LLPS-Hos-2517
PPP2R1B

▼ OVERVIEW


Status: Reviewed
Protein Name: Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform; PP2A subunit A isoform PR65-beta; PP2A subunit A isoform R1-beta
Gene Name: PPP2R1B
Ensembl Gene: ENSG00000137713.15
Ensembl Protein: ENSP00000410671.2
Organism: Homo sapiens
Taxa ID: 9606
LLPS Type: Others


▼ PROPERTY



——— Disorder propensity (calculated by IUPred2A)

▼ Classification


Condensates:
CondensateDescriptionTissue/CellPMIDs
Stress granule
"...By adding known stress granule components not identified by mass spectrometry to this list, we created the first stress granule proteome for a mammalian cell."
U2OS cells26777405
NucleolusPredicted from orthologsN/A(View)

▼ FUNCTION


The PR65 subunit of protein phosphatase 2A serves as a scaffolding molecule to coordinate the assembly of the catalytic subunit and a variable regulatory B subunit.

▼ SEQUENCE


Protein Sequence (FASTA)
1     MAGASELGTG  PGAAGGDGDD  SLYPIAVLID  ELRNEDVQLR  LNSIKKLSTI  ALALGVERTR  60
61    SELLPFLTDT  IYDEDEVLLA  LAEQLGNFTG  LVGGPDFAHC  LLPPLENLAT  VEETVVRDKA  120
121   VESLRQISQE  HTPVALEAYF  VPLVKRLASG  DWFTSRTSAC  GLFSVCYPRA  SNAVKAEIRQ  180
181   QFRSLCSDDT  PMVRRAAASK  LGEFAKVLEL  DSVKSEIVPL  FTSLASDEQD  SVRLLAVEAC  240
241   VSIAQLLSQD  DLETLVMPTL  RQAAEDKSWR  VRYMVADRFS  ELQKAMGPKI  TLNDLIPAFQ  300
301   NLLKDCEAEV  RAAAAHKVKE  LGENLPIEDR  ETIIMNQILP  YIKELVSDTN  QHVKSALASV  360
361   IMGLSTILGK  ENTIEHLLPL  FLAQLKDECP  DVRLNIISNL  DCVNEVIGIR  QLSQSLLPAI  420
421   VELAEDAKWR  VRLAIIEYMP  LLAGQLGVEF  FDEKLNSLCM  AWLVDHVYAI  REAATNNLMK  480
481   LVQKFGTEWA  QNTIVPKVLV  MANDPNYLHR  MTTLFCINAL  SEACGQEITT  KQMLPIVLKM  540
541   AGDQVANVRF  NVAKSLQKIG  PILDTNALQG  EVKPVLQKLG  QDEDMDVKYF  AQEAISVVAQ  600
601   RLRKLEFPVK  DSGEPSVPRA  DKNHFPRPTV  PGEDMGKGPV  YQLRGDTRDT  LAQLGIAELV  660
661   HFSQSTD  667
Nucleotide CDS Sequence (FASTA)
1     ATGGCGGGCG  CATCAGAGCT  CGGGACCGGC  CCAGGAGCAG  CGGGTGGAGA  TGGAGATGAT  60
61    TCGCTATACC  CGATCGCGGT  TTTAATCGAC  GAGCTCCGCA  ATGAAGACGT  GCAGCTCCGA  120
121   CTCAACAGTA  TTAAGAAGTT  ATCAACAATT  GCCCTAGCAC  TTGGAGTAGA  AAGGACCCGA  180
181   AGTGAATTGT  TGCCATTTCT  TACAGATACA  ATTTATGATG  AAGATGAGGT  ACTATTAGCT  240
241   CTTGCTGAGC  AGCTGGGAAA  TTTCACTGGC  CTAGTGGGAG  GTCCTGACTT  TGCCCACTGT  300
301   CTGCTGCCTC  CTTTGGAAAA  TCTGGCAACT  GTGGAAGAGA  CTGTTGTTCG  TGACAAGGCT  360
361   GTGGAGTCCC  TGAGACAGAT  CTCCCAGGAG  CATACTCCTG  TTGCTCTGGA  AGCTTATTTT  420
421   GTACCTCTGG  TGAAACGCTT  AGCAAGTGGG  GATTGGTTCA  CCTCTCGCAC  ATCTGCATGT  480
481   GGTTTGTTCA  GCGTTTGCTA  TCCCAGGGCA  TCAAATGCTG  TTAAAGCAGA  AATCAGACAG  540
541   CAATTCCGTT  CCTTGTGCTC  AGATGACACA  CCAATGGTAC  GACGTGCTGC  TGCTTCCAAA  600
601   TTGGGTGAAT  TTGCAAAAGT  TTTGGAATTA  GACAGTGTGA  AAAGTGAAAT  TGTTCCACTG  660
661   TTCACTAGTC  TAGCTTCAGA  TGAACAGGAT  TCAGTGCGCC  TCCTTGCTGT  GGAAGCTTGT  720
721   GTCAGTATTG  CCCAGTTATT  GTCTCAGGAT  GACCTTGAGA  CTTTGGTGAT  GCCTACACTT  780
781   CGACAAGCAG  CAGAAGATAA  ATCTTGGCGC  GTTCGCTATA  TGGTGGCTGA  CAGATTTTCA  840
841   GAGCTCCAGA  AAGCCATGGG  TCCTAAAATC  ACCCTAAATG  ACCTCATCCC  CGCCTTTCAG  900
901   AACCTACTTA  AAGACTGTGA  AGCTGAAGTC  CGGGCAGCTG  CTGCCCACAA  AGTAAAAGAA  960
961   CTTGGTGAGA  ACTTGCCCAT  TGAAGATAGA  GAGACCATAA  TTATGAATCA  AATTCTGCCT  1020
1021  TATATAAAGG  AATTAGTATC  CGATACCAAT  CAACATGTCA  AATCGGCTCT  AGCTTCTGTA  1080
1081  ATTATGGGAT  TGTCTACTAT  TTTGGGCAAA  GAAAATACCA  TTGAACATCT  TCTACCTCTT  1140
1141  TTCTTAGCTC  AGTTAAAGGA  TGAGTGTCCT  GACGTTCGTT  TGAATATCAT  CTCCAATTTG  1200
1201  GATTGTGTAA  ATGAAGTGAT  TGGAATCCGT  CAGCTCTCTC  AGTCTCTCCT  TCCTGCCATA  1260
1261  GTGGAGCTGG  CAGAAGATGC  CAAATGGAGG  GTCCGCCTGG  CCATCATTGA  GTATATGCCG  1320
1321  CTGCTGGCAG  GCCAGCTGGG  TGTGGAATTC  TTTGATGAAA  AGCTGAATTC  TTTATGTATG  1380
1381  GCTTGGCTCG  TGGACCATGT  ATACGCCATC  CGAGAAGCTG  CCACCAACAA  CCTCATGAAA  1440
1441  CTAGTTCAGA  AGTTTGGTAC  AGAGTGGGCC  CAAAATACTA  TTGTTCCCAA  AGTGTTAGTA  1500
1501  ATGGCAAATG  ATCCTAATTA  CTTGCATAGA  ATGACCACTT  TATTCTGCAT  TAATGCACTG  1560
1561  TCTGAGGCCT  GTGGTCAGGA  AATAACTACT  AAGCAAATGC  TGCCCATCGT  ATTAAAAATG  1620
1621  GCAGGAGACC  AAGTAGCAAA  TGTTCGCTTC  AATGTGGCCA  AATCTCTACA  AAAGATTGGA  1680
1681  CCAATTCTAG  ATACCAATGC  TTTACAGGGA  GAAGTGAAGC  CAGTACTACA  GAAGTTAGGT  1740
1741  CAAGATGAAG  ACATGGATGT  CAAATACTTT  GCACAGGAAG  CTATAAGTGT  GGTGGCACAA  1800
1801  AGGCTGAGGA  AGCTAGAATT  TCCTGTGAAG  GACAGTGGAG  AACCCAGTGT  CCCTCGGGCT  1860
1861  GACAAGAACC  ACTTCCCAAG  ACCCACAGTG  CCTGGAGAGG  ACATGGGGAA  GGGACCAGTG  1920
1921  TATCAGTTGC  GTGGAGATAC  TAGAGACACA  CTTGCCCAGC  TGGGAATTGC  AGAGCTAGTG  1980
1981  CATTTCTCCC  AAAGCACAGA  CTAA  2004

▼ KEYWORD


ID
Family
Acetylation
Alternative splicing
Complete proteome
Polymorphism
Reference proteome
Repeat

▼ GENE ONTOLOGY


ID
Classification
Description
Cellular Component
Cytoplasm
Cellular Component
Extracellular exosome
Cellular Component
Membrane raft
Cellular Component
Protein phosphatase type 2A complex
Molecular Function
Protein phosphatase regulator activity
Biological Process
Apoptotic process involved in morphogenesis
Biological Process
Positive regulation of extrinsic apoptotic signaling pathway in absence of ligand
Biological Process
Protein dephosphorylation

▼ KEGG



▼ ORTHOLOGY


DrLLPS IDOrganismIdentityE-valueScore
LLPS-Pat-2397Pan troglodytes99.550.01327
LLPS-Chs-3072Chlorocebus sabaeus98.830.01174
LLPS-Mal-4022Mandrillus leucophaeus98.410.01267
LLPS-Man-2652Macaca nemestrina98.350.01308
LLPS-Rhb-3400Rhinopithecus bieti98.350.01308
LLPS-Mam-1230Macaca mulatta98.350.01308
LLPS-Cea-4166Cercocebus atys98.350.01308
LLPS-Maf-0200Macaca fascicularis98.20.01305
LLPS-Paa-1753Papio anubis98.20.01307
LLPS-Otg-3256Otolemur garnettii97.410.01153
LLPS-Nol-4084Nomascus leucogenys97.150.01284
LLPS-Caf-2272Canis familiaris96.890.01139
LLPS-Ict-4215Ictidomys tridecemlineatus96.270.01211
LLPS-Ran-1977Rattus norvegicus96.20.01142
LLPS-Caj-2790Callithrix jacchus95.830.01143
LLPS-Eqc-0437Equus caballus95.80.01197
LLPS-Fec-2497Felis catus95.340.01123
LLPS-Bot-1422Bos taurus95.30.01197
LLPS-Aon-0850Aotus nancymaae95.220.01228
LLPS-Orc-1411Oryctolagus cuniculus95.140.01198
LLPS-Sah-1244Sarcophilus harrisii94.240.01044
LLPS-Cap-0058Cavia porcellus94.170.01183
LLPS-Fud-0303Fukomys damarensis93.840.01171
LLPS-Cas-1577Carlito syrichta93.820.01240
LLPS-Myl-2358Myotis lucifugus93.490.01013
LLPS-Sus-1370Sus scrofa93.00.01202
LLPS-Urm-1539Ursus maritimus92.870.01164
LLPS-Dio-1680Dipodomys ordii92.750.01082
LLPS-Mod-1314Monodelphis domestica92.650.01104
LLPS-Tut-2051Tursiops truncatus92.650.01229
LLPS-Loa-0596Loxodonta africana90.950.01234
LLPS-Poa-0229Pongo abelii90.850.01194
LLPS-Aim-0798Ailuropoda melanoleuca90.810.01232
LLPS-Mup-1116Mustela putorius furo90.650.01225
LLPS-Ova-0688Ovis aries90.580.01215
LLPS-Mea-1314Mesocricetus auratus89.630.01221
LLPS-Mum-3896Mus musculus89.60.01218
LLPS-Leo-0619Lepisosteus oculatus89.480.01063
LLPS-Orn-1642Oreochromis niloticus89.460.01065
LLPS-Gaa-1538Gasterosteus aculeatus89.460.01066
LLPS-Scf-2916Scleropages formosus89.460.01064
LLPS-Scm-0132Scophthalmus maximus89.410.01061
LLPS-Lac-1158Latimeria chalumnae89.290.01064
LLPS-Icp-1404Ictalurus punctatus89.290.01062
LLPS-Pof-0248Poecilia formosa89.120.01065
LLPS-Orl-2630Oryzias latipes89.120.01060
LLPS-Xim-0092Xiphophorus maculatus89.120.01065
LLPS-Tar-1575Takifugu rubripes89.120.01056
LLPS-Ten-2959Tetraodon nigroviridis89.110.0 637
LLPS-Asm-3314Astyanax mexicanus88.950.01059
LLPS-Dar-1373Danio rerio88.430.01051
LLPS-Ora-0695Ornithorhynchus anatinus88.430.01053
LLPS-Pes-1479Pelodiscus sinensis87.411e-80 259
LLPS-Pap-3073Pan paniscus86.180.01033
LLPS-Gog-2543Gorilla gorilla86.180.01033
LLPS-Anc-1252Anolis carolinensis85.280.01032
LLPS-Xet-2242Xenopus tropicalis83.130.0 976
LLPS-Fia-3005Ficedula albicollis81.366e-2398.6
LLPS-Anp-1484Anas platyrhynchos80.772e-37 139
LLPS-Tag-1552Taeniopygia guttata75.192e-125 380
LLPS-Drm-1136Drosophila melanogaster72.460.0 815
LLPS-Cii-1356Ciona intestinalis70.470.0 862
LLPS-Cis-0698Ciona savignyi67.870.0 819
LLPS-Cae-0133Caenorhabditis elegans62.540.0 728
LLPS-Hea-1831Helianthus annuus58.550.0 674
LLPS-Dac-1936Daucus carota58.190.0 668
LLPS-Sob-2236Sorghum bicolor58.030.0 662
LLPS-Hov-0509Hordeum vulgare57.860.0 669
LLPS-Mae-0043Manihot esculenta57.840.0 663
LLPS-Mua-0501Musa acuminata57.690.0 668
LLPS-Tra-0270Triticum aestivum57.690.0 665
LLPS-Brd-2227Brachypodium distachyon57.690.0 664
LLPS-Met-0728Medicago truncatula57.670.0 662
LLPS-Ors-1128Oryza sativa57.510.0 665
LLPS-Org-0321Oryza glaberrima57.510.0 665
LLPS-Orb-1281Oryza barthii57.510.0 665
LLPS-Ori-0326Oryza indica57.510.0 665
LLPS-Orni-0892Oryza nivara57.510.0 665
LLPS-Lep-0103Leersia perrieri57.510.0 664
LLPS-Orgl-0579Oryza glumaepatula57.510.0 665
LLPS-Amt-0448Amborella trichopoda57.340.0 661
LLPS-Prp-2192Prunus persica57.340.0 669
LLPS-Brr-2699Brassica rapa57.320.0 657
LLPS-Sot-0132Solanum tuberosum57.320.0 659
LLPS-Zem-0039Zea mays57.310.0 666
LLPS-Pot-0056Populus trichocarpa57.270.0 667
LLPS-Nia-0504Nicotiana attenuata57.190.0 662
LLPS-Sol-1237Solanum lycopersicum57.190.0 662
LLPS-Cus-0413Cucumis sativus57.190.0 660
LLPS-Vir-0801Vigna radiata57.170.0 647
LLPS-Sei-1838Setaria italica57.140.0 664
LLPS-Orbr-1254Oryza brachyantha56.990.0 659
LLPS-Thc-0908Theobroma cacao56.970.0 656
LLPS-Bro-0175Brassica oleracea56.97e-160 474
LLPS-Coc-1057Corchorus capsularis56.850.0 657
LLPS-Glm-0870Glycine max56.850.0 658
LLPS-Viv-0848Vitis vinifera56.820.0 657
LLPS-Gor-1183Gossypium raimondii56.80.0 658
LLPS-Phv-0485Phaseolus vulgaris56.790.0 658
LLPS-Via-0910Vigna angularis56.790.0 657
LLPS-Arl-0317Arabidopsis lyrata56.670.0 663
LLPS-Art-0279Arabidopsis thaliana56.50.0 655
LLPS-Brn-0233Brassica napus56.240.0 659
LLPS-Php-2338Physcomitrella patens56.210.0 652
LLPS-Orr-0287Oryza rufipogon56.160.0 656
LLPS-Sem-0412Selaginella moellendorffii55.770.0 645
LLPS-Orp-0931Oryza punctata55.040.0 646
LLPS-Spr-0095Sporisorium reilianum54.440.0 627
LLPS-Usm-0664Ustilago maydis54.140.0 620
LLPS-Fus-0356Fusarium solani53.950.0 625
LLPS-Chr-0546Chlamydomonas reinhardtii53.570.0 600
LLPS-Crn-1011Cryptococcus neoformans53.520.0 593
LLPS-Trr-0710Trichoderma reesei53.510.0 625
LLPS-Fuv-0929Fusarium verticillioides53.420.0 624
LLPS-Cog-0880Colletotrichum gloeosporioides53.190.0 625
LLPS-Tum-1243Tuber melanosporum53.170.0 606
LLPS-Phn-0294Phaeosphaeria nodorum53.160.0 615
LLPS-Trv-0860Trichoderma virens53.150.0 625
LLPS-Gag-0983Gaeumannomyces graminis53.110.0 621
LLPS-Map-1095Magnaporthe poae53.110.0 620
LLPS-Nef-0922Neosartorya fischeri53.090.0 620
LLPS-Pytr-0336Pyrenophora triticirepentis53.090.0 617
LLPS-Pyt-0618Pyrenophora teres53.090.0 617
LLPS-Cogr-0043Colletotrichum graminicola52.980.0 627
LLPS-Asn-1065Aspergillus nidulans52.920.0 615
LLPS-Lem-0418Leptosphaeria maculans52.920.0 615
LLPS-Dos-0163Dothistroma septosporum52.820.0 613
LLPS-Mao-0468Magnaporthe oryzae52.770.0 620
LLPS-Asfu-0230Aspergillus fumigatus52.750.0 618
LLPS-Asc-1044Aspergillus clavatus52.750.0 619
LLPS-Scp-0718Schizosaccharomyces pombe52.740.0 607
LLPS-Ved-1116Verticillium dahliae52.650.0 623
LLPS-Miv-0108Microbotryum violaceum52.640.0 559
LLPS-Ast-0446Aspergillus terreus52.590.0 622
LLPS-Coo-0407Colletotrichum orbiculare52.480.0 619
LLPS-Beb-0584Beauveria bassiana52.440.0 607
LLPS-Put-0461Puccinia triticina52.410.0 579
LLPS-Asni-0118Aspergillus niger52.250.0 608
LLPS-Scj-1048Schizosaccharomyces japonicus52.240.0 588
LLPS-Zyt-0347Zymoseptoria tritici52.160.0 613
LLPS-Scc-1347Schizosaccharomyces cryophilus52.140.0 592
LLPS-Nec-0150Neurospora crassa51.930.0 612
LLPS-Pug-0628Puccinia graminis51.90.0 571
LLPS-Mel-0197Melampsora laricipopulina51.880.0 573
LLPS-Scs-0286Sclerotinia sclerotiorum51.660.0 619
LLPS-Fuo-0783Fusarium oxysporum51.590.0 583
LLPS-Blg-0276Blumeria graminis51.240.0 604
LLPS-Abg-0350Absidia glauca50.690.0 577
LLPS-Aso-0864Aspergillus oryzae50.50.0 588
LLPS-Asf-0159Aspergillus flavus50.50.0 588
LLPS-Gas-0284Galdieria sulphuraria49.325e-177 524
LLPS-Cym-0661Cyanidioschyzon merolae47.535e-160 481
LLPS-Osl-0064Ostreococcus lucimarinus47.30.0 539
LLPS-Chc-0570Chondrus crispus46.915e-161 488
LLPS-Asg-0382Ashbya gossypii44.679e-153 462
LLPS-Kop-0684Komagataella pastoris44.084e-153 464
LLPS-Sac-0484Saccharomyces cerevisiae44.043e-160 483
LLPS-Yal-0557Yarrowia lipolytica43.976e-158 476
LLPS-Orm-0557Oryza meridionalis40.211e-47 175