LLPS-Hos-a044
FUT8

▼ OVERVIEW

Status: Unreviewed
Protein Name: Alpha-(1,6)-fucosyltransferase
Gene Name: FUT8
Ensembl Gene: ENSG00000033170.16
Ensembl Protein: ENSP00000452105.1
Organism: Homo sapiens
Taxa ID: 9606
LLPS Type: Others
PDB: 2DE0 (X) More


▼ PROPERTY


——— Disorder propensity (calculated by IUPred2A)

▼ Classification

Condensates:
CondensateEvidenceOrthologs
Postsynaptic densityPredicted from orthologs(View)

▼ FUNCTION

Catalyzes the addition of fucose in alpha 1-6 linkage to the first GlcNAc residue, next to the peptide chains in N-glycans.

▼ SEQUENCE

Protein Sequence (FASTA)
1     MRPWTGSWRW  IMLILFAWGT  LLFYIGGHLV  RDNDHPDHSS  RELSKILAKL  ERLKQQNEDL  60
61    RRMAESLRIP  EGPIDQGPAI  GRVRVLEEQL  VKAKEQIENY  KKQTRNGLGK  DHEILRRRIE  120
121   NGAKELWFFL  QSELKKLKNL  EGNELQRHAD  EFLLDLGHHE  RSIMTDLYYL  SQTDGAGDWR  180
181   EKEAKDLTEL  VQRRITYLQN  PKDCSKAKKL  VCNINKGCGY  GCQLHHVVYC  FMIAYGTQRT  240
241   LILESQNWRY  ATGGWETVFR  PVSETCTDRS  GISTGHWSGE  VKDKNVQVVE  LPIVDSLHPR  300
301   PPYLPLAVPE  DLADRLVRVH  GDPAVWWVSQ  FVKYLIRPQP  WLEKEIEEAT  KKLGFKHPVI  360
361   GVHVRRTDKV  GTEAAFHPIE  EYMVHVEEHF  QLLARRMQVD  KKRVYLATDD  PSLLKEAKTK  420
421   YPNYEFISDN  SISWSAGLHN  RYTENSLRGV  ILDIHFLSQA  DFLVCTFSSQ  VCRVAYEIMQ  480
481   TLHPDASANF  HSLDDIYYFG  GQNAHNQIAI  YAHQPRTADE  IPMEPGDIIG  VAGNHWDGYS  540
541   KGVNRKLGRT  GLYPSYKVRE  KIETVKYPTY  PEAEK  575
Nucleotide CDS Sequence (FASTA)
1     ATGCGGCCAT  GGACTGGTTC  CTGGCGTTGG  ATTATGCTCA  TTCTTTTTGC  CTGGGGGACC  60
61    TTGCTGTTTT  ATATAGGTGG  TCACTTGGTA  CGAGATAATG  ACCATCCTGA  TCACTCTAGC  120
121   CGAGAACTGT  CCAAGATTCT  GGCAAAGCTT  GAACGCTTAA  AACAACAGAA  TGAAGACTTG  180
181   AGGCGAATGG  CCGAATCTCT  CCGGATACCA  GAAGGCCCTA  TTGATCAGGG  GCCAGCTATA  240
241   GGAAGAGTAC  GCGTTTTAGA  AGAGCAGCTT  GTTAAGGCCA  AAGAACAGAT  TGAAAATTAC  300
301   AAGAAACAGA  CCAGAAATGG  TCTGGGGAAG  GATCATGAAA  TCCTGAGGAG  GAGGATTGAA  360
361   AATGGAGCTA  AAGAGCTCTG  GTTTTTCCTA  CAGAGTGAAT  TGAAGAAATT  AAAGAACTTA  420
421   GAAGGAAATG  AACTCCAAAG  ACATGCAGAT  GAATTTCTTT  TGGATTTAGG  ACATCATGAA  480
481   AGGTCTATAA  TGACGGATCT  ATACTACCTC  AGTCAGACAG  ATGGAGCAGG  TGATTGGCGG  540
541   GAAAAAGAGG  CCAAAGATCT  GACAGAACTG  GTTCAGCGGA  GAATAACATA  TCTTCAGAAT  600
601   CCCAAGGACT  GCAGCAAAGC  CAAAAAGCTG  GTGTGTAATA  TCAACAAAGG  CTGTGGCTAT  660
661   GGCTGTCAGC  TCCATCATGT  GGTCTACTGC  TTCATGATTG  CATATGGCAC  CCAGCGAACA  720
721   CTCATCTTGG  AATCTCAGAA  TTGGCGCTAT  GCTACTGGTG  GATGGGAGAC  TGTATTTAGG  780
781   CCTGTAAGTG  AGACATGCAC  AGACAGATCT  GGCATCTCCA  CTGGACACTG  GTCAGGTACC  840
841   CCAATTATGA  ATTTATTAGT  GATAACTCTA  TTTCCTGGTC  AGCTGGACTG  CACAATCGAT  900
901   ACACAGAAAA  TTCACTTCGT  GGAGTGA  927

▼ KEYWORD

ID
Family
3D-structure
Alternative splicing
Complete proteome
Congenital disorder of glycosylation
Disease mutation
Disulfide bond
Glycosyltransferase
Golgi apparatus
Membrane
Phosphoprotein
Polymorphism
Reference proteome
SH3 domain
SH3-binding
Signal-anchor
Transferase
Transmembrane
Transmembrane helix

▼ GENE ONTOLOGY

ID
Classification
Description
Cellular Component
Cytosol
Cellular Component
Extracellular exosome
Cellular Component
Golgi apparatus
Cellular Component
Golgi cisterna membrane
Cellular Component
Golgi membrane
Cellular Component
Integral component of membrane
Cellular Component
Membrane
Molecular Function
Alpha-(1->6)-fucosyltransferase activity
Molecular Function
Glycoprotein 6-alpha-L-fucosyltransferase activity
Molecular Function
SH3 domain binding
Biological Process
Cell migration
Biological Process
GDP-L-fucose metabolic process
Biological Process
In utero embryonic development
Biological Process
Integrin-mediated signaling pathway
Biological Process
L-fucose catabolic process
Biological Process
N-glycan fucosylation
Biological Process
N-glycan processing
Biological Process
Oligosaccharide biosynthetic process
Biological Process
Protein glycosylation in Golgi
Biological Process
Protein N-linked glycosylation
Biological Process
Protein N-linked glycosylation via asparagine
Biological Process
Receptor metabolic process
Biological Process
Regulation of cellular response to oxidative stress
Biological Process
Regulation of gene expression
Biological Process
Respiratory gaseous exchange
Biological Process
Transforming growth factor beta receptor signaling pathway

▼ KEGG


▼ ORTHOLOGY

DrLLPS IDOrganismIdentityE-valueScore
LLPS-Pat-a043Pan troglodytes100.00.01199
LLPS-Gog-a043Gorilla gorilla100.00.01199
LLPS-Mal-a044Mandrillus leucophaeus99.830.01199
LLPS-Cea-a045Cercocebus atys99.830.01199
LLPS-Maf-a043Macaca fascicularis99.830.01199
LLPS-Pap-a043Pan paniscus99.830.01197
LLPS-Poa-a043Pongo abelii99.830.01198
LLPS-Mam-a044Macaca mulatta99.830.01199
LLPS-Rhb-a043Rhinopithecus bieti99.830.01199
LLPS-Nol-a045Nomascus leucogenys99.830.01198
LLPS-Man-a044Macaca nemestrina99.830.01199
LLPS-Aon-a046Aotus nancymaae99.650.01197
LLPS-Caj-a043Callithrix jacchus99.650.01196
LLPS-Paa-a044Papio anubis99.650.01196
LLPS-Chs-a046Chlorocebus sabaeus99.650.01197
LLPS-Otg-a044Otolemur garnettii98.960.01191
LLPS-Myl-a047Myotis lucifugus98.430.01184
LLPS-Orc-a044Oryctolagus cuniculus98.260.01184
LLPS-Bot-a048Bos taurus98.260.01184
LLPS-Mup-a046Mustela putorius furo98.090.01180
LLPS-Caf-a043Canis familiaris98.090.01179
LLPS-Urm-a044Ursus maritimus98.090.01181
LLPS-Cap-a045Cavia porcellus98.090.01182
LLPS-Fud-a046Fukomys damarensis98.090.01181
LLPS-Aim-a045Ailuropoda melanoleuca97.910.01179
LLPS-Dio-a045Dipodomys ordii97.910.01180
LLPS-Loa-a045Loxodonta africana97.910.01182
LLPS-Ova-a048Ovis aries97.910.01181
LLPS-Fec-a047Felis catus97.740.01176
LLPS-Eqc-a048Equus caballus97.570.01175
LLPS-Sus-a046Sus scrofa97.020.01159
LLPS-Ran-a047Rattus norvegicus96.870.01168
LLPS-Ict-a046Ictidomys tridecemlineatus96.870.01169
LLPS-Mum-a046Mus musculus96.520.01167
LLPS-Mea-a042Mesocricetus auratus96.350.01164
LLPS-Ora-a040Ornithorhynchus anatinus95.515e-105322
LLPS-Sah-a044Sarcophilus harrisii95.230.0735
LLPS-Pes-a040Pelodiscus sinensis94.440.01142
LLPS-Mod-a042Monodelphis domestica94.270.01143
LLPS-Gaga-a041Gallus gallus93.910.01135
LLPS-Tag-a041Taeniopygia guttata93.750.01132
LLPS-Meg-a036Meleagris gallopavo93.750.01135
LLPS-Anp-a038Anas platyrhynchos93.40.01129
LLPS-Fia-a042Ficedula albicollis93.040.01123
LLPS-Anc-a042Anolis carolinensis92.530.01128
LLPS-Xet-a040Xenopus tropicalis90.310.01111
LLPS-Lac-a038Latimeria chalumnae87.00.01080
LLPS-Leo-a033Lepisosteus oculatus85.790.01053
LLPS-Scf-a036Scleropages formosus84.060.01032
LLPS-Orl-a039Oryzias latipes82.120.01008
LLPS-Pof-a042Poecilia formosa81.940.01010
LLPS-Xim-a040Xiphophorus maculatus81.770.01006
LLPS-Asm-a037Astyanax mexicanus81.740.01016
LLPS-Tar-a040Takifugu rubripes81.250.01000
LLPS-Dar-a040Danio rerio81.080.01017
LLPS-Ten-a037Tetraodon nigroviridis81.080.01003
LLPS-Cas-a042Carlito syrichta81.040.0932
LLPS-Gaa-a036Gasterosteus aculeatus80.90.0997
LLPS-Scm-a035Scophthalmus maximus80.760.0999
LLPS-Icp-a041Ictalurus punctatus80.730.0994
LLPS-Cis-a014Ciona savignyi55.840.0572
LLPS-Cii-a017Ciona intestinalis55.55e-159470