LLPS-Hos-0278
CHCHD3

▼ OVERVIEW

Status: Reviewed
Protein Name: MICOS complex subunit MIC19; Coiled-coil-helix-coiled-coil-helix domain-containing protein 3
Gene Name: CHCHD3, MIC19, MINOS3
Ensembl Gene: ENSG00000106554.12
Ensembl Protein: ENSP00000493081.1
Organism: Homo sapiens
Taxa ID: 9606
LLPS Type: Client


▼ PROPERTY


——— Disorder propensity (calculated by IUPred2A)

▼ Classification

Condensates:
CondensateDescriptionTissue/CellPMIDs
Stress granule
"...By adding known stress granule components not identified by mass spectrometry to this list, we created the first stress granule proteome for a mammalian cell."
U2OS cells26777405
Postsynaptic density
"...We report the first direct comparison of the proteome of triplicate isolates of mouse and human cortical postsynaptic densities. The mouse postsynaptic density comprised 1556 proteins and the human one 1461."
Human cortex23071613

▼ FUNCTION

Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane. Has also been shown to function as a transcription factor which binds to the BAG1 promoter and represses BAG1 transcription. Plays an important role in the maintenance of the MICOS complex stability and the mitochondrial cristae morphology (PubMed:25781180).

▼ SEQUENCE

Protein Sequence (FASTA)
1     MGGTTSTRRV  TFEADENENI  TVVKGIRLSE  NVIDRMKESS  PSGSKSQRYS  GAYGASVSDE  60
61    ELKRRVAEEL  ALEQAKKESE  DQKREETSET  ALRKFCVQSF  SSNFLESQNM  YTLLLKQAKE  120
121   LDRERAAANE  QLTRAILRER  ICSEEERAKA  KHLARQLEEK  DRVLKKQDAF  YKEQLARLEE  180
181   RSSEFYRVTT  EQYQKAAEEV  EAKFKFGEMK  YHKTGLFILL  PLVPVWLLVG  ELVTSPSFQA  240
241   T  241
Nucleotide CDS Sequence (FASTA)
1     ATGGGTGGGA  CCACCAGCAC  CCGCCGGGTC  ACCTTCGAGG  CGGACGAGAA  TGAGAACATC  60
61    ACCGTGGTGA  AGGGCATCCG  GCTTTCGGAA  AATGTGATTG  ATCGAATGAA  GGAATCCTCT  120
121   CCATCTGGTT  CGAAGTCTCA  GCGGTATTCT  GGTGCTTATG  GTGCCTCAGT  TTCTGATGAA  180
181   GAATTGAAAA  GAAGAGTAGC  TGAGGAGCTG  GCATTGGAGC  AAGCCAAGAA  AGAATCCGAA  240
241   GATCAGAAAC  GACTAAAGCA  AGCCAAAGAG  CTGGACCGAG  AGAGGGCTGC  TGCCAATGAG  300
301   CAGTTAACCA  GAGCCATCCT  TCGGGAGAGG  ATATGTAGCG  AGGAGGAACG  CGCTAAGGCA  360
361   AAGCACCTGG  CTAGGCAGCT  GGAAGAGAAA  GACCGAGTGC  TAAAGAAGCA  GGATGCATTC  420
421   TACAAAGAAC  AGCTGGCTAG  ACTGGAGGAG  AGGAGCTCAG  AGTTCTACAG  AGTCACCACT  480
481   GAACAATATC  AGAAAGCTGC  TGAAGAGGTG  GAAGCAAAGT  TCAAGCGATA  TGAGTCTCAT  540
541   CCAGTCTGTG  CTGATCTGCA  GGCCAAAATT  CTTCAGTGTT  ACCGTGAGAA  CACCCACCAG  600
601   ACCCTCAAAT  GCTCCGCTCT  GGCCACCCAG  TATATGCACT  GTGTCAATCA  TGCCAAACAG  660
661   AGCATGCTTG  AGAAGGGAGG  ATAA  684

▼ KEYWORD

ID
Family
Acetylation
Complete proteome
Cytoplasm
Disulfide bond
Lipoprotein
Membrane
Mitochondrion
Mitochondrion inner membrane
Myristate
Nucleus
Phosphoprotein
Reference proteome
Repressor
Transcription
Transcription regulation

▼ GENE ONTOLOGY

ID
Classification
Description
Cellular Component
Cytoplasm
Cellular Component
Extracellular exosome
Cellular Component
MICOS complex
Cellular Component
Mitochondrial inner membrane
Cellular Component
Mitochondrion
Cellular Component
Nucleus
Molecular Function
DNA-binding transcription repressor activity, RNA polymerase II-specific
Molecular Function
Molecular adaptor activity
Molecular Function
Phosphatase binding
Biological Process
Cristae formation
Biological Process
Inner mitochondrial membrane organization
Biological Process
Mitochondrial fusion
Biological Process
Negative regulation of transcription by RNA polymerase II

▼ KEGG


▼ ORTHOLOGY

DrLLPS IDOrganismIdentityE-valueScore
LLPS-Pap-2096Pan paniscus99.173e-142 405
LLPS-Pat-3402Pan troglodytes98.761e-140 401
LLPS-Gog-2894Gorilla gorilla98.341e-140 401
LLPS-Cea-4371Cercocebus atys97.12e-139 398
LLPS-Maf-1276Macaca fascicularis96.693e-137 393
LLPS-Man-2563Macaca nemestrina96.693e-137 393
LLPS-Mam-1888Macaca mulatta96.693e-137 393
LLPS-Cas-0020Carlito syrichta95.453e-37 132
LLPS-Paa-3778Papio anubis93.365e-138 394
LLPS-Poa-4308Pongo abelii84.884e-99 295
LLPS-Aon-0134Aotus nancymaae82.932e-96 289
LLPS-Mal-2694Mandrillus leucophaeus82.383e-96 288
LLPS-Meg-1944Meleagris gallopavo81.824e-1674.7
LLPS-Nol-0916Nomascus leucogenys78.771e-88 269
LLPS-Eqc-1718Equus caballus78.641e-89 274
LLPS-Chs-2092Chlorocebus sabaeus78.545e-90 272
LLPS-Fud-1458Fukomys damarensis78.31e-92 278
LLPS-Myl-3914Myotis lucifugus78.051e-90 273
LLPS-Caf-0513Canis familiaris78.054e-90 272
LLPS-Rhb-1956Rhinopithecus bieti77.834e-87 265
LLPS-Orc-2448Oryctolagus cuniculus77.834e-91 275
LLPS-Mea-4150Mesocricetus auratus77.567e-83 254
LLPS-Icp-3878Ictalurus punctatus77.54e-1474.3
LLPS-Tar-0038Takifugu rubripes77.53e-1372.8
LLPS-Orn-0959Oreochromis niloticus77.54e-1371.2
LLPS-Bot-1393Bos taurus77.367e-91 274
LLPS-Cap-0623Cavia porcellus77.362e-91 276
LLPS-Loa-2432Loxodonta africana77.073e-86 262
LLPS-Caj-3282Callithrix jacchus76.895e-86 262
LLPS-Mup-1196Mustela putorius furo76.591e-84 258
LLPS-Mum-0267Mus musculus76.425e-90 272
LLPS-Urm-0199Ursus maritimus76.11e-84 258
LLPS-Ere-0874Erinaceus europaeus75.613e-81 249
LLPS-Fec-2251Felis catus75.474e-84 257
LLPS-Aim-2511Ailuropoda melanoleuca75.128e-83 253
LLPS-Asm-2605Astyanax mexicanus75.05e-1371.6
LLPS-Orl-0006Oryzias latipes75.06e-1371.6
LLPS-Dar-2130Danio rerio74.425e-1370.9
LLPS-Dio-0591Dipodomys ordii72.646e-85 259
LLPS-Ict-2345Ictidomys tridecemlineatus72.63e-81 250
LLPS-Ran-0929Rattus norvegicus72.174e-85 259
LLPS-Sus-0004Sus scrofa71.893e-78 242
LLPS-Ova-1074Ovis aries69.641e-76 238
LLPS-Gaa-3601Gasterosteus aculeatus68.753e-1371.6
LLPS-Lac-1632Latimeria chalumnae67.063e-29 112
LLPS-Scm-1870Scophthalmus maximus66.676e-1371.6
LLPS-Pof-0686Poecilia formosa64.295e-1473.9
LLPS-Ora-1344Ornithorhynchus anatinus64.086e-63 203
LLPS-Mod-0796Monodelphis domestica63.414e-68 216
LLPS-Gaga-0323Gallus gallus61.848e-61 197
LLPS-Tag-2360Taeniopygia guttata61.175e-62 199
LLPS-Sah-0279Sarcophilus harrisii59.912e-63 204
LLPS-Fia-1272Ficedula albicollis59.511e-57 190
LLPS-Pes-1156Pelodiscus sinensis58.496e-59 193
LLPS-Anp-1406Anas platyrhynchos58.17e-43 149
LLPS-Anc-2094Anolis carolinensis58.11e-57 189
LLPS-Xim-2020Xiphophorus maculatus57.34e-23 100
LLPS-Leo-3348Lepisosteus oculatus52.361e-50 172
LLPS-Xet-2602Xenopus tropicalis52.079e-50 169
LLPS-Scf-0953Scleropages formosus38.783e-36 135
LLPS-Ten-1911Tetraodon nigroviridis26.794e-0650.8