LLPS-Loa-2432
CHCHD3
Integrated Annotations
▼ OVERVIEW
| Status: | Unreviewed |
| Protein Name: | MICOS complex subunit |
| Gene Name: | CHCHD3 |
| Ensembl Gene: | ENSLAFG00000003135.3 |
| Ensembl Protein: | ENSLAFP00000002607.3 |
| Organism: | Loxodonta africana |
| Taxa ID: | 9785 |
| LLPS Type: | Others |
▼ Classification
Condensates:
| Condensate | Evidence | Orthologs |
|---|---|---|
| Stress granule, Postsynaptic density | Predicted from orthologs | (View) |
▼ FUNCTION
| Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane. |
▼ CROSS REFERENCE
| Database | Nucleotide ID | Protein ID |
|---|---|---|
| Ensembl | ENSLAFT00000003134.3 | ENSLAFP00000002607.3 |
| UniProt | G3SRR8, G3SRR8_LOXAF |
▼ SEQUENCE
| Protein Sequence (FASTA) |
|---|
1 MGGTASTRRV TFEADENENI TVVKGIRLSE NVIDRMKESS PSGSKSPRYS GGYGASVSEE 60 61 ELKRRVAEEL ALEQAKKESE KQKRLKQGKE LDQEMANEQL TRAILQERLS SEEERSKAKH 120 121 LAKQLEEKDR VIKKQDAFYK EQLARLEERS SEFYKVTTEQ YQKAAEEVEA KFKRYDFHPV 180 181 CADLQAQILQ CYRQNTHQTL SCSALATQYM QCVNQAKQ 218 |
| Nucleotide CDS Sequence (FASTA) |
1 ATGGGCGGGA CGGCTAGCAC CCGCCGGGTC ACCTTCGAGG CGGACGAGAA TGAGAACATC 60 61 ACGGTGGTGA AGGGCATCCG GCTTTCGGAA AATGTGATTG ATCGAATGAA GGAATCCTCT 120 121 CCGTCTGGTT CGAAGTCTCC ACGGTATTCT GGTGGTTATG GTGCCTCAGT TTCTGAAGAA 180 181 GAATTGAAAA GAAGAGTAGC CGAGGAGCTG GCATTGGAGC AAGCTAAGAA AGAATCTGAA 240 241 AAGCAAAAAC GACTAAAGCA AGGCAAAGAA CTGGACCAGG AGATGGCCAA TGAGCAGTTA 300 301 ACCAGAGCTA TTCTTCAGGA GAGGCTCTCC AGTGAGGAGG AACGCTCTAA GGCGAAGCAC 360 361 CTGGCTAAGC AGCTGGAAGA GAAAGATCGA GTGATAAAGA AGCAGGATGC CTTCTACAAA 420 421 GAGCAGCTGG CTAGACTGGA GGAAAGGAGC TCAGAGTTCT ACAAAGTCAC CACTGAGCAA 480 481 TATCAGAAAG CTGCTGAAGA GGTGGAAGCA AAGTTCAAGC GGTATGATTT TCACCCAGTG 540 541 TGTGCTGACC TGCAGGCCCA GATTCTCCAG TGTTACCGCC AGAACACCCA CCAGACCCTC 600 601 AGCTGCTCTG CTCTGGCCAC CCAATACATG CAGTGTGTCA ACCAGGCCAA ACAG 654 |
▼ KEYWORD
▼ GENE ONTOLOGY
ID | Classification | Description |
Cellular Component | MICOS complex | |
Cellular Component | Nucleus | |
Molecular Function | DNA-binding transcription repressor activity, RNA polymerase II-specific | |
Molecular Function | Phosphatase binding | |
Molecular Function | Protein-containing complex scaffold activity | |
Biological Process | Cristae formation | |
Biological Process | Mitochondrial fusion |
▼ ORTHOLOGY
| DrLLPS ID | Organism | Identity | E-value | Score |
|---|---|---|---|---|
| LLPS-Cas-0020 | Carlito syrichta | 93.94 | 2e-23 | 95.5 |
| LLPS-Bot-1393 | Bos taurus | 90.91 | 2e-108 | 318 |
| LLPS-Fud-1458 | Fukomys damarensis | 90.45 | 7e-106 | 311 |
| LLPS-Cap-0623 | Cavia porcellus | 90.0 | 2e-107 | 315 |
| LLPS-Aon-0134 | Aotus nancymaae | 90.0 | 1e-105 | 311 |
| LLPS-Orc-2448 | Oryctolagus cuniculus | 89.55 | 9e-107 | 314 |
| LLPS-Poa-4308 | Pongo abelii | 89.55 | 3e-105 | 310 |
| LLPS-Caf-0513 | Canis familiaris | 89.55 | 8e-108 | 317 |
| LLPS-Ova-1074 | Ovis aries | 88.89 | 8e-106 | 311 |
| LLPS-Fec-2251 | Felis catus | 88.44 | 3e-104 | 308 |
| LLPS-Sus-0004 | Sus scrofa | 88.44 | 3e-104 | 308 |
| LLPS-Mup-1196 | Mustela putorius furo | 88.18 | 6e-106 | 311 |
| LLPS-Myl-3914 | Myotis lucifugus | 88.18 | 5e-105 | 309 |
| LLPS-Rhb-1956 | Rhinopithecus bieti | 88.0 | 1e-102 | 304 |
| LLPS-Urm-0199 | Ursus maritimus | 87.73 | 2e-106 | 313 |
| LLPS-Nol-0916 | Nomascus leucogenys | 87.56 | 1e-102 | 303 |
| LLPS-Mal-2694 | Mandrillus leucophaeus | 87.56 | 1e-102 | 303 |
| LLPS-Man-4414 | Macaca nemestrina | 87.27 | 3e-103 | 305 |
| LLPS-Mea-4150 | Mesocricetus auratus | 87.27 | 1e-102 | 303 |
| LLPS-Paa-1122 | Papio anubis | 87.27 | 2e-103 | 305 |
| LLPS-Ict-2345 | Ictidomys tridecemlineatus | 87.11 | 2e-102 | 303 |
| LLPS-Eqc-1718 | Equus caballus | 87.1 | 1e-72 | 229 |
| LLPS-Ere-0874 | Erinaceus europaeus | 86.7 | 5e-99 | 294 |
| LLPS-Caj-3282 | Callithrix jacchus | 86.67 | 2e-102 | 303 |
| LLPS-Cea-4555 | Cercocebus atys | 86.36 | 2e-102 | 303 |
| LLPS-Maf-4089 | Macaca fascicularis | 86.36 | 3e-100 | 297 |
| LLPS-Aim-2511 | Ailuropoda melanoleuca | 86.36 | 8e-105 | 308 |
| LLPS-Mum-0267 | Mus musculus | 85.91 | 3e-102 | 302 |
| LLPS-Dio-0591 | Dipodomys ordii | 85.45 | 5e-103 | 304 |
| LLPS-Pof-0686 | Poecilia formosa | 84.21 | 2e-13 | 71.6 |
| LLPS-Meg-1944 | Meleagris gallopavo | 84.21 | 3e-13 | 66.2 |
| LLPS-Ran-0929 | Rattus norvegicus | 84.09 | 5e-101 | 299 |
| LLPS-Chs-2092 | Chlorocebus sabaeus | 83.64 | 5e-98 | 291 |
| LLPS-Pap-4009 | Pan paniscus | 82.57 | 6e-89 | 268 |
| LLPS-Pat-2821 | Pan troglodytes | 82.11 | 7e-87 | 263 |
| LLPS-Orn-0959 | Oreochromis niloticus | 81.58 | 9e-13 | 69.7 |
| LLPS-Gog-4075 | Gorilla gorilla | 80.45 | 1e-94 | 283 |
| LLPS-Orl-0006 | Oryzias latipes | 78.95 | 1e-12 | 70.5 |
| LLPS-Icp-3878 | Ictalurus punctatus | 78.95 | 1e-13 | 72.8 |
| LLPS-Scf-0953 | Scleropages formosus | 78.95 | 5e-13 | 69.7 |
| LLPS-Tar-0038 | Takifugu rubripes | 78.95 | 1e-12 | 70.1 |
| LLPS-Mam-1888 | Macaca mulatta | 77.67 | 1e-64 | 207 |
| LLPS-Hos-0278 | Homo sapiens | 77.07 | 1e-63 | 204 |
| LLPS-Dar-2130 | Danio rerio | 76.32 | 4e-12 | 67.8 |
| LLPS-Scm-1870 | Scophthalmus maximus | 76.32 | 2e-12 | 70.1 |
| LLPS-Asm-2605 | Astyanax mexicanus | 76.32 | 2e-12 | 69.3 |
| LLPS-Gaa-3601 | Gasterosteus aculeatus | 76.32 | 2e-12 | 68.6 |
| LLPS-Sah-0279 | Sarcophilus harrisii | 71.62 | 6e-89 | 268 |
| LLPS-Mod-0796 | Monodelphis domestica | 70.74 | 6e-89 | 269 |
| LLPS-Tag-2360 | Taeniopygia guttata | 68.57 | 5e-53 | 174 |
| LLPS-Ora-1344 | Ornithorhynchus anatinus | 66.67 | 4e-83 | 254 |
| LLPS-Pes-1156 | Pelodiscus sinensis | 65.25 | 5e-83 | 254 |
| LLPS-Lac-1632 | Latimeria chalumnae | 65.12 | 1e-47 | 160 |
| LLPS-Anc-2094 | Anolis carolinensis | 64.96 | 1e-76 | 238 |
| LLPS-Anp-1406 | Anas platyrhynchos | 64.19 | 7e-33 | 122 |
| LLPS-Gaga-0323 | Gallus gallus | 62.17 | 2e-77 | 239 |
| LLPS-Fia-1272 | Ficedula albicollis | 60.0 | 2e-75 | 235 |
| LLPS-Leo-3348 | Lepisosteus oculatus | 58.9 | 1e-70 | 223 |
| LLPS-Xim-2020 | Xiphophorus maculatus | 58.59 | 2e-41 | 149 |
| LLPS-Xet-2602 | Xenopus tropicalis | 58.58 | 1e-73 | 230 |
| LLPS-Ten-1911 | Tetraodon nigroviridis | 40.83 | 2e-20 | 91.3 |
| LLPS-Cis-1958 | Ciona savignyi | 35.0 | 2e-12 | 66.6 |
| LLPS-Drm-0635 | Drosophila melanogaster | 34.52 | 1e-08 | 57.0 |
| LLPS-Cii-2319 | Ciona intestinalis | 33.75 | 8e-12 | 65.1 |