LLPS-Asfu-0024
trm8
Integrated Annotations
▼ OVERVIEW
| Status: | Unreviewed |
| Protein Name: | tRNA (guanine-N(7)-)-methyltransferase; Transfer RNA methyltransferase 8; tRNA (guanine(46)-N(7))-methyltransferase; tRNA(m7G46)-methyltransferase |
| Gene Name: | trm8, AFUA_4G12280 |
| Ensembl Gene: | AFUA_4G12280 |
| Ensembl Protein: | EAL89565 |
| Organism: | Aspergillus fumigatus |
| Taxa ID: | 330879 |
| LLPS Type: | Others |
▼ Classification
Condensates:
| Condensate | Evidence | Orthologs |
|---|---|---|
| Nucleolus, Others | Predicted from orthologs | (View) |
▼ FUNCTION
| Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA. |
▼ CROSS REFERENCE
| Database | Nucleotide ID | Protein ID |
|---|---|---|
| Ensembl | EAL89565 | EAL89565 |
| UniProt | Q4WQB9, TRMB_ASPFU | |
| GeneBank | AAHF01000005 | EAL89565.1 |
| RefSeq | XM_746510.1 | XP_751603.1 |
▼ SEQUENCE
| Protein Sequence (FASTA) |
|---|
1 MTPPPPKRQK RDEYRKATAE ATSQSGASDV AEIKLPKKKY YRQRAHANPF SDHHLKYPLS 60 61 PAHMDWSSHY PAFVNPDPSH INLAGARRLL KDVEVVDIGC GFGGLLIGLA PLLPESLIVG 120 121 MEIRVSVLEY VTTRIQALRA QQQKLRAATA TATAASETPS QQQAQIDGKQ ANANAAADAA 180 181 SPAPSTDTEH MPTTLVPGSY ENISAIRSNT MKFFPNFFAR HQLSKIFICF PDPHFKARKH 240 241 KARIISETLN AEYAYALRPG GLLYTITDVE EYHHWILRHF GVELGAEEES EEKSTSPNAN 300 301 ANAGVRELFE RVSEEELEKD ECVRVMKEAT EEGKKVARNK GNKYVAVFRR KTDPEWPA 358 |
| Nucleotide CDS Sequence (FASTA) |
1 ATGACACCAC CCCCGCCCAA ACGCCAAAAG CGGGACGAAT ACCGCAAAGC AACAGCAGAG 60 61 GCCACCTCAC AATCCGGCGC CAGCGACGTC GCGGAGATCA AGCTGCCCAA GAAGAAGTAC 120 121 TATCGCCAGC GGGCGCACGC AAACCCCTTC TCGGACCACC ATCTGAAATA CCCCCTCAGC 180 181 CCGGCGCACA TGGACTGGTC ATCGCATTAT CCTGCTTTTG TGAATCCGGA CCCGTCGCAT 240 241 ATCAATCTCG CCGGGGCCCG GAGGCTCCTG AAGGATGTGG AGGTCGTGGA TATCGGGTGT 300 301 GGTTTTGGCG GGTTACTCAT TGGGCTTGCG CCTCTGCTGC CGGAGTCGCT GATAGTCGGC 360 361 ATGGAGATCC GCGTCTCGGT CCTCGAATAC GTGACGACGC GCATCCAAGC CCTCCGGGCC 420 421 CAGCAGCAGA AGCTCAGGGC TGCCACTGCA ACCGCGACAG CAGCGTCGGA AACTCCGTCT 480 481 CAGCAGCAAG CTCAGATAGA CGGGAAACAA GCAAACGCAA ACGCAGCTGC AGATGCAGCG 540 541 TCACCCGCCC CCTCCACCGA CACCGAGCAC ATGCCTACCA CTCTCGTCCC GGGCTCCTAT 600 601 GAAAACATCT CCGCAATCCG CAGCAATACC ATGAAATTCT TCCCTAATTT CTTCGCCCGA 660 661 CACCAGCTTT CCAAGATTTT CATTTGCTTC CCGGACCCGC ACTTCAAGGC CCGCAAGCAC 720 721 AAGGCCCGGA TTATCTCCGA GACGCTCAAT GCTGAGTACG CCTACGCTCT GCGGCCCGGT 780 781 GGGCTCTTGT ATACCATTAC CGATGTGGAA GAGTATCATC ATTGGATTCT GAGGCATTTT 840 841 GGGGTGGAGT TGGGAGCCGA GGAGGAGAGT GAGGAGAAGA GCACCAGTCC GAATGCGAAT 900 901 GCGAATGCTG GGGTGAGGGA ACTCTTTGAG CGGGTTTCGG AGGAGGAGCT GGAGAAGGAC 960 961 GAGTGTGTGC GGGTTATGAA GGAGGCCACC GAGGAAGGGA AGAAGGTGGC TCGGAATAAG 1020 1021 GGGAACAAGT ACGTGGCTGT CTTTCGGCGA AAGACGGATC CTGAATGGCC TGCATGA 1077 |
▼ KEYWORD
▼ GENE ONTOLOGY
ID | Classification | Description |
Cellular Component | Nucleus | |
Molecular Function | TRNA (guanine-N7-)-methyltransferase activity | |
Molecular Function | TRNA binding | |
Biological Process | RNA (guanine-N7)-methylation | |
Biological Process | TRNA methylation |
▼ ORTHOLOGY
| DrLLPS ID | Organism | Identity | E-value | Score |
|---|---|---|---|---|
| LLPS-Nef-1120 | Neosartorya fischeri | 92.78 | 1e-170 | 487 |
| LLPS-Asni-1091 | Aspergillus niger | 79.63 | 2e-74 | 239 |
| LLPS-Asc-0830 | Aspergillus clavatus | 75.14 | 9e-148 | 428 |
| LLPS-Asn-1148 | Aspergillus nidulans | 73.26 | 6e-77 | 247 |
| LLPS-Pytr-1400 | Pyrenophora triticirepentis | 69.49 | 2e-22 | 98.2 |
| LLPS-Ast-0037 | Aspergillus terreus | 67.51 | 5e-131 | 386 |
| LLPS-Pes-0624 | Pelodiscus sinensis | 66.67 | 5e-31 | 123 |
| LLPS-Aso-0866 | Aspergillus oryzae | 65.08 | 3e-131 | 386 |
| LLPS-Asf-1109 | Aspergillus flavus | 65.08 | 3e-131 | 386 |
| LLPS-Put-0509 | Puccinia triticina | 64.29 | 1e-31 | 128 |
| LLPS-Trv-1237 | Trichoderma virens | 62.14 | 9e-23 | 104 |
| LLPS-Hea-2567 | Helianthus annuus | 61.33 | 3e-26 | 110 |
| LLPS-Fuo-0315 | Fusarium oxysporum | 60.38 | 6e-21 | 94.7 |
| LLPS-Cogr-0757 | Colletotrichum graminicola | 60.38 | 2e-52 | 181 |
| LLPS-Phn-0484 | Phaeosphaeria nodorum | 60.0 | 2e-17 | 84.7 |
| LLPS-Coo-0795 | Colletotrichum orbiculare | 58.49 | 4e-52 | 178 |
| LLPS-Trr-0866 | Trichoderma reesei | 58.0 | 1e-43 | 167 |
| LLPS-Fuv-0858 | Fusarium verticillioides | 57.96 | 9e-51 | 175 |
| LLPS-Scs-1068 | Sclerotinia sclerotiorum | 57.86 | 5e-50 | 175 |
| LLPS-Cog-0543 | Colletotrichum gloeosporioides | 57.23 | 2e-56 | 190 |
| LLPS-Asg-1139 | Ashbya gossypii | 57.14 | 2e-22 | 99.4 |
| LLPS-Beb-1168 | Beauveria bassiana | 56.88 | 2e-51 | 178 |
| LLPS-Lem-0766 | Leptosphaeria maculans | 56.33 | 2e-48 | 179 |
| LLPS-Ved-0660 | Verticillium dahliae | 56.05 | 2e-52 | 181 |
| LLPS-Fus-0636 | Fusarium solani | 55.94 | 5e-43 | 166 |
| LLPS-Zyt-0819 | Zymoseptoria tritici | 55.62 | 4e-48 | 169 |
| LLPS-Scf-3970 | Scleropages formosus | 55.19 | 3e-38 | 142 |
| LLPS-Cis-1154 | Ciona savignyi | 55.14 | 1e-22 | 99.8 |
| LLPS-Cii-1235 | Ciona intestinalis | 55.05 | 3e-22 | 98.6 |
| LLPS-Pyt-1340 | Pyrenophora teres | 54.72 | 2e-46 | 166 |
| LLPS-Mao-1367 | Magnaporthe oryzae | 54.66 | 2e-47 | 168 |
| LLPS-Gag-1201 | Gaeumannomyces graminis | 54.43 | 4e-48 | 170 |
| LLPS-Yal-0284 | Yarrowia lipolytica | 53.91 | 1e-21 | 97.4 |
| LLPS-Map-0499 | Magnaporthe poae | 53.8 | 3e-46 | 166 |
| LLPS-Xet-0942 | Xenopus tropicalis | 53.59 | 1e-36 | 139 |
| LLPS-Orl-1593 | Oryzias latipes | 53.5 | 5e-38 | 142 |
| LLPS-Arl-2546 | Arabidopsis lyrata | 53.47 | 6e-17 | 83.2 |
| LLPS-Art-0451 | Arabidopsis thaliana | 53.47 | 2e-17 | 84.7 |
| LLPS-Aim-0741 | Ailuropoda melanoleuca | 53.33 | 1e-16 | 82.8 |
| LLPS-Urm-1460 | Ursus maritimus | 53.33 | 1e-16 | 82.8 |
| LLPS-Scm-0750 | Scophthalmus maximus | 53.25 | 6e-38 | 143 |
| LLPS-Gaa-2548 | Gasterosteus aculeatus | 52.87 | 1e-37 | 141 |
| LLPS-Icp-0016 | Ictalurus punctatus | 52.53 | 2e-38 | 143 |
| LLPS-Scj-1249 | Schizosaccharomyces japonicus | 52.5 | 6e-44 | 159 |
| LLPS-Sot-1664 | Solanum tuberosum | 52.48 | 7e-15 | 77.4 |
| LLPS-Gor-2186 | Gossypium raimondii | 52.48 | 2e-15 | 79.0 |
| LLPS-Nia-2075 | Nicotiana attenuata | 52.48 | 1e-14 | 76.3 |
| LLPS-Coc-0585 | Corchorus capsularis | 52.48 | 5e-16 | 80.5 |
| LLPS-Myl-0724 | Myotis lucifugus | 52.43 | 4e-15 | 78.2 |
| LLPS-Cap-2423 | Cavia porcellus | 52.38 | 4e-17 | 84.0 |
| LLPS-Usm-0446 | Ustilago maydis | 52.38 | 3e-16 | 83.2 |
| LLPS-Paa-0808 | Papio anubis | 52.29 | 2e-16 | 82.8 |
| LLPS-Orn-1596 | Oreochromis niloticus | 52.23 | 5e-39 | 144 |
| LLPS-Dar-1364 | Danio rerio | 52.2 | 1e-38 | 143 |
| LLPS-Nec-0438 | Neurospora crassa | 51.9 | 1e-46 | 166 |
| LLPS-Otg-0214 | Otolemur garnettii | 51.9 | 3e-35 | 135 |
| LLPS-Abg-0861 | Absidia glauca | 51.89 | 2e-17 | 87.4 |
| LLPS-Eqc-2186 | Equus caballus | 51.85 | 2e-17 | 85.1 |
| LLPS-Maf-1208 | Macaca fascicularis | 51.82 | 1e-16 | 82.4 |
| LLPS-Chs-3354 | Chlorocebus sabaeus | 51.82 | 2e-16 | 82.4 |
| LLPS-Cea-2001 | Cercocebus atys | 51.82 | 1e-16 | 82.4 |
| LLPS-Gog-2704 | Gorilla gorilla | 51.82 | 2e-16 | 82.4 |
| LLPS-Dio-2850 | Dipodomys ordii | 51.82 | 3e-16 | 81.3 |
| LLPS-Mal-3549 | Mandrillus leucophaeus | 51.82 | 2e-16 | 82.4 |
| LLPS-Hos-0501 | Homo sapiens | 51.82 | 1e-16 | 82.8 |
| LLPS-Pat-1804 | Pan troglodytes | 51.82 | 2e-16 | 82.4 |
| LLPS-Pap-0543 | Pan paniscus | 51.82 | 2e-16 | 82.4 |
| LLPS-Man-3595 | Macaca nemestrina | 51.82 | 1e-16 | 82.4 |
| LLPS-Rhb-0741 | Rhinopithecus bieti | 51.82 | 2e-16 | 82.0 |
| LLPS-Chc-0301 | Chondrus crispus | 51.76 | 8e-24 | 101 |
| LLPS-Blg-0393 | Blumeria graminis | 51.59 | 3e-46 | 165 |
| LLPS-Sol-0651 | Solanum lycopersicum | 51.49 | 9e-15 | 77.0 |
| LLPS-Thc-0982 | Theobroma cacao | 51.49 | 2e-15 | 79.0 |
| LLPS-Dac-1099 | Daucus carota | 51.49 | 1e-14 | 76.3 |
| LLPS-Via-1775 | Vigna angularis | 51.49 | 2e-14 | 76.3 |
| LLPS-Met-2240 | Medicago truncatula | 51.49 | 9e-15 | 77.0 |
| LLPS-Cus-0403 | Cucumis sativus | 51.49 | 7e-14 | 74.3 |
| LLPS-Mae-1444 | Manihot esculenta | 51.49 | 5e-17 | 83.2 |
| LLPS-Bro-0864 | Brassica oleracea | 51.49 | 5e-15 | 80.5 |
| LLPS-Mel-0679 | Melampsora laricipopulina | 51.4 | 7e-15 | 79.0 |
| LLPS-Poa-0271 | Pongo abelii | 51.33 | 5e-17 | 84.3 |
| LLPS-Orc-2306 | Oryctolagus cuniculus | 51.27 | 8e-35 | 135 |
| LLPS-Ict-3282 | Ictidomys tridecemlineatus | 51.27 | 7e-36 | 137 |
| LLPS-Sus-1090 | Sus scrofa | 50.91 | 3e-16 | 81.6 |
| LLPS-Nol-2201 | Nomascus leucogenys | 50.82 | 1e-17 | 85.9 |
| LLPS-Tum-1445 | Tuber melanosporum | 50.63 | 2e-45 | 163 |
| LLPS-Ova-0239 | Ovis aries | 50.63 | 5e-34 | 132 |
| LLPS-Cas-2715 | Carlito syrichta | 50.63 | 6e-34 | 132 |
| LLPS-Bot-0431 | Bos taurus | 50.62 | 6e-35 | 134 |
| LLPS-Loa-4107 | Loxodonta africana | 50.62 | 3e-35 | 135 |
| LLPS-Gas-0867 | Galdieria sulphuraria | 50.6 | 2e-22 | 98.6 |
| LLPS-Vir-1205 | Vigna radiata | 50.5 | 5e-14 | 74.7 |
| LLPS-Pot-0531 | Populus trichocarpa | 50.5 | 5e-16 | 80.5 |
| LLPS-Aon-0656 | Aotus nancymaae | 50.44 | 6e-16 | 80.5 |
| LLPS-Mum-3613 | Mus musculus | 50.43 | 9e-16 | 80.1 |
| LLPS-Ran-2670 | Rattus norvegicus | 50.43 | 1e-15 | 80.1 |
| LLPS-Mup-0314 | Mustela putorius furo | 50.32 | 9e-34 | 131 |
| LLPS-Fec-2627 | Felis catus | 50.32 | 9e-34 | 131 |
| LLPS-Fud-1157 | Fukomys damarensis | 50.31 | 1e-35 | 136 |
| LLPS-Kop-0228 | Komagataella pastoris | 50.0 | 5e-40 | 149 |
| LLPS-Xim-3169 | Xiphophorus maculatus | 50.0 | 2e-14 | 76.3 |
| LLPS-Scp-0469 | Schizosaccharomyces pombe | 50.0 | 2e-41 | 152 |
| LLPS-Tut-0720 | Tursiops truncatus | 50.0 | 8e-34 | 132 |
| LLPS-Pof-0068 | Poecilia formosa | 50.0 | 3e-14 | 75.5 |
| LLPS-Viv-0949 | Vitis vinifera | 50.0 | 2e-14 | 75.9 |
| LLPS-Lac-0381 | Latimeria chalumnae | 50.0 | 1e-24 | 105 |
| LLPS-Miv-0420 | Microbotryum violaceum | 49.68 | 6e-36 | 140 |
| LLPS-Ten-2211 | Tetraodon nigroviridis | 49.53 | 2e-16 | 81.6 |
| LLPS-Glm-2282 | Glycine max | 49.5 | 4e-15 | 78.2 |
| LLPS-Brn-0608 | Brassica napus | 49.5 | 6e-15 | 77.8 |
| LLPS-Brr-2353 | Brassica rapa | 49.5 | 3e-15 | 78.2 |
| LLPS-Prp-1534 | Prunus persica | 49.5 | 4e-14 | 75.1 |
| LLPS-Sac-0962 | Saccharomyces cerevisiae | 49.23 | 7e-21 | 94.7 |
| LLPS-Mua-1580 | Musa acuminata | 49.15 | 3e-14 | 75.9 |
| LLPS-Mod-0614 | Monodelphis domestica | 49.07 | 2e-15 | 79.0 |
| LLPS-Caf-2143 | Canis familiaris | 49.07 | 3e-33 | 129 |
| LLPS-Scc-1345 | Schizosaccharomyces cryophilus | 49.06 | 1e-37 | 142 |
| LLPS-Anc-3046 | Anolis carolinensis | 49.06 | 1e-13 | 73.6 |
| LLPS-Ora-0582 | Ornithorhynchus anatinus | 49.02 | 2e-32 | 127 |
| LLPS-Sei-0715 | Setaria italica | 49.02 | 6e-11 | 66.2 |
| LLPS-Asm-1566 | Astyanax mexicanus | 48.54 | 1e-15 | 79.3 |
| LLPS-Lep-1278 | Leersia perrieri | 48.51 | 8e-12 | 69.7 |
| LLPS-Pug-0146 | Puccinia graminis | 48.43 | 2e-40 | 152 |
| LLPS-Mam-0577 | Macaca mulatta | 48.41 | 2e-16 | 82.4 |
| LLPS-Tar-0483 | Takifugu rubripes | 48.34 | 6e-36 | 136 |
| LLPS-Sob-1176 | Sorghum bicolor | 48.04 | 1e-12 | 70.9 |
| LLPS-Zem-0189 | Zea mays | 48.04 | 1e-12 | 70.9 |
| LLPS-Sem-2075 | Selaginella moellendorffii | 48.0 | 2e-13 | 73.6 |
| LLPS-Cae-1050 | Caenorhabditis elegans | 47.52 | 2e-14 | 76.3 |
| LLPS-Phv-1475 | Phaseolus vulgaris | 47.52 | 3e-13 | 72.4 |
| LLPS-Caj-2934 | Callithrix jacchus | 47.13 | 7e-34 | 132 |
| LLPS-Orp-0260 | Oryza punctata | 47.06 | 7e-12 | 68.9 |
| LLPS-Orbr-1230 | Oryza brachyantha | 46.53 | 6e-12 | 69.3 |
| LLPS-Amt-1908 | Amborella trichopoda | 46.53 | 3e-11 | 66.6 |
| LLPS-Orb-1956 | Oryza barthii | 46.08 | 6e-12 | 69.3 |
| LLPS-Ori-1173 | Oryza indica | 46.08 | 4e-12 | 69.3 |
| LLPS-Orgl-0639 | Oryza glumaepatula | 46.08 | 4e-12 | 69.3 |
| LLPS-Orr-1955 | Oryza rufipogon | 46.08 | 4e-12 | 69.3 |
| LLPS-Org-0012 | Oryza glaberrima | 46.08 | 4e-12 | 69.3 |
| LLPS-Orni-0704 | Oryza nivara | 45.1 | 1e-11 | 67.8 |
| LLPS-Chr-0400 | Chlamydomonas reinhardtii | 44.94 | 2e-27 | 114 |
| LLPS-Php-1677 | Physcomitrella patens | 44.81 | 4e-33 | 130 |
| LLPS-Brd-0497 | Brachypodium distachyon | 44.76 | 2e-10 | 64.7 |
| LLPS-Orm-1204 | Oryza meridionalis | 44.35 | 3e-12 | 71.2 |
| LLPS-Spr-0025 | Sporisorium reilianum | 44.25 | 5e-63 | 211 |
| LLPS-Tra-2729 | Triticum aestivum | 44.16 | 5e-31 | 124 |
| LLPS-Crn-1264 | Cryptococcus neoformans | 43.64 | 1e-63 | 211 |
| LLPS-Hov-1070 | Hordeum vulgare | 43.09 | 5e-13 | 72.4 |
| LLPS-Osl-0060 | Ostreococcus lucimarinus | 42.41 | 4e-31 | 124 |
| LLPS-Dos-1216 | Dothistroma septosporum | 40.69 | 4e-71 | 230 |
| LLPS-Drm-0778 | Drosophila melanogaster | 33.33 | 6e-34 | 131 |
| LLPS-Cym-0577 | Cyanidioschyzon merolae | 31.06 | 4e-17 | 84.0 |