LLPS-Hos-2777
LIMK2

▼ OVERVIEW

Status: Reviewed
Protein Name: LIM domain kinase 2
Gene Name: LIMK2
Ensembl Gene: ENSG00000182541.17
Ensembl Protein: ENSP00000384602.1
Organism: Homo sapiens
Taxa ID: 9606
LLPS Type: Others
PDB: 1X6A (A) More


▼ PROPERTY


——— Disorder propensity (calculated by IUPred2A)

▼ Classification

Condensates:
CondensateDescriptionTissue/CellPMIDs
Centrosome/Spindle pole body
"...MiCroKiTS 4.0: a database of midbody, centrosome, kinetochore, telomere and spindle."
N/A16455074, 18000399

▼ FUNCTION

Displays serine/threonine-specific phosphorylation of myelin basic protein and histone (MBP) in vitro.

▼ SEQUENCE

Protein Sequence (FASTA)
1     MGSYLSVPAY  FTSRDLFRCS  ECQDSLTNWY  YEKDGKLYCP  KDYWGKFGEF  CHGCSLLMTG  60
61    PFMVAGEFKY  HPECFACMSC  KVIIEDGDAY  ALVQHATLYC  GKCHNEVVLA  PMFERLSTES  120
121   VQEQLPYSVT  LISMPATTEG  RRGFSVSVES  ACSNYATTVQ  VKEVNRMHIS  PNNRNAIHPG  180
181   DRILEINGTP  VRTLRVEEVE  DAISQTSQTL  QLLIEHDPVS  QRLDQLRLEA  RLAPHMQNAG  240
241   HPHALSTLDT  KENLEGTLRR  RSLRRSNSIS  KSPGPSSPKE  PLLFSRDISR  SESLRCSSSY  300
301   SQQIFRPCDL  IHGEVLGKGF  FGQAIKVTHK  ATGKVMVMKE  LIRCDEETQK  TFLTEVKVMR  360
361   SLDHPNVLKF  IGVLYKDKKL  NLLTEYIEGG  TLKDFLRSMD  PFPWQQKVRF  AKGIASGMAY  420
421   LHSMCIIHRD  LNSHNCLIKL  DKTVVVADFG  LSRLIVEERK  RAPMEKATTK  KRTLRKNDRK  480
481   KRYTVVGNPY  WMAPEMLNGK  SYDETVDIFS  FGIVLCEIIG  QVYADPDCLP  RTLDFGLNVK  540
541   LFWEKFVPTD  CPPAFFPLAA  ICCRLEPESR  APPGAAGEGP  GCADDEGPVR  RQGKVTIKYD  600
601   PKELRKHLNL  EEWILEQLTR  LYDCQEEEIS  ELEIDVDELL  DMESDDAWAS  RVKELLVDCY  660
661   KPTEAFISGL  LDKIRAMQKL  STPQKK  686
Nucleotide CDS Sequence (FASTA)
1     ATGTCCGCGC  TGGCGGGTGA  AGATGTCTGG  AGGTGTCCAG  GCTGTGGGGA  CCACATTGCT  60
61    CCAAGCCAGA  TATGGTACAG  GACTGTCAAC  GAAACCTGGC  ACGGCTCTTG  CTTCCGGTGT  120
121   TCAGAATGCC  AGGATTCCCT  CACCAACTGG  TACTATGAGA  AGGATGGGAA  GCTCTACTGC  180
181   CCCAAGGACT  ACTGGGGGAA  GTTTGGGGAG  TTCTGTCATG  GGTGCTCCCT  GCTGATGACA  240
241   GGGCCTTTTA  TGGTGGCTGG  GGAGTTCAAG  TACCACCCAG  AGTGCTTTGC  CTGTATGAGC  300
301   TGCAAGGTGA  TCATTGAGGA  TGGGGATGCA  TATGCACTGG  TGCAGCATGC  CACCCTCTAC  360
361   TGTGGGAAGT  GCCACAATGA  GGTGGTGCTG  GCACCCATGT  TTGAGAGACT  CTCCACAGAG  420
421   TCTGTTCAGG  AGCAGCTGCC  CTACTCTGTC  ACGCTCATCT  CCATGCCGGC  CACCACTGAA  480
481   GGCAGGCGGG  GCTTCTCCGT  GTCCGTGGAG  AGTGCCTGCT  CCAACTACGC  CACCACTGTG  540
541   CAAGTGAAAG  AGGTCAACCG  GATGCACATC  AGTCCCAACA  ATCGAAACGC  CATCCACCCT  600
601   GGGGACCGCA  TCCTGGAGAT  CAATGGGACC  CCCGTCCGCA  CACTTCGAGT  GGAGGAGGTG  660
661   GAGGATGCAA  TTAGCCAGAC  GAGCCAGACA  CTTCAGCTGT  TGATTGAACA  TGACCCCGTC  720
721   TCCCAACGCC  TGGACCAGCT  GCGGCTGGAG  GCCCGGCTCG  CTCCTCACAT  GCAGAATGCC  780
781   GGACACCCCC  ACGCCCTCAG  CACCCTGGAC  ACCAAGGAGA  ATCTGGAGGG  GACACTGAGG  840
841   AGACGTTCCC  TAAGGCGCAG  TAACAGTATC  TCCAAGTCCC  CTGGCCCCAG  CTCCCCAAAG  900
901   GAGCCCCTGC  TGTTCAGCCG  TGACATCAGC  CGCTCAGAAT  CCCTTCGTTG  TTCCAGCAGC  960
961   TATTCACAGC  AGATCTTCCG  GCCCTGTGAC  CTAATCCATG  GGGAGGTCCT  GGGGAAGGGC  1020
1021  TTCTTTGGGC  AGGCTATCAA  GGTGACACAC  AAAGCCACGG  GCAAAGTGAT  GGTCATGAAA  1080
1081  GAGTTAATTC  GATGTGATGA  GGAGACCCAG  AAAACTTTTC  TGACTGAGGT  GAAAGTGATG  1140
1141  CGCAGCCTGG  ACCACCCCAA  TGTGCTCAAG  TTCATTGGTG  TGCTGTACAA  GGATAAGAAG  1200
1201  CTGAACCTCC  TGACAGAGTA  CATTGAGGGG  GGCACACTGA  AGGACTTTCT  GCGCAGTATG  1260
1261  GATCCGTTCC  CCTGGCAGCA  GAAGGTCAGG  TTTGCCAAAG  GAATCGCCTC  CGGAATGGCC  1320
1321  TATTTGCACT  CTATGTGCAT  CATCCACCGG  GATCTGAACT  CGCACAACTG  CCTCATCAAG  1380
1381  TTGGACAAGA  CTGTGGTGGT  GGCAGACTTT  GGGCTGTCAC  GGCTCATAGT  GGAAGAGAGG  1440
1441  AAAAGGGCCC  CCATGGAGAA  GGCCACCACC  AAGAAACGCA  CCTTGCGCAA  GAACGACCGC  1500
1501  AAGAAGCGCT  ACACGGTGGT  GGGAAACCCC  TACTGGATGG  CCCCTGAGAT  GCTGAACGGA  1560
1561  AAGAGCTATG  ATGAGACGGT  GGATATCTTC  TCCTTTGGGA  TCGTTCTCTG  TGAGATCATT  1620
1621  GGGCAGGTGT  ATGCAGATCC  TGACTGCCTT  CCCCGAACAC  TGGACTTTGG  CCTCAACGTG  1680
1681  AAGCTTTTCT  GGGAGAAGTT  TGTTCCCACA  GATTGTCCCC  CGGCCTTCTT  CCCGCTGGCC  1740
1741  GCCATCTGCT  GCAGACTGGA  GCCTGAGAGC  AGACCAGCAT  TCTCGAAATT  GGAGGACTCC  1800
1801  TTTGAGGCCC  TCTCCCTGTA  CCTGGGGGAG  CTGGGCATCC  CGCTGCCTGC  AGAGCTGGAG  1860
1861  GAGTTGGACC  ACACTGTGAG  CATGCAGTAC  GGCCTGACCC  GGGACTCACC  TCCCTAG  1917

▼ KEYWORD

ID
Family
3D-structure
Alternative splicing
ATP-binding
Complete proteome
Cytoplasm
Kinase
LIM domain
Metal-binding
Nucleotide-binding
Nucleus
Phosphoprotein
Polymorphism
Reference proteome
Repeat
Serine/threonine-protein kinase
Transferase
Zinc

▼ GENE ONTOLOGY

ID
Classification
Description
Cellular Component
Cis-Golgi network
Cellular Component
Cytoplasm
Cellular Component
Nucleus
Molecular Function
ATP binding
Molecular Function
Metal ion binding
Molecular Function
Protein heterodimerization activity
Molecular Function
Protein serine/threonine kinase activity
Biological Process
Actin cytoskeleton organization
Biological Process
Cornea development in camera-type eye
Biological Process
Head development
Biological Process
Phosphorylation
Biological Process
Spermatogenesis

▼ KEGG


▼ ORTHOLOGY

DrLLPS IDOrganismIdentityE-valueScore
LLPS-Nol-4128Nomascus leucogenys99.270.01056
LLPS-Mal-0493Mandrillus leucophaeus99.090.01056
LLPS-Paa-2692Papio anubis99.090.01056
LLPS-Mam-0520Macaca mulatta98.910.01054
LLPS-Man-2741Macaca nemestrina98.910.01054
LLPS-Cea-1885Cercocebus atys98.910.01055
LLPS-Chs-3540Chlorocebus sabaeus98.910.01054
LLPS-Maf-4303Macaca fascicularis98.910.01054
LLPS-Rhb-4000Rhinopithecus bieti98.720.01053
LLPS-Pap-4233Pan paniscus98.540.01266
LLPS-Aon-3355Aotus nancymaae98.540.01046
LLPS-Gog-4746Gorilla gorilla98.10.01261
LLPS-Caj-2788Callithrix jacchus98.00.01040
LLPS-Poa-3847Pongo abelii97.260.0 803
LLPS-Urm-2180Ursus maritimus96.810.01068
LLPS-Aim-4031Ailuropoda melanoleuca96.810.01066
LLPS-Fec-0920Felis catus96.720.01028
LLPS-Fud-3941Fukomys damarensis96.720.01032
LLPS-Ict-4224Ictidomys tridecemlineatus96.540.01026
LLPS-Cas-2657Carlito syrichta96.540.01031
LLPS-Mup-3671Mustela putorius furo96.540.01028
LLPS-Dio-2736Dipodomys ordii96.460.01059
LLPS-Eqc-4070Equus caballus96.360.01026
LLPS-Caf-3288Canis familiaris96.360.01031
LLPS-Cap-4312Cavia porcellus96.170.01026
LLPS-Sus-2295Sus scrofa96.170.01024
LLPS-Tut-1774Tursiops truncatus96.160.01016
LLPS-Orc-3809Oryctolagus cuniculus95.990.01024
LLPS-Otg-3101Otolemur garnettii95.750.01055
LLPS-Pat-2868Pan troglodytes95.340.01224
LLPS-Mum-4757Mus musculus95.260.01009
LLPS-Loa-3879Loxodonta africana95.220.01047
LLPS-Myl-3115Myotis lucifugus95.040.01045
LLPS-Ran-4713Rattus norvegicus94.90.01008
LLPS-Bot-1817Bos taurus94.90.01008
LLPS-Mod-1806Monodelphis domestica91.80.0 978
LLPS-Ora-2633Ornithorhynchus anatinus91.330.01007
LLPS-Gaga-2641Gallus gallus88.340.0 944
LLPS-Anp-2535Anas platyrhynchos88.160.0 940
LLPS-Tag-3590Taeniopygia guttata87.980.0 939
LLPS-Fia-2186Ficedula albicollis87.980.0 940
LLPS-Meg-2551Meleagris gallopavo87.610.0 969
LLPS-Pes-2940Pelodiscus sinensis83.420.0 885
LLPS-Sah-3501Sarcophilus harrisii81.720.0 895
LLPS-Leo-3207Lepisosteus oculatus74.590.0 777
LLPS-Scf-3924Scleropages formosus72.840.0 769
LLPS-Orn-4071Oreochromis niloticus72.480.0 748
LLPS-Icp-1483Ictalurus punctatus72.30.0 755
LLPS-Scm-1785Scophthalmus maximus71.530.0 738
LLPS-Xim-3187Xiphophorus maculatus71.530.0 754
LLPS-Ten-2615Tetraodon nigroviridis71.20.0 738
LLPS-Pof-2776Poecilia formosa71.120.0 759
LLPS-Lac-3568Latimeria chalumnae70.932e-151 453
LLPS-Orl-3083Oryzias latipes70.730.0 728
LLPS-Dar-4104Danio rerio70.480.0 741
LLPS-Gaa-2056Gasterosteus aculeatus70.250.0 736
LLPS-Asm-2451Astyanax mexicanus69.940.0 649
LLPS-Tar-0337Takifugu rubripes68.220.0 745
LLPS-Xet-1785Xenopus tropicalis60.280.0 607
LLPS-Drm-0992Drosophila melanogaster55.121e-87 304
LLPS-Anc-2963Anolis carolinensis54.880.0 566
LLPS-Mea-2054Mesocricetus auratus43.943e-40 159
LLPS-Ova-3064Ovis aries43.413e-41 162
LLPS-Cii-1568Ciona intestinalis42.295e-125 391
LLPS-Cis-1021Ciona savignyi41.992e-46 169
LLPS-Mua-2429Musa acuminata34.724e-29 124
LLPS-Php-1333Physcomitrella patens34.552e-25 115
LLPS-Sot-0844Solanum tuberosum34.263e-26 115
LLPS-Gas-1313Galdieria sulphuraria34.15e-28 125
LLPS-Chc-1190Chondrus crispus33.331e-25 114
LLPS-Sol-1189Solanum lycopersicum33.335e-27 120
LLPS-Thc-0086Theobroma cacao33.184e-25 114
LLPS-Glm-1884Glycine max33.184e-26 117
LLPS-Org-1266Oryza glaberrima33.027e-25 113
LLPS-Orr-2001Oryza rufipogon33.027e-25 113
LLPS-Ors-0939Oryza sativa33.027e-25 113
LLPS-Ori-0065Oryza indica33.021e-24 112
LLPS-Orb-2327Oryza barthii33.028e-25 112
LLPS-Lep-0717Leersia perrieri32.864e-25 113
LLPS-Sob-2344Sorghum bicolor32.551e-24 112
LLPS-Zem-0879Zea mays31.312e-27 122
LLPS-Brd-2373Brachypodium distachyon31.315e-27 120
LLPS-Tra-3065Triticum aestivum30.848e-27 120
LLPS-Scj-1599Schizosaccharomyces japonicus30.581e-25 115
LLPS-Fuv-0689Fusarium verticillioides29.671e-25 112
LLPS-Sei-1386Setaria italica29.446e-25 114