LLPS-Hos-2716
EIF1AY

▼ OVERVIEW

Status: Reviewed
Protein Name: Eukaryotic translation initiation factor 1A, Y-chromosomal
Gene Name: EIF1AY
Ensembl Gene: ENSG00000198692.9
Ensembl Protein: ENSP00000372222.3
Organism: Homo sapiens
Taxa ID: 9606
LLPS Type: LLPS regulator


▼ PROPERTY


——— Disorder propensity (calculated by IUPred2A)

▼ Classification

Condensates:
CondensateDescriptionTissue/CellPMIDs
Nucleolus
"...Thus, we analyzed the orthologous groups of the remaining 2316 identified proteins to the human nucleolar proteins. We detected 361 orthologues in NoPDB from the 2316 A. thaliana proteins."
N/A26980300
P-bodyPredicted from orthologsN/A(View)

▼ FUNCTION

Seems to be required for maximal rate of protein biosynthesis. Enhances ribosome dissociation into subunits and stabilizes the binding of the initiator Met-tRNA(I) to 40 S ribosomal subunits (By similarity).

▼ SEQUENCE

Protein Sequence (FASTA)
1     MPKNKGKGGK  NRRRGKNENE  SEKRELVFKE  DGQEYAQVIK  MLGNGRLEAL  CFDGVKRLCH  60
61    IRGKLRKKVW  INTSDIILVG  LRDYQDNKAD  VILKYNADEA  RSLKAYGELP  EHAKINETDT  120
121   FGPGDDDEIQ  FDDIGDDDED  IDDI  144
Nucleotide CDS Sequence (FASTA)
1     ATGCCCAAGA  ATAAAGGTAA  AGGAGGTAAA  AACAGGCGCA  GGGGTAAAAA  TGAGAATGAA  60
61    TCTGAAAAAA  GAGAGTTGGT  GTTTAAAGAG  GATGGACAAG  AGTATGCTCA  GGTAATCAAA  120
121   ATGTTGGGAA  ATGGACGATT  GGAAGCATTG  TGTTTTGATG  GTGTAAAGAG  GTTATGCCAT  180
181   ATCAGAGGGA  AATTGAGAAA  AAAGGTTTGG  ATAAATACAT  CAGACATTAT  ATTGGTTGGT  240
241   CTACGGGACT  ATCAGGATAA  CAAAGCTGAT  GTAATTTTAA  AGTACAATGC  AGATGAAGCT  300
301   AGAAGCCTGA  AGGCATATGG  CGAGCTTCCA  GAACATGCTA  AAATCAATGA  AACAGACACA  360
361   TTTGGTCCTG  GAGATGATGA  TGAAATCCAG  TTTGACGATA  TTGGAGATGA  TGATGAAGAC  420
421   ATTGATGATA  TCTAA  435

▼ KEYWORD

ID
Family
Complete proteome
Initiation factor
Isopeptide bond
Protein biosynthesis
Reference proteome
Ubl conjugation

▼ GENE ONTOLOGY

ID
Classification
Description
Molecular Function
Translation initiation factor activity

▼ KEGG


▼ ORTHOLOGY

DrLLPS IDOrganismIdentityE-valueScore
LLPS-Mam-3049Macaca mulatta100.01e-65 203
LLPS-Gaga-0449Gallus gallus100.08e-66 203
LLPS-Anc-2621Anolis carolinensis100.08e-66 203
LLPS-Meg-0485Meleagris gallopavo100.06e-66 204
LLPS-Pat-2944Pan troglodytes100.07e-66 204
LLPS-Anp-0650Anas platyrhynchos100.06e-66 204
LLPS-Pes-1837Pelodiscus sinensis100.01e-65 203
LLPS-Rhb-3673Rhinopithecus bieti100.06e-42 140
LLPS-Chs-0802Chlorocebus sabaeus100.08e-66 203
LLPS-Poa-0294Pongo abelii98.981e-65 203
LLPS-Caf-0924Canis familiaris98.981e-65 203
LLPS-Cap-0477Cavia porcellus98.981e-65 203
LLPS-Xet-1865Xenopus tropicalis98.981e-65 203
LLPS-Cas-2288Carlito syrichta98.981e-65 203
LLPS-Ict-0085Ictidomys tridecemlineatus98.987e-65 202
LLPS-Pap-3088Pan paniscus98.988e-65 201
LLPS-Mod-0364Monodelphis domestica98.981e-65 203
LLPS-Fec-0909Felis catus98.981e-65 203
LLPS-Otg-3429Otolemur garnettii98.982e-65 202
LLPS-Scf-1985Scleropages formosus98.981e-64 201
LLPS-Bot-2068Bos taurus98.981e-65 203
LLPS-Ran-0159Rattus norvegicus98.981e-65 203
LLPS-Mal-0799Mandrillus leucophaeus98.985e-65 202
LLPS-Paa-1630Papio anubis98.986e-65 202
LLPS-Aim-1021Ailuropoda melanoleuca98.981e-65 203
LLPS-Mup-0404Mustela putorius furo98.981e-65 202
LLPS-Ova-1935Ovis aries98.981e-65 203
LLPS-Myl-1863Myotis lucifugus98.981e-65 203
LLPS-Mum-3487Mus musculus98.981e-65 203
LLPS-Mea-1599Mesocricetus auratus98.981e-65 203
LLPS-Sus-1229Sus scrofa98.988e-66 204
LLPS-Aon-0639Aotus nancymaae98.986e-65 202
LLPS-Sah-0995Sarcophilus harrisii98.989e-66 203
LLPS-Cea-0068Cercocebus atys98.985e-65 202
LLPS-Fud-0928Fukomys damarensis98.981e-65 203
LLPS-Caj-1011Callithrix jacchus98.982e-65 203
LLPS-Tag-0973Taeniopygia guttata98.855e-57 179
LLPS-Fia-0968Ficedula albicollis98.82e-54 173
LLPS-Eqc-0756Equus caballus97.962e-65 202
LLPS-Dar-2406Danio rerio97.962e-65 203
LLPS-Pof-0937Poecilia formosa97.963e-65 202
LLPS-Orn-1367Oreochromis niloticus97.964e-65 202
LLPS-Xim-0787Xiphophorus maculatus97.963e-65 202
LLPS-Dio-0239Dipodomys ordii97.963e-65 202
LLPS-Gaa-0829Gasterosteus aculeatus97.967e-65 201
LLPS-Ora-1159Ornithorhynchus anatinus97.962e-65 202
LLPS-Orl-2635Oryzias latipes97.964e-65 202
LLPS-Leo-0516Lepisosteus oculatus97.962e-65 203
LLPS-Icp-1705Ictalurus punctatus97.962e-65 202
LLPS-Asm-0877Astyanax mexicanus97.943e-64 199
LLPS-Urm-1329Ursus maritimus96.943e-64 199
LLPS-Orc-0796Oryctolagus cuniculus96.943e-65 202
LLPS-Maf-0083Macaca fascicularis96.78e-59 186
LLPS-Loa-3025Loxodonta africana95.962e-62 195
LLPS-Gog-1375Gorilla gorilla95.921e-62 195
LLPS-Lac-1639Latimeria chalumnae94.649e-32 114
LLPS-Ten-1642Tetraodon nigroviridis92.868e-60 188
LLPS-Tar-1987Takifugu rubripes89.82e-57 182
LLPS-Ast-1099Aspergillus terreus86.68e-56 178
LLPS-Aso-0611Aspergillus oryzae86.66e-56 178
LLPS-Asf-0546Aspergillus flavus86.66e-56 178
LLPS-Asn-1016Aspergillus nidulans86.68e-56 178
LLPS-Asni-0949Aspergillus niger86.67e-56 178
LLPS-Dos-0150Dothistroma septosporum85.572e-54 175
LLPS-Asfu-0581Aspergillus fumigatus85.576e-55 177
LLPS-Nef-0263Neosartorya fischeri85.571e-55 178
LLPS-Blg-0247Blumeria graminis85.571e-53 173
LLPS-Tum-0439Tuber melanosporum85.572e-54 174
LLPS-Asc-0023Aspergillus clavatus85.571e-55 177
LLPS-Scs-0923Sclerotinia sclerotiorum85.574e-54 174
LLPS-Zyt-0854Zymoseptoria tritici85.422e-53 172
LLPS-Cii-0528Ciona intestinalis84.957e-53 172
LLPS-Nec-0187Neurospora crassa84.691e-53 173
LLPS-Ved-0335Verticillium dahliae83.752e-40 139
LLPS-Cogr-1153Colletotrichum graminicola83.672e-53 172
LLPS-Pug-0475Puccinia graminis83.671e-54 174
LLPS-Cog-0885Colletotrichum gloeosporioides83.673e-53 172
LLPS-Coo-0058Colletotrichum orbiculare83.672e-53 172
LLPS-Scm-1225Scophthalmus maximus83.654e-53 172
LLPS-Pytr-0198Pyrenophora triticirepentis83.519e-54 173
LLPS-Pyt-0242Pyrenophora teres83.519e-54 173
LLPS-Lem-0360Leptosphaeria maculans83.519e-54 173
LLPS-Drm-0383Drosophila melanogaster83.332e-52 169
LLPS-Cis-0522Ciona savignyi83.331e-42 144
LLPS-Fuo-0064Fusarium oxysporum82.471e-53 172
LLPS-Fus-0181Fusarium solani82.479e-54 173
LLPS-Fuv-0508Fusarium verticillioides82.472e-53 172
LLPS-Nol-1320Nomascus leucogenys81.633e-47 156
LLPS-Man-0514Macaca nemestrina81.633e-47 156
LLPS-Beb-0072Beauveria bassiana81.443e-52 169
LLPS-Miv-0192Microbotryum violaceum81.441e-52 170
LLPS-Usm-0526Ustilago maydis81.257e-50 163
LLPS-Osl-0021Ostreococcus lucimarinus81.252e-52 169
LLPS-Put-0527Puccinia triticina80.959e-1775.1
LLPS-Mel-0063Melampsora laricipopulina80.651e-48 159
LLPS-Spr-0249Sporisorium reilianum80.616e-49 160
LLPS-Trv-1095Trichoderma virens79.381e-50 165
LLPS-Trr-0510Trichoderma reesei79.386e-51 166
LLPS-Prp-0969Prunus persica79.351e-46 154
LLPS-Viv-0098Vitis vinifera79.351e-46 154
LLPS-Gor-1772Gossypium raimondii79.351e-46 154
LLPS-Amt-1020Amborella trichopoda79.351e-46 154
LLPS-Cus-0868Cucumis sativus79.351e-46 154
LLPS-Sol-0975Solanum lycopersicum79.351e-46 155
LLPS-Hea-0641Helianthus annuus79.353e-46 154
LLPS-Php-1324Physcomitrella patens79.351e-46 154
LLPS-Thc-0352Theobroma cacao79.351e-46 154
LLPS-Scj-0213Schizosaccharomyces japonicus78.359e-48 157
LLPS-Coc-1118Corchorus capsularis78.262e-46 154
LLPS-Pot-2709Populus trichocarpa78.266e-46 152
LLPS-Phv-1205Phaseolus vulgaris78.267e-46 152
LLPS-Mae-0136Manihot esculenta78.264e-46 153
LLPS-Via-1209Vigna angularis78.266e-46 153
LLPS-Sot-0073Solanum tuberosum78.262e-46 154
LLPS-Vir-1228Vigna radiata78.266e-46 153
LLPS-Glm-2365Glycine max78.266e-46 153
LLPS-Mua-0416Musa acuminata78.266e-46 152
LLPS-Nia-0354Nicotiana attenuata77.323e-47 156
LLPS-Yal-0472Yarrowia lipolytica77.322e-48 159
LLPS-Dac-0110Daucus carota77.323e-47 156
LLPS-Bro-1793Brassica oleracea77.171e-46 154
LLPS-Zem-0102Zea mays77.172e-45 151
LLPS-Brr-1061Brassica rapa77.171e-46 154
LLPS-Art-0680Arabidopsis thaliana77.171e-46 154
LLPS-Orp-0049Oryza punctata77.171e-45 152
LLPS-Sob-1656Sorghum bicolor77.172e-45 151
LLPS-Orbr-1353Oryza brachyantha77.175e-46 153
LLPS-Sei-1067Setaria italica77.173e-45 153
LLPS-Arl-1340Arabidopsis lyrata77.171e-46 154
LLPS-Brn-0978Brassica napus77.171e-46 154
LLPS-Chr-1275Chlamydomonas reinhardtii77.083e-48 159
LLPS-Gas-0156Galdieria sulphuraria76.925e-47 155
LLPS-Met-0441Medicago truncatula76.672e-43 146
LLPS-Scp-0438Schizosaccharomyces pombe76.531e-47 157
LLPS-Abg-1081Absidia glauca76.293e-48 158
LLPS-Sem-0214Selaginella moellendorffii76.092e-45 151
LLPS-Orr-1025Oryza rufipogon75.761e-45 152
LLPS-Orm-1363Oryza meridionalis75.761e-45 152
LLPS-Org-1309Oryza glaberrima75.761e-45 152
LLPS-Ors-0672Oryza sativa75.761e-45 152
LLPS-Orgl-0435Oryza glumaepatula75.761e-45 152
LLPS-Lep-0112Leersia perrieri75.761e-45 152
LLPS-Orb-1393Oryza barthii75.761e-45 152
LLPS-Ori-1106Oryza indica75.761e-45 152
LLPS-Orni-0751Oryza nivara75.761e-45 152
LLPS-Phn-0062Phaeosphaeria nodorum75.264e-45 150
LLPS-Scc-0786Schizosaccharomyces cryophilus75.262e-44 148
LLPS-Tru-1083Triticum urartu74.752e-45 152
LLPS-Hov-0674Hordeum vulgare74.752e-45 152
LLPS-Tra-1857Triticum aestivum74.752e-45 152
LLPS-Brd-0107Brachypodium distachyon74.751e-45 152
LLPS-Kop-0634Komagataella pastoris74.231e-48 160
LLPS-Chc-0720Chondrus crispus73.124e-45 150
LLPS-Cae-0095Caenorhabditis elegans72.346e-42 145
LLPS-Sac-0477Saccharomyces cerevisiae72.161e-45 152
LLPS-Asg-0280Ashbya gossypii70.11e-45 152
LLPS-Crn-0118Cryptococcus neoformans69.773e-36 128
LLPS-Cym-0056Cyanidioschyzon merolae68.752e-41 141
LLPS-Gag-0225Gaeumannomyces graminis40.43e-1984.3
LLPS-Map-0020Magnaporthe poae40.44e-1984.3
LLPS-Mao-0267Magnaporthe oryzae31.32e-1265.9