LLPS-Hos-4904
GDPD1
▼ OVERVIEW
Status: | Unreviewed |
Protein Name: | Lysophospholipase D GDPD1; Glycerophosphodiester phosphodiesterase 4; Glycerophosphodiester phosphodiesterase domain-containing protein 1 |
Gene Name: | GDPD1, GDE4 |
Ensembl Gene: | ENSG00000153982.10 |
Ensembl Protein: | ENSP00000284116.4 |
Organism: | Homo sapiens |
Taxa ID: | 9606 |
LLPS Type: | LLPS regulator |
▼ Classification
Condensates:
Condensate | Evidence | Orthologs |
---|---|---|
Stress granule | Predicted from orthologs | (View) |
▼ FUNCTION
Hydrolyzes lysoglycerophospholipids to produce lysophosphatidic acid (LPA) and the corresponding amines. Shows a preference for 1-O-alkyl-sn-glycero-3-phosphocholine (lyso-PAF), lysophosphatidylethanolamine (lyso-PE) and lysophosphatidylcholine (lyso-PC). May be involved in bioactive N-acylethanolamine biosynthesis. Does not display glycerophosphodiester phosphodiesterase activity, since it cannot hydrolyze either glycerophosphoinositol or glycerophosphocholine. |
▼ CROSS REFERENCE
Database | Nucleotide ID | Protein ID |
---|---|---|
Ensembl | ENST00000284116.8 | ENSP00000284116.4 |
Ensembl | ENST00000581276.5 | ENSP00000464690.1 |
Ensembl | ENST00000581140.5 | ENSP00000463273.1 |
Ensembl | ENST00000578026.5 | ENSP00000462895.1 |
Ensembl | ENST00000579076.1 | ENSP00000464351.1 |
Ensembl | ENST00000579020.5 | ENSP00000463818.1 |
UniProt | Q8N9F7, GDPD1_HUMAN, A8W735, Q56VR1, Q8N4E3 | |
GeneBank | BC034432, AK094770, CH471109, AC099850, AY271346, EU192951, AC091059 | AAH34432.1, ABW73991.1, EAW94412.1, AAQ01751.1, BAC04419.1 |
RefSeq | NM_001165993.1, NM_001165994.1, NM_182569.3 | NP_001159465.1, NP_001159466.1, NP_872375.2 |
Entrez | 284161 |
▼ SEQUENCE
Protein Sequence (FASTA) |
---|
1 MSSTAAFYLL STLGGYLVTS FLLLKYPTLL HQRKKQRFLS KHISHRGGAG ENLENTMAAF 60 61 QHAVKIGTDM LELDCHITKD EQVVVSHDEN LKRATGVNVN ISDLKYCELP PYLGKLDVSF 120 121 QRACQCEGKD NRIPLLKEVF EAFPNTPINI DIKVNNNVLI KKVSELVKRY NREHLTVWGN 180 181 ANYEIVEKCY KENSDIPILF SLQRVLLILG LFFTGLLPFV PIREQFFEIP MPSIILKLKE 240 241 PHTMSRSQKF LIWLSDLLLM RKALFDHLTA RGIQVYIWVL NEEQEYKRAF DLGATGVMTD 300 301 YPTKLRDFLH NFSA 314 |
Nucleotide CDS Sequence (FASTA) |
1 ATGTCGTCCA CTGCGGCTTT TTACCTTCTC TCTACGCTAG GAGGATACTT GGTGACCTCA 60 61 TTCTTGTTGC TTAAATACCC GACCTTGCTG CACCAGAGAA AGAAGCAGCG ATTCCTCAGT 120 121 AAACACATCT CTCACCGCGG AGGTGCTGGA GAAAATTTGG AGAATACAAT GGCAGCCTTT 180 181 CAGCATGCGG TTAAAATCGG AACTGATATG CTAGAATTGG ACTGCCATAT CACAAAAGAT 240 241 GAACAAGTTG TAGTGTCACA TGATGAGAAT CTAAAGAGAG CAACTGGGGT CAATGTAAAC 300 301 ATCTCTGATC TCAAATACTG TGAGCTCCCA CCTTACCTTG GCAAACTGGA TGTCTCATTT 360 361 CAAAGAGCAT GCCAGTGTGA AGGAAAAGAT AACCGAATTC CATTACTGAA GGAAGTTTTT 420 421 GAGGCCTTTC CTAACACTCC CATTAACATC GATATCAAAG TCAACAACAA TGTGCTGATT 480 481 AAGAAGGTTT CAGAGTTGGT GAAGCGGTAT AATCGAGAAC ACTTAACAGT GTGGGGTAAT 540 541 GCCAATTATG AAATTGTAGA AAAGTGCTAC AAAGAGAATT CAGATATTCC TATACTCTTC 600 601 AGTCTACAAC GTGTCCTGCT CATTCTTGGC CTTTTCTTCA CTGGCCTCTT GCCCTTTGTG 660 661 CCCATTCGAG AACAGTTTTT TGAAATCCCA ATGCCTTCTA TTATACTGAA GCTAAAAGAA 720 721 CCACACACCA TGTCCAGAAG TCAAAAGTTT CTCATCTGGC TTTCTGATCT CTTACTAATG 780 781 AGGAAAGCTT TGTTTGACCA CCTAACTGCT CGAGGCATTC AAGTGTATAT TTGGGTATTA 840 841 AATGAAGAAC AAGAATACAA AAGAGCTTTT GATTTGGGAG CAACTGGGGT GATGACAGAC 900 901 TATCCAACAA AGCTTAGGGA TTTTTTACAT AACTTTTCAG CATAG 945 |
▼ KEYWORD
▼ GENE ONTOLOGY
ID | Classification | Description |
Cellular Component | Endoplasmic reticulum membrane | |
Cellular Component | Integral component of membrane | |
Cellular Component | Membrane | |
Cellular Component | Perinuclear region of cytoplasm | |
Molecular Function | Alkylglycerophosphoethanolamine phosphodiesterase activity | |
Molecular Function | Lysophospholipase activity | |
Molecular Function | Metal ion binding | |
Molecular Function | Phosphoric diester hydrolase activity | |
Biological Process | Glycerophospholipid catabolic process | |
Biological Process | N-acylethanolamine metabolic process | |
Biological Process | Phospholipid metabolic process |
▼ ANNOTATION
Drug | ||||
CTD |
Physicochemical | ||||
Compute pI/Mw | AAindex |
Function | ||||
PIRSF | CellMarker | RaftProt |
Localization | ||||
COMPARTMENTS |
Methylation | ||||
TCGA | ICGC | MethyCancer |
▼ ORTHOLOGY
DrLLPS ID | Organism | Identity | E-value | Score |
---|---|---|---|---|
LLPS-Pat-2218 | Pan troglodytes | 100.0 | 0.0 | 625 |
LLPS-Gog-2456 | Gorilla gorilla | 100.0 | 0.0 | 625 |
LLPS-Poa-4003 | Pongo abelii | 99.68 | 0.0 | 624 |
LLPS-Man-0826 | Macaca nemestrina | 99.04 | 0.0 | 621 |
LLPS-Mam-2425 | Macaca mulatta | 99.04 | 0.0 | 621 |
LLPS-Cea-1321 | Cercocebus atys | 99.04 | 0.0 | 621 |
LLPS-Maf-3690 | Macaca fascicularis | 99.04 | 0.0 | 621 |
LLPS-Paa-4571 | Papio anubis | 99.04 | 0.0 | 621 |
LLPS-Chs-2718 | Chlorocebus sabaeus | 98.73 | 0.0 | 619 |
LLPS-Caj-3444 | Callithrix jacchus | 98.09 | 0.0 | 617 |
LLPS-Fec-2694 | Felis catus | 96.82 | 0.0 | 609 |
LLPS-Urm-3920 | Ursus maritimus | 96.5 | 0.0 | 607 |
LLPS-Aim-2594 | Ailuropoda melanoleuca | 96.5 | 0.0 | 607 |
LLPS-Cas-1427 | Carlito syrichta | 96.18 | 0.0 | 607 |
LLPS-Caf-4102 | Canis familiaris | 96.18 | 0.0 | 605 |
LLPS-Sus-0547 | Sus scrofa | 96.17 | 0.0 | 605 |
LLPS-Otg-3957 | Otolemur garnettii | 95.86 | 0.0 | 586 |
LLPS-Ict-3823 | Ictidomys tridecemlineatus | 95.86 | 0.0 | 603 |
LLPS-Eqc-4285 | Equus caballus | 94.9 | 0.0 | 599 |
LLPS-Cap-3793 | Cavia porcellus | 93.63 | 0.0 | 588 |
LLPS-Orc-0099 | Oryctolagus cuniculus | 93.31 | 0.0 | 586 |
LLPS-Mum-4972 | Mus musculus | 92.04 | 0.0 | 575 |
LLPS-Mea-1609 | Mesocricetus auratus | 91.4 | 0.0 | 574 |
LLPS-Xim-4170 | Xiphophorus maculatus | 73.86 | 1e-162 | 463 |
LLPS-Orn-0537 | Oreochromis niloticus | 73.2 | 4e-163 | 464 |
LLPS-Pof-0842 | Poecilia formosa | 73.2 | 2e-161 | 460 |
LLPS-Asm-1097 | Astyanax mexicanus | 71.66 | 6e-160 | 456 |
LLPS-Orl-3542 | Oryzias latipes | 70.92 | 8e-160 | 459 |
LLPS-Lac-2252 | Latimeria chalumnae | 65.61 | 1e-149 | 430 |
LLPS-Lem-1115 | Leptosphaeria maculans | 48.48 | 1e-10 | 65.9 |
LLPS-Pyt-0122 | Pyrenophora teres | 46.97 | 2e-10 | 65.9 |
LLPS-Cis-2010 | Ciona savignyi | 45.61 | 5e-07 | 54.3 |
LLPS-Scc-1026 | Schizosaccharomyces cryophilus | 45.31 | 3e-10 | 64.3 |
LLPS-Scs-0448 | Sclerotinia sclerotiorum | 45.0 | 4e-09 | 57.8 |
LLPS-Usm-0483 | Ustilago maydis | 44.23 | 3e-06 | 52.4 |
LLPS-Cog-0091 | Colletotrichum gloeosporioides | 44.12 | 7e-09 | 60.5 |
LLPS-Gag-0488 | Gaeumannomyces graminis | 44.12 | 9e-11 | 66.2 |
LLPS-Fuo-1369 | Fusarium oxysporum | 43.24 | 2e-11 | 68.2 |
LLPS-Fuv-1335 | Fusarium verticillioides | 43.24 | 3e-11 | 67.8 |
LLPS-Zyt-1321 | Zymoseptoria tritici | 42.03 | 3e-08 | 57.8 |
LLPS-Mup-0059 | Mustela putorius furo | 41.75 | 1e-77 | 247 |
LLPS-Fud-0431 | Fukomys damarensis | 41.58 | 3e-79 | 251 |
LLPS-Ova-2933 | Ovis aries | 41.58 | 2e-76 | 243 |
LLPS-Tut-0409 | Tursiops truncatus | 41.42 | 2e-77 | 246 |
LLPS-Map-1329 | Magnaporthe poae | 41.18 | 7e-10 | 63.5 |
LLPS-Bot-4326 | Bos taurus | 41.04 | 3e-75 | 240 |
LLPS-Dos-1322 | Dothistroma septosporum | 37.33 | 6e-09 | 60.5 |
LLPS-Beb-0705 | Beauveria bassiana | 34.83 | 1e-09 | 62.8 |
LLPS-Ran-4085 | Rattus norvegicus | 34.26 | 2e-08 | 58.5 |
LLPS-Tum-0163 | Tuber melanosporum | 31.85 | 3e-11 | 66.6 |
LLPS-Scj-0336 | Schizosaccharomyces japonicus | 31.78 | 8e-07 | 54.3 |
LLPS-Spr-1453 | Sporisorium reilianum | 31.06 | 2e-07 | 55.8 |
LLPS-Kop-1098 | Komagataella pastoris | 31.03 | 2e-07 | 55.8 |
LLPS-Mel-1030 | Melampsora laricipopulina | 29.32 | 1e-07 | 56.6 |
LLPS-Crn-0261 | Cryptococcus neoformans | 28.16 | 3e-07 | 55.5 |
LLPS-Coo-1491 | Colletotrichum orbiculare | 27.92 | 1e-12 | 71.6 |
LLPS-Scp-0797 | Schizosaccharomyces pombe | 27.61 | 9e-16 | 80.1 |
LLPS-Abg-1674 | Absidia glauca | 27.08 | 3e-08 | 58.2 |
LLPS-Ved-1229 | Verticillium dahliae | 26.8 | 3e-14 | 76.3 |
LLPS-Nec-1265 | Neurospora crassa | 26.52 | 2e-13 | 73.9 |
LLPS-Phn-0137 | Phaeosphaeria nodorum | 26.18 | 2e-12 | 70.9 |
LLPS-Cogr-0259 | Colletotrichum graminicola | 23.72 | 2e-09 | 62.0 |
LLPS-Cae-1460 | Caenorhabditis elegans | 23.51 | 2e-12 | 70.9 |