• Disorder
  • Domain
  • PTM
  • Variation
  • Mutation
  • Interaction
  • Disease
  • Drug
  • Physicochemical
  • Function
  • Proteomics
  • Structure
  • Localization
  • Expression
  • Element
  • Methylation

LLPS-Loa-0812
ATP2A1

Integrated Annotations

▼ OVERVIEW


Status: Unreviewed
Protein Name: Calcium-transporting ATPase
Gene Name: ATP2A1
Ensembl Gene: ENSLAFG00000016717.4
Ensembl Protein: ENSLAFP00000014028.4
Organism: Loxodonta africana
Taxa ID: 9785
LLPS Type: LLPS regulator


▼ PROPERTY



——— Disorder propensity (calculated by IUPred2A)

▼ Classification


Condensates:
CondensateEvidenceOrthologs
Stress granule, Postsynaptic densityPredicted from orthologs(View)

▼ FUNCTION


This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium.

▼ CROSS REFERENCE


DatabaseNucleotide IDProtein ID
EnsemblENSLAFT00000016717.4ENSLAFP00000014028.4
UniProtG3THI2, G3THI2_LOXAF

▼ SEQUENCE


Protein Sequence (FASTA)
1     MEAAHSKTTE  ECLAYFGVSE  TTGLTPDQVK  RHLEKYGHNE  LPAEEGKSLW  ELVIEQFEDL  60
61    LVRILLLAAC  ISFVLAWFEE  GEETVTAFVE  PFVILLILIA  NAIVGVWQER  NAENAIEALK  120
121   EYEPEMGKVY  RADRKAVQRI  KARDIVPGDI  VEVAVGDKVP  ADIRILSIKS  TTLRVDQSIL  180
181   TGESVSVIKH  TDPVPDPRAV  NQDKKNMLFS  GTNIAAGKAL  GIVASTGVNT  EIGKIRDQMA  240
241   ATEQDKTPLQ  QKLDEFGEQL  SKVISLICVA  VWLINIGHFS  DPVHGGSWIR  GAIYYFKIAV  300
301   ALAVAAIPEG  LPAVITTCLA  LGTRRMAKKN  AIVRSLPSVE  TLGCTSVICS  DKTGTLTTNQ  360
361   MSVCKMFIVD  KIDGDFCALN  EFSITGSTYA  PEGEILKNDK  PVRAGQYDGL  VELATICALC  420
421   NDSSLDFNET  KGIYEKVGEA  TETALTTLVE  KMNVFNTDVR  SLSKVERANA  CNSVIRQLMK  480
481   KEFTLEFSRD  RKSMSVYCSP  AKSRAAVGNK  MFVKGAPEGV  IDRCNYVRVG  TTRVPMTGPV  540
541   KEKILSVIKE  WGTGRDTLRC  LALATRDTPP  KREDMFLEDS  AKFIEYEVDL  TFVGVVGMLD  600
601   PPRKEVTGSI  QLCRDAGIRV  IMITGDNKGT  AIAICRRIGI  FGENEEVAER  AYTGREFDDL  660
661   PLPEQREACR  RACCFARVEP  THKSKIVEYL  QSYDEITAMT  GDGVNDAPAL  KKAEIGIAMG  720
721   SGTAVAKTAS  EMVLADDNFS  TIVAAVEEGR  AIYNNMKQFI  RYLISSNVGE  VVCIFLTAAL  780
781   GLPEALIPVQ  LLWVNLVTDG  LPATALGFNP  PDLDIMDRPP  RTPKEPLISG  WLFFRYMAIG  840
841   GYVGAATVGA  AAWWFMYAED  GPHVTYSQLT  HFMKCTEDNA  HFEGVDCEVF  EASEPMTMAL  900
901   SVLVTIEMCN  ALNSLSENQS  LIRMPPWVNI  WLVGSIGLSM  SLHFLILYID  PLPMIFKLQA  960
961   LTVNQWLMVL  KISLPVIGLD  EILKFIARNY  LEGKRFSLQG  ALRASRALEP  GAESLCALCP  1020
1021  HTLFLPFLSW  PCRTSVHQGG  ALQA  1044
Nucleotide CDS Sequence (FASTA)
1     ATGGAGGCTG  CACACTCCAA  GACCACGGAG  GAATGTTTGG  CCTATTTTGG  GGTGAGTGAG  60
61    ACCACAGGCC  TCACCCCAGA  CCAAGTTAAG  CGGCACCTGG  AGAAGTACGG  CCACAATGAG  120
121   CTCCCTGCTG  AGGAAGGAAA  GTCCCTGTGG  GAGTTGGTGA  TAGAGCAGTT  TGAAGACCTC  180
181   CTGGTGCGCA  TCCTTCTCCT  GGCCGCCTGC  ATTTCCTTTG  TGCTGGCCTG  GTTTGAGGAA  240
241   GGTGAAGAGA  CCGTCACGGC  CTTTGTTGAA  CCCTTCGTCA  TCCTCTTGAT  CCTCATTGCC  300
301   AACGCCATAG  TGGGGGTTTG  GCAGGAGCGT  AATGCAGAGA  ATGCCATAGA  GGCTCTGAAG  360
361   GAATATGAGC  CTGAGATGGG  AAAGGTCTAC  CGGGCTGATC  GAAAGGCAGT  GCAAAGGATC  420
421   AAGGCTCGGG  ACATTGTCCC  CGGGGACATT  GTGGAGGTGG  CTGTGGGGGA  CAAAGTCCCT  480
481   GCAGATATCC  GAATCCTCTC  CATCAAATCC  ACCACCCTCC  GGGTTGACCA  GTCCATCCTC  540
541   ACAGGTGAGT  CTGTCTCTGT  CATCAAGCAC  ACAGACCCTG  TTCCTGACCC  CCGAGCTGTC  600
601   AACCAGGACA  AGAAGAACAT  GCTTTTCTCG  GGTACCAACA  TTGCAGCTGG  CAAGGCCTTA  660
661   GGCATTGTGG  CCAGCACGGG  CGTGAACACC  GAGATTGGGA  AGATTCGTGA  CCAAATGGCT  720
721   GCCACAGAAC  AGGACAAGAC  CCCTCTGCAG  CAGAAGCTGG  ATGAGTTTGG  GGAGCAGCTC  780
781   TCCAAGGTTA  TCTCCCTCAT  CTGCGTGGCC  GTCTGGCTCA  TCAACATTGG  CCACTTCAGT  840
841   GATCCTGTCC  ATGGAGGCTC  TTGGATCCGT  GGTGCCATCT  ACTACTTCAA  GATTGCTGTG  900
901   GCTCTGGCTG  TGGCTGCAAT  CCCAGAAGGT  CTTCCTGCAG  TCATCACCAC  CTGCCTGGCC  960
961   CTGGGGACCC  GCCGGATGGC  AAAGAAGAAT  GCTATTGTGA  GGAGCTTACC  CTCAGTTGAG  1020
1021  ACCCTGGGCT  GCACCTCTGT  CATCTGTTCC  GACAAGACAG  GCACCCTCAC  CACCAACCAG  1080
1081  ATGTCTGTCT  GCAAGATGTT  TATCGTTGAC  AAGATAGATG  GGGACTTCTG  CGCTCTGAAT  1140
1141  GAGTTCTCCA  TCACTGGTTC  CACTTATGCT  CCAGAAGGAG  AGATCTTGAA  GAATGATAAG  1200
1201  CCAGTGCGGG  CAGGGCAGTA  TGATGGGCTG  GTGGAGCTGG  CCACCATTTG  TGCCCTCTGC  1260
1261  AATGACTCCT  CCTTGGATTT  CAATGAGACC  AAAGGTATCT  ATGAGAAGGT  CGGTGAGGCC  1320
1321  ACTGAGACGG  CCCTTACCAC  CCTGGTGGAG  AAGATGAATG  TATTCAACAC  TGATGTGAGA  1380
1381  AGCCTCTCGA  AGGTGGAGAG  GGCCAATGCC  TGCAACTCGG  TGATCCGCCA  GCTAATGAAG  1440
1441  AAGGAGTTCA  CACTGGAGTT  CTCCCGAGAC  AGAAAGTCCA  TGTCTGTCTA  TTGCTCCCCA  1500
1501  GCCAAATCCC  GGGCTGCTGT  GGGCAACAAG  ATGTTTGTCA  AGGGTGCCCC  TGAGGGGGTC  1560
1561  ATCGATCGCT  GTAACTACGT  GCGAGTTGGC  ACAACCAGGG  TACCGATGAC  AGGGCCGGTG  1620
1621  AAGGAGAAGA  TCTTGTCAGT  GATCAAGGAG  TGGGGCACCG  GCCGAGACAC  CCTGCGCTGC  1680
1681  CTGGCCCTGG  CCACCCGGGA  CACCCCCCCG  AAGCGAGAGG  ACATGTTTCT  GGAAGACTCT  1740
1741  GCGAAGTTCA  TAGAGTATGA  GGTGGACCTG  ACTTTCGTTG  GCGTGGTGGG  CATGTTGGAC  1800
1801  CCACCCCGCA  AGGAGGTCAC  AGGCTCCATC  CAGCTGTGCC  GTGATGCTGG  AATCCGAGTA  1860
1861  ATTATGATCA  CAGGGGACAA  CAAGGGCACG  GCCATCGCCA  TCTGCCGACG  AATTGGCATC  1920
1921  TTTGGCGAGA  ACGAGGAGGT  GGCAGAACGT  GCCTACACCG  GCCGGGAGTT  TGACGACCTA  1980
1981  CCGCTGCCTG  AGCAGCGGGA  GGCCTGCCGC  CGTGCCTGCT  GTTTTGCCCG  TGTGGAGCCC  2040
2041  ACCCACAAGT  CCAAGATTGT  GGAATATCTG  CAGTCCTACG  ACGAGATCAC  AGCCATGACA  2100
2101  GGCGATGGCG  TCAATGACGC  CCCTGCACTG  AAAAAGGCTG  AGATCGGCAT  TGCCATGGGA  2160
2161  TCCGGCACCG  CCGTGGCCAA  GACGGCCTCA  GAGATGGTGC  TGGCAGATGA  TAATTTCTCC  2220
2221  ACCATCGTGG  CTGCTGTGGA  GGAGGGCCGC  GCCATCTACA  ACAACATGAA  GCAGTTCATC  2280
2281  CGCTACCTCA  TTTCCTCCAA  CGTGGGCGAG  GTGGTCTGCA  TCTTCCTGAC  AGCCGCTTTG  2340
2341  GGGCTGCCCG  AGGCCCTTAT  CCCTGTGCAG  CTGCTGTGGG  TCAACCTGGT  GACAGATGGG  2400
2401  CTCCCAGCCA  CAGCCCTGGG  CTTCAACCCG  CCAGACCTGG  ACATCATGGA  CCGCCCCCCA  2460
2461  CGCACCCCAA  AGGAACCCCT  CATCAGTGGC  TGGCTCTTCT  TCCGCTATAT  GGCAATTGGG  2520
2521  GGCTATGTGG  GTGCAGCTAC  CGTGGGAGCA  GCTGCCTGGT  GGTTCATGTA  TGCAGAGGAT  2580
2581  GGGCCTCATG  TCACCTACAG  CCAGCTGACT  CACTTTATGA  AGTGCACTGA  GGACAACGCC  2640
2641  CACTTTGAAG  GTGTGGACTG  TGAGGTCTTT  GAGGCCTCTG  AGCCCATGAC  CATGGCCTTG  2700
2701  TCTGTGCTGG  TCACCATCGA  GATGTGCAAC  GCTCTCAACA  GCCTGTCTGA  GAACCAGTCC  2760
2761  CTCATACGGA  TGCCACCATG  GGTGAACATC  TGGCTGGTGG  GCTCCATCGG  CCTCTCCATG  2820
2821  TCCCTCCATT  TTCTCATCCT  CTACATCGAC  CCCTTGCCGA  TGATCTTCAA  GCTCCAGGCC  2880
2881  TTGACAGTTA  ACCAGTGGCT  CATGGTCCTC  AAGATCTCAC  TTCCAGTCAT  CGGGCTCGAC  2940
2941  GAGATCCTCA  AGTTCATTGC  TCGGAACTAT  CTGGAGGGTA  AGAGGTTCTC  CCTCCAAGGA  3000
3001  GCCCTCAGAG  CCTCGAGAGC  CCTTGAACCT  GGGGCAGAGT  CCCTCTGCGC  GCTGTGCCCA  3060
3061  CACACCCTCT  TCCTTCCTTT  CCTTTCTTGG  CCCTGTAGGA  CCAGTGTCCA  CCAGGGAGGA  3120
3121  GCACTCCAGG  CC  3132

▼ KEYWORD


ID
Family
ATP-binding
Calcium
Calcium transport
Complete proteome
Ion transport
Membrane
Nucleotide-binding
Reference proteome
Transmembrane
Transmembrane helix
Transport

▼ GENE ONTOLOGY


ID
Classification
Description
Cellular Component
Integral component of membrane
Cellular Component
Mitochondrion
Cellular Component
Sarcoplasmic reticulum membrane
Molecular Function
ATP binding
Molecular Function
Calcium ion binding
Molecular Function
Calcium-transporting ATPase activity
Molecular Function
Protein homodimerization activity
Biological Process
Apoptotic mitochondrial changes
Biological Process
Calcium ion import
Biological Process
Intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
Biological Process
Maintenance of mitochondrion location
Biological Process
Negative regulation of endoplasmic reticulum calcium ion concentration
Biological Process
Positive regulation of endoplasmic reticulum calcium ion concentration
Biological Process
Positive regulation of fast-twitch skeletal muscle fiber contraction
Biological Process
Positive regulation of mitochondrial calcium ion concentration
Biological Process
Relaxation of skeletal muscle

▼ ORTHOLOGY


DrLLPS IDOrganismIdentityE-valueScore
LLPS-Chs-4713Chlorocebus sabaeus95.770.01847
LLPS-Sus-4452Sus scrofa95.770.01851
LLPS-Bot-4435Bos taurus95.670.01847
LLPS-Ova-3715Ovis aries95.380.01844
LLPS-Hos-2153Homo sapiens95.070.01835
LLPS-Caf-3397Canis familiaris95.060.01837
LLPS-Mum-3231Mus musculus94.970.01833
LLPS-Poa-1361Pongo abelii94.870.01833
LLPS-Myl-0452Myotis lucifugus94.860.01835
LLPS-Cap-4509Cavia porcellus94.660.01823
LLPS-Aim-1581Ailuropoda melanoleuca94.660.01833
LLPS-Mup-2103Mustela putorius furo94.660.01833
LLPS-Aon-2606Aotus nancymaae94.570.01822
LLPS-Caj-2365Callithrix jacchus94.570.01826
LLPS-Fec-0196Felis catus94.380.01746
LLPS-Otg-1150Otolemur garnettii94.260.01825
LLPS-Pat-2580Pan troglodytes94.20.01816
LLPS-Cas-3690Carlito syrichta94.180.01816
LLPS-Ict-1887Ictidomys tridecemlineatus93.670.01808
LLPS-Mam-3630Macaca mulatta92.90.01830
LLPS-Mal-4270Mandrillus leucophaeus92.80.01827
LLPS-Paa-0840Papio anubis92.80.01827
LLPS-Rhb-0713Rhinopithecus bieti92.610.01827
LLPS-Dio-3250Dipodomys ordii91.490.01826
LLPS-Sah-1432Sarcophilus harrisii90.940.01744
LLPS-Orc-3972Oryctolagus cuniculus90.840.01756
LLPS-Mea-3730Mesocricetus auratus90.790.01747
LLPS-Man-2081Macaca nemestrina90.020.01766
LLPS-Fud-3983Fukomys damarensis89.250.01802
LLPS-Eqc-4821Equus caballus88.80.01642
LLPS-Nol-2520Nomascus leucogenys88.620.01721
LLPS-Cea-4263Cercocebus atys87.940.01695
LLPS-Anc-1668Anolis carolinensis87.920.01703
LLPS-Xet-2026Xenopus tropicalis87.90.01721
LLPS-Lac-2450Latimeria chalumnae86.480.01726
LLPS-Scf-0205Scleropages formosus85.290.01682
LLPS-Xim-3917Xiphophorus maculatus84.720.01658
LLPS-Orn-1977Oreochromis niloticus84.620.01654
LLPS-Pof-1694Poecilia formosa84.520.01650
LLPS-Dar-0621Danio rerio84.180.01656
LLPS-Orl-2826Oryzias latipes83.920.01647
LLPS-Tar-0881Takifugu rubripes83.870.01638
LLPS-Asm-1182Astyanax mexicanus83.580.01657
LLPS-Ten-2679Tetraodon nigroviridis83.30.01637
LLPS-Scm-1501Scophthalmus maximus83.120.01635
LLPS-Icp-0928Ictalurus punctatus82.680.01625
LLPS-Cii-2282Ciona intestinalis75.30.01478
LLPS-Ere-0611Erinaceus europaeus75.10.01473
LLPS-Cis-1886Ciona savignyi69.870.01420
LLPS-Tum-0687Tuber melanosporum57.292e-131 423
LLPS-Chc-1130Chondrus crispus57.110.01011
LLPS-Php-0746Physcomitrella patens53.910.0 942
LLPS-Gas-0443Galdieria sulphuraria53.820.0 964
LLPS-Beb-1404Beauveria bassiana53.580.0 921
LLPS-Asc-1223Aspergillus clavatus53.290.0 960
LLPS-Spr-1571Sporisorium reilianum52.410.0 956
LLPS-Lep-2258Leersia perrieri52.30.0 911
LLPS-Ors-0878Oryza sativa51.630.0 703
LLPS-Osl-1393Ostreococcus lucimarinus51.240.0 860
LLPS-Coc-1501Corchorus capsularis51.050.0 895
LLPS-Hea-0729Helianthus annuus50.960.0 855
LLPS-Prp-1286Prunus persica50.920.0 863
LLPS-Orm-2105Oryza meridionalis50.810.0 914
LLPS-Sot-0914Solanum tuberosum50.630.0 845
LLPS-Nia-1011Nicotiana attenuata50.580.0 843
LLPS-Orbr-1475Oryza brachyantha50.360.0 800
LLPS-Ori-0411Oryza indica50.280.0 933
LLPS-Sol-1514Solanum lycopersicum50.190.0 837
LLPS-Brd-1759Brachypodium distachyon50.050.0 837
LLPS-Viv-2026Vitis vinifera50.00.0 853
LLPS-Sem-1426Selaginella moellendorffii50.00.0 829
LLPS-Hov-0438Hordeum vulgare49.950.0 796
LLPS-Tra-1370Triticum aestivum49.950.0 835
LLPS-Met-1193Medicago truncatula49.90.0 852
LLPS-Orp-1105Oryza punctata49.810.0 846
LLPS-Dac-0445Daucus carota49.760.0 842
LLPS-Orr-1838Oryza rufipogon49.710.0 843
LLPS-Orni-0324Oryza nivara49.710.0 845
LLPS-Orgl-2089Oryza glumaepatula49.710.0 845
LLPS-Sei-1223Setaria italica49.710.0 843
LLPS-Zem-2183Zea mays49.660.0 845
LLPS-Via-1216Vigna angularis49.660.0 837
LLPS-Org-1329Oryza glaberrima49.610.0 842
LLPS-Bro-2818Brassica oleracea49.570.0 843
LLPS-Vir-1078Vigna radiata49.570.0 832
LLPS-Sob-0876Sorghum bicolor49.560.0 845
LLPS-Brr-2371Brassica rapa49.520.0 845
LLPS-Art-2246Arabidopsis thaliana49.520.0 847
LLPS-Arl-0737Arabidopsis lyrata49.430.0 855
LLPS-Glm-1090Glycine max49.330.0 854
LLPS-Gor-0349Gossypium raimondii49.280.0 849
LLPS-Cus-1692Cucumis sativus49.280.0 838
LLPS-Amt-0385Amborella trichopoda49.230.0 830
LLPS-Orb-0171Oryza barthii49.130.0 827
LLPS-Pot-0858Populus trichocarpa49.10.0 840
LLPS-Mae-1551Manihot esculenta49.060.0 839
LLPS-Thc-0558Theobroma cacao49.00.0 845
LLPS-Phv-1729Phaseolus vulgaris48.990.0 835
LLPS-Brn-0528Brassica napus48.520.0 810
LLPS-Tru-0939Triticum urartu48.340.0 657
LLPS-Mua-0035Musa acuminata44.940.0 705
LLPS-Scp-0372Schizosaccharomyces pombe34.183e-141 453
LLPS-Pytr-0749Pyrenophora triticirepentis33.891e-122 404
LLPS-Scj-1503Schizosaccharomyces japonicus33.641e-132 431
LLPS-Scc-1445Schizosaccharomyces cryophilus33.635e-139 447
LLPS-Pyt-0578Pyrenophora teres33.632e-121 403
LLPS-Put-0353Puccinia triticina33.561e-113 384
LLPS-Yal-0555Yarrowia lipolytica33.52e-123 406
LLPS-Tag-1513Taeniopygia guttata33.42e-133 434
LLPS-Pes-0443Pelodiscus sinensis33.234e-135 437
LLPS-Pug-1162Puccinia graminis33.144e-114 385
LLPS-Fia-1728Ficedula albicollis33.094e-132 430
LLPS-Gaga-1529Gallus gallus32.928e-134 436
LLPS-Kop-0614Komagataella pastoris32.832e-126 414
LLPS-Meg-0937Meleagris gallopavo32.796e-134 436
LLPS-Usm-0913Ustilago maydis32.654e-104 357
LLPS-Tut-1236Tursiops truncatus32.589e-135 438
LLPS-Miv-0269Microbotryum violaceum32.565e-128 422
LLPS-Ora-1982Ornithorhynchus anatinus32.513e-131 428
LLPS-Gaa-0746Gasterosteus aculeatus32.474e-115 379
LLPS-Mod-2256Monodelphis domestica32.311e-133 435
LLPS-Pap-2119Pan paniscus32.279e-134 436
LLPS-Urm-2751Ursus maritimus32.271e-134 438
LLPS-Asni-0437Aspergillus niger32.199e-117 391
LLPS-Maf-2887Macaca fascicularis32.177e-132 431
LLPS-Gog-2068Gorilla gorilla32.175e-132 431
LLPS-Ran-0892Rattus norvegicus32.075e-131 427
LLPS-Leo-2113Lepisosteus oculatus32.041e-137 444
LLPS-Mel-0162Melampsora laricipopulina32.044e-117 388
LLPS-Sac-0379Saccharomyces cerevisiae32.042e-123 407
LLPS-Zyt-1381Zymoseptoria tritici32.023e-121 404
LLPS-Nec-0245Neurospora crassa32.04e-122 405
LLPS-Crn-1382Cryptococcus neoformans31.963e-119 396
LLPS-Anp-3166Anas platyrhynchos31.854e-117 390
LLPS-Asfu-0222Aspergillus fumigatus31.711e-115 389
LLPS-Asg-0286Ashbya gossypii31.693e-123 407
LLPS-Cae-1943Caenorhabditis elegans31.651e-129 424
LLPS-Nef-1620Neosartorya fischeri31.611e-114 386
LLPS-Phn-0948Phaeosphaeria nodorum31.491e-126 417
LLPS-Ast-0799Aspergillus terreus31.431e-123 410
LLPS-Abg-0539Absidia glauca31.344e-119 394
LLPS-Trv-0570Trichoderma virens31.226e-125 414
LLPS-Map-0070Magnaporthe poae31.182e-121 405
LLPS-Mao-1187Magnaporthe oryzae31.013e-115 388
LLPS-Dos-1314Dothistroma septosporum30.756e-120 401
LLPS-Coo-1527Colletotrichum orbiculare30.683e-118 396
LLPS-Trr-0695Trichoderma reesei30.673e-126 417
LLPS-Drm-1881Drosophila melanogaster30.675e-115 387
LLPS-Gag-1472Gaeumannomyces graminis30.232e-120 402
LLPS-Cog-0183Colletotrichum gloeosporioides30.224e-118 395
LLPS-Cogr-1003Colletotrichum graminicola30.052e-113 382
LLPS-Fuv-1080Fusarium verticillioides29.942e-113 383
LLPS-Fus-0532Fusarium solani29.647e-114 384
LLPS-Aso-0039Aspergillus oryzae28.922e-100 347
LLPS-Asf-1211Aspergillus flavus28.926e-100 346
LLPS-Ved-1406Verticillium dahliae28.887e-109 370