• Disorder
  • Domain
  • PTM
  • Variation
  • Mutation
  • Interaction
  • Disease
  • Drug
  • Physicochemical
  • Function
  • Proteomics
  • Structure
  • Localization
  • Expression
  • Element
  • Methylation

LLPS-Dio-0230
Top3a

Integrated Annotations

▼ OVERVIEW


Status: Unreviewed
Protein Name: DNA topoisomerase
Gene Name: Top3a
Ensembl Gene: ENSDORG00000005350.2
Ensembl Protein: ENSDORP00000017933.1
Organism: Dipodomys ordii
Taxa ID: 10020
LLPS Type: Others


▼ PROPERTY



——— Disorder propensity (calculated by IUPred2A)

▼ Classification


Condensates:
CondensateEvidenceOrthologs
PML nuclear bodyPredicted from orthologs(View)

▼ FUNCTION


Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand.

▼ SEQUENCE


Protein Sequence (FASTA)
1     MIFPVSRFAL  PWLQRSGSRV  LSRAAMEVAL  RGVRKVLCVA  EKNDAAKGIA  DLLSNGRMRR  60
61    REGLSKFNKI  YEFDYHLCGQ  SVTMVMTSVS  GHLLAHDFQM  QFRKWQSCNP  LVLFEAEIEK  120
121   YCPDNFVDIK  KTLEREIRQC  QALVIWTDCD  REGENIGFEI  IHVCKAVKPS  LQVLRARFSE  180
181   ITPRAVRMAC  ENLTEPDQRV  SDAVDVRQEL  DLRIGAAFTR  FQTLRLQKIF  PEVLAEQLIS  240
241   YGSCQFPTLG  FVVERFKAIQ  TFVPEIFHKI  KVTHDHRDGT  VEFNWKRHRL  FNHTACLVLY  300
301   QLCMEDPRAT  VVEVKSKPKS  KWRPQALDTV  ELEKLASRKL  RINAKETMRI  AEKLYTQGYI  360
361   SYPRTETNIF  PKDLNLMALV  EQQTSDPHWG  AFAQSILERG  GPNPRNGNKS  DQAHPPIHPT  420
421   KYTSNLQGDE  RRLYEFIVRH  FLACCSQDAQ  GQETTVEIDI  AQERFVAHGL  IILARNYLDV  480
481   YPYDHWSDKL  LPLYEQGSCF  QPSTVEMVDG  ETSPPQLLTE  ADLIALMEKH  GIGTDATHAE  540
541   HIETIKARMY  VGLTSDKRFL  PGHLGMGLVE  GYDSMGYEMS  KPDLRAELEA  DLKLICEGKK  600
601   DKFVVLRQQV  QKYKQVFIEA  VAKATKLDEA  LSQYFGERAE  VAQQEDIYPA  MPEPIRKCPQ  660
661   CNKDMVLKTK  KSGGFYLSCT  GFPECRSAIW  FPDSVLEASR  DDSVCSVCQP  PPVYRLKLKF  720
721   KRGSLPPTMP  LEFVGCIGGC  DETLKEILDL  RFSRGGAPRA  SQASGLLQAS  QALNRVDSSQ  780
781   QSHSQLRSSR  QTGPSMPLHQ  TLQPPTGTGE  SNSVTCNCGQ  EAVLLTVRKE  GPNQGRQFYK  840
841   CSGGGCNFFL  WADSSHQSGG  GLPTPASRPP  GSSMGRLPGP  GNQSGGFGNP  SDGSGGSTSC  900
901   LCSQPAVTRT  VQKDGPNKGR  QFHTCAKPRE  QQCGFFQWAD  ENVAPGTFAA  PPWPGGRGKT  960
961   QGPEARSKRA  RANSSDVGST  TKKPRKCSLC  HQPGHTRPFC  PQNR  1004
Nucleotide CDS Sequence (FASTA)
1     ATGATTTTCC  CGGTCTCCCG  CTTCGCGCTC  CCCTGGCTGC  AGCGGTCTGG  AAGCCGTGTC  60
61    TTGTCCCGCG  CCGCCATGGA  AGTGGCTCTC  CGAGGCGTTC  GGAAAGTCCT  CTGTGTGGCT  120
121   GAGAAGAACG  ACGCGGCCAA  GGGCATTGCA  GACCTGCTGT  CCAACGGTCG  TATGAGGCGG  180
181   AGAGAAGGAC  TTTCTAAATT  CAATAAGATC  TATGAATTTG  ATTATCATCT  GTGTGGCCAG  240
241   AGTGTTACCA  TGGTAATGAC  CTCGGTTTCT  GGACATTTGC  TGGCTCATGA  TTTCCAGATG  300
301   CAGTTTCGAA  AATGGCAGAG  CTGCAACCCA  CTTGTCCTCT  TTGAAGCAGA  AATTGAAAAG  360
361   TACTGCCCAG  ACAATTTTGT  AGACATCAAG  AAAACTCTAG  AACGAGAGAT  ACGGCAGTGC  420
421   CAGGCCCTGG  TGATCTGGAC  TGACTGTGAC  AGAGAAGGTG  AAAACATTGG  GTTTGAGATT  480
481   ATCCACGTGT  GCAAGGCTGT  GAAGCCCAGT  CTGCAGGTGT  TGAGAGCCCG  TTTCTCTGAG  540
541   ATTACACCCC  GTGCTGTCAG  GATGGCCTGT  GAAAACCTCA  CTGAGCCTGA  TCAGAGAGTG  600
601   AGCGATGCTG  TGGATGTGAG  GCAAGAGCTA  GATCTGAGGA  TTGGAGCGGC  CTTCACTAGG  660
661   TTCCAGACCC  TACGGCTTCA  GAAGATTTTT  CCTGAGGTGC  TAGCAGAGCA  GCTTATCAGC  720
721   TATGGCAGCT  GCCAGTTCCC  AACACTGGGA  TTCGTGGTGG  AGAGGTTCAA  AGCCATTCAG  780
781   ACTTTTGTAC  CAGAAATCTT  TCACAAAATC  AAAGTAACTC  ATGATCACAG  AGATGGTACT  840
841   GTAGAATTCA  ACTGGAAAAG  GCATCGTCTC  TTTAACCACA  CAGCTTGTCT  TGTCCTCTAT  900
901   CAGTTATGTA  TGGAGGATCC  CAGGGCAACT  GTGGTAGAGG  TAAAGTCTAA  GCCAAAGAGC  960
961   AAGTGGAGGC  CTCAAGCTTT  GGATACTGTG  GAGCTGGAGA  AGCTGGCTTC  TCGCAAGTTG  1020
1021  AGAATAAATG  CTAAAGAAAC  CATGCGGATT  GCTGAAAAGC  TCTATACTCA  AGGGTACATC  1080
1081  AGCTATCCCC  GAACAGAAAC  AAACATTTTT  CCCAAAGACT  TAAACCTGAT  GGCATTGGTA  1140
1141  GAACAGCAGA  CTTCTGATCC  ACACTGGGGG  GCCTTTGCCC  AAAGCATTCT  GGAGCGGGGT  1200
1201  GGCCCCAACC  CACGCAATGG  GAACAAATCT  GACCAAGCTC  ATCCTCCTAT  TCACCCCACC  1260
1261  AAATACACCA  GCAACTTACA  GGGAGATGAA  CGAAGATTGT  ATGAGTTCAT  TGTTCGCCAT  1320
1321  TTTCTGGCTT  GCTGCTCCCA  GGATGCTCAG  GGACAGGAAA  CCACTGTGGA  GATTGACATT  1380
1381  GCTCAGGAAC  GCTTTGTGGC  CCATGGCCTC  ATAATCCTGG  CCCGAAACTA  CCTGGATGTA  1440
1441  TATCCATATG  ATCACTGGAG  TGACAAGCTC  CTTCCTCTCT  ATGAGCAAGG  CTCCTGCTTT  1500
1501  CAGCCCAGTA  CTGTGGAGAT  GGTGGATGGA  GAGACAAGCC  CGCCCCAGCT  GCTTACTGAA  1560
1561  GCTGACCTCA  TTGCCCTCAT  GGAGAAGCAT  GGCATCGGTA  CCGATGCCAC  TCATGCAGAG  1620
1621  CACATTGAAA  CCATCAAAGC  CCGGATGTAT  GTGGGGCTCA  CTTCAGACAA  GCGATTCCTC  1680
1681  CCTGGTCACC  TGGGCATGGG  ACTTGTGGAA  GGTTATGATT  CCATGGGCTA  TGAGATGTCT  1740
1741  AAACCTGACC  TCCGGGCTGA  GCTGGAAGCT  GATCTGAAGT  TGATCTGTGA  GGGCAAGAAG  1800
1801  GACAAATTTG  TGGTTCTAAG  GCAGCAAGTG  CAGAAATATA  AGCAGGTTTT  CATTGAAGCA  1860
1861  GTGGCTAAGG  CAACGAAATT  GGACGAGGCT  TTGTCCCAAT  ACTTTGGGGA  AAGGGCAGAG  1920
1921  GTGGCCCAAC  AAGAGGATAT  CTACCCAGCC  ATGCCAGAGC  CCATCCGGAA  GTGCCCACAG  1980
1981  TGCAACAAGG  ACATGGTCCT  CAAGACCAAG  AAAAGTGGCG  GGTTCTACCT  CAGCTGCACA  2040
2041  GGTTTCCCTG  AGTGTCGATC  AGCTATTTGG  TTTCCTGACT  CAGTGCTGGA  GGCCAGCAGG  2100
2101  GATGATAGCG  TGTGTTCGGT  TTGTCAGCCA  CCCCCTGTAT  ACAGGTTGAA  GTTAAAATTT  2160
2161  AAGCGTGGCA  GCCTTCCACC  AACCATGCCT  CTAGAATTTG  TGGGTTGCAT  TGGTGGATGT  2220
2221  GATGAGACCC  TGAAGGAGAT  CTTGGACCTG  AGATTTTCAC  GGGGCGGTGC  CCCCAGAGCA  2280
2281  AGCCAGGCCT  CTGGCCTCCT  TCAGGCCAGC  CAGGCCCTGA  ACAGGGTGGA  CAGTAGCCAA  2340
2341  CAAAGCCACT  CCCAGCTCCG  TAGCAGCCGA  CAGACTGGAC  CCTCGATGCC  TCTGCACCAG  2400
2401  ACCCTCCAAC  CACCAACTGG  CACTGGTGAA  AGCAACTCTG  TGACATGCAA  CTGTGGCCAG  2460
2461  GAGGCTGTGC  TGCTCACTGT  CCGCAAGGAG  GGCCCTAACC  AGGGTCGGCA  GTTTTACAAG  2520
2521  TGCAGTGGTG  GTGGCTGCAA  CTTTTTTCTG  TGGGCTGACA  GCAGCCATCA  GTCAGGAGGA  2580
2581  GGACTTCCCA  CCCCTGCCTC  AAGACCTCCA  GGAAGCTCCA  TGGGACGCCT  ACCAGGCCCA  2640
2641  GGCAACCAGT  CGGGTGGTTT  TGGTAACCCT  AGTGATGGAA  GTGGTGGCAG  CACATCCTGC  2700
2701  CTGTGCAGCC  AGCCTGCCGT  GACACGGACT  GTGCAGAAGG  ACGGACCCAA  CAAAGGGCGC  2760
2761  CAGTTCCATA  CGTGTGCCAA  GCCACGAGAG  CAGCAATGTG  GCTTCTTTCA  GTGGGCTGAC  2820
2821  GAGAATGTGG  CACCAGGGAC  TTTTGCAGCT  CCACCCTGGC  CAGGAGGCAG  AGGAAAAACT  2880
2881  CAGGGGCCAG  AGGCCAGGAG  CAAAAGAGCC  AGAGCCAATT  CCTCAGATGT  GGGATCCACA  2940
2941  ACAAAGAAGC  CCCGGAAATG  CAGCCTTTGC  CACCAGCCTG  GACATACCAG  ACCTTTCTGT  3000
3001  CCTCAGAACA  GATGA  3015

▼ KEYWORD


ID
Family
Complete proteome
DNA-binding
Isomerase
Reference proteome
Topoisomerase

▼ GENE ONTOLOGY


ID
Classification
Description
Cellular Component
Chromosome
Cellular Component
Mitochondrion
Cellular Component
PML body
Molecular Function
DNA topoisomerase type I activity
Molecular Function
Single-stranded DNA binding
Molecular Function
Zinc ion binding
Biological Process
Chromosome separation
Biological Process
DNA topological change
Biological Process
Mitochondrial DNA metabolic process

▼ ORTHOLOGY


DrLLPS IDOrganismIdentityE-valueScore
LLPS-Cas-3313Carlito syrichta90.040.01847
LLPS-Poa-2941Pongo abelii89.560.01368
LLPS-Ict-4524Ictidomys tridecemlineatus89.00.01818
LLPS-Eqc-2413Equus caballus88.740.01703
LLPS-Paa-3924Papio anubis88.650.01802
LLPS-Nol-2588Nomascus leucogenys88.550.01809
LLPS-Pat-3597Pan troglodytes88.550.01805
LLPS-Gog-2781Gorilla gorilla88.550.01808
LLPS-Pap-4161Pan paniscus88.450.01801
LLPS-Maf-3492Macaca fascicularis88.450.01798
LLPS-Mam-3898Macaca mulatta88.350.01796
LLPS-Mal-3597Mandrillus leucophaeus88.350.01798
LLPS-Mum-0824Mus musculus88.350.01819
LLPS-Caj-2263Callithrix jacchus88.250.01788
LLPS-Chs-2228Chlorocebus sabaeus88.250.01790
LLPS-Hos-3920Homo sapiens88.150.01797
LLPS-Aon-3430Aotus nancymaae88.150.01790
LLPS-Rhb-2590Rhinopithecus bieti87.850.01768
LLPS-Fec-3044Felis catus87.190.01773
LLPS-Caf-2126Canis familiaris86.710.01774
LLPS-Man-0151Macaca nemestrina86.550.01732
LLPS-Mup-4194Mustela putorius furo86.480.01785
LLPS-Loa-0421Loxodonta africana86.040.01748
LLPS-Fud-1511Fukomys damarensis85.860.01753
LLPS-Myl-4128Myotis lucifugus85.50.01736
LLPS-Cea-2201Cercocebus atys85.460.01723
LLPS-Aim-2109Ailuropoda melanoleuca85.30.01754
LLPS-Orc-2298Oryctolagus cuniculus85.150.01732
LLPS-Cap-2925Cavia porcellus84.870.01743
LLPS-Tut-2066Tursiops truncatus84.820.01718
LLPS-Bot-1322Bos taurus84.810.01739
LLPS-Sus-3972Sus scrofa84.720.01603
LLPS-Otg-4668Otolemur garnettii84.680.01724
LLPS-Ran-1501Rattus norvegicus84.060.01711
LLPS-Ova-2267Ovis aries81.990.01680
LLPS-Ora-3041Ornithorhynchus anatinus78.330.01509
LLPS-Mod-1920Monodelphis domestica76.970.01433
LLPS-Sah-0521Sarcophilus harrisii76.850.01429
LLPS-Leo-3171Lepisosteus oculatus75.520.01219
LLPS-Pes-0581Pelodiscus sinensis75.260.01477
LLPS-Tag-1730Taeniopygia guttata73.450.01472
LLPS-Gaga-3482Gallus gallus72.960.01498
LLPS-Fia-0416Ficedula albicollis72.940.01492
LLPS-Meg-2249Meleagris gallopavo72.860.01478
LLPS-Anp-1470Anas platyrhynchos72.430.01480
LLPS-Anc-2219Anolis carolinensis71.480.01482
LLPS-Scm-3854Scophthalmus maximus70.830.01031
LLPS-Xet-1874Xenopus tropicalis70.470.01466
LLPS-Lac-1515Latimeria chalumnae69.630.01451
LLPS-Dar-2100Danio rerio67.820.01350
LLPS-Cii-0057Ciona intestinalis67.590.0 605
LLPS-Asm-2414Astyanax mexicanus67.280.01339
LLPS-Orn-1364Oreochromis niloticus66.870.01328
LLPS-Icp-0337Ictalurus punctatus66.50.01337
LLPS-Gaa-1714Gasterosteus aculeatus66.120.01306
LLPS-Orl-2261Oryzias latipes66.030.01320
LLPS-Pof-2213Poecilia formosa65.850.01311
LLPS-Ten-3413Tetraodon nigroviridis65.710.01306
LLPS-Tar-0875Takifugu rubripes65.680.01321
LLPS-Scf-2085Scleropages formosus65.140.01310
LLPS-Xim-2777Xiphophorus maculatus64.830.01305
LLPS-Drm-2055Drosophila melanogaster57.740.0 798
LLPS-Cis-1626Ciona savignyi54.740.01055
LLPS-Cae-1040Caenorhabditis elegans52.380.0 644
LLPS-Lem-1498Leptosphaeria maculans49.433e-159 494
LLPS-Cogr-0301Colletotrichum graminicola48.662e-158 490
LLPS-Mel-1129Melampsora laricipopulina47.980.0 570
LLPS-Dos-1213Dothistroma septosporum47.941e-155 483
LLPS-Phv-0757Phaseolus vulgaris47.580.0 624
LLPS-Pug-1379Puccinia graminis47.210.0 577
LLPS-Usm-1447Ustilago maydis46.952e-177 550
LLPS-Gag-1075Gaeumannomyces graminis46.952e-153 478
LLPS-Crn-1513Cryptococcus neoformans46.750.0 577
LLPS-Lep-1213Leersia perrieri46.70.0 701
LLPS-Map-0349Magnaporthe poae46.371e-154 477
LLPS-Php-0140Physcomitrella patens46.350.0 681
LLPS-Tum-0272Tuber melanosporum46.18e-178 539
LLPS-Vir-2195Vigna radiata46.06e-125 394
LLPS-Zyt-0362Zymoseptoria tritici45.966e-171 521
LLPS-Ast-0680Aspergillus terreus45.843e-167 510
LLPS-Asni-0752Aspergillus niger45.832e-178 541
LLPS-Miv-0725Microbotryum violaceum45.771e-173 543
LLPS-Asf-1012Aspergillus flavus45.71e-175 534
LLPS-Aso-0126Aspergillus oryzae45.71e-175 534
LLPS-Scj-1127Schizosaccharomyces japonicus45.54e-171 521
LLPS-Nef-1300Neosartorya fischeri45.452e-164 503
LLPS-Blg-1309Blumeria graminis45.342e-150 465
LLPS-Art-2786Arabidopsis thaliana45.250.0 730
LLPS-Sem-2334Selaginella moellendorffii45.210.0 658
LLPS-Prp-2331Prunus persica45.060.0 723
LLPS-Cog-0502Colletotrichum gloeosporioides44.973e-172 526
LLPS-Asc-1061Aspergillus clavatus44.92e-173 528
LLPS-Spr-1272Sporisorium reilianum44.896e-172 536
LLPS-Asn-1186Aspergillus nidulans44.824e-172 525
LLPS-Sob-2355Sorghum bicolor44.70.0 715
LLPS-Arl-1807Arabidopsis lyrata44.580.0 728
LLPS-Gor-0208Gossypium raimondii44.470.0 729
LLPS-Asfu-0834Aspergillus fumigatus44.432e-171 523
LLPS-Pot-0931Populus trichocarpa44.370.0 746
LLPS-Orbr-0745Oryza brachyantha44.310.0 731
LLPS-Brn-1784Brassica napus44.250.0 725
LLPS-Zem-0820Zea mays44.230.0 712
LLPS-Ved-0985Verticillium dahliae44.125e-173 531
LLPS-Bro-0025Brassica oleracea44.090.0 725
LLPS-Glm-0250Glycine max44.050.0 705
LLPS-Orgl-2063Oryza glumaepatula44.00.0 684
LLPS-Thc-2364Theobroma cacao43.970.0 730
LLPS-Orni-2403Oryza nivara43.930.0 724
LLPS-Amt-1181Amborella trichopoda43.890.0 721
LLPS-Coc-2106Corchorus capsularis43.880.0 720
LLPS-Met-0959Medicago truncatula43.870.0 708
LLPS-Brr-0171Brassica rapa43.80.0 719
LLPS-Orr-2223Oryza rufipogon43.720.0 715
LLPS-Orp-2409Oryza punctata43.70.0 653
LLPS-Mua-1088Musa acuminata43.660.0 701
LLPS-Scs-1007Sclerotinia sclerotiorum43.642e-172 526
LLPS-Brd-2511Brachypodium distachyon43.620.0 726
LLPS-Sei-1313Setaria italica43.580.0 704
LLPS-Nec-0149Neurospora crassa43.51e-176 538
LLPS-Sol-1400Solanum lycopersicum43.440.0 702
LLPS-Asg-0783Ashbya gossypii43.345e-151 469
LLPS-Pytr-1443Pyrenophora triticirepentis43.313e-174 531
LLPS-Scp-1626Schizosaccharomyces pombe43.221e-164 505
LLPS-Cus-2358Cucumis sativus43.070.0 693
LLPS-Phn-0489Phaeosphaeria nodorum43.041e-164 507
LLPS-Org-2193Oryza glaberrima42.940.0 707
LLPS-Tra-2993Triticum aestivum42.790.0 719
LLPS-Abg-0148Absidia glauca42.793e-165 509
LLPS-Fus-1258Fusarium solani42.738e-167 511
LLPS-Pyt-1406Pyrenophora teres42.663e-170 521
LLPS-Trr-0654Trichoderma reesei42.493e-168 516
LLPS-Scc-1305Schizosaccharomyces cryophilus42.454e-160 493
LLPS-Hea-1113Helianthus annuus42.320.0 615
LLPS-Dac-1521Daucus carota42.233e-177 539
LLPS-Sac-1502Saccharomyces cerevisiae41.965e-147 460
LLPS-Orm-0598Oryza meridionalis41.810.0 660
LLPS-Ori-2383Oryza indica41.80.0 671
LLPS-Trv-0138Trichoderma virens41.735e-163 502
LLPS-Coo-0573Colletotrichum orbiculare41.434e-160 495
LLPS-Mao-1435Magnaporthe oryzae41.232e-161 498
LLPS-Osl-0774Ostreococcus lucimarinus41.054e-154 478
LLPS-Beb-1430Beauveria bassiana40.991e-153 478
LLPS-Chc-1176Chondrus crispus40.813e-143 459
LLPS-Kop-0573Komagataella pastoris40.792e-135 428
LLPS-Orb-1976Oryza barthii40.590.0 632
LLPS-Fuv-0167Fusarium verticillioides40.541e-119 384
LLPS-Gas-0466Galdieria sulphuraria39.842e-142 447
LLPS-Yal-0495Yarrowia lipolytica39.841e-138 437
LLPS-Mea-1469Mesocricetus auratus38.084e-131 425
LLPS-Urm-3092Ursus maritimus38.022e-127 414
LLPS-Via-2237Vigna angularis37.363e-126 411
LLPS-Nia-0807Nicotiana attenuata36.535e-120 395
LLPS-Chr-0369Chlamydomonas reinhardtii36.315e-125 409
LLPS-Viv-0132Vitis vinifera36.133e-117 386
LLPS-Ors-1914Oryza sativa34.651e-118 391
LLPS-Cym-0612Cyanidioschyzon merolae34.493e-115 380
LLPS-Hov-1442Hordeum vulgare34.026e-118 389
LLPS-Tru-1706Triticum urartu33.757e-115 381