LLPS-Mal-3549
METTL1
Integrated Annotations
▼ OVERVIEW
| Status: | Unreviewed |
| Protein Name: | tRNA (guanine-N(7)-)-methyltransferase; Methyltransferase-like protein 1; tRNA (guanine(46)-N(7))-methyltransferase; tRNA(m7G46)-methyltransferase |
| Gene Name: | METTL1 |
| Ensembl Gene: | ENSMLEG00000032975.1 |
| Ensembl Protein: | ENSMLEP00000017535.1 |
| Organism: | Mandrillus leucophaeus |
| Taxa ID: | 9568 |
| LLPS Type: | Others |
▼ Classification
Condensates:
| Condensate | Evidence | Orthologs |
|---|---|---|
| Nucleolus, PML nuclear body | Predicted from orthologs | (View) |
▼ FUNCTION
| Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA. |
▼ CROSS REFERENCE
| Database | Nucleotide ID | Protein ID |
|---|---|---|
| Ensembl | ENSMLET00000041013.1 | ENSMLEP00000017535.1 |
| Ensembl | ENSMLET00000041008.1 | ENSMLEP00000017531.1 |
| UniProt | A0A2K5YPQ4, A0A2K5YPQ4_MANLE | |
| RefSeq | XM_011988611.1 | XP_011844001.1 |
▼ SEQUENCE
| Protein Sequence (FASTA) |
|---|
1 MAASLTCASG LCLHVDLVEK PRTGIMAAET WNVAGAEAPP PQKRYYRQRA HSNPMADHTL 60 61 RYPVKPEEMD WSELYPEFFA PLTQNQSHDD PKDKKEKRAQ AQVEFADIGC GYGGLLVELS 120 121 PLFPDTLILG LEIRVKVSDY VQDRIRALRA APGGGFQNIA CLRSNAMKHL PNFFYKGQLT 180 181 KMFFLFPDPH FKRTKHKWRI ISPTLLAEYA YVLRVGGLVY TITDVLELHD WMCTHFEEHP 240 241 LFERVPLEDL SEDPIVGHLG TSTEEGKKVL RNGGKNFPAI FRRIQDPVLQ AVTPQTSLLG 300 301 H 301 |
| Nucleotide CDS Sequence (FASTA) |
1 ATGGCTGCGT CATTAACCTG CGCCTCTGGC CTGTGTCTCC ACGTGGATTT GGTAGAGAAA 60 61 CCCCGGACTG GGATCATGGC AGCCGAGACT TGGAACGTGG CCGGAGCAGA GGCCCCGCCG 120 121 CCCCAGAAGC GCTACTACCG GCAACGTGCT CACTCCAACC CCATGGCGGA CCACACGCTG 180 181 CGCTACCCTG TGAAGCCAGA GGAGATGGAC TGGTCTGAGC TATACCCAGA GTTCTTCGCT 240 241 CCACTCACTC AAAATCAGAG CCACGATGAC CCAAAGGATA AGAAAGAAAA GAGAGCTCAG 300 301 GCCCAAGTGG AGTTTGCAGA CATAGGCTGT GGCTATGGTG GCCTGTTAGT GGAACTGTCA 360 361 CCGCTGTTCC CAGATACACT GATTCTGGGT CTAGAGATCC GGGTGAAGGT CTCAGACTAT 420 421 GTACAAGACC GGATTCGGGC CCTACGCGCA GCTCCCGGAG GTGGCTTCCA GAACATCGCC 480 481 TGTCTCCGCA GCAATGCCAT GAAGCACCTT CCTAACTTCT TCTACAAGGG CCAGCTGACA 540 541 AAGATGTTCT TCCTCTTCCC CGACCCACAT TTCAAGCGGA CAAAGCACAA GTGGCGAATC 600 601 ATCAGTCCCA CCCTGCTAGC AGAATATGCC TACGTGCTGA GAGTTGGGGG ACTGGTATAT 660 661 ACCATAACCG ATGTGCTGGA GCTACACGAC TGGATGTGCA CTCATTTCGA AGAACACCCG 720 721 CTGTTTGAGC GTGTGCCTCT GGAGGACCTG AGTGAAGACC CCATTGTGGG ACATCTAGGC 780 781 ACCTCAACTG AGGAGGGGAA GAAAGTTCTA CGTAATGGAG GGAAGAATTT CCCAGCCATC 840 841 TTCCGAAGAA TACAAGATCC CGTCCTCCAG GCAGTGACCC CCCAAACCAG CCTGCTTGGT 900 901 CACTGA 906 |
▼ KEYWORD
▼ GENE ONTOLOGY
ID | Classification | Description |
Cellular Component | Cytosol | |
Cellular Component | Nucleolus | |
Cellular Component | Nucleoplasm | |
Molecular Function | TRNA (guanine-N7-)-methyltransferase activity | |
Molecular Function | TRNA binding |
▼ ORTHOLOGY
| DrLLPS ID | Organism | Identity | E-value | Score |
|---|---|---|---|---|
| LLPS-Man-3595 | Macaca nemestrina | 99.64 | 0.0 | 574 |
| LLPS-Maf-1208 | Macaca fascicularis | 99.64 | 0.0 | 574 |
| LLPS-Mam-0577 | Macaca mulatta | 99.34 | 0.0 | 623 |
| LLPS-Cea-2001 | Cercocebus atys | 99.28 | 0.0 | 572 |
| LLPS-Gog-2704 | Gorilla gorilla | 99.0 | 0.0 | 620 |
| LLPS-Paa-0808 | Papio anubis | 99.0 | 0.0 | 617 |
| LLPS-Chs-3354 | Chlorocebus sabaeus | 98.91 | 0.0 | 572 |
| LLPS-Rhb-0741 | Rhinopithecus bieti | 98.67 | 0.0 | 617 |
| LLPS-Aon-0656 | Aotus nancymaae | 98.55 | 0.0 | 569 |
| LLPS-Pat-1804 | Pan troglodytes | 98.34 | 0.0 | 615 |
| LLPS-Pap-0543 | Pan paniscus | 98.34 | 0.0 | 615 |
| LLPS-Poa-0271 | Pongo abelii | 98.33 | 0.0 | 615 |
| LLPS-Hos-0501 | Homo sapiens | 98.19 | 0.0 | 566 |
| LLPS-Nol-2201 | Nomascus leucogenys | 97.67 | 0.0 | 612 |
| LLPS-Myl-0724 | Myotis lucifugus | 95.75 | 0.0 | 517 |
| LLPS-Caj-2934 | Callithrix jacchus | 95.68 | 0.0 | 602 |
| LLPS-Dio-2850 | Dipodomys ordii | 95.45 | 0.0 | 527 |
| LLPS-Urm-1460 | Ursus maritimus | 95.06 | 0.0 | 523 |
| LLPS-Caf-2143 | Canis familiaris | 94.42 | 5e-162 | 458 |
| LLPS-Cap-2423 | Cavia porcellus | 93.61 | 0.0 | 521 |
| LLPS-Fud-1157 | Fukomys damarensis | 93.23 | 0.0 | 519 |
| LLPS-Ict-3282 | Ictidomys tridecemlineatus | 93.21 | 0.0 | 516 |
| LLPS-Cas-2715 | Carlito syrichta | 93.14 | 0.0 | 538 |
| LLPS-Eqc-2186 | Equus caballus | 92.91 | 0.0 | 518 |
| LLPS-Fec-2627 | Felis catus | 92.42 | 0.0 | 535 |
| LLPS-Mup-0314 | Mustela putorius furo | 92.42 | 0.0 | 534 |
| LLPS-Otg-0214 | Otolemur garnettii | 92.06 | 0.0 | 534 |
| LLPS-Bot-0431 | Bos taurus | 92.06 | 0.0 | 527 |
| LLPS-Mum-3613 | Mus musculus | 91.73 | 0.0 | 514 |
| LLPS-Ran-2670 | Rattus norvegicus | 91.35 | 0.0 | 509 |
| LLPS-Aim-0741 | Ailuropoda melanoleuca | 90.97 | 0.0 | 533 |
| LLPS-Sus-1090 | Sus scrofa | 90.61 | 0.0 | 520 |
| LLPS-Ova-0239 | Ovis aries | 90.28 | 0.0 | 511 |
| LLPS-Tut-0720 | Tursiops truncatus | 89.44 | 0.0 | 550 |
| LLPS-Orc-2306 | Oryctolagus cuniculus | 89.05 | 0.0 | 524 |
| LLPS-Mod-0614 | Monodelphis domestica | 88.89 | 5e-171 | 482 |
| LLPS-Anc-3046 | Anolis carolinensis | 79.2 | 4e-148 | 424 |
| LLPS-Ora-0582 | Ornithorhynchus anatinus | 77.83 | 9e-126 | 366 |
| LLPS-Pes-0624 | Pelodiscus sinensis | 77.05 | 4e-100 | 301 |
| LLPS-Scf-3970 | Scleropages formosus | 75.51 | 6e-131 | 379 |
| LLPS-Loa-4107 | Loxodonta africana | 75.35 | 5e-146 | 419 |
| LLPS-Gaa-2548 | Gasterosteus aculeatus | 75.2 | 1e-129 | 376 |
| LLPS-Xet-0942 | Xenopus tropicalis | 74.6 | 5e-141 | 407 |
| LLPS-Orl-1593 | Oryzias latipes | 74.39 | 6e-129 | 374 |
| LLPS-Icp-0016 | Ictalurus punctatus | 74.09 | 7e-133 | 384 |
| LLPS-Asm-1566 | Astyanax mexicanus | 74.09 | 3e-132 | 383 |
| LLPS-Orn-1596 | Oreochromis niloticus | 73.98 | 8e-129 | 374 |
| LLPS-Dar-1364 | Danio rerio | 73.68 | 8e-132 | 381 |
| LLPS-Ten-2211 | Tetraodon nigroviridis | 73.09 | 1e-128 | 374 |
| LLPS-Tar-0483 | Takifugu rubripes | 72.36 | 1e-127 | 371 |
| LLPS-Xim-3169 | Xiphophorus maculatus | 71.15 | 1e-127 | 371 |
| LLPS-Pof-0068 | Poecilia formosa | 69.69 | 1e-126 | 369 |
| LLPS-Scm-0750 | Scophthalmus maximus | 63.89 | 1e-119 | 352 |
| LLPS-Cis-1154 | Ciona savignyi | 62.86 | 3e-108 | 322 |
| LLPS-Ors-0458 | Oryza sativa | 62.03 | 3e-27 | 107 |
| LLPS-Usm-0446 | Ustilago maydis | 61.03 | 8e-47 | 167 |
| LLPS-Cii-1235 | Ciona intestinalis | 60.82 | 1e-107 | 321 |
| LLPS-Kop-0228 | Komagataella pastoris | 59.68 | 9e-99 | 300 |
| LLPS-Spr-0025 | Sporisorium reilianum | 59.56 | 9e-49 | 172 |
| LLPS-Cae-1050 | Caenorhabditis elegans | 59.36 | 8e-106 | 316 |
| LLPS-Mel-0679 | Melampsora laricipopulina | 59.26 | 2e-46 | 166 |
| LLPS-Coo-0795 | Colletotrichum orbiculare | 58.95 | 2e-75 | 236 |
| LLPS-Drm-0778 | Drosophila melanogaster | 58.91 | 3e-104 | 312 |
| LLPS-Abg-0861 | Absidia glauca | 58.23 | 2e-94 | 307 |
| LLPS-Pug-0146 | Puccinia graminis | 58.09 | 2e-46 | 166 |
| LLPS-Beb-1168 | Beauveria bassiana | 58.06 | 4e-98 | 297 |
| LLPS-Php-1677 | Physcomitrella patens | 57.79 | 2e-94 | 289 |
| LLPS-Ved-0660 | Verticillium dahliae | 57.54 | 4e-89 | 274 |
| LLPS-Put-0509 | Puccinia triticina | 57.5 | 5e-39 | 148 |
| LLPS-Sac-0962 | Saccharomyces cerevisiae | 57.2 | 1e-98 | 298 |
| LLPS-Yal-0284 | Yarrowia lipolytica | 56.63 | 1e-94 | 288 |
| LLPS-Zyt-0819 | Zymoseptoria tritici | 56.63 | 2e-94 | 287 |
| LLPS-Lem-0766 | Leptosphaeria maculans | 56.2 | 6e-90 | 291 |
| LLPS-Asg-1139 | Ashbya gossypii | 56.03 | 8e-96 | 291 |
| LLPS-Trv-1237 | Trichoderma virens | 55.74 | 5e-83 | 278 |
| LLPS-Cus-0403 | Cucumis sativus | 55.74 | 2e-94 | 286 |
| LLPS-Sei-0715 | Setaria italica | 55.65 | 7e-94 | 286 |
| LLPS-Mua-1580 | Musa acuminata | 55.43 | 2e-97 | 294 |
| LLPS-Zem-0189 | Zea mays | 55.34 | 6e-97 | 293 |
| LLPS-Sob-1176 | Sorghum bicolor | 55.29 | 8e-98 | 295 |
| LLPS-Lac-0381 | Latimeria chalumnae | 55.25 | 6e-77 | 241 |
| LLPS-Trr-0866 | Trichoderma reesei | 55.14 | 9e-83 | 278 |
| LLPS-Pot-0531 | Populus trichocarpa | 54.92 | 4e-92 | 281 |
| LLPS-Fus-0636 | Fusarium solani | 54.89 | 7e-82 | 275 |
| LLPS-Pytr-1400 | Pyrenophora triticirepentis | 54.89 | 5e-65 | 210 |
| LLPS-Pyt-1340 | Pyrenophora teres | 54.89 | 2e-94 | 288 |
| LLPS-Mao-1367 | Magnaporthe oryzae | 54.86 | 4e-96 | 292 |
| LLPS-Orbr-1230 | Oryza brachyantha | 54.84 | 5e-95 | 289 |
| LLPS-Crn-1264 | Cryptococcus neoformans | 54.65 | 2e-97 | 296 |
| LLPS-Fuv-0858 | Fusarium verticillioides | 54.55 | 2e-78 | 244 |
| LLPS-Orp-0260 | Oryza punctata | 54.51 | 8e-93 | 283 |
| LLPS-Org-0012 | Oryza glaberrima | 54.51 | 2e-93 | 284 |
| LLPS-Orr-1955 | Oryza rufipogon | 54.51 | 2e-93 | 284 |
| LLPS-Orni-0704 | Oryza nivara | 54.51 | 3e-93 | 284 |
| LLPS-Ori-1173 | Oryza indica | 54.51 | 2e-93 | 284 |
| LLPS-Orb-1956 | Oryza barthii | 54.51 | 6e-93 | 283 |
| LLPS-Tra-0581 | Triticum aestivum | 54.51 | 3e-92 | 282 |
| LLPS-Orgl-0639 | Oryza glumaepatula | 54.51 | 2e-93 | 284 |
| LLPS-Fuo-0315 | Fusarium oxysporum | 54.44 | 1e-92 | 283 |
| LLPS-Lep-1278 | Leersia perrieri | 54.29 | 3e-93 | 287 |
| LLPS-Cogr-0757 | Colletotrichum graminicola | 54.26 | 1e-93 | 286 |
| LLPS-Hov-1070 | Hordeum vulgare | 54.22 | 1e-92 | 283 |
| LLPS-Coc-0585 | Corchorus capsularis | 53.69 | 4e-92 | 281 |
| LLPS-Sol-0651 | Solanum lycopersicum | 53.69 | 4e-90 | 275 |
| LLPS-Sot-1664 | Solanum tuberosum | 53.69 | 6e-91 | 278 |
| LLPS-Nec-0438 | Neurospora crassa | 53.67 | 2e-93 | 285 |
| LLPS-Cog-0543 | Colletotrichum gloeosporioides | 53.65 | 3e-73 | 232 |
| LLPS-Scp-0469 | Schizosaccharomyces pombe | 53.46 | 3e-88 | 271 |
| LLPS-Viv-0949 | Vitis vinifera | 53.28 | 1e-91 | 279 |
| LLPS-Thc-0982 | Theobroma cacao | 53.28 | 9e-92 | 280 |
| LLPS-Map-0499 | Magnaporthe poae | 53.26 | 5e-91 | 281 |
| LLPS-Brd-0497 | Brachypodium distachyon | 53.23 | 5e-91 | 278 |
| LLPS-Asfu-0024 | Aspergillus fumigatus | 53.04 | 2e-30 | 122 |
| LLPS-Osl-0060 | Ostreococcus lucimarinus | 53.04 | 3e-89 | 274 |
| LLPS-Hea-2567 | Helianthus annuus | 52.91 | 3e-66 | 216 |
| LLPS-Mae-1444 | Manihot esculenta | 52.87 | 8e-92 | 280 |
| LLPS-Prp-1534 | Prunus persica | 52.87 | 2e-90 | 276 |
| LLPS-Dac-1099 | Daucus carota | 52.87 | 2e-90 | 276 |
| LLPS-Met-2240 | Medicago truncatula | 52.87 | 4e-89 | 273 |
| LLPS-Phv-1475 | Phaseolus vulgaris | 52.46 | 9e-92 | 280 |
| LLPS-Vir-1205 | Vigna radiata | 52.46 | 2e-92 | 281 |
| LLPS-Via-1775 | Vigna angularis | 52.46 | 2e-91 | 279 |
| LLPS-Tum-1445 | Tuber melanosporum | 52.42 | 2e-83 | 260 |
| LLPS-Blg-0393 | Blumeria graminis | 52.4 | 6e-95 | 289 |
| LLPS-Scj-1249 | Schizosaccharomyces japonicus | 52.31 | 2e-86 | 267 |
| LLPS-Gor-2186 | Gossypium raimondii | 52.24 | 1e-88 | 272 |
| LLPS-Art-0451 | Arabidopsis thaliana | 52.24 | 3e-89 | 273 |
| LLPS-Arl-2546 | Arabidopsis lyrata | 52.24 | 2e-89 | 274 |
| LLPS-Asni-1091 | Aspergillus niger | 52.09 | 9e-74 | 235 |
| LLPS-Nia-2075 | Nicotiana attenuata | 52.05 | 3e-89 | 273 |
| LLPS-Gag-1201 | Gaeumannomyces graminis | 51.96 | 2e-92 | 283 |
| LLPS-Sem-2075 | Selaginella moellendorffii | 51.95 | 5e-89 | 273 |
| LLPS-Scc-1345 | Schizosaccharomyces cryophilus | 51.72 | 2e-86 | 267 |
| LLPS-Glm-2282 | Glycine max | 51.64 | 1e-90 | 277 |
| LLPS-Phn-0484 | Phaeosphaeria nodorum | 51.5 | 1e-84 | 263 |
| LLPS-Bro-0864 | Brassica oleracea | 51.34 | 2e-84 | 276 |
| LLPS-Miv-0420 | Microbotryum violaceum | 51.11 | 4e-32 | 127 |
| LLPS-Orm-1204 | Oryza meridionalis | 51.0 | 2e-87 | 273 |
| LLPS-Scs-1068 | Sclerotinia sclerotiorum | 50.99 | 2e-85 | 265 |
| LLPS-Chr-0400 | Chlamydomonas reinhardtii | 50.94 | 7e-86 | 266 |
| LLPS-Brn-0608 | Brassica napus | 50.57 | 7e-92 | 281 |
| LLPS-Amt-1908 | Amborella trichopoda | 50.21 | 9e-83 | 257 |
| LLPS-Brr-2353 | Brassica rapa | 50.0 | 1e-90 | 277 |
| LLPS-Dos-1216 | Dothistroma septosporum | 50.0 | 3e-86 | 267 |
| LLPS-Chc-0301 | Chondrus crispus | 48.92 | 4e-56 | 186 |
| LLPS-Asf-1109 | Aspergillus flavus | 46.37 | 2e-84 | 263 |
| LLPS-Aso-0866 | Aspergillus oryzae | 46.37 | 2e-84 | 263 |
| LLPS-Asc-0830 | Aspergillus clavatus | 44.84 | 4e-78 | 248 |
| LLPS-Ast-0037 | Aspergillus terreus | 44.79 | 2e-82 | 259 |
| LLPS-Asn-1148 | Aspergillus nidulans | 41.57 | 2e-79 | 252 |
| LLPS-Nef-1120 | Neosartorya fischeri | 39.58 | 1e-59 | 201 |
| LLPS-Gas-0867 | Galdieria sulphuraria | 39.48 | 6e-51 | 174 |
| LLPS-Cym-0577 | Cyanidioschyzon merolae | 34.57 | 4e-42 | 152 |