LLPS-Drm-0751
MED10
▼ OVERVIEW
| Status: | Unreviewed |
| Protein Name: | Mediator of RNA polymerase II transcription subunit 10; Mediator complex subunit 10; dMED10; dTRAP15 |
| Gene Name: | MED10, Nut2, CG5057 |
| Ensembl Gene: | FBgn0036581 |
| Ensembl Protein: | FBpp0305737 |
| Organism: | Drosophila melanogaster |
| Taxa ID: | 7227 |
| LLPS Type: | Others |
▼ Classification
Condensates:
| Condensate | Evidence | Orthologs |
|---|---|---|
| Nucleolus | Predicted from orthologs | (View) |
▼ FUNCTION
| Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity). Required for activated transcription of the MtnA, MtnB and MtnD genes. |
▼ CROSS REFERENCE
| Database | Nucleotide ID | Protein ID |
|---|---|---|
| Ensembl | FBtr0333560 | FBpp0305737 |
| Ensembl | FBtr0301481 | FBpp0290696 |
| UniProt | Q9GYU7, MED10_DROME, Q9VUZ9 | |
| GeneBank | AY005465, AE014296, AY118450 | AAF97815.1, AAF49523.3, AAM48479.1 |
| RefSeq | NM_001275002.1, NM_140592.4 | NP_001261931.1, NP_648849.3 |
| Entrez | 39777 |
▼ SEQUENCE
| Protein Sequence (FASTA) |
|---|
1 MSAPLENLET QLEMFIENVR QIRIIVSDFQ PQGQNVLNQK INSLVTGLQE IDKLRSQVQD 60 61 VYVPFEVFFD YIDQDKNPQL YTKDCVEKAL AKNEEVKGKI EGLKKFKTNL LLELYKTFPN 120 121 EMNNYRAYRK DSM 133 |
| Nucleotide CDS Sequence (FASTA) |
1 ATGTCTGCAC CGCTAGAGAA CCTTGAGACC CAGCTAGAGA TGTTCATCGA GAATGTTCGT 60 61 CAGATCCGCA TAATCGTAAG CGATTTTCAG CCACAGGGTC AAAATGTACT CAACCAGAAA 120 121 ATTAACAGCT TGGTGACCGG CCTACAAGAG ATCGACAAGC TGCGCTCCCA GGTGCAGGAC 180 181 GTCTATGTGC CATTTGAAGT GTTTTTTGAC TACATCGACC AAGACAAGAA TCCTCAGCTG 240 241 TACACCAAGG ATTGCGTGGA GAAGGCACTG GCCAAGAACG AGGAGGTCAA GGGCAAGATC 300 301 GAGGGCCTGA AGAAGTTCAA AACGAATCTG CTGCTGGAGC TGTATAAAAC ATTTCCCAAT 360 361 GAGATGAACA ACTACCGCGC TTATCGCAAG GACTCCATG 399 |
▼ KEYWORD
▼ GENE ONTOLOGY
ID | Classification | Description |
Cellular Component | Mediator complex | |
Cellular Component | Nucleus | |
Molecular Function | Transcription coregulator activity | |
Biological Process | Negative regulation of neuroblast proliferation | |
Biological Process | Positive regulation of transcription by RNA polymerase II | |
Biological Process | Transcription by RNA polymerase II |
▼ ANNOTATION
| Physicochemical | ||||
| AAindex | ||||
| Localization | ||||
| COMPARTMENTS | ||||
| Expression | ||||
| ArrayExpress | ||||
| Element | ||||
| RAID | microRNA.org | |||
▼ ORTHOLOGY
| DrLLPS ID | Organism | Identity | E-value | Score |
|---|---|---|---|---|
| LLPS-Urm-0426 | Ursus maritimus | 66.67 | 4e-22 | 92.0 |
| LLPS-Orc-1786 | Oryctolagus cuniculus | 64.41 | 3e-20 | 84.3 |
| LLPS-Xet-1602 | Xenopus tropicalis | 63.57 | 9e-52 | 167 |
| LLPS-Pes-1007 | Pelodiscus sinensis | 62.79 | 7e-32 | 114 |
| LLPS-Aim-2678 | Ailuropoda melanoleuca | 62.5 | 3e-32 | 115 |
| LLPS-Fud-1983 | Fukomys damarensis | 62.5 | 3e-32 | 115 |
| LLPS-Sah-1048 | Sarcophilus harrisii | 62.5 | 3e-32 | 115 |
| LLPS-Caf-1904 | Canis familiaris | 62.5 | 1e-35 | 125 |
| LLPS-Mod-3181 | Monodelphis domestica | 62.5 | 2e-40 | 137 |
| LLPS-Anp-0126 | Anas platyrhynchos | 62.5 | 4e-32 | 115 |
| LLPS-Leo-1125 | Lepisosteus oculatus | 61.42 | 8e-50 | 162 |
| LLPS-Lac-2661 | Latimeria chalumnae | 61.24 | 3e-50 | 163 |
| LLPS-Mal-1246 | Mandrillus leucophaeus | 60.47 | 3e-50 | 163 |
| LLPS-Paa-3030 | Papio anubis | 60.47 | 3e-50 | 163 |
| LLPS-Mup-0354 | Mustela putorius furo | 60.47 | 5e-50 | 162 |
| LLPS-Myl-0735 | Myotis lucifugus | 60.47 | 5e-50 | 162 |
| LLPS-Bot-2440 | Bos taurus | 60.47 | 5e-50 | 162 |
| LLPS-Gog-0720 | Gorilla gorilla | 60.47 | 5e-50 | 162 |
| LLPS-Caj-3252 | Callithrix jacchus | 60.47 | 5e-50 | 162 |
| LLPS-Maf-2202 | Macaca fascicularis | 60.47 | 3e-50 | 163 |
| LLPS-Chs-1409 | Chlorocebus sabaeus | 60.47 | 3e-50 | 163 |
| LLPS-Cea-0863 | Cercocebus atys | 60.47 | 3e-50 | 163 |
| LLPS-Aon-1884 | Aotus nancymaae | 60.47 | 5e-50 | 162 |
| LLPS-Sus-1871 | Sus scrofa | 60.47 | 5e-50 | 162 |
| LLPS-Gaga-0538 | Gallus gallus | 60.47 | 8e-50 | 162 |
| LLPS-Nol-3971 | Nomascus leucogenys | 60.47 | 5e-50 | 162 |
| LLPS-Tag-1863 | Taeniopygia guttata | 60.47 | 1e-49 | 162 |
| LLPS-Poa-0259 | Pongo abelii | 60.47 | 5e-50 | 162 |
| LLPS-Eqc-3001 | Equus caballus | 60.47 | 5e-50 | 162 |
| LLPS-Mam-0863 | Macaca mulatta | 60.47 | 3e-50 | 163 |
| LLPS-Fia-3640 | Ficedula albicollis | 60.47 | 6e-50 | 162 |
| LLPS-Rhb-2306 | Rhinopithecus bieti | 60.47 | 3e-50 | 163 |
| LLPS-Pat-2785 | Pan troglodytes | 60.47 | 5e-50 | 162 |
| LLPS-Pap-1761 | Pan paniscus | 60.47 | 5e-50 | 162 |
| LLPS-Meg-2231 | Meleagris gallopavo | 60.47 | 9e-50 | 162 |
| LLPS-Hos-1073 | Homo sapiens | 60.47 | 5e-50 | 162 |
| LLPS-Man-3442 | Macaca nemestrina | 60.47 | 3e-50 | 163 |
| LLPS-Loa-0699 | Loxodonta africana | 60.0 | 3e-48 | 158 |
| LLPS-Ran-1007 | Rattus norvegicus | 59.69 | 2e-49 | 161 |
| LLPS-Dio-0589 | Dipodomys ordii | 59.69 | 1e-49 | 161 |
| LLPS-Mea-3212 | Mesocricetus auratus | 59.69 | 2e-49 | 161 |
| LLPS-Anc-2106 | Anolis carolinensis | 59.69 | 3e-49 | 160 |
| LLPS-Otg-1471 | Otolemur garnettii | 59.69 | 1e-49 | 161 |
| LLPS-Fec-1436 | Felis catus | 59.69 | 1e-49 | 162 |
| LLPS-Mum-1975 | Mus musculus | 59.63 | 1e-39 | 136 |
| LLPS-Dar-3568 | Danio rerio | 59.54 | 2e-49 | 161 |
| LLPS-Cap-2640 | Cavia porcellus | 59.09 | 1e-50 | 164 |
| LLPS-Orl-2768 | Oryzias latipes | 59.06 | 1e-48 | 159 |
| LLPS-Orn-3047 | Oreochromis niloticus | 59.06 | 1e-47 | 156 |
| LLPS-Pof-0590 | Poecilia formosa | 58.91 | 2e-48 | 158 |
| LLPS-Icp-3644 | Ictalurus punctatus | 58.78 | 2e-49 | 161 |
| LLPS-Gaa-0361 | Gasterosteus aculeatus | 58.27 | 7e-47 | 154 |
| LLPS-Xim-2392 | Xiphophorus maculatus | 58.02 | 1e-48 | 159 |
| LLPS-Asm-0837 | Astyanax mexicanus | 58.02 | 2e-49 | 160 |
| LLPS-Ten-0850 | Tetraodon nigroviridis | 57.48 | 1e-47 | 156 |
| LLPS-Scm-0834 | Scophthalmus maximus | 57.48 | 9e-47 | 154 |
| LLPS-Ova-2666 | Ovis aries | 56.92 | 1e-44 | 148 |
| LLPS-Tar-2340 | Takifugu rubripes | 56.69 | 2e-47 | 156 |
| LLPS-Cas-2052 | Carlito syrichta | 48.44 | 5e-32 | 116 |
| LLPS-Cae-0398 | Caenorhabditis elegans | 43.55 | 7e-26 | 101 |
| LLPS-Coc-0038 | Corchorus capsularis | 40.35 | 4e-19 | 84.0 |
| LLPS-Art-2344 | Arabidopsis thaliana | 39.66 | 1e-16 | 77.4 |
| LLPS-Cus-0935 | Cucumis sativus | 39.47 | 6e-16 | 75.9 |
| LLPS-Thc-1487 | Theobroma cacao | 39.47 | 2e-17 | 79.3 |
| LLPS-Vir-0545 | Vigna radiata | 38.74 | 3e-15 | 73.6 |
| LLPS-Glm-1275 | Glycine max | 38.74 | 2e-15 | 73.6 |
| LLPS-Phv-1346 | Phaseolus vulgaris | 38.74 | 3e-15 | 73.2 |
| LLPS-Pot-1836 | Populus trichocarpa | 38.74 | 7e-16 | 75.1 |
| LLPS-Arl-1333 | Arabidopsis lyrata | 38.6 | 4e-17 | 79.3 |
| LLPS-Dac-0465 | Daucus carota | 38.6 | 2e-15 | 73.9 |
| LLPS-Brn-0390 | Brassica napus | 38.6 | 5e-18 | 81.6 |
| LLPS-Prp-0820 | Prunus persica | 38.6 | 6e-17 | 78.2 |
| LLPS-Gor-0458 | Gossypium raimondii | 38.6 | 2e-16 | 76.6 |
| LLPS-Mae-1614 | Manihot esculenta | 37.84 | 1e-14 | 71.6 |
| LLPS-Viv-1177 | Vitis vinifera | 37.72 | 1e-15 | 74.7 |
| LLPS-Hea-0148 | Helianthus annuus | 36.84 | 2e-14 | 70.9 |
| LLPS-Tru-1800 | Triticum urartu | 36.05 | 3e-07 | 50.4 |
| LLPS-Orgl-1455 | Oryza glumaepatula | 36.04 | 5e-14 | 70.1 |
| LLPS-Orni-0319 | Oryza nivara | 36.04 | 5e-14 | 69.7 |
| LLPS-Orb-2306 | Oryza barthii | 36.04 | 5e-14 | 70.1 |
| LLPS-Ori-0180 | Oryza indica | 36.04 | 5e-14 | 69.7 |
| LLPS-Org-1412 | Oryza glaberrima | 36.04 | 5e-14 | 69.7 |
| LLPS-Orm-0993 | Oryza meridionalis | 36.04 | 2e-14 | 71.2 |
| LLPS-Orr-1464 | Oryza rufipogon | 36.04 | 5e-14 | 69.7 |
| LLPS-Ors-0420 | Oryza sativa | 36.04 | 5e-14 | 69.7 |
| LLPS-Met-2006 | Medicago truncatula | 36.0 | 2e-15 | 73.9 |
| LLPS-Sei-1593 | Setaria italica | 35.96 | 2e-14 | 71.2 |
| LLPS-Hov-0722 | Hordeum vulgare | 35.96 | 5e-14 | 69.7 |
| LLPS-Brd-0212 | Brachypodium distachyon | 35.96 | 6e-14 | 69.7 |
| LLPS-Tra-1527 | Triticum aestivum | 35.96 | 2e-14 | 70.9 |
| LLPS-Lep-1323 | Leersia perrieri | 35.96 | 1e-14 | 71.6 |
| LLPS-Mua-1933 | Musa acuminata | 35.96 | 4e-15 | 73.2 |
| LLPS-Zem-1093 | Zea mays | 35.96 | 1e-14 | 71.6 |
| LLPS-Orbr-0997 | Oryza brachyantha | 35.96 | 1e-14 | 71.6 |
| LLPS-Sob-0737 | Sorghum bicolor | 35.96 | 2e-14 | 71.2 |
| LLPS-Nia-0078 | Nicotiana attenuata | 35.96 | 1e-13 | 68.6 |
| LLPS-Sot-0685 | Solanum tuberosum | 35.09 | 3e-13 | 67.8 |
| LLPS-Sol-0528 | Solanum lycopersicum | 35.09 | 3e-13 | 67.8 |
| LLPS-Amt-1006 | Amborella trichopoda | 35.09 | 1e-14 | 71.6 |
| LLPS-Orp-1610 | Oryza punctata | 35.09 | 1e-13 | 68.9 |
| LLPS-Tum-1104 | Tuber melanosporum | 34.17 | 9e-13 | 65.9 |
| LLPS-Yal-0476 | Yarrowia lipolytica | 32.67 | 2e-07 | 50.4 |
| LLPS-Abg-1686 | Absidia glauca | 31.3 | 4e-14 | 69.7 |
| LLPS-Php-1651 | Physcomitrella patens | 31.3 | 5e-14 | 69.7 |
| LLPS-Scs-1109 | Sclerotinia sclerotiorum | 30.67 | 1e-06 | 48.5 |
| LLPS-Kop-1305 | Komagataella pastoris | 30.65 | 4e-07 | 49.7 |
| LLPS-Brr-2946 | Brassica rapa | 29.63 | 4e-09 | 55.5 |
| LLPS-Sem-0396 | Selaginella moellendorffii | 29.47 | 5e-06 | 47.0 |
| LLPS-Miv-1523 | Microbotryum violaceum | 28.43 | 5e-09 | 55.8 |
| LLPS-Blg-1458 | Blumeria graminis | 27.86 | 3e-06 | 47.4 |
| LLPS-Asg-0312 | Ashbya gossypii | 27.64 | 1e-06 | 48.1 |
| LLPS-Trv-1164 | Trichoderma virens | 27.59 | 2e-06 | 48.1 |
| LLPS-Dos-1596 | Dothistroma septosporum | 27.12 | 1e-06 | 48.5 |
| LLPS-Trr-0016 | Trichoderma reesei | 26.4 | 8e-07 | 48.5 |
| LLPS-Usm-0097 | Ustilago maydis | 23.48 | 2e-08 | 53.9 |