAGCCG  1500
1501  GAGGAGCAGC  AGCCCGAGCA  GCAGCAGAAG  CAAAAACCGA  AAGTCACTGC  AGACGGAACG  1560
1561  TACGCCACTC  AGACGGCTCT  CTCGAGCACT  GTAACCACGT  CAAAAAAGAA  CGAGAAGCCG  1620
1621  CCACTCCGAC  GTTTCCTGCT  CGACGGCGAG  TTCTTCCTCG  GAGCATCGCT  AGCCACAGTG  1680
1681  CTCACGAAGC  TCGCCCAACA  ATTCACCGAG  CTCAACGGAG  CCGCGAGCGA  ACGTGCGAAT  1740
1741  CGATTCAGAG  CCGAGTGTAT  GCTTATCCTC  TCGTCGATTA  TTCATTTGGC  AAAGAGTGGG  1800
1801  CTGTGCATTG  TGCATCAACA  AGTCAACGAG  GATGATCTCG  ATCGAATGGG  AGCAACAATT  1860
1861  AAGATTTTGG  CTCAAGGGAT  TCCGGGGCTC  GACGAGCAGT  ACGGCGACGA  TTGTAAGAAG  1920
1921  AGTTTAGAGT  TGATGCTCGG  AGCCAAGTCG  ATTAGTCGGC  TTGATGTTAC  TACTGAGAAG  1980
1981  ATGGCTTCCA  CCACGGCTGC  TGGATATCGA  TCCAAAGATT  TTGTGGAAAT  TGATAAAACT  2040
2041  ATCAATTTTA  CGCAGCTCTC  TGCTCGGAGC  AACCAGCAAG  GCGAGAATTT  GTTCGACTTA  2100
2101  TCGCTCTCGC  AGGCTCTTGG  AACAGCTCCG  AAGGCTCAAA  AATTCGACTT  TTCGAGCTCA  2160
2161  AAACTGGGAA  AAGTGATTCA  ACTCGCCGGA  TTTTCGGATC  CAATCTACGC  TGAAGCCTAT  2220
2221  GTCAATGTGA  ATCAGTATGA  TATTGTGCTC  GACGTGCTCA  TTGTCAATCA  AACATCGGAT  2280
2281  ACACTTCAAA  ATGTTTCCCT  TGAGCTCGCC  ACTGTTGGAG  ACTTGAAGCT  TGTCGATAAG  2340
2341  CCGACACCGG  TTACACTTGC  TCCCAATGAT  TTTTCGAATA  TTAAAGCGAC  GGTGAAGGTT  2400
2401  GCGTCGACGG  AGAATGGTGT  GATCTTTTCA  ACGATTTCGT  ATGATGTGAC  AGGATCTACG  2460
2461  TCGGATCGGA  ATTGTGTCTA  TTTGCAGGAT  ATTAAGATTG  ATATTATGGA  TTACATAGTG  2520
2521  CCTGGCAACG  TGACAGACAC  AGAATTCCGT  ACAATGTGGA  GTGATTTCGA  ATGGGAGAAT  2580
2581  AAGGTGAACG  TGATGACGCC  GATTCGTGAT  CTACGGGATT  TCCTTAATCA  TTTGTCGACA  2640
2641  TCTACGAATA  TGAAGGTTTT  GACTGGAGAT  GCGGCGATTG  AAGGCGACTG  TGGATTCCTG  2700
2701  GCAGCCAATC  TATGTGCTCA  TTCGATTTTC  GGTGAAGATG  CTCTCGCGAA  CGTCTCTGTC  2760
2761  GAGAAGGCTC  TTCCGATGGA  TGACTCGTCG  CCGATCGTCG  GTCATATTCG  GATCCGTGCA  2820
2821  AAGAGCCAAG  GAATGTGCCT  GACACTGGGT  GATAAGCTGA  GCTCGGCAAT  GCGTTCACGA  2880
2881  CGTGATGGTC  AACCGATTGC  TGCTCCGTCG  GCTTGA  2916

▼ KEYWORD

ID
Family
Complete proteome
Cytoplasm
Cytoplasmic vesicle
ER-Golgi transport
Golgi apparatus
Membrane
Protein transport
Proteomics identification
Reference proteome
Transport

▼ GENE ONTOLOGY

ID
Classification
Description
Cellular Component
COPI vesicle coat
Cellular Component
Golgi membrane
Molecular Function
Structural molecule activity
Biological Process
Endoplasmic reticulum to Golgi vesicle-mediated transport
Biological Process
Intra-Golgi vesicle-mediated transport
Biological Process
Intracellular protein transport

▼ ORTHOLOGY

DrLLPS IDOrganismIdentityE-valueScore
LLPS-Bot-3719Bos taurus60.820.01128
LLPS-Caf-0457Canis familiaris60.710.01125
LLPS-Fec-1204Felis catus60.710.01127
LLPS-Urm-1075Ursus maritimus60.710.01125
LLPS-Mup-1185Mustela putorius furo60.710.01125
LLPS-Myl-0968Myotis lucifugus60.710.01125
LLPS-Sus-1571Sus scrofa60.710.01125
LLPS-Gaga-2161Gallus gallus60.650.01120
LLPS-Rhb-1181Rhinopithecus bieti60.550.01066
LLPS-Meg-1794Meleagris gallopavo60.540.01118
LLPS-Mod-1223Monodelphis domestica60.50.01120
LLPS-Loa-0928Loxodonta africana60.50.01122
LLPS-Ran-1991Rattus norvegicus60.50.01120
LLPS-Mea-1084Mesocricetus auratus60.50.01119
LLPS-Mum-3123Mus musculus60.50.01120
LLPS-Sah-2401Sarcophilus harrisii60.50.01120
LLPS-Aim-0390Ailuropoda melanoleuca60.460.01120
LLPS-Anc-0415Anolis carolinensis60.440.01117
LLPS-Cas-1835Carlito syrichta60.40.01119
LLPS-Otg-0153Otolemur garnettii60.40.01118
LLPS-Orc-3659Oryctolagus cuniculus60.40.01117
LLPS-Dio-1813Dipodomys ordii60.40.01118
LLPS-Caj-2193Callithrix jacchus60.40.01119
LLPS-Fud-2757Fukomys damarensis60.40.01116
LLPS-Ora-2089Ornithorhynchus anatinus60.40.01120
LLPS-Ict-2430Ictidomys tridecemlineatus60.360.01102
LLPS-Lac-3204Latimeria chalumnae60.330.01117
LLPS-Nol-3476Nomascus leucogenys60.290.01118
LLPS-Mam-0593Macaca mulatta60.290.01118
LLPS-Pat-2825Pan troglodytes60.290.01118
LLPS-Pap-1335Pan paniscus60.290.01118
LLPS-Hos-0878Homo sapiens60.290.01118
LLPS-Man-0081Macaca nemestrina60.290.01118
LLPS-Paa-1295Papio anubis60.290.01118
LLPS-Gog-2908Gorilla gorilla60.290.01120
LLPS-Chs-1088Chlorocebus sabaeus60.290.01118
LLPS-Maf-0769Macaca fascicularis60.290.01118
LLPS-Aon-1386Aotus nancymaae60.290.01118
LLPS-Cea-2771Cercocebus atys60.290.01118
LLPS-Tag-2074Taeniopygia guttata60.230.01117
LLPS-Fia-0098Ficedula albicollis60.230.01117
LLPS-Leo-0719Lepisosteus oculatus60.230.01118
LLPS-Poa-3158Pongo abelii60.190.01114
LLPS-Pes-1104Pelodiscus sinensis60.150.01110
LLPS-Anp-1857Anas platyrhynchos60.10.01110
LLPS-Cap-0222Cavia porcellus60.080.01105
LLPS-Xet-3513Xenopus tropicalis60.060.01110
LLPS-Orn-0687Oreochromis niloticus60.020.01113
LLPS-Tar-1398Takifugu rubripes59.980.01116
LLPS-Scm-1566Scophthalmus maximus59.920.01112
LLPS-Scf-1946Scleropages formosus59.920.01109
LLPS-Orl-0331Oryzias latipes59.870.01111
LLPS-Pof-1486Poecilia formosa59.810.01110
LLPS-Dar-3626Danio rerio59.810.01112
LLPS-Xim-2337Xiphophorus maculatus59.810.01111
LLPS-Ova-0366Ovis aries59.790.01099
LLPS-Ten-1413Tetraodon nigroviridis59.770.01110
LLPS-Icp-0536Ictalurus punctatus59.710.01113
LLPS-Tut-0032Tursiops truncatus59.670.01093
LLPS-Gaa-1396Gasterosteus aculeatus59.650.01100
LLPS-Mal-2957Mandrillus leucophaeus59.410.01085
LLPS-Cis-1132Ciona savignyi58.90.01057
LLPS-Eqc-0909Equus caballus58.890.01105
LLPS-Cii-1062Ciona intestinalis58.670.01060
LLPS-Asm-3294Astyanax mexicanus58.630.01079
LLPS-Drm-1511Drosophila melanogaster57.580.01060
LLPS-Put-0553Puccinia triticina51.717e-63 234
LLPS-Mel-0325Melampsora laricipopulina47.150.0 827
LLPS-Abg-1258Absidia glauca47.040.0 831
LLPS-Pug-1048Puccinia graminis46.990.0 825
LLPS-Usm-1210Ustilago maydis46.220.0 791
LLPS-Spr-0760Sporisorium reilianum45.930.0 789
LLPS-Miv-0088Microbotryum violaceum45.250.0 762
LLPS-Gag-1037Gaeumannomyces graminis45.250.0 791
LLPS-Cog-0339Colletotrichum gloeosporioides45.130.0 791
LLPS-Asn-0703Aspergillus nidulans45.110.0 800
LLPS-Coo-0688Colletotrichum orbiculare45.030.0 790
LLPS-Zyt-0063Zymoseptoria tritici44.960.0 798
LLPS-Cogr-1084Colletotrichum graminicola44.930.0 787
LLPS-Dos-0900Dothistroma septosporum44.590.0 797
LLPS-Ved-0427Verticillium dahliae44.570.0 786
LLPS-Map-0631Magnaporthe poae44.570.0 790
LLPS-Trr-0135Trichoderma reesei44.360.0 778
LLPS-Ast-0655Aspergillus terreus44.360.0 796
LLPS-Crn-0591Cryptococcus neoformans44.360.0 776
LLPS-Php-0965Physcomitrella patens44.310.0 755
LLPS-Nec-0099Neurospora crassa44.270.0 780
LLPS-Glm-0817Glycine max44.270.0 743
LLPS-Trv-0587Trichoderma virens44.260.0 780
LLPS-Mao-0580Magnaporthe oryzae44.260.0 783
LLPS-Asc-1293Aspergillus clavatus44.260.0 779
LLPS-Nef-1195Neosartorya fischeri44.160.0 801
LLPS-Aso-1288Aspergillus oryzae44.160.0 796
LLPS-Asfu-0364Aspergillus fumigatus44.050.0 798
LLPS-Asni-0411Aspergillus niger44.050.0 792
LLPS-Scs-0004Sclerotinia sclerotiorum44.010.0 806
LLPS-Amt-0271Amborella trichopoda43.990.0 742
LLPS-Fuo-1159Fusarium oxysporum43.850.0 773
LLPS-Fus-0827Fusarium solani43.850.0 768
LLPS-Fuv-0955Fusarium verticillioides43.850.0 773
LLPS-Cus-1529Cucumis sativus43.830.0 749
LLPS-Lem-1356Leptosphaeria maculans43.780.0 768
LLPS-Dac-0641Daucus carota43.770.0 726
LLPS-Beb-0236Beauveria bassiana43.740.0 778
LLPS-Tum-0194Tuber melanosporum43.730.0 791
LLPS-Sem-0922Selaginella moellendorffii43.710.0 728
LLPS-Blg-0221Blumeria graminis43.70.0 797
LLPS-Sot-1926Solanum tuberosum43.560.0 730
LLPS-Phv-0892Phaseolus vulgaris43.550.0 735
LLPS-Prp-0951Prunus persica43.540.0 726
LLPS-Sol-2470Solanum lycopersicum43.460.0 730
LLPS-Pytr-1037Pyrenophora triticirepentis43.390.0 764
LLPS-Pyt-0296Pyrenophora teres43.390.0 764
LLPS-Nia-0289Nicotiana attenuata43.370.0 724
LLPS-Hea-1605Helianthus annuus43.360.0 736
LLPS-Vir-1137Vigna radiata43.340.0 736
LLPS-Brr-2351Brassica rapa43.310.0 718
LLPS-Pot-2741Populus trichocarpa43.310.0 729
LLPS-Brn-0651Brassica napus43.310.0 718
LLPS-Bro-2577Brassica oleracea43.20.0 717
LLPS-Orbr-1266Oryza brachyantha43.180.0 685
LLPS-Viv-2307Vitis vinifera43.150.0 731
LLPS-Osl-0744Ostreococcus lucimarinus43.120.0 718
LLPS-Met-1340Medicago truncatula43.030.0 730
LLPS-Gor-0668Gossypium raimondii43.020.0 724
LLPS-Lep-1659Leersia perrieri42.970.0 682
LLPS-Via-2110Vigna angularis42.90.0 689
LLPS-Orp-1832Oryza punctata42.870.0 682
LLPS-Arl-0020Arabidopsis lyrata42.860.0 704
LLPS-Art-2215Arabidopsis thaliana42.780.0 709
LLPS-Org-0790Oryza glaberrima42.770.0 682
LLPS-Orm-0616Oryza meridionalis42.770.0 678
LLPS-Orgl-0817Oryza glumaepatula42.770.0 680
LLPS-Orni-0945Oryza nivara42.770.0 681
LLPS-Thc-0384Theobroma cacao42.740.0 724
LLPS-Orr-0058Oryza rufipogon42.670.0 679
LLPS-Ors-1802Oryza sativa42.670.0 679
LLPS-Orb-1358Oryza barthii42.670.0 678
LLPS-Ori-1192Oryza indica42.650.0 679
LLPS-Mae-1490Manihot esculenta42.640.0 725
LLPS-Asf-1398Aspergillus flavus42.610.0 753
LLPS-Chc-0026Chondrus crispus42.510.0 720
LLPS-Coc-1850Corchorus capsularis42.430.0 716
LLPS-Chr-1100Chlamydomonas reinhardtii42.310.0 694
LLPS-Tra-0872Triticum aestivum42.290.0 682
LLPS-Hov-1370Hordeum vulgare42.290.0 681
LLPS-Mua-2005Musa acuminata42.220.0 677
LLPS-Zem-2465Zea mays42.20.0 663
LLPS-Brd-0889Brachypodium distachyon42.160.0 676
LLPS-Sei-0585Setaria italica42.00.0 673
LLPS-Sob-1179Sorghum bicolor41.90.0 672
LLPS-Yal-1010Yarrowia lipolytica41.580.0 701
LLPS-Tru-1252Triticum urartu41.540.0 641
LLPS-Phn-0357Phaeosphaeria nodorum40.830.0 711
LLPS-Gas-1344Galdieria sulphuraria39.960.0 641
LLPS-Kop-1021Komagataella pastoris39.670.0 656
LLPS-Scc-0763Schizosaccharomyces cryophilus39.520.0 659
LLPS-Asg-1236Ashbya gossypii39.450.0 639
LLPS-Sac-0174Saccharomyces cerevisiae39.280.0 648
LLPS-Scp-0723Schizosaccharomyces pombe39.170.0 640
LLPS-Scj-0220Schizosaccharomyces japonicus38.760.0 614
LLPS-Cym-1103Cyanidioschyzon merolae34.083e-159 507