• Disorder
  • Domain
  • PTM
  • Variation
  • Mutation
  • Interaction
  • Disease
  • Drug
  • Physicochemical
  • Function
  • Proteomics
  • Structure
  • Localization
  • Expression
  • Element
  • Methylation

LLPS-Man-0151
TOP3A

Integrated Annotations

▼ OVERVIEW


Status: Unreviewed
Protein Name: DNA topoisomerase
Gene Name: TOP3A
Ensembl Gene: ENSMNEG00000041105.1
Ensembl Protein: ENSMNEP00000035991.1
Organism: Macaca nemestrina
Taxa ID: 9545
LLPS Type: Others


▼ PROPERTY



——— Disorder propensity (calculated by IUPred2A)

▼ Classification


Condensates:
CondensateEvidenceOrthologs
PML nuclear bodyPredicted from orthologs(View)

▼ FUNCTION


Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand.

▼ CROSS REFERENCE


DatabaseNucleotide IDProtein ID
EnsemblENSMNET00000060452.1ENSMNEP00000035991.1
UniProtA0A2K6DJC0, A0A2K6DJC0_MACNE

▼ SEQUENCE


Protein Sequence (FASTA)
1     MIFPVLRSAF  RWLRQPGDRA  FSRAAMEVAL  RGVRKVLCVA  EKNDAAKGIA  DLLSNGRMRR  60
61    REGLSKFNKI  YEFDYHLYGQ  NVTMVMTSVS  GHLLAHDFRM  QFRKWSSCNP  LVLFEAEIEK  120
121   YCPENFVDIK  KTLERETRQC  QALVIWTDCD  REGENIGFEI  IHVCKTVKPN  LQVLRARFSE  180
181   ITPHAVRTAC  ENLTEPDQRV  SDAVDVRQEL  DLRIGAAFTR  FQTLRLQKIF  PEVLAEQLIS  240
241   YGSCQFPTLG  FVVERFKAIQ  AFVPEIFHRI  KVTHDHKDGI  VEFNWKRHRL  FNHTACLVLY  300
301   QLCMEDPMAT  VVEVRSKPKS  KWRPQALDTV  VCSGQAVSGT  GETLIAEKLY  TQGYISYPRT  360
361   ETNIFPRDLN  LTVLVEQQTP  DPRWGAFAQS  ILERGGPTPR  NGNKSDQAHP  PIHPTKYTNS  420
421   LQGDEQRLYE  FIVRHFLACC  SQDAQGQETT  VEIDIAQERF  VAHGLVILAR  NYLDVYPYDH  480
481   WSDKILPVYE  RGSRFQPSTV  EMVDGETSPP  KLLTEADLIA  LMEKHGIGTD  ATHAEHIETI  540
541   KARMYVGLTP  DKRFLPGHLG  MGLVEGYDSM  GYEMSKPDLR  AELEADLKLI  CDGKKDKFVV  600
601   LRQQVQKYKQ  VFIEAVAKAK  KLDEALAQYF  GNGTELAQQE  EIYPAMPEPI  RKCPQCNKDM  660
661   VLKTKKNGGF  YLSCMGFPEC  RSAMWLPDSV  LEASRDSSVC  PVCQPHPVYR  LKLKFKRGSL  720
721   PPTMPLEFVC  CIGGCDETLR  EILDLRFSRG  PPRAIQPSGH  LQASQSLNRM  DNSQHPQPAD  780
781   SRQTGPSKVL  ARTLPPPTAA  GESNSVTCNC  GQEAVLLTVR  KEGPNQGRQF  FKCNGGSCNF  840
841   FLWADSPNQG  AGGPPASAYR  PLSGSLGRPP  GPGIHLGGFG  NPGDGSGTGT  SCLCSQPAVT  900
901   RTVQKDGPNK  GRQFHTCAKP  REQQCGFFQW  VDENTAPGTS  GAPSWTGDRG  RILGLEARSK  960
961   RSRASSSDTG  STAKKPRKCS  LCHQPGHTRP  FCPQNR  996
Nucleotide CDS Sequence (FASTA)
1     ATGATCTTTC  CTGTCCTCCG  CTCCGCGTTT  CGGTGGCTGC  GACAGCCCGG  AGACCGTGCC  60
61    TTTTCCCGCG  CCGCCATGGA  GGTGGCCCTC  CGAGGCGTGC  GGAAAGTCCT  CTGTGTGGCC  120
121   GAAAAAAACG  ACGCGGCCAA  GGGGATCGCC  GACCTGCTGT  CCAACGGTCG  CATGAGGCGG  180
181   AGAGAAGGAC  TTTCAAAATT  CAACAAGATC  TATGAATTTG  ATTATCACCT  GTATGGCCAG  240
241   AATGTTACCA  TGGTAATGAC  TTCGGTTTCT  GGACATTTAC  TGGCTCATGA  TTTCCGGATG  300
301   CAGTTTCGAA  AATGGTCAAG  CTGCAACCCT  CTTGTCCTCT  TTGAAGCAGA  AATTGAAAAG  360
361   TACTGCCCAG  AGAATTTTGT  AGACATCAAG  AAAACTCTGG  AACGAGAGAC  TCGCCAGTGC  420
421   CAGGCTCTGG  TGATCTGGAC  TGACTGTGAT  AGAGAAGGCG  AAAACATTGG  GTTTGAGATT  480
481   ATCCACGTGT  GTAAGACTGT  AAAGCCCAAT  CTGCAGGTGT  TGCGAGCCCG  ATTCTCTGAG  540
541   ATCACACCCC  ATGCCGTCAG  GACAGCTTGT  GAAAACCTGA  CTGAGCCTGA  TCAGAGGGTG  600
601   AGCGATGCTG  TGGATGTGAG  GCAGGAGCTG  GACCTGAGGA  TTGGAGCTGC  CTTTACTAGG  660
661   TTCCAGACCC  TGCGGCTTCA  GAAGATTTTT  CCTGAGGTGC  TGGCAGAGCA  GCTCATCAGT  720
721   TACGGCAGCT  GCCAGTTCCC  CACATTGGGC  TTTGTGGTGG  AGCGATTCAA  AGCCATTCAG  780
781   GCTTTTGTAC  CAGAAATCTT  CCACAGAATT  AAAGTAACTC  ATGACCACAA  AGATGGTATC  840
841   GTAGAATTCA  ACTGGAAAAG  GCATCGACTC  TTTAACCACA  CGGCTTGCCT  AGTTCTCTAT  900
901   CAGTTGTGTA  TGGAGGATCC  CATGGCAACT  GTGGTAGAGG  TCAGATCTAA  GCCCAAGAGC  960
961   AAGTGGCGGC  CTCAAGCTTT  GGACACTGTG  GTATGTTCCG  GACAGGCTGT  TTCAGGCACT  1020
1021  GGGGAAACAC  TGATTGCTGA  GAAGCTCTAC  ACTCAAGGGT  ACATCAGCTA  TCCCCGAACA  1080
1081  GAAACAAACA  TTTTTCCCAG  AGACTTAAAC  CTGACGGTGT  TGGTGGAACA  GCAGACCCCC  1140
1141  GATCCACGCT  GGGGGGCCTT  TGCCCAGAGC  ATTCTAGAGC  GGGGTGGTCC  CACCCCACGC  1200
1201  AATGGGAACA  AGTCTGACCA  AGCTCACCCT  CCCATTCACC  CCACCAAATA  CACCAACAGC  1260
1261  TTACAGGGAG  ACGAACAGCG  ACTGTACGAG  TTTATTGTTC  GCCATTTCCT  GGCCTGCTGC  1320
1321  TCCCAGGATG  CTCAGGGGCA  GGAGACCACA  GTGGAGATCG  ACATCGCTCA  GGAACGCTTT  1380
1381  GTGGCCCACG  GCCTCGTGAT  TCTGGCCCGA  AACTATCTGG  ACGTGTATCC  ATATGATCAC  1440
1441  TGGAGTGACA  AGATCCTCCC  TGTCTATGAG  CGAGGCTCCC  GCTTTCAGCC  CAGCACCGTG  1500
1501  GAGATGGTGG  ATGGGGAGAC  CAGCCCGCCC  AAGCTGCTCA  CCGAGGCCGA  CCTCATTGCC  1560
1561  CTCATGGAGA  AGCACGGCAT  TGGTACGGAT  GCCACTCATG  CGGAGCACAT  CGAGACCATC  1620
1621  AAAGCCCGGA  TGTACGTGGG  ACTCACCCCA  GACAAGCGGT  TCCTCCCTGG  GCACCTGGGC  1680
1681  ATGGGACTTG  TGGAAGGTTA  TGATTCCATG  GGCTATGAAA  TGTCTAAGCC  TGACCTCCGG  1740
1741  GCTGAGCTGG  AAGCTGATCT  GAAGCTGATC  TGTGATGGCA  AGAAGGACAA  ATTTGTGGTT  1800
1801  CTAAGGCAGC  AAGTGCAGAA  ATACAAGCAG  GTTTTCATCG  AAGCGGTGGC  TAAAGCAAAG  1860
1861  AAATTGGATG  AGGCCTTGGC  CCAGTACTTT  GGGAATGGGA  CAGAGTTGGC  CCAGCAAGAA  1920
1921  GAGATCTACC  CAGCCATGCC  AGAGCCCATC  AGGAAGTGCC  CACAGTGCAA  CAAGGACATG  1980
1981  GTCCTCAAGA  CCAAGAAGAA  CGGCGGGTTC  TACCTCAGCT  GCATGGGTTT  CCCGGAGTGT  2040
2041  CGCTCAGCCA  TGTGGCTTCC  TGACTCGGTG  CTGGAGGCCA  GCAGGGACAG  CAGCGTGTGT  2100
2101  CCAGTTTGTC  AGCCACATCC  TGTGTACAGG  TTGAAGTTAA  AGTTTAAGCG  CGGTAGCCTT  2160
2161  CCCCCGACCA  TGCCTCTGGA  GTTTGTTTGC  TGCATCGGTG  GATGCGACGA  GACCCTGAGG  2220
2221  GAGATCCTGG  ACCTGAGATT  TTCACGGGGC  CCCCCCAGGG  CTATCCAGCC  CTCTGGTCAC  2280
2281  CTGCAGGCTA  GCCAGTCTCT  GAACAGGATG  GACAATAGCC  AGCACCCCCA  GCCTGCTGAC  2340
2341  AGCAGACAGA  CTGGGCCCTC  AAAGGTTCTG  GCCCGGACCC  TCCCACCACC  CACGGCTGCT  2400
2401  GGTGAAAGCA  ATTCTGTGAC  CTGCAACTGT  GGCCAGGAGG  CTGTGCTGCT  TACTGTCCGT  2460
2461  AAGGAGGGCC  CCAACCAGGG  CCGGCAATTC  TTTAAGTGTA  ACGGGGGTAG  CTGCAACTTC  2520
2521  TTCCTGTGGG  CAGACAGCCC  CAATCAGGGA  GCAGGAGGGC  CTCCCGCCTC  GGCATATAGA  2580
2581  CCCCTAAGCG  GCTCCCTGGG  ACGCCCACCA  GGCCCAGGGA  TCCACCTGGG  TGGGTTTGGC  2640
2641  AACCCTGGTG  ATGGCAGTGG  TACTGGCACA  TCCTGCCTGT  GCAGCCAGCC  CGCCGTCACA  2700
2701  CGGACTGTAC  AGAAGGATGG  GCCCAACAAG  GGGCGCCAGT  TCCACACGTG  TGCCAAGCCG  2760
2761  AGAGAGCAGC  AGTGTGGCTT  CTTCCAGTGG  GTCGATGAGA  ACACCGCTCC  AGGGACTTCT  2820
2821  GGAGCCCCGT  CCTGGACAGG  AGACAGAGGA  AGAATCCTGG  GGTTGGAAGC  CAGAAGCAAA  2880
2881  AGGTCCCGGG  CCAGTTCCTC  AGACACGGGG  TCCACAGCAA  AGAAACCCCG  GAAATGCAGC  2940
2941  CTTTGCCACC  AACCTGGACA  CACCCGTCCC  TTTTGTCCTC  AGAACAGATG  A  2991

▼ KEYWORD


ID
Family
Complete proteome
DNA-binding
Isomerase
Reference proteome
Topoisomerase

▼ GENE ONTOLOGY


ID
Classification
Description
Cellular Component
Chromosome
Cellular Component
Mitochondrion
Cellular Component
PML body
Molecular Function
DNA topoisomerase type I activity
Molecular Function
Single-stranded DNA binding
Molecular Function
Zinc ion binding
Biological Process
Chromosome separation
Biological Process
DNA topological change
Biological Process
Mitochondrial DNA metabolic process

▼ ORTHOLOGY


DrLLPS IDOrganismIdentityE-valueScore
LLPS-Mam-3898Macaca mulatta97.80.01980
LLPS-Maf-3492Macaca fascicularis97.70.01978
LLPS-Chs-2228Chlorocebus sabaeus97.60.01969
LLPS-Paa-3924Papio anubis97.20.01969
LLPS-Mal-3597Mandrillus leucophaeus97.10.01964
LLPS-Rhb-2590Rhinopithecus bieti96.90.01953
LLPS-Gog-2781Gorilla gorilla95.50.01936
LLPS-Nol-2588Nomascus leucogenys95.30.01932
LLPS-Pat-3597Pan troglodytes95.30.01935
LLPS-Pap-4161Pan paniscus95.00.01927
LLPS-Hos-3920Homo sapiens94.610.01919
LLPS-Cea-2201Cercocebus atys94.110.01886
LLPS-Aon-3430Aotus nancymaae93.310.01857
LLPS-Poa-2941Pongo abelii92.990.01410
LLPS-Caj-2263Callithrix jacchus92.710.01865
LLPS-Cas-3313Carlito syrichta90.440.01809
LLPS-Eqc-2413Equus caballus87.050.01694
LLPS-Dio-0230Dipodomys ordii86.750.01750
LLPS-Caf-2126Canis familiaris86.570.01726
LLPS-Fec-3044Felis catus86.060.01725
LLPS-Mup-4194Mustela putorius furo85.940.01732
LLPS-Ict-4524Ictidomys tridecemlineatus85.520.01733
LLPS-Mum-0824Mus musculus85.240.01748
LLPS-Myl-4128Myotis lucifugus85.20.01689
LLPS-Fud-1511Fukomys damarensis84.720.01714
LLPS-Loa-0421Loxodonta africana84.440.01689
LLPS-Aim-2109Ailuropoda melanoleuca84.380.01705
LLPS-Otg-4668Otolemur garnettii84.250.01686
LLPS-Bot-1322Bos taurus83.880.01672
LLPS-Orc-2298Oryctolagus cuniculus83.650.01695
LLPS-Sus-3972Sus scrofa83.280.01590
LLPS-Tut-2066Tursiops truncatus82.140.01655
LLPS-Cap-2925Cavia porcellus81.930.01678
LLPS-Ran-1501Rattus norvegicus81.750.01635
LLPS-Ova-2267Ovis aries81.050.01636
LLPS-Ora-3041Ornithorhynchus anatinus76.550.01463
LLPS-Mod-1920Monodelphis domestica75.730.01409
LLPS-Pes-0581Pelodiscus sinensis75.260.01458
LLPS-Sah-0521Sarcophilus harrisii75.160.01386
LLPS-Leo-3171Lepisosteus oculatus73.620.01194
LLPS-Tag-1730Taeniopygia guttata72.560.01448
LLPS-Anp-1470Anas platyrhynchos72.050.01461
LLPS-Gaga-3482Gallus gallus71.970.01454
LLPS-Fia-0416Ficedula albicollis71.820.01449
LLPS-Meg-2249Meleagris gallopavo71.770.01447
LLPS-Anc-2219Anolis carolinensis70.030.01448
LLPS-Lac-1515Latimeria chalumnae69.780.01420
LLPS-Xet-1874Xenopus tropicalis69.460.01439
LLPS-Scm-3854Scophthalmus maximus68.860.0 985
LLPS-Asm-2414Astyanax mexicanus66.090.01315
LLPS-Scf-2085Scleropages formosus65.040.01294
LLPS-Icp-0337Ictalurus punctatus64.780.01293
LLPS-Orn-1364Oreochromis niloticus64.590.01289
LLPS-Dar-2100Danio rerio64.40.01318
LLPS-Gaa-1714Gasterosteus aculeatus64.250.01266
LLPS-Orl-2261Oryzias latipes63.990.01274
LLPS-Pof-2213Poecilia formosa63.860.01265
LLPS-Tar-0875Takifugu rubripes63.750.01278
LLPS-Cii-0057Ciona intestinalis63.660.0 558
LLPS-Ten-3413Tetraodon nigroviridis63.630.01253
LLPS-Xim-2777Xiphophorus maculatus62.20.01249
LLPS-Drm-2055Drosophila melanogaster54.790.0 750
LLPS-Cis-1626Ciona savignyi53.480.01011
LLPS-Cae-1040Caenorhabditis elegans50.330.0 617
LLPS-Lem-1498Leptosphaeria maculans48.966e-151 473
LLPS-Dos-1213Dothistroma septosporum47.924e-147 461
LLPS-Cogr-0301Colletotrichum graminicola47.812e-149 466
LLPS-Nec-0149Neurospora crassa47.136e-153 476
LLPS-Ved-0985Verticillium dahliae47.052e-147 464
LLPS-Mel-1129Melampsora laricipopulina46.561e-180 551
LLPS-Pug-1379Puccinia graminis46.424e-176 551
LLPS-Phv-0757Phaseolus vulgaris46.290.0 593
LLPS-Beb-1430Beauveria bassiana46.184e-146 457
LLPS-Tum-0272Tuber melanosporum46.031e-170 520
LLPS-Crn-1513Cryptococcus neoformans45.697e-178 553
LLPS-Ast-0680Aspergillus terreus45.242e-158 487
LLPS-Gag-1075Gaeumannomyces graminis45.142e-143 451
LLPS-Asni-0752Aspergillus niger45.092e-167 512
LLPS-Coo-0573Colletotrichum orbiculare44.928e-139 439
LLPS-Map-0349Magnaporthe poae44.761e-143 448
LLPS-Nef-1300Neosartorya fischeri44.74e-154 475
LLPS-Vir-2195Vigna radiata44.673e-114 365
LLPS-Usm-1447Ustilago maydis44.671e-166 522
LLPS-Zyt-0362Zymoseptoria tritici44.574e-159 490
LLPS-Aso-0126Aspergillus oryzae44.552e-163 501
LLPS-Asf-1012Aspergillus flavus44.552e-163 501
LLPS-Pot-0931Populus trichocarpa44.420.0 716
LLPS-Miv-0725Microbotryum violaceum44.267e-164 517
LLPS-Spr-1272Sporisorium reilianum44.238e-0654.3
LLPS-Art-2786Arabidopsis thaliana44.190.0 707
LLPS-Asn-1186Aspergillus nidulans44.189e-164 502
LLPS-Scj-1127Schizosaccharomyces japonicus44.171e-160 494
LLPS-Arl-1807Arabidopsis lyrata44.130.0 701
LLPS-Prp-2331Prunus persica44.050.0 699
LLPS-Lep-1213Leersia perrieri44.020.0 665
LLPS-Cog-0502Colletotrichum gloeosporioides43.82e-162 501
LLPS-Sem-2334Selaginella moellendorffii43.720.0 632
LLPS-Glm-0250Glycine max43.610.0 679
LLPS-Orbr-0745Oryza brachyantha43.580.0 695
LLPS-Asc-1061Aspergillus clavatus43.415e-159 490
LLPS-Asfu-0834Aspergillus fumigatus43.414e-160 493
LLPS-Coc-2106Corchorus capsularis43.360.0 699
LLPS-Thc-2364Theobroma cacao43.350.0 697
LLPS-Bro-0025Brassica oleracea43.260.0 690
LLPS-Sob-2355Sorghum bicolor43.250.0 683
LLPS-Orp-2409Oryza punctata43.230.0 613
LLPS-Blg-1309Blumeria graminis43.224e-140 438
LLPS-Brr-0171Brassica rapa43.140.0 681
LLPS-Sol-1400Solanum lycopersicum43.110.0 688
LLPS-Brn-1784Brassica napus43.110.0 688
LLPS-Met-0959Medicago truncatula43.030.0 679
LLPS-Amt-1181Amborella trichopoda42.910.0 685
LLPS-Orgl-2063Oryza glumaepatula42.840.0 651
LLPS-Mua-1088Musa acuminata42.810.0 668
LLPS-Gor-0208Gossypium raimondii42.790.0 689
LLPS-Cus-2358Cucumis sativus42.740.0 671
LLPS-Orr-2223Oryza rufipogon42.590.0 681
LLPS-Zem-0820Zea mays42.590.0 678
LLPS-Orni-2403Oryza nivara42.550.0 691
LLPS-Sei-1313Setaria italica42.480.0 672
LLPS-Pytr-1443Pyrenophora triticirepentis42.454e-165 507
LLPS-Scs-1007Sclerotinia sclerotiorum42.383e-164 505
LLPS-Phn-0489Phaeosphaeria nodorum42.345e-154 479
LLPS-Fus-1258Fusarium solani42.274e-162 499
LLPS-Asg-0783Ashbya gossypii42.051e-138 437
LLPS-Org-2193Oryza glaberrima41.980.0 669
LLPS-Scc-1305Schizosaccharomyces cryophilus41.951e-152 473
LLPS-Abg-0148Absidia glauca41.918e-153 476
LLPS-Brd-2511Brachypodium distachyon41.810.0 690
LLPS-Tra-2993Triticum aestivum41.50.0 693
LLPS-Pyt-1406Pyrenophora teres41.292e-160 495
LLPS-Php-0140Physcomitrella patens41.170.0 662
LLPS-Trv-0138Trichoderma virens41.158e-155 480
LLPS-Trr-0654Trichoderma reesei41.153e-158 489
LLPS-Scp-1626Schizosaccharomyces pombe40.974e-153 474
LLPS-Orm-0598Oryza meridionalis40.830.0 629
LLPS-Ori-2383Oryza indica40.820.0 637
LLPS-Sac-1502Saccharomyces cerevisiae40.549e-136 430
LLPS-Mao-1435Magnaporthe oryzae40.511e-153 477
LLPS-Kop-0573Komagataella pastoris40.465e-129 411
LLPS-Dac-1521Daucus carota40.462e-162 500
LLPS-Osl-0774Ostreococcus lucimarinus40.413e-144 452
LLPS-Gas-0466Galdieria sulphuraria40.134e-135 428
LLPS-Hea-1113Helianthus annuus39.970.0 582
LLPS-Chc-1176Chondrus crispus39.521e-134 436
LLPS-Fuv-0167Fusarium verticillioides38.867e-112 363
LLPS-Yal-0495Yarrowia lipolytica38.671e-127 407
LLPS-Orb-1976Oryza barthii38.450.0 592
LLPS-Viv-0132Vitis vinifera36.951e-111 371
LLPS-Urm-3092Ursus maritimus36.781e-118 391
LLPS-Nia-0807Nicotiana attenuata36.25e-114 379
LLPS-Mea-1469Mesocricetus auratus36.093e-123 403
LLPS-Chr-0369Chlamydomonas reinhardtii34.934e-115 382
LLPS-Via-2237Vigna angularis34.863e-121 398
LLPS-Tru-1706Triticum urartu33.232e-106 358
LLPS-Ors-1914Oryza sativa33.097e-111 370
LLPS-Hov-1442Hordeum vulgare32.649e-111 370