• Disorder▼
  • Domain▼
  • PTM▼
  • Variation▼
  • Mutation▼
  • Interaction▼
  • Disease▼
  • Drug▼
  • Physicochemical▼
  • Function▼
  • Proteomics▼
  • Structure▼
  • Localization▼
  • Expression▼
  • Element▼
  • Methylation▼

LLPS-Met-1149
25488966

Integrated Annotations

▼ OVERVIEW

Status: Unreviewed
Protein Name: Imidazole glycerol phosphate synthase hisHF
Gene Name: 25488966, MTR_3g052850, MtrunA17_Chr3g0099401
Ensembl Gene: MTR_3g052850
Ensembl Protein: KEH33850
Organism: Medicago truncatula
Taxa ID: 3880
LLPS Type: Client


▼ PROPERTY


——— Disorder propensity (calculated by IUPred2A)

▼ Classification

Condensates:
CondensateEvidenceOrthologs
NucleolusPredicted from orthologs(View)

▼ FUNCTION

IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The glutaminase domain produces the ammonia necessary for the cyclase domain to produce IGP and AICAR from PRFAR. The ammonia is channeled to the active site of the cyclase domain.

▼ CROSS REFERENCE

▼ SEQUENCE

Protein Sequence (FASTA)
1     MEAPPLTPSC  SPTSLLLRHK  NPLSFNTFPR  SRNVKTPTNF  SIRASSSTSN  DSVVTLLDYG  60
61    AGNVRSVRNA  IRFLGFEIKD  VQTPEDILNA  SRLVFPGVGA  FAPAMEVLSK  TGMGEALCSY  120
121   IEKDRPFLGI  CLGLQLLFES  SEENGPIKGL  GLIPGTVGRF  DSSNGFRVPH  IGWNALQITK  180
181   DSEILDDVGN  HHVYFVHSYR  AMPSDDNKDW  VSSTCDYGDK  FIASIRRGNV  HAVQFHPEKS  240
241   GDVGLSILRR  FLYPNSSVAK  KTGEGKASKL  AKRVIACLDV  RANDNGDLVV  TKGDQYDVRE  300
301   NTKENEVRNL  GKPVELAQQY  YKDGADEVSF  LNITGFRDFP  LGDLPMLQVL  RYTSENVFVP  360
361   LTVGGGIRDF  TDSKGRHYSS  LEVAAEYFRS  GADKISIGSD  AVYAAEEYLR  TGVKTGKTSL  420
421   EQISRVYGNQ  AVVVSIDPRR  VYINNPNDVQ  FQTIKVSSPG  PNGEEYAWYQ  CTVNGGREGR  480
481   PIGAYELAKA  VEELGAGEIL  LNCIDCDGQG  KGFDVGLIKL  ISDAVNIPVI  ASSGAGIPNH  540
541   FSDVFTKTNA  SAALAAGIFH  RKEVPIQSVK  EHLLNEGIEV  RI  582
Nucleotide CDS Sequence (FASTA)
1     ATGGAGGCGC  CGCCGTTAAC  ACCGTCATGC  TCTCCCACTT  CCCTCCTCCT  CCGTCACAAA  60
61    AACCCACTCT  CCTTCAACAC  ATTCCCACGC  TCTCGCAATG  TCAAAACCCC  AACAAATTTC  120
121   TCTATTCGTG  CTTCATCTTC  TACTTCTAAT  GATTCTGTTG  TGACTTTGCT  TGATTATGGT  180
181   GCTGGCAATG  TTCGGAGTGT  TAGGAATGCT  ATCAGATTCC  TTGGATTTGA  AATCAAAGAT  240
241   GTTCAAACCC  CAGAAGACAT  TTTGAATGCA  AGCCGTTTAG  TCTTTCCGGG  TGTTGGAGCA  300
301   TTTGCACCTG  CTATGGAGGT  GTTAAGTAAA  ACTGGGATGG  GTGAAGCACT  TTGTTCATAT  360
361   ATTGAAAAGG  ATCGCCCATT  TTTAGGAATT  TGTCTTGGAC  TTCAATTGCT  TTTTGAATCT  420
421   AGTGAAGAGA  ATGGGCCAAT  AAAAGGTCTT  GGCTTAATAC  CTGGAACCGT  TGGGCGATTT  480
481   GATTCATCAA  ATGGTTTTAG  AGTACCGCAT  ATTGGATGGA  ATGCTTTACA  AATCACAAAG  540
541   GACTCAGAAA  TTTTGGATGA  TGTTGGAAAC  CACCATGTCT  ATTTTGTGCA  CTCTTACCGT  600
601   GCCATGCCTT  CAGATGATAA  CAAAGATTGG  GTATCCTCCA  CCTGTGACTA  TGGTGATAAA  660
661   TTTATAGCAT  CTATTAGAAG  AGGAAATGTG  CATGCAGTTC  AGTTCCATCC  AGAGAAGAGT  720
721   GGAGATGTTG  GTCTCTCTAT  TTTGAGAAGA  TTCTTGTATC  CAAATTCAAG  CGTGGCAAAG  780
781   AAGACTGGTG  AGGGCAAAGC  TTCAAAACTC  GCAAAAAGGG  TGATTGCTTG  TCTCGATGTG  840
841   AGAGCAAATG  ATAACGGGGA  CCTTGTTGTA  ACCAAAGGAG  ACCAGTATGA  TGTAAGAGAA  900
901   AATACAAAAG  AGAACGAGGT  TAGGAATCTT  GGCAAGCCAG  TTGAGCTTGC  TCAACAGTAC  960
961   TATAAAGATG  GAGCTGATGA  GGTCAGCTTT  CTAAACATTA  CTGGATTTCG  CGACTTCCCT  1020
1021  CTTGGTGATC  TACCAATGTT  GCAGGTATTG  CGATACACAT  CAGAAAATGT  TTTTGTGCCC  1080
1081  TTAACAGTTG  GTGGTGGAAT  TCGAGATTTT  ACAGATTCTA  AGGGAAGGCA  CTATTCTAGT  1140
1141  TTGGAAGTAG  CCGCAGAATA  TTTTAGGTCT  GGGGCTGACA  AGATATCCAT  TGGAAGTGAT  1200
1201  GCAGTTTATG  CTGCCGAAGA  ATATTTAAGA  ACTGGAGTAA  AAACAGGGAA  GACCAGCTTA  1260
1261  GAGCAGATAT  CAAGAGTTTA  TGGGAATCAG  GCAGTGGTTG  TTAGTATTGA  TCCCCGTAGG  1320
1321  GTTTACATAA  ACAATCCAAA  TGATGTGCAA  TTCCAGACCA  TAAAGGTTTC  AAGTCCAGGT  1380
1381  CCAAATGGAG  AAGAATATGC  CTGGTATCAG  TGTACAGTTA  ATGGGGGGCG  AGAAGGTCGG  1440
1441  CCAATTGGTG  CTTATGAACT  GGCGAAAGCT  GTTGAAGAAC  TTGGTGCTGG  TGAAATACTA  1500
1501  TTAAATTGCA  TTGATTGTGA  TGGTCAAGGA  AAAGGATTCG  ATGTAGGTTT  AATTAAGTTG  1560
1561  ATCTCAGATG  CCGTCAATAT  CCCTGTGATT  GCAAGTAGTG  GTGCTGGCAT  TCCTAATCAC  1620
1621  TTTTCCGATG  TGTTCACTAA  AACCAATGCA  TCCGCTGCAC  TTGCTGCTGG  CATTTTTCAT  1680
1681  AGGAAGGAGG  TACCTATTCA  GTCAGTGAAA  GAACATTTGT  TGAATGAAGG  CATAGAAGTC  1740
1741  CGAATCTGA  1749

▼ KEYWORD

ID
Family
Amino-acid biosynthesis
Chloroplast
Complete proteome
Glutamine amidotransferase
Histidine biosynthesis
Hydrolase
Lyase
Multifunctional enzyme
Plastid
Reference proteome

▼ GENE ONTOLOGY

ID
Classification
Description
Cellular Component
Chloroplast stroma
Molecular Function
Glutaminase activity
Molecular Function
Imidazoleglycerol-phosphate synthase activity
Molecular Function
Oxo-acid-lyase activity
Biological Process
Glutamine metabolic process
Biological Process
Histidine biosynthetic process

▼ KEGG


▼ ORTHOLOGY

DrLLPS IDOrganismIdentityE-valueScore
LLPS-Phv-2458Phaseolus vulgaris90.410.01031
LLPS-Glm-2750Glycine max90.20.01031
LLPS-Via-1859Vigna angularis89.291e-20 100
LLPS-Dac-1699Daucus carota88.420.0 572
LLPS-Viv-0271Vitis vinifera87.50.0 926
LLPS-Cus-1527Cucumis sativus87.040.0 655
LLPS-Prp-2454Prunus persica86.550.0 982
LLPS-Coc-2160Corchorus capsularis85.970.0 981
LLPS-Mae-2464Manihot esculenta85.580.0 958
LLPS-Gor-2772Gossypium raimondii85.40.0 968
LLPS-Arl-2967Arabidopsis lyrata84.690.0 947
LLPS-Mua-2331Musa acuminata84.20.0 959
LLPS-Nia-2637Nicotiana attenuata84.020.0 897
LLPS-Amt-1100Amborella trichopoda83.830.0 935
LLPS-Bro-0604Brassica oleracea83.210.0 957
LLPS-Brn-0918Brassica napus83.210.0 957
LLPS-Thc-0671Theobroma cacao82.510.0 951
LLPS-Art-0543Arabidopsis thaliana82.430.0 959
LLPS-Pot-1333Populus trichocarpa82.30.0 971
LLPS-Sot-2152Solanum tuberosum81.960.0 966
LLPS-Sol-2278Solanum lycopersicum81.790.0 951
LLPS-Hea-2560Helianthus annuus81.560.0 961
LLPS-Brr-2114Brassica rapa80.50.0 910
LLPS-Sob-1400Sorghum bicolor77.820.0 871
LLPS-Sei-1292Setaria italica77.390.0 874
LLPS-Vir-1449Vigna radiata76.720.0 785
LLPS-Tra-2508Triticum aestivum75.350.0 882
LLPS-Brd-2306Brachypodium distachyon75.00.0 881
LLPS-Ori-2279Oryza indica74.870.0 871
LLPS-Ors-0787Oryza sativa74.510.0 869
LLPS-Orbr-2038Oryza brachyantha74.470.0 867
LLPS-Lep-1040Leersia perrieri74.290.0 870
LLPS-Org-1669Oryza glaberrima74.030.0 869
LLPS-Orni-1951Oryza nivara73.260.0 836
LLPS-Orr-1545Oryza rufipogon73.080.0 835
LLPS-Orb-1635Oryza barthii73.080.0 835
LLPS-Hov-0245Hordeum vulgare72.230.0 862
LLPS-Sem-0029Selaginella moellendorffii71.750.0 788
LLPS-Php-2150Physcomitrella patens71.690.0 804
LLPS-Orm-2004Oryza meridionalis71.630.0 823
LLPS-Orgl-0209Oryza glumaepatula70.240.0 810
LLPS-Tru-0290Triticum urartu70.190.0 800
LLPS-Zem-0460Zea mays70.056e-90 285
LLPS-Orp-1760Oryza punctata67.740.0 759
LLPS-Chr-1493Chlamydomonas reinhardtii63.712e-148 444
LLPS-Osl-0229Ostreococcus lucimarinus63.670.0 693
LLPS-Asf-0804Aspergillus flavus57.381e-90 286
LLPS-Cog-1354Colletotrichum gloeosporioides56.884e-58 198
LLPS-Pytr-1464Pyrenophora triticirepentis56.314e-150 446
LLPS-Abg-1662Absidia glauca56.250.0 605
LLPS-Nef-1148Neosartorya fischeri55.060.0 573
LLPS-Asfu-0820Aspergillus fumigatus54.880.0 568
LLPS-Mao-0891Magnaporthe oryzae54.840.0 574
LLPS-Chc-0166Chondrus crispus54.630.0 571
LLPS-Dos-1096Dothistroma septosporum54.622e-161 476
LLPS-Asc-0554Aspergillus clavatus54.50.0 569
LLPS-Blg-1415Blumeria graminis54.390.0 569
LLPS-Scs-0012Sclerotinia sclerotiorum54.10.0 574
LLPS-Zyt-1427Zymoseptoria tritici54.070.0 551
LLPS-Tum-1225Tuber melanosporum53.960.0 560
LLPS-Map-1305Magnaporthe poae53.940.0 563
LLPS-Fus-1324Fusarium solani53.590.0 563
LLPS-Nec-1448Neurospora crassa53.560.0 570
LLPS-Trr-0759Trichoderma reesei53.490.0 558
LLPS-Scp-1404Schizosaccharomyces pombe53.420.0 565
LLPS-Scc-0936Schizosaccharomyces cryophilus53.220.0 549
LLPS-Ast-1229Aspergillus terreus53.140.0 559
LLPS-Phn-1034Phaeosphaeria nodorum52.920.0 563
LLPS-Cogr-1395Colletotrichum graminicola52.820.0 565
LLPS-Trv-0524Trichoderma virens52.770.0 555
LLPS-Fuv-0572Fusarium verticillioides52.630.0 559
LLPS-Asni-0478Aspergillus niger52.550.0 550
LLPS-Mel-0863Melampsora laricipopulina52.410.0 559
LLPS-Aso-1006Aspergillus oryzae52.360.0 555
LLPS-Ved-0514Verticillium dahliae52.290.0 554
LLPS-Asn-0336Aspergillus nidulans52.280.0 551
LLPS-Fuo-0769Fusarium oxysporum52.270.0 558
LLPS-Pug-1134Puccinia graminis52.210.0 544
LLPS-Lem-0960Leptosphaeria maculans52.210.0 561
LLPS-Yal-1478Yarrowia lipolytica52.20.0 543
LLPS-Gag-0150Gaeumannomyces graminis52.030.0 537
LLPS-Pyt-1389Pyrenophora teres51.930.0 558
LLPS-Scj-1159Schizosaccharomyces japonicus51.850.0 551
LLPS-Beb-1435Beauveria bassiana51.760.0 556
LLPS-Coo-0947Colletotrichum orbiculare51.650.0 542
LLPS-Put-1099Puccinia triticina50.951e-169 503
LLPS-Asg-0523Ashbya gossypii50.640.0 534
LLPS-Sac-1345Saccharomyces cerevisiae50.270.0 531
LLPS-Miv-0582Microbotryum violaceum49.240.0 541
LLPS-Kop-1287Komagataella pastoris49.12e-175 516
LLPS-Usm-0393Ustilago maydis47.681e-171 508
LLPS-Crn-0514Cryptococcus neoformans47.623e-166 494
LLPS-Spr-0676Sporisorium reilianum47.523e-170 504
LLPS-Cym-1059Cyanidioschyzon merolae37.183e-40 154
LLPS-Gas-0452Galdieria sulphuraria36.162e-43 163