LLPS-Hos-2883
HSPA6

▼ OVERVIEW

Status: Reviewed
Protein Name: Heat shock 70 kDa protein 6; Heat shock 70 kDa protein B'
Gene Name: HSPA6, HSP70B'
Ensembl Gene: ENSG00000173110.7
Ensembl Protein: ENSP00000310219.4
Organism: Homo sapiens
Taxa ID: 9606
LLPS Type: Client
PDB: 3FE1 (A) More


▼ PROPERTY


——— Disorder propensity (calculated by IUPred2A)

▼ Classification

Condensates:
CondensateDescriptionTissue/CellPMIDs
Nuclear speckle
"...At 20 min and 1 h after heat shock, HSPA6 localized to perispeckles around the periphera of nuclear speckles which were identified with the SON marker protein."
Human neuronal cells28484369
Nuclear speckle
"...YFP-tagged HSPA6 associated with nuclear speckles, which were identified using the nuclear speckle marker protein SC35."
Human neuronal SH-SY5Y cells27743288
Nuclear speckle
"...HSPA6 and HSPA1A also targeted nuclear speckles, rich in RNA splicing factors, and the granular component of the nucleolus that is involved in rRNA processing and ribosomal subunit assembly."
Human neuronal SH-SY5Y cells27527722
Nucleolus
"...Thus, we analyzed the orthologous groups of the remaining 2316 identified proteins to the human nucleolar proteins. We detected 361 orthologues in NoPDB from the 2316 A. thaliana proteins."
N/A26980300
Postsynaptic density
"...We report the first direct comparison of the proteome of triplicate isolates of mouse and human cortical postsynaptic densities. The mouse postsynaptic density comprised 1556 proteins and the human one 1461."
Human cortex23071613

▼ FUNCTION

Molecular chaperone implicated in a wide variety of cellular processes, including protection of the proteome from stress, folding and transport of newly synthesized polypeptides, activation of proteolysis of misfolded proteins and the formation and dissociation of protein complexes. Plays a pivotal role in the protein quality control system, ensuring the correct folding of proteins, the re-folding of misfolded proteins and controlling the targeting of proteins for subsequent degradation. This is achieved through cycles of ATP binding, ATP hydrolysis and ADP release, mediated by co-chaperones. The affinity for polypeptides is regulated by its nucleotide bound state. In the ATP-bound form, it has a low affinity for substrate proteins. However, upon hydrolysis of the ATP to ADP, it undergoes a conformational change that increases its affinity for substrate proteins. It goes through repeated cycles of ATP hydrolysis and nucleotide exchange, which permits cycles of substrate binding and release (PubMed:26865365).

▼ SEQUENCE

Protein Sequence (FASTA)
1     MQAPRELAVG  IDLGTTYSCV  GVFQQGRVEI  LANDQGNRTT  PSYVAFTDTE  RLVGDAAKSQ  60
61    AALNPHNTVF  DAKRLIGRKF  ADTTVQSDMK  HWPFRVVSEG  GKPKVRVCYR  GEDKTFYPEE  120
121   ISSMVLSKMK  ETAEAYLGQP  VKHAVITVPA  YFNDSQRQAT  KDAGAIAGLN  VLRIINEPTA  180
181   AAIAYGLDRR  GAGERNVLIF  DLGGGTFDVS  VLSIDAGVFE  VKATAGDTHL  GGEDFDNRLV  240
241   NHFMEEFRRK  HGKDLSGNKR  ALRRLRTACE  RAKRTLSSST  QATLEIDSLF  EGVDFYTSIT  300
301   RARFEELCSD  LFRSTLEPVE  KALRDAKLDK  AQIHDVVLVG  GSTRIPKVQK  LLQDFFNGKE  360
361   LNKSINPDEA  VAYGAAVQAA  VLMGDKCEKV  QDLLLLDVAP  LSLGLETAGG  VMTTLIQRNA  420
421   TIPTKQTQTF  TTYSDNQPGV  FIQVYEGERA  MTKDNNLLGR  FELSGIPPAP  RGVPQIEVTF  480
481   DIDANGILSV  TATDRSTGKA  NKITITNDKG  RLSKEEVERM  VHEAEQYKAE  DEAQRDRVAA  540
541   KNSLEAHVFH  VKGSLQEESL  RDKIPEEDRR  KMQDKCREVL  AWLEHNQLAE  KEEYEHQKRE  600
601   LEQICRPIFS  RLYGGPGVPG  GSSCGTQARQ  GDPSTGPIIE  EVD  643
Nucleotide CDS Sequence (FASTA)
1     ATGCAGGCCC  CACGGGAGCT  CGCGGTGGGC  ATCGACCTGG  GCACCACCTA  CTCGTGCGTG  60
61    GGCGTGTTTC  AGCAGGGCCG  CGTGGAGATC  CTGGCCAACG  ACCAGGGCAA  CCGCACCACG  120
121   CCCAGCTACG  TGGCCTTCAC  CGACACCGAG  CGGCTGGTCG  GGGACGCGGC  CAAGAGCCAG  180
181   GCGGCCCTGA  ACCCCCACAA  CACCGTGTTC  GATGCCAAGC  GGCTGATCGG  GCGCAAGTTC  240
241   GCGGACACCA  CGGTGCAGTC  GGACATGAAG  CACTGGCCCT  TCCGGGTGGT  GAGCGAGGGC  300
301   GGCAAGCCCA  AGGTGCGCGT  ATGCTACCGC  GGGGAGGACA  AGACGTTCTA  CCCCGAGGAG  360
361   ATCTCGTCCA  TGGTGCTGAG  CAAGATGAAG  GAGACGGCCG  AGGCGTACCT  GGGCCAGCCC  420
421   GTGAAGCACG  CAGTGATCAC  CGTGCCCGCC  TATTTCAATG  ACTCGCAGCG  CCAGGCCACC  480
481   AAGGACGCGG  GGGCCATCGC  GGGGCTCAAC  GTGTTGCGGA  TCATCAATGA  GCCCACGGCA  540
541   GCTGCCATCG  CCTATGGGCT  GGACCGGCGG  GGCGCGGGAG  AGCGCAACGT  GCTCATTTTT  600
601   GACCTGGGTG  GGGGCACCTT  CGATGTGTCG  GTTCTCTCCA  TTGACGCTGG  TGTCTTTGAG  660
661   GTGAAAGCCA  CTGCTGGAGA  TACCCACCTG  GGAGGAGAGG  ACTTCGACAA  CCGGCTCGTG  720
721   AACCACTTCA  TGGAAGAATT  CCGGCGGAAG  CATGGGAAGG  ACCTGAGCGG  GAACAAGCGT  780
781   GCCCTGCGCA  GGCTGCGCAC  AGCCTGTGAG  CGCGCCAAGC  GCACCCTGTC  CTCCAGCACC  840
841   CAGGCCACCC  TGGAGATAGA  CTCCCTGTTC  GAGGGCGTGG  ACTTCTACAC  GTCCATCACT  900
901   CGTGCCCGCT  TTGAGGAACT  GTGCTCAGAC  CTCTTCCGCA  GCACCCTGGA  GCCGGTGGAG  960
961   AAGGCCCTGC  GGGATGCCAA  GCTGGACAAG  GCCCAGATTC  ATGACGTCGT  CCTGGTGGGG  1020
1021  GGCTCCACAC  GCATCCCCAA  GGTGCAGAAG  TTGCTGCAGG  ACTTCTTCAA  CGGCAAGGAG  1080
1081  CTGAACAAGA  GCATCAACCC  TGATGAGGCT  GTGGCCTATG  GGGCTGCTGT  GCAGGCGGCC  1140
1141  GTGTTGATGG  GGGACAAATG  TGAGAAAGTG  CAGGATCTCC  TGCTGCTGGA  TGTGGCTCCC  1200
1201  CTGTCTCTGG  GGCTGGAGAC  AGCAGGTGGG  GTGATGACCA  CGCTGATCCA  GAGGAACGCC  1260
1261  ACTATCCCCA  CCAAGCAGAC  CCAGACTTTC  ACCACCTACT  CGGACAACCA  GCCTGGGGTC  1320
1321  TTCATCCAGG  TGTATGAGGG  TGAGAGGGCC  ATGACCAAGG  ACAACAACCT  GCTGGGGCGT  1380
1381  TTTGAACTCA  GTGGCATCCC  TCCTGCCCCA  CGTGGAGTCC  CCCAGATAGA  GGTGACTTTT  1440
1441  GACATTGATG  CTAATGGCAT  CCTGAGCGTG  ACAGCCACTG  ACAGGAGCAC  AGGTAAGGCT  1500
1501  AACAAGATCA  CCATCACCAA  TGACAAGGGC  CGGCTGAGCA  AGGAGGAGGT  GGAGAGGATG  1560
1561  GTTCATGAAG  CCGAGCAGTA  CAAGGCTGAG  GATGAGGCCC  AGAGGGACAG  AGTGGCTGCC  1620
1621  AAAAACTCGC  TGGAGGCCCA  TGTCTTCCAT  GTGAAAGGTT  CTTTGCAAGA  GGAAAGCCTT  1680
1681  AGGGACAAGA  TTCCCGAAGA  GGACAGGCGC  AAAATGCAAG  ACAAGTGTCG  GGAAGTCCTT  1740
1741  GCCTGGCTGG  AGCACAACCA  GCTGGCAGAG  AAGGAGGAGT  ATGAGCATCA  GAAGAGGGAG  1800
1801  CTGGAGCAAA  TCTGTCGCCC  CATCTTCTCC  AGGCTCTATG  GGGGGCCTGG  TGTCCCTGGG  1860
1861  GGCAGCAGTT  GTGGCACTCA  AGCCCGCCAG  GGGGACCCCA  GCACCGGCCC  CATCATTGAG  1920
1921  GAGGTTGATT  GA  1932

▼ KEYWORD

ID
Family
3D-structure
ATP-binding
Complete proteome
Methylation
Nucleotide-binding
Polymorphism
Reference proteome
Stress response

▼ GENE ONTOLOGY

ID
Classification
Description
Cellular Component
Blood microparticle
Cellular Component
Centriole
Cellular Component
Cytoplasm
Cellular Component
Cytosol
Cellular Component
Extracellular exosome
Cellular Component
Extracellular region
Cellular Component
Ficolin-1-rich granule lumen
Cellular Component
Nucleus
Cellular Component
Protein-containing complex
Cellular Component
Secretory granule lumen
Molecular Function
ATP binding
Molecular Function
ATPase activity
Molecular Function
ATPase activity, coupled
Molecular Function
Enzyme binding
Molecular Function
Heat shock protein binding
Molecular Function
Misfolded protein binding
Molecular Function
Protein folding chaperone
Molecular Function
Unfolded protein binding
Biological Process
Cellular response to heat
Biological Process
Cellular response to unfolded protein
Biological Process
Chaperone cofactor-dependent protein refolding
Biological Process
Neutrophil degranulation
Biological Process
Protein refolding
Biological Process
Response to unfolded protein

▼ KEGG


▼ ORTHOLOGY

DrLLPS IDOrganismIdentityE-valueScore
LLPS-Poa-2599Pongo abelii98.440.01191
LLPS-Nol-0333Nomascus leucogenys98.440.01188
LLPS-Cas-0772Carlito syrichta96.730.01173
LLPS-Pat-4404Pan troglodytes96.420.01176
LLPS-Caj-0924Callithrix jacchus96.240.01154
LLPS-Bot-4660Bos taurus94.510.01136
LLPS-Ova-3711Ovis aries94.470.01014
LLPS-Cap-2847Cavia porcellus93.160.01133
LLPS-Ict-3661Ictidomys tridecemlineatus93.00.01132
LLPS-Maf-4587Macaca fascicularis89.740.01073
LLPS-Cea-3535Cercocebus atys89.270.01045
LLPS-Rhb-4635Rhinopithecus bieti87.250.01015
LLPS-Orc-3596Oryctolagus cuniculus84.650.01003
LLPS-Caf-0431Canis familiaris84.470.0 991
LLPS-Chs-0084Chlorocebus sabaeus84.320.01005
LLPS-Mup-1328Mustela putorius furo84.310.0 992
LLPS-Dio-1867Dipodomys ordii83.50.0 989
LLPS-Ora-0394Ornithorhynchus anatinus82.950.01021
LLPS-Sah-1328Sarcophilus harrisii82.920.0 994
LLPS-Fec-2423Felis catus82.70.01015
LLPS-Aim-1567Ailuropoda melanoleuca82.550.01016
LLPS-Otg-3422Otolemur garnettii82.390.01014
LLPS-Mod-3341Monodelphis domestica82.270.01023
LLPS-Eqc-0176Equus caballus82.160.01015
LLPS-Tut-0804Tursiops truncatus82.160.01014
LLPS-Ran-0042Rattus norvegicus82.00.01007
LLPS-Myl-0675Myotis lucifugus81.920.01006
LLPS-Loa-1802Loxodonta africana81.530.01013
LLPS-Mum-1293Mus musculus81.530.01005
LLPS-Mea-3681Mesocricetus auratus81.090.0 949
LLPS-Aon-2927Aotus nancymaae80.590.0 970
LLPS-Paa-2596Papio anubis80.360.0 983
LLPS-Cae-0408Caenorhabditis elegans80.230.0 965
LLPS-Anc-1550Anolis carolinensis80.20.0 967
LLPS-Gaga-1460Gallus gallus80.20.0 969
LLPS-Anp-1068Anas platyrhynchos80.20.0 969
LLPS-Meg-0622Meleagris gallopavo80.20.0 970
LLPS-Xet-0246Xenopus tropicalis80.070.0 964
LLPS-Tag-2870Taeniopygia guttata80.030.0 967
LLPS-Man-1230Macaca nemestrina80.030.0 967
LLPS-Urm-0354Ursus maritimus80.030.0 967
LLPS-Pap-2585Pan paniscus80.030.0 967
LLPS-Lac-3661Latimeria chalumnae80.030.0 967
LLPS-Fia-1669Ficedula albicollis80.030.0 968
LLPS-Orn-3641Oreochromis niloticus80.030.0 965
LLPS-Pes-2810Pelodiscus sinensis80.030.0 967
LLPS-Drm-0680Drosophila melanogaster80.030.0 955
LLPS-Mal-0253Mandrillus leucophaeus80.030.0 967
LLPS-Sus-0265Sus scrofa80.030.0 966
LLPS-Fud-1801Fukomys damarensis80.030.0 967
LLPS-Gog-1569Gorilla gorilla80.030.0 967
LLPS-Mam-1291Macaca mulatta79.940.0 996
LLPS-Icp-0040Ictalurus punctatus79.870.0 967
LLPS-Scm-1342Scophthalmus maximus79.70.0 964
LLPS-Orl-2086Oryzias latipes79.70.0 964
LLPS-Scf-0987Scleropages formosus79.540.0 961
LLPS-Dar-0617Danio rerio79.370.0 962
LLPS-Pof-3531Poecilia formosa79.370.0 958
LLPS-Asm-3454Astyanax mexicanus79.370.0 959
LLPS-Xim-2129Xiphophorus maculatus79.210.0 958
LLPS-Gaa-0684Gasterosteus aculeatus79.040.0 952
LLPS-Ten-2048Tetraodon nigroviridis78.710.0 954
LLPS-Cis-0845Ciona savignyi78.220.0 934
LLPS-Leo-3312Lepisosteus oculatus77.480.0 984
LLPS-Cii-0165Ciona intestinalis77.470.0 907
LLPS-Tar-1049Takifugu rubripes77.290.0 966
LLPS-Sob-0277Sorghum bicolor74.710.0 891
LLPS-Asfu-0029Aspergillus fumigatus74.50.0 884
LLPS-Nef-1008Neosartorya fischeri74.340.0 882
LLPS-Aso-0087Aspergillus oryzae74.170.0 884
LLPS-Asf-0953Aspergillus flavus74.170.0 884
LLPS-Hea-1537Helianthus annuus74.060.0 888
LLPS-Orr-1512Oryza rufipogon73.730.0 881
LLPS-Org-1561Oryza glaberrima73.730.0 881
LLPS-Zem-1009Zea mays73.730.0 881
LLPS-Orp-0177Oryza punctata73.730.0 881
LLPS-Ors-2372Oryza sativa73.730.0 881
LLPS-Lep-1122Leersia perrieri73.730.0 881
LLPS-Orgl-0669Oryza glumaepatula73.730.0 881
LLPS-Orb-2064Oryza barthii73.730.0 881
LLPS-Orni-0619Oryza nivara73.730.0 881
LLPS-Scp-1400Schizosaccharomyces pombe73.60.0 882
LLPS-Scj-1500Schizosaccharomyces japonicus73.430.0 890
LLPS-Sei-0872Setaria italica72.540.0 888
LLPS-Mae-0779Manihot esculenta71.880.0 881
LLPS-Nia-0436Nicotiana attenuata71.880.0 882
LLPS-Sot-0561Solanum tuberosum71.880.0 880
LLPS-Sol-0780Solanum lycopersicum71.880.0 881
LLPS-Cus-0398Cucumis sativus71.720.0 881
LLPS-Brn-0135Brassica napus71.520.0 882
LLPS-Tra-1488Triticum aestivum71.230.0 883
LLPS-Thc-1965Theobroma cacao71.030.0 884