LLPS-Hos-4904
GDPD1

▼ OVERVIEW


Status: Unreviewed
Protein Name: Lysophospholipase D GDPD1; Glycerophosphodiester phosphodiesterase 4; Glycerophosphodiester phosphodiesterase domain-containing protein 1
Gene Name: GDPD1, GDE4
Ensembl Gene: ENSG00000153982.10
Ensembl Protein: ENSP00000284116.4
Organism: Homo sapiens
Taxa ID: 9606
LLPS Type: LLPS regulator


▼ PROPERTY



——— Disorder propensity (calculated by IUPred2A)

▼ Classification


Condensates:
CondensateEvidenceOrthologs
Stress granulePredicted from orthologs(View)

▼ FUNCTION


Hydrolyzes lysoglycerophospholipids to produce lysophosphatidic acid (LPA) and the corresponding amines. Shows a preference for 1-O-alkyl-sn-glycero-3-phosphocholine (lyso-PAF), lysophosphatidylethanolamine (lyso-PE) and lysophosphatidylcholine (lyso-PC). May be involved in bioactive N-acylethanolamine biosynthesis. Does not display glycerophosphodiester phosphodiesterase activity, since it cannot hydrolyze either glycerophosphoinositol or glycerophosphocholine.

▼ SEQUENCE


Protein Sequence (FASTA)
1     MSSTAAFYLL  STLGGYLVTS  FLLLKYPTLL  HQRKKQRFLS  KHISHRGGAG  ENLENTMAAF  60
61    QHAVKIGTDM  LELDCHITKD  EQVVVSHDEN  LKRATGVNVN  ISDLKYCELP  PYLGKLDVSF  120
121   QRACQCEGKD  NRIPLLKEVF  EAFPNTPINI  DIKVNNNVLI  KKVSELVKRY  NREHLTVWGN  180
181   ANYEIVEKCY  KENSDIPILF  SLQRVLLILG  LFFTGLLPFV  PIREQFFEIP  MPSIILKLKE  240
241   PHTMSRSQKF  LIWLSDLLLM  RKALFDHLTA  RGIQVYIWVL  NEEQEYKRAF  DLGATGVMTD  300
301   YPTKLRDFLH  NFSA  314
Nucleotide CDS Sequence (FASTA)
1     ATGTCGTCCA  CTGCGGCTTT  TTACCTTCTC  TCTACGCTAG  GAGGATACTT  GGTGACCTCA  60
61    TTCTTGTTGC  TTAAATACCC  GACCTTGCTG  CACCAGAGAA  AGAAGCAGCG  ATTCCTCAGT  120
121   AAACACATCT  CTCACCGCGG  AGGTGCTGGA  GAAAATTTGG  AGAATACAAT  GGCAGCCTTT  180
181   CAGCATGCGG  TTAAAATCGG  AACTGATATG  CTAGAATTGG  ACTGCCATAT  CACAAAAGAT  240
241   GAACAAGTTG  TAGTGTCACA  TGATGAGAAT  CTAAAGAGAG  CAACTGGGGT  CAATGTAAAC  300
301   ATCTCTGATC  TCAAATACTG  TGAGCTCCCA  CCTTACCTTG  GCAAACTGGA  TGTCTCATTT  360
361   CAAAGAGCAT  GCCAGTGTGA  AGGAAAAGAT  AACCGAATTC  CATTACTGAA  GGAAGTTTTT  420
421   GAGGCCTTTC  CTAACACTCC  CATTAACATC  GATATCAAAG  TCAACAACAA  TGTGCTGATT  480
481   AAGAAGGTTT  CAGAGTTGGT  GAAGCGGTAT  AATCGAGAAC  ACTTAACAGT  GTGGGGTAAT  540
541   GCCAATTATG  AAATTGTAGA  AAAGTGCTAC  AAAGAGAATT  CAGATATTCC  TATACTCTTC  600
601   AGTCTACAAC  GTGTCCTGCT  CATTCTTGGC  CTTTTCTTCA  CTGGCCTCTT  GCCCTTTGTG  660
661   CCCATTCGAG  AACAGTTTTT  TGAAATCCCA  ATGCCTTCTA  TTATACTGAA  GCTAAAAGAA  720
721   CCACACACCA  TGTCCAGAAG  TCAAAAGTTT  CTCATCTGGC  TTTCTGATCT  CTTACTAATG  780
781   AGGAAAGCTT  TGTTTGACCA  CCTAACTGCT  CGAGGCATTC  AAGTGTATAT  TTGGGTATTA  840
841   AATGAAGAAC  AAGAATACAA  AAGAGCTTTT  GATTTGGGAG  CAACTGGGGT  GATGACAGAC  900
901   TATCCAACAA  AGCTTAGGGA  TTTTTTACAT  AACTTTTCAG  CATAG  945

▼ KEYWORD


ID
Family
Alternative splicing
Complete proteome
Cytoplasm
Hydrolase
Membrane
Metal-binding
Reference proteome
Transmembrane
Transmembrane helix

▼ GENE ONTOLOGY


ID
Classification
Description
Cellular Component
Endoplasmic reticulum membrane
Cellular Component
Integral component of membrane
Cellular Component
Membrane
Cellular Component
Perinuclear region of cytoplasm
Molecular Function
Alkylglycerophosphoethanolamine phosphodiesterase activity
Molecular Function
Lysophospholipase activity
Molecular Function
Metal ion binding
Molecular Function
Phosphoric diester hydrolase activity
Biological Process
Glycerophospholipid catabolic process
Biological Process
N-acylethanolamine metabolic process
Biological Process
Phospholipid metabolic process

▼ KEGG



▼ ORTHOLOGY


DrLLPS IDOrganismIdentityE-valueScore
LLPS-Pat-2218Pan troglodytes100.00.0 625
LLPS-Gog-2456Gorilla gorilla100.00.0 625
LLPS-Poa-4003Pongo abelii99.680.0 624
LLPS-Man-0826Macaca nemestrina99.040.0 621
LLPS-Mam-2425Macaca mulatta99.040.0 621
LLPS-Cea-1321Cercocebus atys99.040.0 621
LLPS-Maf-3690Macaca fascicularis99.040.0 621
LLPS-Paa-4571Papio anubis99.040.0 621
LLPS-Chs-2718Chlorocebus sabaeus98.730.0 619
LLPS-Caj-3444Callithrix jacchus98.090.0 617
LLPS-Fec-2694Felis catus96.820.0 609
LLPS-Urm-3920Ursus maritimus96.50.0 607
LLPS-Aim-2594Ailuropoda melanoleuca96.50.0 607
LLPS-Cas-1427Carlito syrichta96.180.0 607
LLPS-Caf-4102Canis familiaris96.180.0 605
LLPS-Sus-0547Sus scrofa96.170.0 605
LLPS-Otg-3957Otolemur garnettii95.860.0 586
LLPS-Ict-3823Ictidomys tridecemlineatus95.860.0 603
LLPS-Eqc-4285Equus caballus94.90.0 599
LLPS-Cap-3793Cavia porcellus93.630.0 588
LLPS-Orc-0099Oryctolagus cuniculus93.310.0 586
LLPS-Mum-4972Mus musculus92.040.0 575
LLPS-Mea-1609Mesocricetus auratus91.40.0 574
LLPS-Xim-4170Xiphophorus maculatus73.861e-162 463
LLPS-Orn-0537Oreochromis niloticus73.24e-163 464
LLPS-Pof-0842Poecilia formosa73.22e-161 460
LLPS-Asm-1097Astyanax mexicanus71.666e-160 456
LLPS-Orl-3542Oryzias latipes70.928e-160 459
LLPS-Lac-2252Latimeria chalumnae65.611e-149 430
LLPS-Lem-1115Leptosphaeria maculans48.481e-1065.9
LLPS-Pyt-0122Pyrenophora teres46.972e-1065.9
LLPS-Cis-2010Ciona savignyi45.615e-0754.3
LLPS-Scc-1026Schizosaccharomyces cryophilus45.313e-1064.3
LLPS-Scs-0448Sclerotinia sclerotiorum45.04e-0957.8
LLPS-Usm-0483Ustilago maydis44.233e-0652.4
LLPS-Cog-0091Colletotrichum gloeosporioides44.127e-0960.5
LLPS-Gag-0488Gaeumannomyces graminis44.129e-1166.2
LLPS-Fuo-1369Fusarium oxysporum43.242e-1168.2
LLPS-Fuv-1335Fusarium verticillioides43.243e-1167.8
LLPS-Zyt-1321Zymoseptoria tritici42.033e-0857.8
LLPS-Mup-0059Mustela putorius furo41.751e-77 247
LLPS-Fud-0431Fukomys damarensis41.583e-79 251
LLPS-Ova-2933Ovis aries41.582e-76 243
LLPS-Tut-0409Tursiops truncatus41.422e-77 246
LLPS-Map-1329Magnaporthe poae41.187e-1063.5
LLPS-Bot-4326Bos taurus41.043e-75 240
LLPS-Dos-1322Dothistroma septosporum37.336e-0960.5
LLPS-Beb-0705Beauveria bassiana34.831e-0962.8
LLPS-Ran-4085Rattus norvegicus34.262e-0858.5
LLPS-Tum-0163Tuber melanosporum31.853e-1166.6
LLPS-Scj-0336Schizosaccharomyces japonicus31.788e-0754.3
LLPS-Spr-1453Sporisorium reilianum31.062e-0755.8
LLPS-Kop-1098Komagataella pastoris31.032e-0755.8
LLPS-Mel-1030Melampsora laricipopulina29.321e-0756.6
LLPS-Crn-0261Cryptococcus neoformans28.163e-0755.5
LLPS-Coo-1491Colletotrichum orbiculare27.921e-1271.6
LLPS-Scp-0797Schizosaccharomyces pombe27.619e-1680.1
LLPS-Abg-1674Absidia glauca27.083e-0858.2
LLPS-Ved-1229Verticillium dahliae26.83e-1476.3
LLPS-Nec-1265Neurospora crassa26.522e-1373.9
LLPS-Phn-0137Phaeosphaeria nodorum26.182e-1270.9
LLPS-Cogr-0259Colletotrichum graminicola23.722e-0962.0
LLPS-Cae-1460Caenorhabditis elegans23.512e-1270.9