• Disorder
  • Domain
  • PTM
  • Variation
  • Mutation
  • Interaction
  • Disease
  • Drug
  • Physicochemical
  • Function
  • Proteomics
  • Structure
  • Localization
  • Expression
  • Element
  • Methylation

LLPS-Maf-2677
EGM_02484

Integrated Annotations

▼ OVERVIEW


Status: Unreviewed
Protein Name: DNA topoisomerase
Gene Name: EGM_02484
Ensembl Gene: ENSMFAG00000036588.1
Ensembl Protein: ENSMFAP00000007177.1
Organism: Macaca fascicularis
Taxa ID: 9541
LLPS Type: LLPS regulator


▼ PROPERTY



——— Disorder propensity (calculated by IUPred2A)

▼ Classification


Condensates:
CondensateEvidenceOrthologs
P-body, Stress granule, Chromatoid bodyPredicted from orthologs(View)

▼ FUNCTION


Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand.

▼ CROSS REFERENCE


DatabaseNucleotide IDProtein ID
EnsemblENSMFAT00000025866.1ENSMFAP00000007177.1
UniProtG7PHB7, G7PHB7_MACFA
GeneBankCM001285EHH65673.1

▼ SEQUENCE


Protein Sequence (FASTA)
1     MKTVLMVAEK  PSLAQSIAKI  LSRGSLSSHK  GLNGACSVHE  YTGTFAGQPV  RFKMTSVCGH  60
61    VMTLDFLGKY  NKWDKVDPAE  LFSQAPTEKK  EANPKLNMVK  FLQVEGRGCD  YIVLWLDCDK  120
121   EGENICFEVL  DAVLPVMNKA  YGGEKTVFRA  RFSSITDTDI  CNAMACLGEP  DHNEALSVDA  180
181   RQELDLRIGC  AFTRFQTKYF  QGKYGDLDSS  LISFGPCQTP  TLGFCVERHD  KIQSFKPETY  240
241   WVLQAKVNTD  KDRCLLLDWD  RVRVFDREIA  QMFLNMTKLE  KEAQVEATSR  KEKAKQRPLA  300
301   LNTVEMLRVA  SSSLGMGPQH  AMQTAERLYT  QGYISYPRTE  TTHYPENFDL  KGSLRQQANH  360
361   PYWADTVKRL  LAEGINRPRK  GHDAGDHPPI  TPMKSATEAE  LGGDAWRLYE  YITRHFIATV  420
421   SHDCKYLQST  ISFRIGPELF  TCSGKTVLSP  GFTEIMPWQS  VPLEESLPTC  QRGDTFPVGE  480
481   VKMLEKQTSP  PDYLTEAELI  TLMEKHGIGT  DASIPVHINN  ICQRNYVSVE  SGRRLKPTNL  540
541   GIVLVHGYYK  IDAELVLPTI  RSAVEKQLNL  IAQGKADYRQ  VLGHTLDVFK  RKFHYFVDSI  600
601   AGMDELMEVS  FSPLAATGKP  LSRCGKCHRF  MKYIQAKPSR  LHCSHCDETY  TLPQNGTIKL  660
661   YKELRCPLDD  FELVLWSSGS  RGKSYPLCPY  CYNHPPFRDM  KKGMGCNECT  HPSCQHSLSM  720
721   LGIGQCVECE  SGVLVLDPTS  GPKWKVACNK  CSVVAHCFEN  AHRVRVSTDT  CSVCEAALLD  780
781   VDFNKAKSPL  PGDETQHMGC  VFCDPVFQEL  VELKHAASCH  PMHRGGPGRR  QGRGRGRARR  840
841   PPGKPNPRRP  KDKMSALAAY  FV  862
Nucleotide CDS Sequence (FASTA)
1     ATGAAGACTG  TGCTCATGGT  TGCCGAAAAG  CCGTCCTTGG  CACAGTCAAT  TGCCAAAATC  60
61    CTCTCTAGAG  GGAGCCTGTC  CTCACATAAA  GGGCTGAACG  GGGCCTGTTC  AGTCCACGAG  120
121   TACACTGGGA  CCTTTGCTGG  CCAGCCAGTG  CGCTTCAAGA  TGACGTCTGT  CTGTGGTCAC  180
181   GTGATGACTC  TGGATTTCCT  GGGAAAATAC  AACAAATGGG  ACAAAGTGGA  CCCCGCAGAA  240
241   CTGTTCAGCC  AAGCTCCCAC  GGAGAAGAAG  GAAGCTAACC  CCAAGCTGAA  CATGGTGAAG  300
301   TTCCTGCAGG  TGGAGGGCAG  AGGCTGCGAC  TACATCGTGC  TGTGGCTGGA  CTGCGACAAG  360
361   GAGGGGGAGA  ACATCTGCTT  TGAGGTTCTT  GATGCTGTTC  TGCCCGTCAT  GAACAAGGCC  420
421   TATGGTGGTG  AGAAGACCGT  GTTCCGGGCC  AGGTTTAGCT  CCATCACAGA  CACAGACATC  480
481   TGTAATGCCA  TGGCCTGCCT  GGGCGAGCCT  GACCACAACG  AGGCGCTCTC  AGTGGATGCT  540
541   CGCCAGGAAC  TGGACCTGCG  AATCGGCTGT  GCATTCACCA  GGTTTCAGAC  TAAATATTTC  600
601   CAGGGGAAAT  ACGGTGATTT  AGACAGCTCT  CTCATCTCCT  TTGGGCCGTG  TCAGACTCCA  660
661   ACCCTGGGAT  TCTGTGTGGA  GAGACATGAT  AAAATCCAGT  CCTTCAAACC  AGAGACCTAC  720
721   TGGGTGCTGC  AGGCCAAGGT  TAACACTGAC  AAAGACAGAT  GTCTCCTTTT  GGACTGGGAC  780
781   CGAGTAAGAG  TGTTTGACCG  GGAGATTGCA  CAGATGTTTC  TAAACATGAC  AAAGCTGGAG  840
841   AAGGAAGCCC  AGGTGGAGGC  CACAAGCAGG  AAAGAAAAGG  CCAAGCAGAG  GCCCCTGGCC  900
901   CTGAACACCG  TGGAGATGCT  GCGTGTGGCC  AGCTCTTCTC  TGGGCATGGG  GCCGCAGCAC  960
961   GCCATGCAGA  CGGCCGAGCG  GCTCTACACG  CAAGGCTACA  TCAGCTACCC  ACGGACAGAG  1020
1021  ACCACCCACT  ACCCTGAGAA  CTTTGACCTG  AAGGGCTCTC  TGCGGCAGCA  GGCCAACCAC  1080
1081  CCCTACTGGG  CCGACACGGT  GAAGCGGTTG  TTAGCAGAAG  GTATCAACCG  CCCGAGGAAA  1140
1141  GGCCACGACG  CTGGCGACCA  TCCCCCCATC  ACCCCCATGA  AGTCTGCCAC  AGAGGCCGAA  1200
1201  TTAGGGGGTG  ACGCGTGGCG  GCTCTATGAG  TACATCACCA  GACACTTCAT  CGCCACGGTC  1260
1261  AGCCATGACT  GCAAGTACCT  GCAGAGCACC  ATCTCCTTCA  GGATCGGGCC  CGAGCTCTTC  1320
1321  ACCTGCTCTG  GGAAGACTGT  CCTCTCCCCA  GGCTTCACGG  AGATCATGCC  CTGGCAGAGC  1380
1381  GTGCCCTTGG  AGGAGAGCCT  GCCCACTTGC  CAGCGGGGTG  ACACCTTCCC  TGTGGGCGAG  1440
1441  GTGAAGATGC  TGGAGAAGCA  GACGAGCCCG  CCCGACTACC  TGACAGAGGC  TGAGCTCATC  1500
1501  ACGCTCATGG  AGAAGCATGG  CATCGGCACA  GATGCCAGCA  TCCCTGTGCA  TATCAACAAC  1560
1561  ATCTGCCAGC  GCAACTACGT  CTCCGTGGAG  AGCGGGCGCC  GGCTCAAGCC  CACCAACCTC  1620
1621  GGCATCGTCC  TGGTGCACGG  CTACTACAAG  ATTGATGCAG  AGCTGGTGCT  CCCCACCATC  1680
1681  CGCAGTGCAG  TGGAGAAGCA  GCTGAACCTG  ATCGCCCAGG  GCAAGGCCGA  CTACCGCCAG  1740
1741  GTCCTGGGCC  ACACCCTGGA  CGTGTTCAAG  AGGAAGTTCC  ACTACTTTGT  CGACTCCATT  1800
1801  GCCGGCATGG  ATGAGTTAAT  GGAGGTGTCT  TTCTCGCCGC  TGGCGGCCAC  AGGCAAGCCC  1860
1861  CTCTCACGCT  GTGGGAAGTG  CCACCGCTTC  ATGAAGTACA  TCCAGGCCAA  GCCAAGCCGC  1920
1921  CTGCACTGCT  CGCACTGCGA  TGAGACCTAC  ACACTGCCCC  AGAACGGCAC  CATCAAGCTC  1980
1981  TACAAGGAGC  TCCGCTGCCC  TCTGGATGAC  TTCGAGCTGG  TCCTGTGGTC  ATCAGGCTCT  2040
2041  CGGGGCAAGA  GCTACCCACT  GTGCCCCTAC  TGCTACAACC  ACCCACCCTT  CCGAGACATG  2100
2101  AAGAAAGGCA  TGGGCTGCAA  CGAGTGTACG  CACCCCTCCT  GCCAGCACTC  GCTGAGCATG  2160
2161  TTGGGCATCG  GCCAGTGCGT  GGAATGCGAG  AGCGGCGTGC  TGGTGCTGGA  CCCCACCTCG  2220
2221  GGCCCCAAGT  GGAAGGTGGC  CTGCAACAAG  TGCAGCGTGG  TAGCGCACTG  CTTCGAGAAC  2280
2281  GCCCACCGCG  TGCGGGTGTC  CACCGACACC  TGCAGTGTCT  GTGAGGCCGC  CTTGCTTGAC  2340
2341  GTGGACTTCA  ACAAGGCCAA  GTCCCCACTC  CCGGGCGACG  AGACGCAGCA  CATGGGCTGT  2400
2401  GTCTTCTGTG  ACCCCGTCTT  CCAGGAGCTG  GTGGAGCTGA  AGCATGCGGC  CTCCTGCCAC  2460
2461  CCCATGCACC  GCGGCGGGCC  AGGGAGAAGG  CAGGGTCGAG  GGCGGGGCCG  GGCCAGGAGG  2520
2521  CCCCCTGGGA  AGCCCAACCC  CAGACGGCCC  AAGGACAAGA  TGTCAGCCCT  GGCCGCCTAC  2580
2581  TTCGTATGA  2589

▼ KEYWORD


ID
Family
Complete proteome
DNA-binding
Isomerase
Reference proteome
Topoisomerase

▼ GENE ONTOLOGY


ID
Classification
Description
Molecular Function
DNA binding
Molecular Function
DNA topoisomerase type I activity
Biological Process
DNA topological change

▼ ORTHOLOGY


DrLLPS IDOrganismIdentityE-valueScore
LLPS-Mam-0785Macaca mulatta99.880.01738
LLPS-Man-2046Macaca nemestrina99.770.01736
LLPS-Cea-4715Cercocebus atys99.650.01734
LLPS-Paa-2087Papio anubis99.650.01734
LLPS-Mal-2062Mandrillus leucophaeus99.650.01734
LLPS-Rhb-3920Rhinopithecus bieti99.420.01732
LLPS-Chs-2016Chlorocebus sabaeus99.420.01731
LLPS-Poa-0172Pongo abelii99.190.01728
LLPS-Hos-1197Homo sapiens99.070.01728
LLPS-Gog-0071Gorilla gorilla99.070.01728
LLPS-Pap-2173Pan paniscus98.960.01726
LLPS-Pat-2402Pan troglodytes98.960.01727
LLPS-Caj-0658Callithrix jacchus98.720.01724
LLPS-Aon-3384Aotus nancymaae98.380.01717
LLPS-Otg-1543Otolemur garnettii97.10.01708
LLPS-Ict-0083Ictidomys tridecemlineatus97.10.01707
LLPS-Cas-1523Carlito syrichta96.640.01701
LLPS-Cap-1371Cavia porcellus96.640.01697
LLPS-Fud-1838Fukomys damarensis96.520.01687
LLPS-Dio-0956Dipodomys ordii96.170.01691
LLPS-Eqc-0660Equus caballus96.060.01687
LLPS-Urm-3092Ursus maritimus95.590.01682
LLPS-Myl-2002Myotis lucifugus95.590.01679
LLPS-Aim-1362Ailuropoda melanoleuca95.590.01683
LLPS-Mup-1642Mustela putorius furo95.480.01677
LLPS-Caf-0165Canis familiaris95.360.01675
LLPS-Mum-1234Mus musculus95.360.01670
LLPS-Orc-1956Oryctolagus cuniculus95.250.01658
LLPS-Loa-1317Loxodonta africana95.240.01684
LLPS-Mea-1469Mesocricetus auratus95.240.01677
LLPS-Fec-2806Felis catus94.780.01674
LLPS-Ran-3289Rattus norvegicus94.660.01662
LLPS-Bot-3744Bos taurus93.620.01627
LLPS-Sus-0041Sus scrofa93.390.01657
LLPS-Mod-3110Monodelphis domestica92.00.01630
LLPS-Pes-2013Pelodiscus sinensis89.10.01444
LLPS-Sah-1290Sarcophilus harrisii89.030.01462
LLPS-Anp-2687Anas platyrhynchos88.460.01275
LLPS-Fia-2937Ficedula albicollis88.050.01574
LLPS-Tag-1567Taeniopygia guttata87.840.01526
LLPS-Meg-2008Meleagris gallopavo87.590.01557
LLPS-Gaga-0473Gallus gallus87.350.01558
LLPS-Anc-2296Anolis carolinensis87.350.01563
LLPS-Nol-2076Nomascus leucogenys87.310.01439
LLPS-Xet-1021Xenopus tropicalis84.360.01524
LLPS-Ova-1409Ovis aries83.260.01072
LLPS-Scf-1313Scleropages formosus82.850.01509
LLPS-Asm-3539Astyanax mexicanus82.480.01481
LLPS-Dar-2235Danio rerio81.790.01479
LLPS-Ten-1798Tetraodon nigroviridis81.640.0 803
LLPS-Icp-3061Ictalurus punctatus81.550.01467
LLPS-Lac-1551Latimeria chalumnae81.130.01418
LLPS-Scm-2880Scophthalmus maximus80.510.01472
LLPS-Orl-0472Oryzias latipes80.390.01462
LLPS-Orn-1646Oreochromis niloticus80.050.01462
LLPS-Xim-0136Xiphophorus maculatus79.580.01459
LLPS-Pof-1391Poecilia formosa79.470.01457
LLPS-Leo-0651Lepisosteus oculatus78.210.01383
LLPS-Gaa-2189Gasterosteus aculeatus77.760.01407
LLPS-Cis-0176Ciona savignyi69.234e-114 369
LLPS-Cii-0332Ciona intestinalis62.70.01102
LLPS-Drm-1240Drosophila melanogaster58.320.0 999
LLPS-Php-0057Physcomitrella patens56.060.0 964
LLPS-Amt-1491Amborella trichopoda55.211e-161 487
LLPS-Sem-0109Selaginella moellendorffii54.70.0 923
LLPS-Cae-1753Caenorhabditis elegans54.640.0 915
LLPS-Gor-1458Gossypium raimondii54.260.0 937
LLPS-Mua-0663Musa acuminata54.170.0 893
LLPS-Zem-1756Zea mays53.780.0 927
LLPS-Thc-0851Theobroma cacao53.660.0 922
LLPS-Sob-1839Sorghum bicolor53.540.0 922
LLPS-Viv-0132Vitis vinifera53.490.0 867
LLPS-Coc-1049Corchorus capsularis53.490.0 919
LLPS-Arl-1051Arabidopsis lyrata53.360.0 923
LLPS-Bro-0490Brassica oleracea53.240.0 925
LLPS-Sei-1151Setaria italica53.180.0 920
LLPS-Pot-0536Populus trichocarpa53.060.0 914
LLPS-Prp-0454Prunus persica53.060.0 917
LLPS-Tra-2884Triticum aestivum53.060.0 909
LLPS-Chr-0369Chlamydomonas reinhardtii53.020.0 906
LLPS-Art-2455Arabidopsis thaliana53.00.0 918
LLPS-Brr-0639Brassica rapa52.880.0 914
LLPS-Brn-0993Brassica napus52.880.0 914
LLPS-Mae-1927Manihot esculenta52.869e-124 385
LLPS-Cus-0946Cucumis sativus52.790.0 905
LLPS-Brd-1054Brachypodium distachyon52.760.0 909
LLPS-Hea-0625Helianthus annuus52.640.0 904
LLPS-Ors-1914Oryza sativa52.520.0 907
LLPS-Org-1472Oryza glaberrima52.520.0 907
LLPS-Ori-1362Oryza indica52.520.0 905
LLPS-Abg-0063Absidia glauca52.340.0 884
LLPS-Hov-1442Hordeum vulgare52.280.0 900
LLPS-Sot-1613Solanum tuberosum52.230.0 565
LLPS-Orp-0193Oryza punctata52.160.0 902
LLPS-Met-0141Medicago truncatula52.160.0 916
LLPS-Via-2237Vigna angularis52.10.0 902
LLPS-Orbr-0310Oryza brachyantha51.980.0 903
LLPS-Glm-1452Glycine max51.970.0 906
LLPS-Nia-0807Nicotiana attenuata51.740.0 892
LLPS-Phv-1621Phaseolus vulgaris51.610.0 891
LLPS-Vir-1766Vigna radiata51.290.0 691
LLPS-Sol-2221Solanum lycopersicum50.50.0 823
LLPS-Lep-1134Leersia perrieri50.240.0 856
LLPS-Dac-0868Daucus carota48.770.0 800
LLPS-Orni-1440Oryza nivara48.720.0 832
LLPS-Orb-0347Oryza barthii48.720.0 835
LLPS-Orgl-0874Oryza glumaepatula48.720.0 832
LLPS-Tru-1706Triticum urartu48.570.0 829
LLPS-Orr-0832Oryza rufipogon48.440.0 783
LLPS-Osl-1408Ostreococcus lucimarinus44.310.0 685
LLPS-Gas-1123Galdieria sulphuraria40.310.0 582
LLPS-Ora-3041Ornithorhynchus anatinus37.721e-120 395
LLPS-Tar-0875Takifugu rubripes37.192e-124 407
LLPS-Asni-0752Aspergillus niger37.017e-115 370
LLPS-Nef-1300Neosartorya fischeri36.878e-107 347
LLPS-Mel-1129Melampsora laricipopulina36.733e-107 354
LLPS-Trr-0654Trichoderma reesei36.623e-102 338
LLPS-Asfu-0834Aspergillus fumigatus36.392e-113 367
LLPS-Spr-1272Sporisorium reilianum36.363e-112 374
LLPS-Usm-1447Ustilago maydis36.311e-112 374
LLPS-Beb-1430Beauveria bassiana36.296e-100 332
LLPS-Asg-0783Ashbya gossypii36.273e-108 353
LLPS-Cogr-0301Colletotrichum graminicola36.232e-97 325
LLPS-Asf-1012Aspergillus flavus36.186e-110 358
LLPS-Aso-0126Aspergillus oryzae36.186e-110 358
LLPS-Ved-0985Verticillium dahliae36.092e-96 325
LLPS-Asn-1186Aspergillus nidulans36.021e-109 357
LLPS-Asc-1061Aspergillus clavatus36.026e-112 363
LLPS-Nec-0149Neurospora crassa36.011e-95 322
LLPS-Tut-2066Tursiops truncatus35.979e-127 413
LLPS-Pug-1379Puccinia graminis35.781e-102 350
LLPS-Ast-0680Aspergillus terreus35.545e-102 335
LLPS-Tum-0272Tuber melanosporum35.549e-108 351
LLPS-Orm-0598Oryza meridionalis35.511e-115 380
LLPS-Crn-1513Cryptococcus neoformans35.326e-104 352
LLPS-Zyt-0362Zymoseptoria tritici35.269e-106 347
LLPS-Scs-1007Sclerotinia sclerotiorum35.231e-96 323
LLPS-Map-0349Magnaporthe poae35.193e-95 317
LLPS-Miv-0725Microbotryum violaceum34.354e-103 350
LLPS-Kop-0573Komagataella pastoris34.058e-97 323
LLPS-Sac-1502Saccharomyces cerevisiae33.962e-96 322
LLPS-Scp-1626Schizosaccharomyces pombe33.836e-103 339
LLPS-Trv-0138Trichoderma virens33.444e-102 338
LLPS-Scc-1305Schizosaccharomyces cryophilus33.443e-101 334
LLPS-Scj-1127Schizosaccharomyces japonicus33.117e-101 333
LLPS-Cog-0502Colletotrichum gloeosporioides33.048e-102 337
LLPS-Chc-1176Chondrus crispus31.781e-121 397
LLPS-Pytr-1443Pyrenophora triticirepentis31.744e-96 322
LLPS-Fus-1258Fusarium solani31.731e-96 323
LLPS-Pyt-1406Pyrenophora teres31.295e-95 319