• Disorder
  • Domain
  • PTM
  • Variation
  • Mutation
  • Interaction
  • Disease
  • Drug
  • Physicochemical
  • Function
  • Proteomics
  • Structure
  • Localization
  • Expression
  • Element
  • Methylation

LLPS-Fud-1838
H920_03833

Integrated Annotations

▼ OVERVIEW


Status: Unreviewed
Protein Name: DNA topoisomerase
Gene Name: H920_03833
Ensembl Gene: ENSFDAG00000007325.1
Ensembl Protein: ENSFDAP00000021964.1
Organism: Fukomys damarensis
Taxa ID: 885580
LLPS Type: LLPS regulator


▼ PROPERTY



——— Disorder propensity (calculated by IUPred2A)

▼ Classification


Condensates:
CondensateEvidenceOrthologs
P-body, Stress granule, Chromatoid bodyPredicted from orthologs(View)

▼ FUNCTION


Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand.

▼ SEQUENCE


Protein Sequence (FASTA)
1     MKTVLMVAEK  PSLAQSIAKI  LSRGSMSSHK  GLNGACSVHE  YTGAFAGQPV  RFKMTSVCGH  60
61    VMTLDFLGKY  NKWDKVDPAE  LFSQAPTEKK  EANPKLSMVK  FLQVEGRGCD  YIVLWLDCDK  120
121   EGENICFEVL  DAVLPVMNKT  HSGEKTVFRA  RFSSITDTDI  GNAMAHLGEP  DHNEALSVDA  180
181   RQELDLRIGC  AFTRFQTKYF  QGKYGDLDSS  LISFGPCQTP  TLGFCVERHD  KIQSFKPETY  240
241   WVLQAKVNAD  KDKSLLLDWD  RVRVFDREIA  QMFLNMTKLE  KEAQVEATSR  KEKAKQRPLA  300
301   LNTVEMLRVA  SSALGMGPQH  AMQTAERLYT  QGYISYPRTE  TTHYPENFDL  KGCLRQQANH  360
361   PYWADTVKQL  LTEGINRPRK  GHDAGDHPPI  TPMRSATEDE  LGGDAWRLYE  YITRHFIATV  420
421   SPDCKYLQST  ISFRIGPELF  TCSGKTVISP  GFTEIMPWQS  VPLEESLPTC  QRGDTFAVGE  480
481   VKMLEKQTSP  PDYLTEAELI  TLMEKHGIGT  DASIPVHINN  ICQRNYVTVE  SGRRLKPTNL  540
541   GIVLVHGYYK  IDAELVLPTI  RSAVEKQLNL  IAQGKADYRQ  VLGHTLDVFK  RKFHYFVDSI  600
601   AGMDELMEVS  FSPLAATGKP  LSRCGKCHRF  MKYIQAKPSR  LHCSHCDETY  TLPQNGTIKL  660
661   YKELRCPLDD  FELVLWSSGS  RGKSYPLCPY  CYNHPPFRDM  KKGMGCNECT  HPTCQHSLSM  720
721   LGIGQCVECE  SGVLVLDPTS  GPKWKVACNK  CNVVAHCFEN  AHRVRVSADT  CHTCEAALLD  780
781   VDFNKAKSPL  PGDETQHTGC  VFCDPVFQEL  VELKHAASCH  PMHRGGPGRR  QGRGRARGRR  840
841   PPGKPNPRRP  RDKMSALAAY  FV  862
Nucleotide CDS Sequence (FASTA)
1     ATGAAGACTG  TGCTCATGGT  TGCTGAGAAG  CCTTCCCTGG  CACAGTCCAT  CGCCAAAATC  60
61    CTCTCTCGAG  GGAGCATGTC  TTCACACAAA  GGACTGAATG  GGGCGTGCTC  AGTCCACGAG  120
121   TACACAGGAG  CCTTTGCCGG  CCAGCCAGTC  CGCTTCAAGA  TGACCTCTGT  CTGTGGTCAT  180
181   GTGATGACCC  TGGATTTCCT  GGGAAAGTAC  AACAAGTGGG  ACAAAGTGGA  CCCGGCAGAG  240
241   CTGTTCAGTC  AAGCTCCGAC  AGAGAAGAAG  GAGGCCAACC  CCAAGCTGAG  CATGGTGAAG  300
301   TTCCTGCAGG  TGGAGGGCAG  AGGCTGCGAC  TACATCGTGC  TGTGGCTGGA  CTGTGACAAG  360
361   GAAGGGGAGA  ACATTTGCTT  TGAGGTCCTT  GATGCTGTTC  TGCCGGTCAT  GAATAAGACC  420
421   CACAGCGGTG  AGAAGACTGT  ATTCCGGGCC  AGGTTCAGCT  CCATCACTGA  CACAGACATC  480
481   GGTAATGCTA  TGGCCCACCT  GGGTGAGCCC  GACCACAACG  AGGCGCTCTC  GGTAGATGCC  540
541   CGCCAGGAGC  TGGACCTACG  CATCGGCTGT  GCTTTCACCA  GGTTTCAGAC  CAAATATTTC  600
601   CAGGGGAAAT  ACGGTGATTT  GGATAGTTCT  CTCATCTCCT  TTGGGCCGTG  TCAGACTCCT  660
661   ACCCTGGGAT  TCTGTGTGGA  GAGACATGAT  AAAATCCAGT  CCTTCAAACC  AGAGACCTAT  720
721   TGGGTGCTGC  AGGCCAAGGT  TAATGCTGAC  AAAGACAAAT  CTCTCCTTTT  GGACTGGGAC  780
781   CGAGTGAGAG  TGTTCGATCG  GGAGATTGCA  CAGATGTTTT  TAAACATGAC  CAAGCTGGAG  840
841   AAGGAGGCCC  AGGTGGAGGC  CACAAGCAGG  AAAGAAAAAG  CCAAGCAGAG  GCCGCTGGCC  900
901   CTGAACACTG  TGGAGATGCT  GCGTGTAGCC  AGTTCAGCTC  TGGGCATGGG  ACCTCAGCAT  960
961   GCCATGCAGA  CGGCCGAGCG  GCTGTACACA  CAGGGCTACA  TCAGCTACCC  ACGGACGGAA  1020
1021  ACCACCCACT  ACCCTGAGAA  CTTTGACCTG  AAGGGCTGCC  TGCGGCAACA  GGCCAACCAC  1080
1081  CCCTACTGGG  CAGACACGGT  GAAGCAGTTG  TTAACAGAAG  GTATCAACCG  CCCACGGAAA  1140
1141  GGCCACGATG  CTGGCGACCA  CCCTCCCATC  ACCCCCATGA  GGTCTGCCAC  AGAGGATGAA  1200
1201  TTAGGGGGTG  ATGCATGGCG  GCTGTACGAG  TACATCACCA  GACACTTCAT  TGCCACTGTT  1260
1261  AGCCCCGACT  GCAAGTACCT  GCAGAGCACC  ATCTCCTTCC  GCATTGGGCC  TGAGCTCTTC  1320
1321  ACTTGCTCAG  GGAAGACTGT  CATCTCGCCA  GGCTTCACAG  AGATCATGCC  CTGGCAGAGT  1380
1381  GTGCCCTTGG  AGGAGAGCCT  GCCTACCTGC  CAGAGGGGCG  ACACCTTTGC  AGTGGGCGAG  1440
1441  GTGAAGATGC  TAGAGAAGCA  GACGAGCCCG  CCTGACTACC  TGACTGAAGC  CGAGCTTATC  1500
1501  ACACTCATGG  AGAAGCATGG  CATTGGAACT  GACGCCAGCA  TCCCTGTGCA  CATCAACAAT  1560
1561  ATCTGCCAGC  GCAACTATGT  GACTGTGGAG  AGTGGCCGCC  GGCTCAAGCC  TACCAACCTT  1620
1621  GGCATTGTCC  TGGTGCACGG  TTACTACAAG  ATTGACGCAG  AGCTGGTGCT  CCCCACCATC  1680
1681  CGCAGCGCAG  TGGAGAAGCA  GCTGAACCTG  ATTGCCCAGG  GCAAGGCAGA  CTACCGCCAG  1740
1741  GTCCTGGGCC  ACACGTTGGA  TGTCTTCAAG  AGGAAGTTCC  ACTACTTTGT  CGACTCCATC  1800
1801  GCCGGAATGG  ATGAGTTGAT  GGAGGTGTCT  TTTTCACCCC  TGGCGGCCAC  AGGCAAGCCA  1860
1861  CTCTCACGCT  GTGGAAAGTG  CCACCGGTTC  ATGAAGTACA  TCCAGGCCAA  GCCGAGCCGC  1920
1921  CTGCACTGTT  CCCACTGCGA  CGAGACCTAC  ACCCTCCCGC  AGAATGGCAC  CATCAAGCTC  1980
1981  TATAAGGAGC  TGCGGTGCCC  ACTGGATGAC  TTTGAGCTGG  TTCTGTGGTC  GTCTGGCTCC  2040
2041  CGGGGCAAGA  GCTACCCACT  GTGCCCTTAT  TGCTACAACC  ACCCGCCCTT  CCGAGACATG  2100
2101  AAGAAAGGCA  TGGGCTGCAA  CGAGTGCACA  CACCCCACCT  GCCAGCACTC  TCTGAGCATG  2160
2161  CTGGGCATCG  GCCAGTGTGT  AGAGTGCGAG  AGCGGCGTCC  TCGTGCTGGA  CCCCACTTCA  2220
2221  GGCCCCAAGT  GGAAAGTGGC  CTGCAACAAG  TGCAACGTGG  TGGCCCACTG  CTTTGAGAAC  2280
2281  GCCCACCGCG  TGCGGGTGTC  TGCAGACACC  TGCCACACCT  GTGAGGCTGC  CCTGCTGGAC  2340
2341  GTGGACTTCA  ACAAGGCCAA  GTCCCCATTG  CCAGGTGACG  AGACACAGCA  CACAGGCTGT  2400
2401  GTTTTCTGCG  ACCCCGTCTT  CCAGGAACTG  GTGGAGTTGA  AACATGCAGC  CTCCTGTCAC  2460
2461  CCCATGCACC  GTGGAGGTCC  CGGGAGGAGG  CAGGGCCGAG  GGCGGGCCCG  GGGCCGGCGG  2520
2521  CCACCAGGGA  AGCCCAACCC  CAGGCGGCCA  AGGGACAAGA  TGTCAGCCCT  GGCAGCCTAT  2580
2581  TTCGTATGA  2589

▼ KEYWORD


ID
Family
Complete proteome
DNA-binding
Isomerase
Reference proteome
Topoisomerase

▼ GENE ONTOLOGY


ID
Classification
Description
Cellular Component
Condensed chromosome
Molecular Function
DNA binding
Molecular Function
DNA topoisomerase type I activity
Biological Process
Chromosome segregation
Biological Process
DNA topological change

▼ ORTHOLOGY


DrLLPS IDOrganismIdentityE-valueScore
LLPS-Cap-1371Cavia porcellus98.140.01711
LLPS-Ict-0083Ictidomys tridecemlineatus97.560.01706
LLPS-Dio-0956Dipodomys ordii97.330.01699
LLPS-Poa-0172Pongo abelii97.10.01696
LLPS-Rhb-3920Rhinopithecus bieti96.870.01692
LLPS-Mal-2062Mandrillus leucophaeus96.870.01691
LLPS-Paa-2087Papio anubis96.870.01691
LLPS-Caj-0658Callithrix jacchus96.870.01695
LLPS-Cea-4715Cercocebus atys96.870.01691
LLPS-Hos-1197Homo sapiens96.750.01691
LLPS-Gog-0071Gorilla gorilla96.750.01691
LLPS-Aon-3384Aotus nancymaae96.750.01691
LLPS-Mam-0785Macaca mulatta96.640.01688
LLPS-Pat-2402Pan troglodytes96.640.01689
LLPS-Pap-2173Pan paniscus96.640.01689
LLPS-Chs-2016Chlorocebus sabaeus96.640.01687
LLPS-Man-2046Macaca nemestrina96.520.01687
LLPS-Maf-2677Macaca fascicularis96.520.01686
LLPS-Caf-0165Canis familiaris96.060.01676
LLPS-Otg-1543Otolemur garnettii96.060.01691
LLPS-Eqc-0660Equus caballus95.940.01678
LLPS-Cas-1523Carlito syrichta95.820.01685
LLPS-Urm-3092Ursus maritimus95.820.01675
LLPS-Aim-1362Ailuropoda melanoleuca95.820.01675
LLPS-Mea-1469Mesocricetus auratus95.820.01677
LLPS-Fec-2806Felis catus95.590.01676
LLPS-Mup-1642Mustela putorius furo95.480.01666
LLPS-Mum-1234Mus musculus95.480.01669
LLPS-Myl-2002Myotis lucifugus95.360.01669
LLPS-Loa-1317Loxodonta africana95.240.01675
LLPS-Orc-1956Oryctolagus cuniculus95.020.01653
LLPS-Ran-3289Rattus norvegicus94.780.01657
LLPS-Bot-3744Bos taurus93.50.01621
LLPS-Sus-0041Sus scrofa93.390.01653
LLPS-Mod-3110Monodelphis domestica91.650.01617
LLPS-Pes-2013Pelodiscus sinensis89.490.01442
LLPS-Sah-1290Sarcophilus harrisii89.280.01460
LLPS-Anp-2687Anas platyrhynchos88.870.01281
LLPS-Fia-2937Ficedula albicollis88.630.01583
LLPS-Tag-1567Taeniopygia guttata88.320.01534
LLPS-Meg-2008Meleagris gallopavo88.170.01569
LLPS-Gaga-0473Gallus gallus87.940.01568
LLPS-Anc-2296Anolis carolinensis87.350.01557
LLPS-Nol-2076Nomascus leucogenys85.240.01404
LLPS-Xet-1021Xenopus tropicalis84.70.01526
LLPS-Ova-1409Ovis aries83.720.01073
LLPS-Asm-3539Astyanax mexicanus83.060.01489
LLPS-Scf-1313Scleropages formosus82.730.01504
LLPS-Ten-1798Tetraodon nigroviridis82.30.0 809
LLPS-Dar-2235Danio rerio81.90.01483
LLPS-Lac-1551Latimeria chalumnae81.60.01425
LLPS-Icp-3061Ictalurus punctatus81.440.01462
LLPS-Orl-0472Oryzias latipes80.740.01467
LLPS-Scm-2880Scophthalmus maximus80.510.01469
LLPS-Xim-0136Xiphophorus maculatus80.390.01469
LLPS-Pof-1391Poecilia formosa80.280.01466
LLPS-Orn-1646Oreochromis niloticus79.930.01461
LLPS-Leo-0651Lepisosteus oculatus78.330.01385
LLPS-Gaa-2189Gasterosteus aculeatus77.650.01404
LLPS-Cii-0332Ciona intestinalis62.580.01107
LLPS-Drm-1240Drosophila melanogaster58.320.01001
LLPS-Cis-0176Ciona savignyi56.630.0 697
LLPS-Php-0057Physcomitrella patens56.30.0 967
LLPS-Sem-0109Selaginella moellendorffii55.280.0 929
LLPS-Mua-0663Musa acuminata55.040.0 909
LLPS-Gor-1458Gossypium raimondii54.860.0 947
LLPS-Cae-1753Caenorhabditis elegans54.40.0 919
LLPS-Zem-1756Zea mays54.260.0 938
LLPS-Viv-0132Vitis vinifera54.250.0 881
LLPS-Coc-1049Corchorus capsularis54.220.0 932
LLPS-Sob-1839Sorghum bicolor54.020.0 933
LLPS-Thc-0851Theobroma cacao54.020.0 932
LLPS-Sei-1151Setaria italica53.90.0 933
LLPS-Prp-0454Prunus persica53.890.0 933
LLPS-Arl-1051Arabidopsis lyrata53.720.0 929
LLPS-Pot-0536Populus trichocarpa53.660.0 922
LLPS-Tra-2884Triticum aestivum53.660.0 917
LLPS-Cus-0946Cucumis sativus53.650.0 914
LLPS-Bro-0490Brassica oleracea53.60.0 932
LLPS-Hea-0625Helianthus annuus53.480.0 917
LLPS-Mae-1927Manihot esculenta53.436e-125 389
LLPS-Sot-1613Solanum tuberosum53.40.0 578
LLPS-Brd-1054Brachypodium distachyon53.370.0 923
LLPS-Org-1472Oryza glaberrima53.360.0 923
LLPS-Art-2455Arabidopsis thaliana53.360.0 925
LLPS-Ors-1914Oryza sativa53.360.0 923
LLPS-Ori-1362Oryza indica53.360.0 922
LLPS-Chr-0369Chlamydomonas reinhardtii53.250.0 918
LLPS-Brr-0639Brassica rapa53.240.0 922
LLPS-Brn-0993Brassica napus53.240.0 921
LLPS-Orp-0193Oryza punctata53.00.0 918
LLPS-Glm-1452Glycine max52.930.0 925
LLPS-Hov-1442Hordeum vulgare52.880.0 909
LLPS-Orbr-0310Oryza brachyantha52.820.0 918
LLPS-Via-2237Vigna angularis52.820.0 920
LLPS-Met-0141Medicago truncatula52.760.0 930
LLPS-Nia-0807Nicotiana attenuata52.70.0 907
LLPS-Abg-0063Absidia glauca52.70.0 893
LLPS-Phv-1621Phaseolus vulgaris52.210.0 909
LLPS-Vir-1766Vigna radiata52.210.0 706
LLPS-Sol-2221Solanum lycopersicum51.740.0 841
LLPS-Amt-1491Amborella trichopoda51.691e-164 495
LLPS-Lep-1134Leersia perrieri51.080.0 871
LLPS-Orgl-0874Oryza glumaepatula49.360.0 848
LLPS-Orni-1440Oryza nivara49.360.0 847
LLPS-Orb-0347Oryza barthii49.360.0 850
LLPS-Dac-0868Daucus carota49.260.0 815
LLPS-Tru-1706Triticum urartu49.140.0 837
LLPS-Orr-0832Oryza rufipogon49.080.0 800
LLPS-Osl-1408Ostreococcus lucimarinus44.850.0 692
LLPS-Gas-1123Galdieria sulphuraria39.510.0 574
LLPS-Ora-3041Ornithorhynchus anatinus37.224e-117 385
LLPS-Asni-0752Aspergillus niger37.012e-114 370
LLPS-Tar-0875Takifugu rubripes36.733e-123 403
LLPS-Nef-1300Neosartorya fischeri36.696e-107 348
LLPS-Trr-0654Trichoderma reesei36.622e-102 338
LLPS-Asg-0783Ashbya gossypii36.446e-108 352
LLPS-Asfu-0834Aspergillus fumigatus36.391e-113 367
LLPS-Cogr-0301Colletotrichum graminicola36.234e-98 327
LLPS-Mel-1129Melampsora laricipopulina36.232e-107 355
LLPS-Asf-1012Aspergillus flavus36.181e-109 357
LLPS-Aso-0126Aspergillus oryzae36.181e-109 357
LLPS-Beb-1430Beauveria bassiana36.171e-99 331
LLPS-Asn-1186Aspergillus nidulans36.021e-109 357
LLPS-Tut-2066Tursiops truncatus35.987e-129 418
LLPS-Ved-0985Verticillium dahliae35.971e-96 326
LLPS-Usm-1447Ustilago maydis35.892e-112 374
LLPS-Spr-1272Sporisorium reilianum35.887e-113 375
LLPS-Asc-1061Aspergillus clavatus35.862e-112 364
LLPS-Pug-1379Puccinia graminis35.789e-104 353
LLPS-Dos-1213Dothistroma septosporum35.71e-95 321
LLPS-Ast-0680Aspergillus terreus35.665e-102 335
LLPS-Tum-0272Tuber melanosporum35.633e-110 358
LLPS-Map-0349Magnaporthe poae35.621e-97 323
LLPS-Orm-0598Oryza meridionalis35.21e-117 385
LLPS-Crn-1513Cryptococcus neoformans35.165e-105 355
LLPS-Scs-1007Sclerotinia sclerotiorum35.13e-98 328
LLPS-Zyt-0362Zymoseptoria tritici34.936e-107 350
LLPS-Miv-0725Microbotryum violaceum34.353e-105 356
LLPS-Sac-1502Saccharomyces cerevisiae33.963e-96 322
LLPS-Scp-1626Schizosaccharomyces pombe33.673e-102 337
LLPS-Kop-0573Komagataella pastoris33.614e-97 323
LLPS-Trv-0138Trichoderma virens33.442e-102 338
LLPS-Scc-1305Schizosaccharomyces cryophilus33.287e-102 336
LLPS-Scj-1127Schizosaccharomyces japonicus33.112e-102 337
LLPS-Cog-0502Colletotrichum gloeosporioides33.047e-103 340
LLPS-Pytr-1443Pyrenophora triticirepentis32.361e-97 326
LLPS-Fus-1258Fusarium solani32.046e-98 326
LLPS-Chc-1176Chondrus crispus31.442e-122 399
LLPS-Pyt-1406Pyrenophora teres31.443e-96 322