LLPS-Hos-2517
PPP2R1B
▼ OVERVIEW
Status: | Reviewed |
Protein Name: | Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform; PP2A subunit A isoform PR65-beta; PP2A subunit A isoform R1-beta |
Gene Name: | PPP2R1B |
Ensembl Gene: | ENSG00000137713.15 |
Ensembl Protein: | ENSP00000410671.2 |
Organism: | Homo sapiens |
Taxa ID: | 9606 |
LLPS Type: | Others |
▼ Classification
Condensates:
Condensate | Description | Tissue/Cell | PMIDs |
---|---|---|---|
Stress granule | "...By adding known stress granule components not identified by mass spectrometry to this list, we created the first stress granule proteome for a mammalian cell." | U2OS cells | 26777405 |
Nucleolus | Predicted from orthologs | N/A | (View) |
▼ FUNCTION
The PR65 subunit of protein phosphatase 2A serves as a scaffolding molecule to coordinate the assembly of the catalytic subunit and a variable regulatory B subunit. |
▼ CROSS REFERENCE
▼ SEQUENCE
Protein Sequence (FASTA) |
---|
1 MAGASELGTG PGAAGGDGDD SLYPIAVLID ELRNEDVQLR LNSIKKLSTI ALALGVERTR 60 61 SELLPFLTDT IYDEDEVLLA LAEQLGNFTG LVGGPDFAHC LLPPLENLAT VEETVVRDKA 120 121 VESLRQISQE HTPVALEAYF VPLVKRLASG DWFTSRTSAC GLFSVCYPRA SNAVKAEIRQ 180 181 QFRSLCSDDT PMVRRAAASK LGEFAKVLEL DSVKSEIVPL FTSLASDEQD SVRLLAVEAC 240 241 VSIAQLLSQD DLETLVMPTL RQAAEDKSWR VRYMVADRFS ELQKAMGPKI TLNDLIPAFQ 300 301 NLLKDCEAEV RAAAAHKVKE LGENLPIEDR ETIIMNQILP YIKELVSDTN QHVKSALASV 360 361 IMGLSTILGK ENTIEHLLPL FLAQLKDECP DVRLNIISNL DCVNEVIGIR QLSQSLLPAI 420 421 VELAEDAKWR VRLAIIEYMP LLAGQLGVEF FDEKLNSLCM AWLVDHVYAI REAATNNLMK 480 481 LVQKFGTEWA QNTIVPKVLV MANDPNYLHR MTTLFCINAL SEACGQEITT KQMLPIVLKM 540 541 AGDQVANVRF NVAKSLQKIG PILDTNALQG EVKPVLQKLG QDEDMDVKYF AQEAISVVAQ 600 601 RLRKLEFPVK DSGEPSVPRA DKNHFPRPTV PGEDMGKGPV YQLRGDTRDT LAQLGIAELV 660 661 HFSQSTD 667 |
Nucleotide CDS Sequence (FASTA) |
1 ATGGCGGGCG CATCAGAGCT CGGGACCGGC CCAGGAGCAG CGGGTGGAGA TGGAGATGAT 60 61 TCGCTATACC CGATCGCGGT TTTAATCGAC GAGCTCCGCA ATGAAGACGT GCAGCTCCGA 120 121 CTCAACAGTA TTAAGAAGTT ATCAACAATT GCCCTAGCAC TTGGAGTAGA AAGGACCCGA 180 181 AGTGAATTGT TGCCATTTCT TACAGATACA ATTTATGATG AAGATGAGGT ACTATTAGCT 240 241 CTTGCTGAGC AGCTGGGAAA TTTCACTGGC CTAGTGGGAG GTCCTGACTT TGCCCACTGT 300 301 CTGCTGCCTC CTTTGGAAAA TCTGGCAACT GTGGAAGAGA CTGTTGTTCG TGACAAGGCT 360 361 GTGGAGTCCC TGAGACAGAT CTCCCAGGAG CATACTCCTG TTGCTCTGGA AGCTTATTTT 420 421 GTACCTCTGG TGAAACGCTT AGCAAGTGGG GATTGGTTCA CCTCTCGCAC ATCTGCATGT 480 481 GGTTTGTTCA GCGTTTGCTA TCCCAGGGCA TCAAATGCTG TTAAAGCAGA AATCAGACAG 540 541 CAATTCCGTT CCTTGTGCTC AGATGACACA CCAATGGTAC GACGTGCTGC TGCTTCCAAA 600 601 TTGGGTGAAT TTGCAAAAGT TTTGGAATTA GACAGTGTGA AAAGTGAAAT TGTTCCACTG 660 661 TTCACTAGTC TAGCTTCAGA TGAACAGGAT TCAGTGCGCC TCCTTGCTGT GGAAGCTTGT 720 721 GTCAGTATTG CCCAGTTATT GTCTCAGGAT GACCTTGAGA CTTTGGTGAT GCCTACACTT 780 781 CGACAAGCAG CAGAAGATAA ATCTTGGCGC GTTCGCTATA TGGTGGCTGA CAGATTTTCA 840 841 GAGCTCCAGA AAGCCATGGG TCCTAAAATC ACCCTAAATG ACCTCATCCC CGCCTTTCAG 900 901 AACCTACTTA AAGACTGTGA AGCTGAAGTC CGGGCAGCTG CTGCCCACAA AGTAAAAGAA 960 961 CTTGGTGAGA ACTTGCCCAT TGAAGATAGA GAGACCATAA TTATGAATCA AATTCTGCCT 1020 1021 TATATAAAGG AATTAGTATC CGATACCAAT CAACATGTCA AATCGGCTCT AGCTTCTGTA 1080 1081 ATTATGGGAT TGTCTACTAT TTTGGGCAAA GAAAATACCA TTGAACATCT TCTACCTCTT 1140 1141 TTCTTAGCTC AGTTAAAGGA TGAGTGTCCT GACGTTCGTT TGAATATCAT CTCCAATTTG 1200 1201 GATTGTGTAA ATGAAGTGAT TGGAATCCGT CAGCTCTCTC AGTCTCTCCT TCCTGCCATA 1260 1261 GTGGAGCTGG CAGAAGATGC CAAATGGAGG GTCCGCCTGG CCATCATTGA GTATATGCCG 1320 1321 CTGCTGGCAG GCCAGCTGGG TGTGGAATTC TTTGATGAAA AGCTGAATTC TTTATGTATG 1380 1381 GCTTGGCTCG TGGACCATGT ATACGCCATC CGAGAAGCTG CCACCAACAA CCTCATGAAA 1440 1441 CTAGTTCAGA AGTTTGGTAC AGAGTGGGCC CAAAATACTA TTGTTCCCAA AGTGTTAGTA 1500 1501 ATGGCAAATG ATCCTAATTA CTTGCATAGA ATGACCACTT TATTCTGCAT TAATGCACTG 1560 1561 TCTGAGGCCT GTGGTCAGGA AATAACTACT AAGCAAATGC TGCCCATCGT ATTAAAAATG 1620 1621 GCAGGAGACC AAGTAGCAAA TGTTCGCTTC AATGTGGCCA AATCTCTACA AAAGATTGGA 1680 1681 CCAATTCTAG ATACCAATGC TTTACAGGGA GAAGTGAAGC CAGTACTACA GAAGTTAGGT 1740 1741 CAAGATGAAG ACATGGATGT CAAATACTTT GCACAGGAAG CTATAAGTGT GGTGGCACAA 1800 1801 AGGCTGAGGA AGCTAGAATT TCCTGTGAAG GACAGTGGAG AACCCAGTGT CCCTCGGGCT 1860 1861 GACAAGAACC ACTTCCCAAG ACCCACAGTG CCTGGAGAGG ACATGGGGAA GGGACCAGTG 1920 1921 TATCAGTTGC GTGGAGATAC TAGAGACACA CTTGCCCAGC TGGGAATTGC AGAGCTAGTG 1980 1981 CATTTCTCCC AAAGCACAGA CTAA 2004 |
▼ KEYWORD
▼ GENE ONTOLOGY
ID | Classification | Description |
Cellular Component | Cytoplasm | |
Cellular Component | Extracellular exosome | |
Cellular Component | Membrane raft | |
Cellular Component | Protein phosphatase type 2A complex | |
Molecular Function | Protein phosphatase regulator activity | |
Biological Process | Apoptotic process involved in morphogenesis | |
Biological Process | Positive regulation of extrinsic apoptotic signaling pathway in absence of ligand | |
Biological Process | Protein dephosphorylation |
▼ ANNOTATION
Drug | ||||
CTD |
Physicochemical | ||||
Compute pI/Mw | AAindex |
Localization | ||||
COMPARTMENTS |
Methylation | ||||
TCGA | ICGC | MethyCancer |
▼ ORTHOLOGY
DrLLPS ID | Organism | Identity | E-value | Score |
---|---|---|---|---|
LLPS-Pat-2397 | Pan troglodytes | 99.55 | 0.0 | 1327 |
LLPS-Chs-3072 | Chlorocebus sabaeus | 98.83 | 0.0 | 1174 |
LLPS-Mal-4022 | Mandrillus leucophaeus | 98.41 | 0.0 | 1267 |
LLPS-Man-2652 | Macaca nemestrina | 98.35 | 0.0 | 1308 |
LLPS-Rhb-3400 | Rhinopithecus bieti | 98.35 | 0.0 | 1308 |
LLPS-Mam-1230 | Macaca mulatta | 98.35 | 0.0 | 1308 |
LLPS-Cea-4166 | Cercocebus atys | 98.35 | 0.0 | 1308 |
LLPS-Maf-0200 | Macaca fascicularis | 98.2 | 0.0 | 1305 |
LLPS-Paa-1753 | Papio anubis | 98.2 | 0.0 | 1307 |
LLPS-Otg-3256 | Otolemur garnettii | 97.41 | 0.0 | 1153 |
LLPS-Nol-4084 | Nomascus leucogenys | 97.15 | 0.0 | 1284 |
LLPS-Caf-2272 | Canis familiaris | 96.89 | 0.0 | 1139 |
LLPS-Ict-4215 | Ictidomys tridecemlineatus | 96.27 | 0.0 | 1211 |
LLPS-Ran-1977 | Rattus norvegicus | 96.2 | 0.0 | 1142 |
LLPS-Caj-2790 | Callithrix jacchus | 95.83 | 0.0 | 1143 |
LLPS-Eqc-0437 | Equus caballus | 95.8 | 0.0 | 1197 |
LLPS-Fec-2497 | Felis catus | 95.34 | 0.0 | 1123 |
LLPS-Bot-1422 | Bos taurus | 95.3 | 0.0 | 1197 |
LLPS-Aon-0850 | Aotus nancymaae | 95.22 | 0.0 | 1228 |
LLPS-Orc-1411 | Oryctolagus cuniculus | 95.14 | 0.0 | 1198 |
LLPS-Sah-1244 | Sarcophilus harrisii | 94.24 | 0.0 | 1044 |
LLPS-Cap-0058 | Cavia porcellus | 94.17 | 0.0 | 1183 |
LLPS-Fud-0303 | Fukomys damarensis | 93.84 | 0.0 | 1171 |
LLPS-Cas-1577 | Carlito syrichta | 93.82 | 0.0 | 1240 |
LLPS-Myl-2358 | Myotis lucifugus | 93.49 | 0.0 | 1013 |
LLPS-Sus-1370 | Sus scrofa | 93.0 | 0.0 | 1202 |
LLPS-Urm-1539 | Ursus maritimus | 92.87 | 0.0 | 1164 |
LLPS-Dio-1680 | Dipodomys ordii | 92.75 | 0.0 | 1082 |
LLPS-Mod-1314 | Monodelphis domestica | 92.65 | 0.0 | 1104 |
LLPS-Tut-2051 | Tursiops truncatus | 92.65 | 0.0 | 1229 |
LLPS-Loa-0596 | Loxodonta africana | 90.95 | 0.0 | 1234 |
LLPS-Poa-0229 | Pongo abelii | 90.85 | 0.0 | 1194 |
LLPS-Aim-0798 | Ailuropoda melanoleuca | 90.81 | 0.0 | 1232 |
LLPS-Mup-1116 | Mustela putorius furo | 90.65 | 0.0 | 1225 |
LLPS-Ova-0688 | Ovis aries | 90.58 | 0.0 | 1215 |
LLPS-Mea-1314 | Mesocricetus auratus | 89.63 | 0.0 | 1221 |
LLPS-Mum-3896 | Mus musculus | 89.6 | 0.0 | 1218 |
LLPS-Leo-0619 | Lepisosteus oculatus | 89.48 | 0.0 | 1063 |
LLPS-Orn-1642 | Oreochromis niloticus | 89.46 | 0.0 | 1065 |
LLPS-Gaa-1538 | Gasterosteus aculeatus | 89.46 | 0.0 | 1066 |
LLPS-Scf-2916 | Scleropages formosus | 89.46 | 0.0 | 1064 |
LLPS-Scm-0132 | Scophthalmus maximus | 89.41 | 0.0 | 1061 |
LLPS-Lac-1158 | Latimeria chalumnae | 89.29 | 0.0 | 1064 |
LLPS-Icp-1404 | Ictalurus punctatus | 89.29 | 0.0 | 1062 |
LLPS-Pof-0248 | Poecilia formosa | 89.12 | 0.0 | 1065 |
LLPS-Orl-2630 | Oryzias latipes | 89.12 | 0.0 | 1060 |
LLPS-Xim-0092 | Xiphophorus maculatus | 89.12 | 0.0 | 1065 |
LLPS-Tar-1575 | Takifugu rubripes | 89.12 | 0.0 | 1056 |
LLPS-Ten-2959 | Tetraodon nigroviridis | 89.11 | 0.0 | 637 |
LLPS-Asm-3314 | Astyanax mexicanus | 88.95 | 0.0 | 1059 |
LLPS-Dar-1373 | Danio rerio | 88.43 | 0.0 | 1051 |
LLPS-Ora-0695 | Ornithorhynchus anatinus | 88.43 | 0.0 | 1053 |
LLPS-Pes-1479 | Pelodiscus sinensis | 87.41 | 1e-80 | 259 |
LLPS-Pap-3073 | Pan paniscus | 86.18 | 0.0 | 1033 |
LLPS-Gog-2543 | Gorilla gorilla | 86.18 | 0.0 | 1033 |
LLPS-Anc-1252 | Anolis carolinensis | 85.28 | 0.0 | 1032 |
LLPS-Xet-2242 | Xenopus tropicalis | 83.13 | 0.0 | 976 |
LLPS-Fia-3005 | Ficedula albicollis | 81.36 | 6e-23 | 98.6 |
LLPS-Anp-1484 | Anas platyrhynchos | 80.77 | 2e-37 | 139 |
LLPS-Tag-1552 | Taeniopygia guttata | 75.19 | 2e-125 | 380 |
LLPS-Drm-1136 | Drosophila melanogaster | 72.46 | 0.0 | 815 |
LLPS-Cii-1356 | Ciona intestinalis | 70.47 | 0.0 | 862 |
LLPS-Cis-0698 | Ciona savignyi | 67.87 | 0.0 | 819 |
LLPS-Cae-0133 | Caenorhabditis elegans | 62.54 | 0.0 | 728 |
LLPS-Hea-1831 | Helianthus annuus | 58.55 | 0.0 | 674 |
LLPS-Dac-1936 | Daucus carota | 58.19 | 0.0 | 668 |
LLPS-Sob-2236 | Sorghum bicolor | 58.03 | 0.0 | 662 |
LLPS-Hov-0509 | Hordeum vulgare | 57.86 | 0.0 | 669 |
LLPS-Mae-0043 | Manihot esculenta | 57.84 | 0.0 | 663 |
LLPS-Mua-0501 | Musa acuminata | 57.69 | 0.0 | 668 |
LLPS-Tra-0270 | Triticum aestivum | 57.69 | 0.0 | 665 |
LLPS-Brd-2227 | Brachypodium distachyon | 57.69 | 0.0 | 664 |
LLPS-Met-0728 | Medicago truncatula | 57.67 | 0.0 | 662 |
LLPS-Ors-1128 | Oryza sativa | 57.51 | 0.0 | 665 |
LLPS-Org-0321 | Oryza glaberrima | 57.51 | 0.0 | 665 |
LLPS-Orb-1281 | Oryza barthii | 57.51 | 0.0 | 665 |
LLPS-Ori-0326 | Oryza indica | 57.51 | 0.0 | 665 |
LLPS-Orni-0892 | Oryza nivara | 57.51 | 0.0 | 665 |
LLPS-Lep-0103 | Leersia perrieri | 57.51 | 0.0 | 664 |
LLPS-Orgl-0579 | Oryza glumaepatula | 57.51 | 0.0 | 665 |
LLPS-Amt-0448 | Amborella trichopoda | 57.34 | 0.0 | 661 |
LLPS-Prp-2192 | Prunus persica | 57.34 | 0.0 | 669 |
LLPS-Brr-2699 | Brassica rapa | 57.32 | 0.0 | 657 |
LLPS-Sot-0132 | Solanum tuberosum | 57.32 | 0.0 | 659 |
LLPS-Zem-0039 | Zea mays | 57.31 | 0.0 | 666 |
LLPS-Pot-0056 | Populus trichocarpa | 57.27 | 0.0 | 667 |
LLPS-Nia-0504 | Nicotiana attenuata | 57.19 | 0.0 | 662 |
LLPS-Sol-1237 | Solanum lycopersicum | 57.19 | 0.0 | 662 |
LLPS-Cus-0413 | Cucumis sativus | 57.19 | 0.0 | 660 |
LLPS-Vir-0801 | Vigna radiata | 57.17 | 0.0 | 647 |
LLPS-Sei-1838 | Setaria italica | 57.14 | 0.0 | 664 |
LLPS-Orbr-1254 | Oryza brachyantha | 56.99 | 0.0 | 659 |
LLPS-Thc-0908 | Theobroma cacao | 56.97 | 0.0 | 656 |
LLPS-Bro-0175 | Brassica oleracea | 56.9 | 7e-160 | 474 |
LLPS-Coc-1057 | Corchorus capsularis | 56.85 | 0.0 | 657 |
LLPS-Glm-0870 | Glycine max | 56.85 | 0.0 | 658 |
LLPS-Viv-0848 | Vitis vinifera | 56.82 | 0.0 | 657 |
LLPS-Gor-1183 | Gossypium raimondii | 56.8 | 0.0 | 658 |
LLPS-Phv-0485 | Phaseolus vulgaris | 56.79 | 0.0 | 658 |
LLPS-Via-0910 | Vigna angularis | 56.79 | 0.0 | 657 |
LLPS-Arl-0317 | Arabidopsis lyrata | 56.67 | 0.0 | 663 |
LLPS-Art-0279 | Arabidopsis thaliana | 56.5 | 0.0 | 655 |
LLPS-Brn-0233 | Brassica napus | 56.24 | 0.0 | 659 |
LLPS-Php-2338 | Physcomitrella patens | 56.21 | 0.0 | 652 |
LLPS-Orr-0287 | Oryza rufipogon | 56.16 | 0.0 | 656 |
LLPS-Sem-0412 | Selaginella moellendorffii | 55.77 | 0.0 | 645 |
LLPS-Orp-0931 | Oryza punctata | 55.04 | 0.0 | 646 |
LLPS-Spr-0095 | Sporisorium reilianum | 54.44 | 0.0 | 627 |
LLPS-Usm-0664 | Ustilago maydis | 54.14 | 0.0 | 620 |
LLPS-Fus-0356 | Fusarium solani | 53.95 | 0.0 | 625 |
LLPS-Chr-0546 | Chlamydomonas reinhardtii | 53.57 | 0.0 | 600 |
LLPS-Crn-1011 | Cryptococcus neoformans | 53.52 | 0.0 | 593 |
LLPS-Trr-0710 | Trichoderma reesei | 53.51 | 0.0 | 625 |
LLPS-Fuv-0929 | Fusarium verticillioides | 53.42 | 0.0 | 624 |
LLPS-Cog-0880 | Colletotrichum gloeosporioides | 53.19 | 0.0 | 625 |
LLPS-Tum-1243 | Tuber melanosporum | 53.17 | 0.0 | 606 |
LLPS-Phn-0294 | Phaeosphaeria nodorum | 53.16 | 0.0 | 615 |
LLPS-Trv-0860 | Trichoderma virens | 53.15 | 0.0 | 625 |
LLPS-Gag-0983 | Gaeumannomyces graminis | 53.11 | 0.0 | 621 |
LLPS-Map-1095 | Magnaporthe poae | 53.11 | 0.0 | 620 |
LLPS-Nef-0922 | Neosartorya fischeri | 53.09 | 0.0 | 620 |
LLPS-Pytr-0336 | Pyrenophora triticirepentis | 53.09 | 0.0 | 617 |
LLPS-Pyt-0618 | Pyrenophora teres | 53.09 | 0.0 | 617 |
LLPS-Cogr-0043 | Colletotrichum graminicola | 52.98 | 0.0 | 627 |
LLPS-Asn-1065 | Aspergillus nidulans | 52.92 | 0.0 | 615 |
LLPS-Lem-0418 | Leptosphaeria maculans | 52.92 | 0.0 | 615 |
LLPS-Dos-0163 | Dothistroma septosporum | 52.82 | 0.0 | 613 |
LLPS-Mao-0468 | Magnaporthe oryzae | 52.77 | 0.0 | 620 |
LLPS-Asfu-0230 | Aspergillus fumigatus | 52.75 | 0.0 | 618 |
LLPS-Asc-1044 | Aspergillus clavatus | 52.75 | 0.0 | 619 |
LLPS-Scp-0718 | Schizosaccharomyces pombe | 52.74 | 0.0 | 607 |
LLPS-Ved-1116 | Verticillium dahliae | 52.65 | 0.0 | 623 |
LLPS-Miv-0108 | Microbotryum violaceum | 52.64 | 0.0 | 559 |
LLPS-Ast-0446 | Aspergillus terreus | 52.59 | 0.0 | 622 |
LLPS-Coo-0407 | Colletotrichum orbiculare | 52.48 | 0.0 | 619 |
LLPS-Beb-0584 | Beauveria bassiana | 52.44 | 0.0 | 607 |
LLPS-Put-0461 | Puccinia triticina | 52.41 | 0.0 | 579 |
LLPS-Asni-0118 | Aspergillus niger | 52.25 | 0.0 | 608 |
LLPS-Scj-1048 | Schizosaccharomyces japonicus | 52.24 | 0.0 | 588 |
LLPS-Zyt-0347 | Zymoseptoria tritici | 52.16 | 0.0 | 613 |
LLPS-Scc-1347 | Schizosaccharomyces cryophilus | 52.14 | 0.0 | 592 |
LLPS-Nec-0150 | Neurospora crassa | 51.93 | 0.0 | 612 |
LLPS-Pug-0628 | Puccinia graminis | 51.9 | 0.0 | 571 |
LLPS-Mel-0197 | Melampsora laricipopulina | 51.88 | 0.0 | 573 |
LLPS-Scs-0286 | Sclerotinia sclerotiorum | 51.66 | 0.0 | 619 |
LLPS-Fuo-0783 | Fusarium oxysporum | 51.59 | 0.0 | 583 |
LLPS-Blg-0276 | Blumeria graminis | 51.24 | 0.0 | 604 |
LLPS-Abg-0350 | Absidia glauca | 50.69 | 0.0 | 577 |
LLPS-Aso-0864 | Aspergillus oryzae | 50.5 | 0.0 | 588 |
LLPS-Asf-0159 | Aspergillus flavus | 50.5 | 0.0 | 588 |
LLPS-Gas-0284 | Galdieria sulphuraria | 49.32 | 5e-177 | 524 |
LLPS-Cym-0661 | Cyanidioschyzon merolae | 47.53 | 5e-160 | 481 |
LLPS-Osl-0064 | Ostreococcus lucimarinus | 47.3 | 0.0 | 539 |
LLPS-Chc-0570 | Chondrus crispus | 46.91 | 5e-161 | 488 |
LLPS-Asg-0382 | Ashbya gossypii | 44.67 | 9e-153 | 462 |
LLPS-Kop-0684 | Komagataella pastoris | 44.08 | 4e-153 | 464 |
LLPS-Sac-0484 | Saccharomyces cerevisiae | 44.04 | 3e-160 | 483 |
LLPS-Yal-0557 | Yarrowia lipolytica | 43.97 | 6e-158 | 476 |
LLPS-Orm-0557 | Oryza meridionalis | 40.21 | 1e-47 | 175 |