• Disorder▼
  • Domain▼
  • PTM▼
  • Variation▼
  • Mutation▼
  • Interaction▼
  • Disease▼
  • Drug▼
  • Physicochemical▼
  • Function▼
  • Proteomics▼
  • Structure▼
  • Localization▼
  • Expression▼
  • Element▼
  • Methylation▼

LLPS-Aim-3614
TARBP2

Integrated Annotations

▼ OVERVIEW

Status: Unreviewed
Protein Name: RISC-loading complex subunit TARBP2
Gene Name: TARBP2
Ensembl Gene: ENSAMEG00000012601.1
Ensembl Protein: ENSAMEP00000013275.1
Organism: Ailuropoda melanoleuca
Taxa ID: 9646
LLPS Type: Client


▼ PROPERTY


——— Disorder propensity (calculated by IUPred2A)

▼ Classification

Condensates:
CondensateEvidenceOrthologs
Stress granulePredicted from orthologs(View)

▼ FUNCTION

Required for formation of the RNA induced silencing complex (RISC). Component of the RISC loading complex (RLC), also known as the micro-RNA (miRNA) loading complex (miRLC), which is composed of DICER1, AGO2 and TARBP2. Within the RLC/miRLC, DICER1 and TARBP2 are required to process precursor miRNAs (pre-miRNAs) to mature miRNAs and then load them onto AGO2. AGO2 bound to the mature miRNA constitutes the minimal RISC and may subsequently dissociate from DICER1 and TARBP2. May also play a role in the production of short interfering RNAs (siRNAs) from double-stranded RNA (dsRNA) by DICER1.

▼ CROSS REFERENCE

▼ SEQUENCE

Protein Sequence (FASTA)
1     MSEEEQGSGT  TTGCGLPSIE  QMLAANPGKT  PISLLQEYGT  RIGKTPVYDL  LKAEGQAHQP  60
61    NFTFRVTVGD  TSCTGQGPSK  KAAKHKAAEV  ALKHLKGGSM  LEPALEDSSS  FSPLDSSLPE  120
121   DIPVFTAAAA  ASPVPSALPT  RSPPMEVQPP  VSPQQSECNP  VGALQELVVQ  KGWRLPEYTV  180
181   TQESGPAHRK  EFTMTCRVER  FVEIGSGTSK  KLAKRNAAAK  MLLRVHTVPL  DARDGNEAEP  240
241   DDDHFSIGVG  SRLDGLRNRG  PGCTWDSLRN  SAGEKILSLR  SCSSGTLGAL  GPACCSVLSE  300
301   LSEEQAFHVS  YLDIEELSLS  GLCQCLVELS  TQPATVCHGS  AATREAARGE  AARRALQYLK  360
361   IMAGSR  366
Nucleotide CDS Sequence (FASTA)
1     ATGAGTGAAG  AGGAGCAGGG  CTCCGGCACT  ACCACGGGCT  GCGGGCTGCC  CAGTATAGAG  60
61    CAAATGCTGG  CAGCCAACCC  GGGCAAGACC  CCGATCAGCC  TTCTGCAGGA  GTATGGGACC  120
121   AGAATAGGGA  AGACGCCTGT  GTACGACCTT  CTCAAAGCCG  AGGGCCAAGC  CCACCAGCCT  180
181   AATTTCACCT  TCCGGGTCAC  CGTTGGCGAC  ACCAGCTGCA  CTGGTCAGGG  CCCCAGCAAG  240
241   AAGGCAGCCA  AGCACAAGGC  AGCTGAGGTG  GCCCTCAAAC  ACCTCAAAGG  GGGGAGCATG  300
301   CTGGAGCCGG  CCCTGGAGGA  CAGCAGTTCT  TTTTCTCCCC  TAGACTCGTC  ACTGCCTGAG  360
361   GACATTCCAG  TTTTTACTGC  TGCAGCGGCC  GCTAGTCCTG  TTCCATCTGC  TCTTCCAACC  420
421   AGGAGCCCCC  CCATGGAGGT  GCAGCCCCCT  GTCTCCCCTC  AGCAGTCTGA  GTGCAATCCT  480
481   GTTGGTGCTC  TGCAGGAGCT  GGTGGTGCAG  AAAGGCTGGC  GGTTACCTGA  GTACACAGTG  540
541   ACCCAAGAGT  CTGGGCCAGC  CCACCGCAAA  GAGTTTACCA  TGACCTGCCG  AGTGGAGCGT  600
601   TTCGTTGAGA  TTGGCAGTGG  CACTTCCAAA  AAGCTGGCAA  AGCGTAATGC  GGCGGCCAAA  660
661   ATGCTGCTTC  GAGTGCACAC  GGTGCCTCTG  GATGCCCGGG  ATGGGAATGA  GGCAGAGCCC  720
721   GATGATGATC  ACTTCTCCAT  TGGGGTGGGC  TCCCGCCTGG  ATGGACTTCG  GAACCGGGGC  780
781   CCGGGCTGCA  CCTGGGATTC  TCTGCGAAAT  TCAGCAGGAG  AGAAGATCCT  GTCTCTCCGC  840
841   AGCTGCTCTT  CGGGCACCTT  GGGTGCTCTG  GGCCCTGCCT  GCTGCAGTGT  CCTTAGTGAG  900
901   CTCTCGGAGG  AACAGGCCTT  CCATGTCAGC  TACCTGGATA  TTGAGGAACT  GAGCCTGAGT  960
961   GGGCTCTGCC  AGTGCCTGGT  GGAGCTGTCC  ACACAGCCAG  CTACCGTGTG  TCACGGCTCT  1020
1021  GCAGCGACCC  GAGAGGCGGC  CCGCGGGGAG  GCTGCTCGCC  GCGCCCTGCA  GTACCTCAAA  1080
1081  ATCATGGCGG  GCAGCAGGTG  A  1101

▼ KEYWORD

ID
Family
Complete proteome
Cytoplasm
Nucleus
Reference proteome
RNA-binding
RNA-mediated gene silencing
Translation regulation

▼ GENE ONTOLOGY

ID
Classification
Description
Cellular Component
Micro-ribonucleoprotein complex
Cellular Component
Nuclear body
Cellular Component
Perinuclear region of cytoplasm
Cellular Component
RISC complex
Cellular Component
RISC-loading complex
Molecular Function
Double-stranded RNA binding
Molecular Function
Enzyme binding
Molecular Function
MiRNA binding
Molecular Function
Pre-miRNA binding
Molecular Function
Protein homodimerization activity
Molecular Function
Protein N-terminus binding
Molecular Function
SiRNA binding
Biological Process
MiRNA loading onto RISC involved in gene silencing by miRNA
Biological Process
Multicellular organism growth
Biological Process
Negative regulation of defense response to virus by host
Biological Process
Neural precursor cell proliferation
Biological Process
Positive regulation of muscle cell differentiation
Biological Process
Positive regulation of translation
Biological Process
Positive regulation of viral genome replication
Biological Process
Pre-miRNA processing
Biological Process
Production of siRNA involved in RNA interference
Biological Process
Regulation of production of miRNAs involved in gene silencing by miRNA
Biological Process
Regulation of production of siRNA involved in RNA interference
Biological Process
Regulation of viral transcription
Biological Process
Single fertilization
Biological Process
SiRNA loading onto RISC involved in RNA interference
Biological Process
Skeletal muscle tissue regeneration
Biological Process
Spermatid development
Biological Process
Targeting of mRNA for destruction involved in RNA interference

▼ KEGG


▼ ORTHOLOGY

DrLLPS IDOrganismIdentityE-valueScore
LLPS-Urm-1079Ursus maritimus98.630.0 594
LLPS-Myl-1361Myotis lucifugus98.090.0 590
LLPS-Fec-4223Felis catus97.810.0 600
LLPS-Fia-1158Ficedula albicollis97.672e-2190.9
LLPS-Bot-4395Bos taurus97.270.0 580
LLPS-Eqc-0167Equus caballus96.990.0 583
LLPS-Caf-4155Canis familiaris96.450.0 580
LLPS-Nol-3193Nomascus leucogenys96.450.0 585
LLPS-Hos-1273Homo sapiens96.450.0 585
LLPS-Pap-0957Pan paniscus96.450.0 585
LLPS-Pat-1658Pan troglodytes96.450.0 585
LLPS-Ova-3172Ovis aries96.450.0 575
LLPS-Mup-1932Mustela putorius furo96.450.0 589
LLPS-Mam-2406Macaca mulatta96.170.0 585
LLPS-Sus-2264Sus scrofa96.170.0 594
LLPS-Gog-4718Gorilla gorilla96.170.0 582
LLPS-Cas-3911Carlito syrichta95.90.0 579
LLPS-Man-3351Macaca nemestrina95.90.0 583
LLPS-Rhb-3921Rhinopithecus bieti95.90.0 583
LLPS-Paa-3649Papio anubis95.90.0 583
LLPS-Mal-3928Mandrillus leucophaeus95.90.0 583
LLPS-Maf-4824Macaca fascicularis95.90.0 583
LLPS-Cea-4837Cercocebus atys95.90.0 583
LLPS-Aon-0501Aotus nancymaae95.90.0 575
LLPS-Caj-3374Callithrix jacchus95.90.0 576
LLPS-Otg-2227Otolemur garnettii95.630.0 576
LLPS-Chs-4677Chlorocebus sabaeus95.630.0 588
LLPS-Ict-3488Ictidomys tridecemlineatus94.540.0 572
LLPS-Dio-1827Dipodomys ordii92.921e-139 406
LLPS-Fud-2984Fukomys damarensis92.90.0 573
LLPS-Cap-2061Cavia porcellus92.620.0 570
LLPS-Orc-1938Oryctolagus cuniculus92.620.0 572
LLPS-Mea-2382Mesocricetus auratus92.620.0 574
LLPS-Mum-3724Mus musculus92.350.0 568
LLPS-Orn-2174Oreochromis niloticus92.193e-31 126
LLPS-Ran-1821Rattus norvegicus90.980.0 560
LLPS-Anp-1356Anas platyrhynchos89.133e-2087.8
LLPS-Lac-3769Latimeria chalumnae88.892e-29 120
LLPS-Poa-4380Pongo abelii87.980.0 520
LLPS-Sah-0049Sarcophilus harrisii84.620.0 521
LLPS-Loa-2678Loxodonta africana84.519e-144 416
LLPS-Tag-0991Taeniopygia guttata83.612e-26 110
LLPS-Asm-2550Astyanax mexicanus80.263e-32 129
LLPS-Scm-0327Scophthalmus maximus78.482e-31 126
LLPS-Gaa-3305Gasterosteus aculeatus77.223e-32 129
LLPS-Gaga-3018Gallus gallus74.441e-105 318
LLPS-Anc-3420Anolis carolinensis71.775e-159 458
LLPS-Xet-3813Xenopus tropicalis68.994e-144 420
LLPS-Leo-0333Lepisosteus oculatus68.311e-146 426
LLPS-Scf-2591Scleropages formosus66.392e-135 397
LLPS-Xim-3538Xiphophorus maculatus66.125e-137 401
LLPS-Pof-3389Poecilia formosa65.857e-137 401
LLPS-Tar-1288Takifugu rubripes65.31e-133 393
LLPS-Icp-1975Ictalurus punctatus64.814e-133 392
LLPS-Dar-0133Danio rerio64.751e-139 408
LLPS-Ten-3237Tetraodon nigroviridis64.481e-133 393
LLPS-Pes-1034Pelodiscus sinensis41.543e-0653.1
LLPS-Mod-1709Monodelphis domestica41.183e-0755.5
LLPS-Orl-2182Oryzias latipes41.182e-0756.6
LLPS-Meg-1351Meleagris gallopavo40.34e-0756.2
LLPS-Ora-0903Ornithorhynchus anatinus40.263e-0756.2