LLPS-Hos-a810
CMPK1

▼ OVERVIEW

Status: Reviewed
Protein Name: UMP-CMP kinase; Deoxycytidylate kinase; CK; dCMP kinase; Nucleoside-diphosphate kinase
Gene Name: CMPK1, CMK, CMPK, UCK, UMK, UMPK
Ensembl Gene: ENSG00000162368.13
Ensembl Protein: ENSP00000433782.1
Organism: Homo sapiens
Taxa ID: 9606
LLPS Type: Client
PDB: 1TEV (A) More


▼ PROPERTY


——— Disorder propensity (calculated by IUPred2A)

▼ Classification

Condensates:
CondensateDescriptionTissue/CellPMIDs
Postsynaptic density
"...We report the first direct comparison of the proteome of triplicate isolates of mouse and human cortical postsynaptic densities. The mouse postsynaptic density comprised 1556 proteins and the human one 1461."
Human cortex23071613

▼ FUNCTION

Catalyzes the phosphorylation of pyrimidine nucleoside monophosphates at the expense of ATP. Plays an important role in de novo pyrimidine nucleotide biosynthesis. Has preference for UMP and CMP as phosphate acceptors. Also displays broad nucleoside diphosphate kinase activity.

▼ SEQUENCE

Protein Sequence (FASTA)
1     MLSRCRSGLL  HVLGLSFLLQ  TRRPILLCSP  RLMKPLVVFV  LGGPGAGKGT  QCARIVEKYG  60
61    YTHLSAGELL  RDERKNPDSQ  YGELIEKYIK  EGKIVPVEIT  ISLLKREMDQ  TMAANAQKNK  120
121   FLIDGFPRNQ  DNLQGWNKTM  DGKADVSFVL  FFDCNNEICI  ERCLERGKSS  GRSDDNRESL  180
181   EKRIQTYLQS  TKPIIDLYEE  MGKVKKIDAS  KSVDEVFDEV  VQIFDKEG  228
Nucleotide CDS Sequence (FASTA)
1     ATGCTGAGCC  GCTGCCGCAG  CGGGCTGCTC  CACGTCCTGG  GCCTTAGCTT  CCTGCTGCAG  60
61    ACCCGCCGGC  CGATTCTCCT  CTGCTCTCCA  CGTCTCATGA  AGCCGCTGGT  CGTGTTCGTC  120
121   CTCGGCGGCC  CCGGCGCCGG  CAAGGGGACC  CAGTGCGCCC  GCATCGTCGA  GAAATATGGC  180
181   TACACACACC  TTTCTGCAGG  AGAGCTGCTT  CGTGATGAAA  GGAAGAACCC  AGATTCACAG  240
241   TATGGTGAAC  TTATTGAAAA  GTACATTAAA  GAAGGAAAGA  TTGTACCAGT  TGAGATAACC  300
301   ATCAGTTTAT  TAAAGAGGGA  AATGGATCAG  ACAATGGCTG  CCAATGCTCA  GAAGAATAAA  360
361   TTCTTGATTG  ATGGGTTTCC  AAGAAATCAA  GACAACCTTC  AAGGATGGAA  CAAGACCATG  420
421   GATGGGAAGG  CAGATGTATC  TTTCGTTCTC  TTTTTTGACT  GTAATAATGA  GAATTCAGAC  480
481   CTACCTTCAG  TCAACAAAGC  CAATTATTGA  510

▼ KEYWORD

ID
Family
3D-structure
Acetylation
Alternative initiation
Alternative splicing
ATP-binding
Complete proteome
Cytoplasm
Direct protein sequencing
Isopeptide bond
Kinase
Nucleotide-binding
Nucleus
Phosphoprotein
Pyrimidine biosynthesis
Reference proteome
Transferase
Ubl conjugation

▼ GENE ONTOLOGY

ID
Classification
Description
Cellular Component
Cytoplasm
Cellular Component
Cytosol
Cellular Component
Extracellular exosome
Cellular Component
Nucleolus
Cellular Component
Nucleus
Molecular Function
ATP binding
Molecular Function
Cytidylate kinase activity
Molecular Function
Nucleoside diphosphate kinase activity
Molecular Function
Uridine kinase activity
Molecular Function
Uridylate kinase activity
Biological Process
'de novo' pyrimidine nucleobase biosynthetic process
Biological Process
Nucleobase-containing small molecule interconversion
Biological Process
Nucleoside diphosphate phosphorylation
Biological Process
Nucleoside triphosphate biosynthetic process
Biological Process
Pyrimidine ribonucleotide biosynthetic process

▼ KEGG


▼ ORTHOLOGY

DrLLPS IDOrganismIdentityE-valueScore
LLPS-Pap-a780Pan paniscus99.425e-120349
LLPS-Rhb-a786Rhinopithecus bieti99.371e-111327
LLPS-Pat-a798Pan troglodytes99.123e-165464
LLPS-Cea-a798Cercocebus atys98.685e-164461
LLPS-Maf-a795Macaca fascicularis98.685e-164461
LLPS-Paa-a797Papio anubis98.685e-164461
LLPS-Mam-a783Macaca mulatta98.685e-164461
LLPS-Nol-a781Nomascus leucogenys98.686e-164461
LLPS-Man-a799Macaca nemestrina98.254e-163459
LLPS-Mal-a782Mandrillus leucophaeus97.452e-138395
LLPS-Aon-a801Aotus nancymaae97.381e-160453
LLPS-Poa-a775Pongo abelii97.372e-161455
LLPS-Chs-a784Chlorocebus sabaeus97.373e-161454
LLPS-Caj-a792Callithrix jacchus96.934e-161457
LLPS-Fud-a767Fukomys damarensis95.952e-118343
LLPS-Mea-a758Mesocricetus auratus95.955e-118343
LLPS-Loa-a768Loxodonta africana95.938e-118342
LLPS-Aim-a757Ailuropoda melanoleuca95.351e-115336
LLPS-Ova-a767Ovis aries94.56e-149423
LLPS-Mup-a768Mustela putorius furo94.33e-154437
LLPS-Sus-a796Sus scrofa93.862e-154437
LLPS-Caf-a777Canis familiaris93.422e-152432
LLPS-Fec-a796Felis catus93.421e-151433
LLPS-Eqc-a793Equus caballus93.423e-153434
LLPS-Orc-a745Oryctolagus cuniculus92.988e-147417
LLPS-Ict-a782Ictidomys tridecemlineatus92.113e-147419
LLPS-Myl-a741Myotis lucifugus92.113e-151429
LLPS-Bot-a800Bos taurus92.115e-151428
LLPS-Cap-a794Cavia porcellus91.679e-147418
LLPS-Tag-a688Taeniopygia guttata90.828e-129371
LLPS-Mum-a797Mus musculus90.798e-143407
LLPS-Dio-a764Dipodomys ordii90.353e-144411
LLPS-Gaga-a719Gallus gallus90.315e-129371
LLPS-Anp-a646Anas platyrhynchos89.081e-110324
LLPS-Meg-a643Meleagris gallopavo88.951e-109321
LLPS-Fia-a704Ficedula albicollis88.073e-111325
LLPS-Ran-a790Rattus norvegicus86.844e-136391
LLPS-Pes-a682Pelodiscus sinensis82.685e-104308
LLPS-Ora-a656Ornithorhynchus anatinus82.291e-111327
LLPS-Sah-a715Sarcophilus harrisii82.061e-129375
LLPS-Mod-a757Monodelphis domestica81.339e-128370
LLPS-Gog-a792Gorilla gorilla80.798e-121351
LLPS-Anc-a727Anolis carolinensis79.824e-128370
LLPS-Lac-a703Latimeria chalumnae77.842e-108320
LLPS-Xet-a686Xenopus tropicalis76.683e-120350
LLPS-Urm-a720Ursus maritimus75.946e-87265
LLPS-Dar-a697Danio rerio75.512e-108320
LLPS-Leo-a690Lepisosteus oculatus75.01e-109323
LLPS-Ten-a659Tetraodon nigroviridis75.02e-104310
LLPS-Asm-a692Astyanax mexicanus74.492e-106315
LLPS-Otg-a785Otolemur garnettii73.687e-104309
LLPS-Tar-a660Takifugu rubripes73.64e-104309
LLPS-Orn-a698Oreochromis niloticus72.992e-108320
LLPS-Scf-a676Scleropages formosus72.592e-104310
LLPS-Xim-a704Xiphophorus maculatus72.229e-104308
LLPS-Gaa-a680Gasterosteus aculeatus71.434e-101302
LLPS-Scm-a668Scophthalmus maximus71.435e-105311
LLPS-Pof-a701Poecilia formosa71.353e-97291
LLPS-Orl-a690Oryzias latipes71.24e-61197
LLPS-Icp-a699Ictalurus punctatus71.013e-102305
LLPS-Cae-a107Caenorhabditis elegans54.174e-70223
LLPS-Hov-a055Hordeum vulgare52.368e-55183
LLPS-Pot-a061Populus trichocarpa52.362e-58192
LLPS-Sob-a067Sorghum bicolor52.362e-56187
LLPS-Prp-a052Prunus persica52.087e-57189
LLPS-Orp-a053Oryza punctata51.832e-55184
LLPS-Lep-a051Leersia perrieri51.835e-55184
LLPS-Zem-a064Zea mays51.62e-55185
LLPS-Glm-a072Glycine max51.582e-56187
LLPS-Ors-a063Oryza sativa51.313e-54182
LLPS-Sei-a058Setaria italica51.317e-56186
LLPS-Ori-a062Oryza indica51.313e-54182
LLPS-Brn-a078Brassica napus51.286e-58192
LLPS-Mae-a062Manihot esculenta50.792e-55189
LLPS-Mua-a065Musa acuminata50.791e-55184
LLPS-Bro-a069Brassica oleracea50.772e-57189
LLPS-Tra-a084Triticum aestivum50.776e-57188
LLPS-Brr-a064Brassica rapa50.775e-57189
LLPS-Gor-a067Gossypium raimondii50.269e-54181
LLPS-Coc-a054Corchorus capsularis50.02e-46160
LLPS-Org-a056Oryza glaberrima50.02e-52177