LLPS-Loa-0699
MED10
Integrated Annotations
▼ OVERVIEW
| Status: | Unreviewed |
| Protein Name: | Mediator of RNA polymerase II transcription subunit 10; Mediator complex subunit 10 |
| Gene Name: | MED10 |
| Ensembl Gene: | ENSLAFG00000016146.3 |
| Ensembl Protein: | ENSLAFP00000028155.1 |
| Organism: | Loxodonta africana |
| Taxa ID: | 9785 |
| LLPS Type: | Others |
▼ Classification
Condensates:
| Condensate | Evidence | Orthologs |
|---|---|---|
| Nucleolus | Predicted from orthologs | (View) |
▼ FUNCTION
| Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. |
▼ CROSS REFERENCE
| Database | Nucleotide ID | Protein ID |
|---|---|---|
| Ensembl | ENSLAFT00000030701.1 | ENSLAFP00000028155.1 |
| Ensembl | ENSLAFT00000016142.3 | ENSLAFP00000013552.3 |
| UniProt | G3TGF3, G3TGF3_LOXAF |
▼ SEQUENCE
| Protein Sequence (FASTA) |
|---|
1 MAEKFDHLEE HLEKFVENIR QLGIIVSDFQ PSSQAGLNQK LNFIVTGLQD IDKCRQQLHD 60 61 IMVPLEVFEY IDQGRNPQLY TKECLERALA KNEQVKGKID TMKKDFRLLL IQELSKVFPE 120 121 DMANYRSIRG EDHPPS 136 |
| Nucleotide CDS Sequence (FASTA) |
1 ATGGCGGAGA AGTTCGACCA CCTGGAGGAG CACCTGGAGA AGTTCGTGGA GAACATCCGG 60 61 CAGCTCGGCA TCATCGTCAG CGACTTCCAG CCCAGCAGCC AGGCCGGGCT CAACCAGAAG 120 121 CTGAATTTTA TCGTTACTGG CTTGCAGGAT ATTGATAAGT GCAGACAGCA GCTTCATGAT 180 181 ATTATGGTAC CCCTAGAAGT TTTTGAGTAC ATAGATCAAG GTCGAAACCC CCAGCTCTAC 240 241 ACCAAAGAGT GCCTGGAGAG GGCTCTCGCG AAAAACGAGC AGGTGAAAGG CAAGATTGAC 300 301 ACAATGAAGA AAGATTTTAG GTTGTTGTTG ATTCAAGAAC TTTCTAAAGT ATTCCCAGAA 360 361 GACATGGCCA ATTATCGGAG CATCCGAGGG GAGGACCACC CCCCTTCCTA A 411 |
▼ KEYWORD
▼ GENE ONTOLOGY
ID | Classification | Description |
Cellular Component | Mediator complex | |
Molecular Function | Transcription coregulator activity | |
Biological Process | Positive regulation of transcription by RNA polymerase II | |
Biological Process | Stem cell population maintenance |
▼ ORTHOLOGY
| DrLLPS ID | Organism | Identity | E-value | Score |
|---|---|---|---|---|
| LLPS-Mod-3181 | Monodelphis domestica | 99.03 | 3e-69 | 211 |
| LLPS-Mum-1975 | Mus musculus | 98.06 | 9e-69 | 211 |
| LLPS-Aon-1884 | Aotus nancymaae | 96.32 | 1e-90 | 266 |
| LLPS-Caj-3252 | Callithrix jacchus | 96.32 | 1e-90 | 266 |
| LLPS-Gog-0720 | Gorilla gorilla | 96.32 | 1e-90 | 266 |
| LLPS-Bot-2440 | Bos taurus | 96.32 | 1e-90 | 266 |
| LLPS-Mup-0354 | Mustela putorius furo | 96.32 | 1e-90 | 266 |
| LLPS-Hos-1073 | Homo sapiens | 96.32 | 1e-90 | 266 |
| LLPS-Pap-1761 | Pan paniscus | 96.32 | 1e-90 | 266 |
| LLPS-Pat-2785 | Pan troglodytes | 96.32 | 1e-90 | 266 |
| LLPS-Poa-0259 | Pongo abelii | 96.32 | 1e-90 | 266 |
| LLPS-Eqc-3001 | Equus caballus | 96.32 | 1e-90 | 266 |
| LLPS-Nol-3971 | Nomascus leucogenys | 96.32 | 1e-90 | 266 |
| LLPS-Sus-1871 | Sus scrofa | 95.59 | 1e-89 | 263 |
| LLPS-Cea-0863 | Cercocebus atys | 95.59 | 4e-89 | 262 |
| LLPS-Maf-2202 | Macaca fascicularis | 95.59 | 4e-89 | 262 |
| LLPS-Mea-3212 | Mesocricetus auratus | 95.59 | 5e-90 | 264 |
| LLPS-Chs-1409 | Chlorocebus sabaeus | 95.59 | 4e-89 | 262 |
| LLPS-Dio-0589 | Dipodomys ordii | 95.59 | 7e-90 | 264 |
| LLPS-Paa-3030 | Papio anubis | 95.59 | 4e-89 | 262 |
| LLPS-Mal-1246 | Mandrillus leucophaeus | 95.59 | 4e-89 | 262 |
| LLPS-Myl-0735 | Myotis lucifugus | 95.59 | 5e-90 | 264 |
| LLPS-Ran-1007 | Rattus norvegicus | 95.59 | 5e-90 | 264 |
| LLPS-Man-3442 | Macaca nemestrina | 95.59 | 4e-89 | 262 |
| LLPS-Fec-1436 | Felis catus | 95.59 | 3e-90 | 265 |
| LLPS-Rhb-2306 | Rhinopithecus bieti | 95.59 | 4e-89 | 262 |
| LLPS-Mam-0863 | Macaca mulatta | 95.59 | 4e-89 | 262 |
| LLPS-Urm-0426 | Ursus maritimus | 95.38 | 7e-38 | 133 |
| LLPS-Otg-1471 | Otolemur garnettii | 94.85 | 1e-89 | 263 |
| LLPS-Fud-1983 | Fukomys damarensis | 94.74 | 4e-59 | 184 |
| LLPS-Aim-2678 | Ailuropoda melanoleuca | 94.74 | 3e-59 | 184 |
| LLPS-Sah-1048 | Sarcophilus harrisii | 94.68 | 2e-58 | 182 |
| LLPS-Caf-1904 | Canis familiaris | 94.29 | 9e-66 | 201 |
| LLPS-Cap-2640 | Cavia porcellus | 94.07 | 3e-87 | 257 |
| LLPS-Ova-2666 | Ovis aries | 92.7 | 4e-85 | 252 |
| LLPS-Xet-1602 | Xenopus tropicalis | 91.91 | 4e-87 | 257 |
| LLPS-Meg-2231 | Meleagris gallopavo | 91.85 | 2e-85 | 253 |
| LLPS-Gaga-0538 | Gallus gallus | 91.85 | 1e-85 | 253 |
| LLPS-Lac-2661 | Latimeria chalumnae | 91.18 | 2e-86 | 255 |
| LLPS-Fia-3640 | Ficedula albicollis | 91.11 | 9e-85 | 251 |
| LLPS-Anc-2106 | Anolis carolinensis | 90.37 | 1e-83 | 248 |
| LLPS-Tag-1863 | Taeniopygia guttata | 90.37 | 4e-84 | 249 |
| LLPS-Leo-1125 | Lepisosteus oculatus | 88.97 | 9e-82 | 243 |
| LLPS-Orc-1786 | Oryctolagus cuniculus | 88.89 | 4e-38 | 130 |
| LLPS-Pes-1007 | Pelodiscus sinensis | 88.04 | 1e-52 | 168 |
| LLPS-Scm-0834 | Scophthalmus maximus | 85.82 | 6e-80 | 239 |
| LLPS-Dar-3568 | Danio rerio | 85.29 | 1e-78 | 235 |
| LLPS-Pof-0590 | Poecilia formosa | 85.07 | 3e-78 | 234 |
| LLPS-Ten-0850 | Tetraodon nigroviridis | 84.85 | 3e-77 | 232 |
| LLPS-Orl-2768 | Oryzias latipes | 84.44 | 3e-78 | 234 |
| LLPS-Xim-2392 | Xiphophorus maculatus | 84.33 | 6e-77 | 231 |
| LLPS-Tar-2340 | Takifugu rubripes | 84.09 | 4e-77 | 231 |
| LLPS-Gaa-0361 | Gasterosteus aculeatus | 83.58 | 8e-78 | 233 |
| LLPS-Orn-3047 | Oreochromis niloticus | 83.58 | 1e-78 | 235 |
| LLPS-Icp-3644 | Ictalurus punctatus | 83.09 | 2e-76 | 230 |
| LLPS-Asm-0837 | Astyanax mexicanus | 82.35 | 7e-77 | 231 |
| LLPS-Anp-0126 | Anas platyrhynchos | 81.73 | 2e-55 | 175 |
| LLPS-Cas-2052 | Carlito syrichta | 75.19 | 2e-58 | 184 |
| LLPS-Drm-0751 | Drosophila melanogaster | 60.0 | 3e-48 | 158 |
| LLPS-Blg-1458 | Blumeria graminis | 44.83 | 2e-09 | 56.6 |
| LLPS-Cae-0398 | Caenorhabditis elegans | 44.09 | 4e-28 | 107 |
| LLPS-Orb-2306 | Oryza barthii | 41.07 | 2e-18 | 82.0 |
| LLPS-Ori-0180 | Oryza indica | 41.07 | 3e-18 | 81.6 |
| LLPS-Orni-0319 | Oryza nivara | 41.07 | 3e-18 | 81.6 |
| LLPS-Orgl-1455 | Oryza glumaepatula | 41.07 | 2e-18 | 82.0 |
| LLPS-Hov-0722 | Hordeum vulgare | 41.07 | 8e-18 | 80.5 |
| LLPS-Tra-1527 | Triticum aestivum | 41.07 | 1e-18 | 82.8 |
| LLPS-Ors-0420 | Oryza sativa | 41.07 | 3e-18 | 81.6 |
| LLPS-Orr-1464 | Oryza rufipogon | 41.07 | 3e-18 | 81.6 |
| LLPS-Orm-0993 | Oryza meridionalis | 41.07 | 2e-17 | 79.7 |
| LLPS-Org-1412 | Oryza glaberrima | 41.07 | 3e-18 | 81.6 |
| LLPS-Tru-1631 | Triticum urartu | 41.07 | 4e-18 | 81.6 |
| LLPS-Coc-0038 | Corchorus capsularis | 39.5 | 2e-20 | 87.8 |
| LLPS-Zem-1093 | Zea mays | 39.5 | 7e-19 | 83.6 |
| LLPS-Scs-1109 | Sclerotinia sclerotiorum | 39.47 | 3e-10 | 58.5 |
| LLPS-Art-2344 | Arabidopsis thaliana | 39.1 | 3e-19 | 84.3 |
| LLPS-Php-1651 | Physcomitrella patens | 38.6 | 1e-17 | 79.7 |
| LLPS-Brd-0212 | Brachypodium distachyon | 38.4 | 7e-18 | 80.9 |
| LLPS-Nef-0468 | Neosartorya fischeri | 38.1 | 2e-07 | 50.8 |
| LLPS-Asfu-1097 | Aspergillus fumigatus | 38.1 | 2e-07 | 50.8 |
| LLPS-Asn-0501 | Aspergillus nidulans | 37.84 | 6e-09 | 55.1 |
| LLPS-Thc-1487 | Theobroma cacao | 37.82 | 1e-18 | 82.8 |
| LLPS-Lep-1323 | Leersia perrieri | 37.6 | 3e-18 | 81.6 |
| LLPS-Orp-1610 | Oryza punctata | 37.6 | 6e-18 | 80.9 |
| LLPS-Orbr-0997 | Oryza brachyantha | 37.6 | 3e-18 | 81.6 |
| LLPS-Mua-1933 | Musa acuminata | 37.4 | 9e-17 | 77.8 |
| LLPS-Dac-0465 | Daucus carota | 36.72 | 3e-18 | 82.0 |
| LLPS-Sei-1593 | Setaria italica | 36.72 | 9e-19 | 83.6 |
| LLPS-Sob-0737 | Sorghum bicolor | 36.72 | 1e-18 | 82.8 |
| LLPS-Brr-2946 | Brassica rapa | 36.67 | 4e-07 | 50.1 |
| LLPS-Asc-1447 | Aspergillus clavatus | 36.51 | 2e-06 | 47.8 |
| LLPS-Zyt-1314 | Zymoseptoria tritici | 36.21 | 3e-07 | 48.9 |
| LLPS-Gor-0458 | Gossypium raimondii | 35.94 | 1e-18 | 82.8 |
| LLPS-Nia-0078 | Nicotiana attenuata | 35.94 | 2e-17 | 79.3 |
| LLPS-Prp-0820 | Prunus persica | 35.94 | 4e-20 | 86.7 |
| LLPS-Arl-1333 | Arabidopsis lyrata | 35.82 | 2e-19 | 86.3 |
| LLPS-Amt-1006 | Amborella trichopoda | 35.77 | 2e-16 | 76.3 |
| LLPS-Brn-0390 | Brassica napus | 35.16 | 1e-19 | 86.3 |
| LLPS-Hea-0148 | Helianthus annuus | 35.16 | 1e-17 | 79.7 |
| LLPS-Ast-0454 | Aspergillus terreus | 34.92 | 7e-06 | 46.6 |
| LLPS-Met-2006 | Medicago truncatula | 34.65 | 6e-17 | 78.2 |
| LLPS-Sol-0528 | Solanum lycopersicum | 34.38 | 6e-17 | 78.2 |
| LLPS-Sot-0685 | Solanum tuberosum | 34.38 | 6e-17 | 78.2 |
| LLPS-Cus-0935 | Cucumis sativus | 34.38 | 4e-17 | 79.3 |
| LLPS-Pot-1836 | Populus trichocarpa | 34.38 | 1e-17 | 80.1 |
| LLPS-Kop-1305 | Komagataella pastoris | 34.34 | 2e-10 | 59.3 |
| LLPS-Viv-1177 | Vitis vinifera | 34.33 | 1e-18 | 82.8 |
| LLPS-Yal-0476 | Yarrowia lipolytica | 33.96 | 4e-10 | 58.5 |
| LLPS-Glm-1275 | Glycine max | 33.86 | 6e-16 | 75.5 |
| LLPS-Vir-0545 | Vigna radiata | 33.86 | 7e-16 | 75.1 |
| LLPS-Phv-1346 | Phaseolus vulgaris | 33.86 | 4e-16 | 75.9 |
| LLPS-Tum-1104 | Tuber melanosporum | 33.62 | 2e-13 | 68.2 |
| LLPS-Mae-1614 | Manihot esculenta | 33.59 | 2e-16 | 76.6 |
| LLPS-Sem-0396 | Selaginella moellendorffii | 32.97 | 1e-08 | 54.3 |
| LLPS-Abg-1686 | Absidia glauca | 32.74 | 5e-14 | 69.7 |
| LLPS-Asg-0312 | Ashbya gossypii | 32.2 | 4e-09 | 55.5 |
| LLPS-Mel-0741 | Melampsora laricipopulina | 31.11 | 1e-05 | 46.6 |
| LLPS-Miv-1523 | Microbotryum violaceum | 31.01 | 6e-13 | 67.0 |
| LLPS-Sac-1366 | Saccharomyces cerevisiae | 29.77 | 1e-08 | 54.3 |
| LLPS-Put-0962 | Puccinia triticina | 28.68 | 1e-07 | 51.6 |
| LLPS-Trr-0016 | Trichoderma reesei | 28.33 | 9e-10 | 57.4 |
| LLPS-Usm-0097 | Ustilago maydis | 27.59 | 3e-10 | 59.3 |
| LLPS-Trv-1164 | Trichoderma virens | 27.42 | 9e-10 | 57.4 |
| LLPS-Pug-0384 | Puccinia graminis | 27.13 | 8e-06 | 47.0 |
| LLPS-Dos-1596 | Dothistroma septosporum | 27.12 | 3e-08 | 53.1 |
| LLPS-Beb-0937 | Beauveria bassiana | 26.67 | 4e-07 | 50.4 |
| LLPS-Fuv-0713 | Fusarium verticillioides | 26.61 | 2e-08 | 53.9 |
| LLPS-Fuo-1078 | Fusarium oxysporum | 26.61 | 2e-08 | 53.9 |
| LLPS-Spr-0801 | Sporisorium reilianum | 25.86 | 3e-08 | 53.5 |
| LLPS-Pyt-0397 | Pyrenophora teres | 25.64 | 2e-06 | 48.5 |
| LLPS-Pytr-1627 | Pyrenophora triticirepentis | 25.64 | 1e-06 | 48.1 |
| LLPS-Coo-1261 | Colletotrichum orbiculare | 25.4 | 7e-08 | 54.7 |
| LLPS-Mao-0431 | Magnaporthe oryzae | 24.41 | 1e-09 | 57.0 |
| LLPS-Scp-1456 | Schizosaccharomyces pombe | 23.97 | 6e-08 | 52.0 |
| LLPS-Map-0708 | Magnaporthe poae | 22.83 | 4e-07 | 50.4 |