LLPS-Dio-a764
Cmpk1
Integrated Annotations
▼ OVERVIEW
| Status: | Unreviewed |
| Protein Name: | UMP-CMP kinase; Deoxycytidylate kinase; CK; dCMP kinase; Nucleoside-diphosphate kinase |
| Gene Name: | Cmpk1, CMPK, CMPK1 |
| Ensembl Gene: | ENSDORG00000004576.2 |
| Ensembl Protein: | ENSDORP00000004283.2 |
| Organism: | Dipodomys ordii |
| Taxa ID: | 10020 |
| LLPS Type: | Others |
▼ Classification
Condensates:
| Condensate | Evidence | Orthologs |
|---|---|---|
| Postsynaptic density | Predicted from orthologs | (View) |
▼ FUNCTION
| Catalyzes the phosphorylation of pyrimidine nucleoside monophosphates at the expense of ATP. Plays an important role in de novo pyrimidine nucleotide biosynthesis. Has preference for UMP and CMP as phosphate acceptors. Also displays broad nucleoside diphosphate kinase activity. |
▼ CROSS REFERENCE
| Database | Nucleotide ID | Protein ID |
|---|---|---|
| Ensembl | ENSDORT00000004574.2 | ENSDORP00000004283.2 |
| UniProt | A0A1S3F9B1, A0A1S3F9B1_DIPOR | |
| RefSeq | , XM_013016993.1 | , XP_012872447.1, XP_012872447.1 |
▼ SEQUENCE
| Protein Sequence (FASTA) |
|---|
1 MLSRCRCRLL RTINARPLPP ILPSLLLSPR RLMKPVVVFV LGGPGAGKGT QCARIVEKYG 60 61 YTHLSAGELL RDERKNPDSQ YGELIEKYIK EGKIVPVEIT ISLLKREMDQ TMAANAQKNK 120 121 FLIDGFPRNQ DNLQGWNKTM DGKADVSFVL FFDCNNEICI ERCLERGKSS GRSDDNRESL 180 181 EKRIQTYLQS TKPIIDLYEE MGKVKKIDAS KSVDEVFDDV VKIFDKEG 228 |
| Nucleotide CDS Sequence (FASTA) |
1 ATGCTGAGCC GCTGTCGCTG CCGCTTGCTG CGCACCATTA ACGCCCGACC GCTGCCGCCG 60 61 ATCCTCCCGT CGCTTCTCCT CTCCCCTCGC CGCCTCATGA AGCCGGTGGT CGTGTTCGTC 120 121 CTCGGCGGTC CCGGCGCCGG CAAGGGGACC CAGTGCGCCC GCATCGTCGA GNNNNNNNNN 180 181 NNNNNNNNNN NNNNNNNNNN NNNNNNNNNN NNNNNNNNNN NNNNNNNNNN NNNNNNNNNN 240 241 NNNNNNNNNN NNNNNNNNNN NNNNNNNNNN NNNNNNNNNN NNNNNNNNNN NNNNNNNNNN 300 301 NNNNNNNNNN NNNNNNNNGA AATGGATCAA ACAATGGCTG CCAATGCTCA GAAGAATAAA 360 361 TTCTTGATTG ATGGGTTTCC AAGAAATCAA GACAATCTTC AAGGTTGGAA CAAGACCATG 420 421 GATGGAAAGG CAGATGTATC TTTTGTTTTA TTTTTCGACT GTAATAATGA GATCTGTATT 480 481 GAACGGTGCC TTGAGAGAGG GAAAAGTAGT GGTAGGAGTG ATGACAACAG AGAGAGCTTG 540 541 GAAAAGAGAA TTCAGACTTA TCTTCAGTCA ACAAAACCAA TTATTGATCT ATATGAGGAA 600 601 ATGGGGAAAG TTAAGAAAAT AGATGCTTCT AAATCGGTGG ATGAAGTTTT TGATGATGTG 660 661 GTGAAGATTT TTGACAAAGA AGGCTAA 687 |
▼ KEYWORD
▼ GENE ONTOLOGY
ID | Classification | Description |
Cellular Component | Cytoplasm | |
Cellular Component | Nucleolus | |
Molecular Function | ATP binding | |
Molecular Function | Cytidylate kinase activity | |
Molecular Function | Nucleoside diphosphate kinase activity | |
Molecular Function | Uridylate kinase activity | |
Biological Process | 'de novo' pyrimidine nucleobase biosynthetic process | |
Biological Process | Nucleoside triphosphate biosynthetic process | |
Biological Process | Pyrimidine nucleotide biosynthetic process |
▼ ORTHOLOGY
| DrLLPS ID | Organism | Identity | E-value | Score |
|---|---|---|---|---|
| LLPS-Mum-a797 | Mus musculus | 3e-140 | 401 | undefined |
| LLPS-Hos-a810 | Homo sapiens | 3e-144 | 411 | undefined |