• Disorder▼
  • Domain▼
  • PTM▼
  • Variation▼
  • Mutation▼
  • Interaction▼
  • Disease▼
  • Drug▼
  • Physicochemical▼
  • Function▼
  • Proteomics▼
  • Structure▼
  • Localization▼
  • Expression▼
  • Element▼
  • Methylation▼

LLPS-Mea-2382
Tarbp2

Integrated Annotations

▼ OVERVIEW

Status: Unreviewed
Protein Name: RISC-loading complex subunit TARBP2
Gene Name: Tarbp2, TARBP2
Ensembl Gene: ENSMAUG00000019805.1
Ensembl Protein: ENSMAUP00000022342.1
Organism: Mesocricetus auratus
Taxa ID: 10036
LLPS Type: Others


▼ PROPERTY


——— Disorder propensity (calculated by IUPred2A)

▼ Classification

Condensates:
CondensateEvidenceOrthologs
Stress granulePredicted from orthologs(View)

▼ FUNCTION

Required for formation of the RNA induced silencing complex (RISC). Component of the RISC loading complex (RLC), also known as the micro-RNA (miRNA) loading complex (miRLC), which is composed of DICER1, AGO2 and TARBP2. Within the RLC/miRLC, DICER1 and TARBP2 are required to process precursor miRNAs (pre-miRNAs) to mature miRNAs and then load them onto AGO2. AGO2 bound to the mature miRNA constitutes the minimal RISC and may subsequently dissociate from DICER1 and TARBP2. May also play a role in the production of short interfering RNAs (siRNAs) from double-stranded RNA (dsRNA) by DICER1.

▼ CROSS REFERENCE

▼ SEQUENCE

Protein Sequence (FASTA)
1     MSEEEQGSGT  TTGCGLPSIE  QMLAANPGKT  PISLLQEYGT  RIGKTPVYDL  LKAEGQAHQP  60
61    NFTFRVTVGD  TSCTGQGPSK  KAAKHKAAEV  ALKHLKGGSM  LEPALEDSSS  FSLLDSSLPE  120
121   DTPVIAAEVA  VPVPSAILTR  SPPMEMQPPV  SPQQSECNPV  GALQELVVQK  GWRLPEYMVT  180
181   QESGPAHRKE  FTMTCRVERF  IEIGSGTSKK  LAKRNAAAKM  LLRVHTVPLD  ARDGNEAEPD  240
241   DDHFSIGVSS  RLDGLRNRGP  GCTWDSLRNS  VGEKILSLRS  CSVGSLGTLG  SACCNVLSEL  300
301   SEEQAFHVSY  LDIEELSLSG  LCQCLVELST  QPATVCHGSA  TTREAARGEA  ARRALQYLRI  360
361   MAGSK  365
Nucleotide CDS Sequence (FASTA)
1     ATGAGTGAAG  AGGAGCAGGG  CTCCGGCACT  ACCACAGGCT  GCGGGCTGCC  CAGCATAGAG  60
61    CAAATGCTGG  CCGCCAACCC  GGGCAAGACC  CCGATCAGCC  TTCTTCAGGA  GTATGGGACC  120
121   AGAATAGGAA  AGACGCCCGT  GTACGACCTT  CTCAAAGCCG  AGGGCCAAGC  CCATCAGCCT  180
181   AATTTCACCT  TCCGGGTCAC  CGTTGGCGAC  ACCAGCTGCA  CTGGTCAGGG  CCCCAGCAAG  240
241   AAGGCAGCCA  AGCACAAGGC  AGCTGAGGTG  GCCCTCAAAC  ACCTCAAAGG  GGGGAGCATG  300
301   CTGGAACCAG  CCCTGGAGGA  CAGCAGTTCT  TTTTCTCTCC  TAGACTCTTC  ACTGCCTGAG  360
361   GATACTCCTG  TCATTGCTGC  AGAAGTTGCT  GTCCCTGTTC  CATCTGCTAT  ACTAACCAGG  420
421   AGCCCTCCCA  TGGAGATGCA  GCCCCCTGTC  TCCCCTCAGC  AGTCTGAGTG  CAACCCTGTT  480
481   GGTGCTCTGC  AGGAACTTGT  GGTGCAAAAG  GGCTGGCGTT  TGCCAGAGTA  CATGGTGACC  540
541   CAGGAGTCTG  GACCTGCTCA  CCGCAAAGAG  TTCACCATGA  CCTGCCGAGT  GGAGCGCTTC  600
601   ATTGAGATTG  GCAGTGGCAC  TTCCAAAAAG  CTGGCAAAGC  GTAATGCAGC  AGCTAAAATG  660
661   CTGCTTCGAG  TGCACACAGT  ACCCCTGGAC  GCCAGGGATG  GCAACGAGGC  GGAACCTGAT  720
721   GACGATCATT  TTTCCATTGG  TGTGAGCTCC  CGCCTGGATG  GACTTCGGAA  CCGGGGGCCA  780
781   GGCTGCACCT  GGGATTCCCT  GCGCAATTCT  GTGGGAGAAA  AGATCCTGTC  CCTTCGGAGT  840
841   TGCTCTGTGG  GCTCTCTAGG  GACTCTGGGC  TCTGCCTGCT  GCAATGTCCT  TAGTGAACTC  900
901   TCTGAGGAGC  AGGCTTTCCA  TGTCAGCTAC  CTGGACATTG  AAGAATTGAG  CTTGAGTGGG  960
961   CTCTGCCAGT  GCCTAGTGGA  ACTGTCCACC  CAGCCAGCCA  CTGTGTGCCA  TGGTTCTGCA  1020
1021  ACTACCAGGG  AGGCAGCCCG  AGGTGAGGCT  GCTCGCCGCG  CCCTCCAGTA  CCTCAGGATC  1080
1081  ATGGCCGGTA  GCAAGTAA  1098

▼ KEYWORD

ID
Family
Complete proteome
Cytoplasm
Nucleus
Reference proteome
RNA-binding
RNA-mediated gene silencing
Translation regulation

▼ GENE ONTOLOGY

ID
Classification
Description
Cellular Component
Micro-ribonucleoprotein complex
Cellular Component
Nuclear body
Cellular Component
Perinuclear region of cytoplasm
Cellular Component
RISC complex
Cellular Component
RISC-loading complex
Molecular Function
Double-stranded RNA binding
Molecular Function
Enzyme binding
Molecular Function
MiRNA binding
Molecular Function
Pre-miRNA binding
Molecular Function
Protein homodimerization activity
Molecular Function
Protein N-terminus binding
Molecular Function
SiRNA binding
Biological Process
MiRNA loading onto RISC involved in gene silencing by miRNA
Biological Process
Multicellular organism growth
Biological Process
Negative regulation of defense response to virus by host
Biological Process
Neural precursor cell proliferation
Biological Process
Positive regulation of muscle cell differentiation
Biological Process
Positive regulation of translation
Biological Process
Positive regulation of viral genome replication
Biological Process
Pre-miRNA processing
Biological Process
Production of siRNA involved in RNA interference
Biological Process
Regulation of production of miRNAs involved in gene silencing by miRNA
Biological Process
Regulation of production of siRNA involved in RNA interference
Biological Process
Regulation of viral transcription
Biological Process
Single fertilization
Biological Process
SiRNA loading onto RISC involved in RNA interference
Biological Process
Skeletal muscle tissue regeneration
Biological Process
Spermatid development
Biological Process
Targeting of mRNA for destruction involved in RNA interference

▼ ORTHOLOGY

DrLLPS IDOrganismIdentityE-valueScore
LLPS-Mum-3724Mus musculus96.990.0 598
LLPS-Ran-1821Rattus norvegicus96.160.0 592
LLPS-Dio-1827Dipodomys ordii95.582e-143 416
LLPS-Eqc-0167Equus caballus94.810.0 580
LLPS-Mup-1932Mustela putorius furo94.790.0 585
LLPS-Nol-3193Nomascus leucogenys93.990.0 580
LLPS-Pat-1658Pan troglodytes93.990.0 580
LLPS-Pap-0957Pan paniscus93.990.0 580
LLPS-Hos-1273Homo sapiens93.990.0 580
LLPS-Rhb-3921Rhinopithecus bieti93.990.0 576
LLPS-Aon-0501Aotus nancymaae93.990.0 581
LLPS-Caj-3374Callithrix jacchus93.990.0 582
LLPS-Ict-3488Ictidomys tridecemlineatus93.720.0 580
LLPS-Sus-2264Sus scrofa93.720.0 582
LLPS-Gog-4718Gorilla gorilla93.720.0 577
LLPS-Mam-2406Macaca mulatta93.440.0 578
LLPS-Fec-4223Felis catus93.440.0 581
LLPS-Man-3351Macaca nemestrina93.440.0 578
LLPS-Mal-3928Mandrillus leucophaeus93.440.0 578
LLPS-Paa-3649Papio anubis93.440.0 578
LLPS-Maf-4824Macaca fascicularis93.440.0 578
LLPS-Cea-4837Cercocebus atys93.440.0 578
LLPS-Cas-3911Carlito syrichta93.170.0 577
LLPS-Myl-1361Myotis lucifugus93.170.0 577
LLPS-Chs-4677Chlorocebus sabaeus93.170.0 580
LLPS-Fia-1158Ficedula albicollis93.021e-2088.6
LLPS-Otg-2227Otolemur garnettii92.90.0 581
LLPS-Bot-4395Bos taurus92.90.0 574
LLPS-Caf-4155Canis familiaris92.620.0 565
LLPS-Aim-3614Ailuropoda melanoleuca92.620.0 575
LLPS-Urm-1079Ursus maritimus92.350.0 569
LLPS-Ova-3172Ovis aries92.350.0 571
LLPS-Orn-2174Oreochromis niloticus92.192e-31 126
LLPS-Fud-2984Fukomys damarensis91.260.0 566
LLPS-Cap-2061Cavia porcellus90.980.0 566
LLPS-Orc-1938Oryctolagus cuniculus90.980.0 570
LLPS-Anp-1356Anas platyrhynchos89.133e-2088.2
LLPS-Lac-3769Latimeria chalumnae88.891e-29 121
LLPS-Poa-4380Pongo abelii86.10.0 516
LLPS-Tag-0991Taeniopygia guttata83.612e-26 110
LLPS-Sah-0049Sarcophilus harrisii82.641e-180 513
LLPS-Loa-2678Loxodonta africana81.341e-138 403
LLPS-Asm-2550Astyanax mexicanus80.262e-32 129
LLPS-Dar-0133Danio rerio77.222e-32 129
LLPS-Gaa-3305Gasterosteus aculeatus77.223e-32 129
LLPS-Gaga-3018Gallus gallus72.652e-103 313
LLPS-Anc-3420Anolis carolinensis71.826e-157 452
LLPS-Scm-3089Scophthalmus maximus69.815e-1784.7
LLPS-Xet-3813Xenopus tropicalis68.162e-144 421
LLPS-Leo-0333Lepisosteus oculatus67.121e-142 416
LLPS-Scf-2591Scleropages formosus66.036e-135 396
LLPS-Xim-3538Xiphophorus maculatus65.213e-135 397
LLPS-Pof-3389Poecilia formosa64.936e-135 396
LLPS-Icp-1975Ictalurus punctatus64.531e-130 386
LLPS-Tar-1288Takifugu rubripes64.386e-133 391
LLPS-Ten-3237Tetraodon nigroviridis64.113e-133 392
LLPS-Meg-1772Meleagris gallopavo43.751e-0654.7
LLPS-Mod-1406Monodelphis domestica43.752e-0653.5
LLPS-Pes-1034Pelodiscus sinensis43.757e-0755.1
LLPS-Ora-0903Ornithorhynchus anatinus40.542e-0757.0
LLPS-Orl-2182Oryzias latipes40.33e-0756.2