LLPS-Hos-2472
TYRO3

▼ OVERVIEW


Status: Reviewed
Protein Name: Tyrosine-protein kinase receptor TYRO3; Tyrosine-protein kinase BYK; Tyrosine-protein kinase DTK; Tyrosine-protein kinase RSE; Tyrosine-protein kinase SKY; Tyrosine-protein kinase TIF
Gene Name: TYRO3, BYK, DTK, RSE, SKY, TIF
Ensembl Gene: ENSG00000092445.11
Ensembl Protein: ENSP00000455441.1
Organism: Homo sapiens
Taxa ID: 9606
LLPS Type: Others
PDB: 1RHF (A) More


▼ PROPERTY



——— Disorder propensity (calculated by IUPred2A)

▼ Classification


Condensates:
CondensateDescriptionTissue/CellPMIDs
Nucleolus
"...Thus, we analyzed the orthologous groups of the remaining 2316 identified proteins to the human nucleolar proteins. We detected 361 orthologues in NoPDB from the 2316 A. thaliana proteins."
N/A26980300

▼ FUNCTION


Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to several ligands including TULP1 or GAS6. Regulates many physiological processes including cell survival, migration and differentiation. Ligand binding at the cell surface induces dimerization and autophosphorylation of TYRO3 on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with PIK3R1 and thereby enhances PI3-kinase activity. Activates the AKT survival pathway, including nuclear translocation of NF-kappa-B and up-regulation of transcription of NF-kappa-B-regulated genes. TYRO3 signaling plays a role in various processes such as neuron protection from excitotoxic injury, platelet aggregation and cytoskeleton reorganization. Plays also an important role in inhibition of Toll-like receptors (TLRs)-mediated innate immune response by activating STAT1, which selectively induces production of suppressors of cytokine signaling SOCS1 and SOCS3.

▼ SEQUENCE


Protein Sequence (FASTA)
1     MALRRSMGRP  GLPPLPLPPP  PRLGLLLAAL  ASLLLPESAA  AGLKLMGAPV  KLTVSQGQPV  60
61    KLNCSVEGME  EPDIQWVKDG  AVVQNLDQLY  IPVSEQHWIG  FLSLKSVERS  DAGRYWCQVE  120
121   DGGETEISQP  VWLTVEGVPF  FTVEPKDLAV  PPNAPFQLSC  EAVGPPEPVT  IVWWRGTTKI  180
181   GGPAPSPSVL  NVTGVTQSTM  FSCEAHNLKG  LASSRTATVH  LQALPAAPFN  ITVTKLSSSN  240
241   ASVAWMPGAD  GRALLQSCTV  QVTQAPGGWE  VLAVVVPVPP  FTCLLRDLVP  ATNYSLRVRC  300
301   ANALGPSPYA  DWVPFQTKGL  APASAPQNLH  AIRTDSGLIL  EWEEVIPEAP  LEGPLGPYKL  360
361   SWVQDNGTQD  ELTVEGTRAN  LTGWDPQKDL  IVRVCVSNAV  GCGPWSQPLV  VSSHDRAGQQ  420
421   GPPHSRTSWV  PVVLGVLTAL  VTAAALALIL  LRKRRKETRF  GQAFDSVMAR  GEPAVHFRAA  480
481   RSFNRERPER  IEATLDSLGI  SDELKEKLED  VLIPEQQFTL  GRMLGKGEFG  SVREAQLKQE  540
541   DGSFVKVAVK  MLKADIIASS  DIEEFLREAA  CMKEFDHPHV  AKLVGVSLRS  RAKGRLPIPM  600
601   VILPFMKHGD  LHAFLLASRI  GENPFNLPLQ  TLIRFMVDIA  CGMEYLSSRN  FIHRDLAARN  660
661   CMLAEDMTVC  VADFGLSRKI  YSGDYYRQGC  ASKLPVKWLA  LESLADNLYT  VQSDVWAFGV  720
721   TMWEIMTRGQ  TPYAGIENAE  IYNYLIGGNR  LKQPPECMED  VYDLMYQCWS  ADPKQRPSFT  780
781   CLRMELENIL  GQLSVLSASQ  DPLYINIERA  EEPTAGGSLE  LPGRDQPYSG  AGDGSGMGAV  840
841   GGTPSDCRYI  LTPGGLAEQP  GQAEHQPESP  LNETQRLLLL  QQGLLPHSSC  890
Nucleotide CDS Sequence (FASTA)
1     ATGGCGCTGA  GGCGGAGCAT  GGGGCGGCCG  GGGCTCCCGC  CGCTGCCGCT  GCCGCCGCCA  60
61    CCGCGGCTCG  GGCTGCTGCT  GGCGGCTCTG  GCTTCTCTGC  TGCTCCCGGA  GTCCGCCGCC  120
121   GCAGGTCTGA  AGCTCATGGG  AGCCCCGGTG  AAGCTGACAG  TGTCTCAGGG  GCAGCCGGTG  180
181   AAGCTCAACT  GCAGTGTGGA  GGGGATGGAG  GAGCCTGACA  TCCAGTGGGT  GAAGGATGGG  240
241   GCTGTGGTCC  AGAACTTGGA  CCAGTTGTAC  ATCCCAGTCA  GCGAGCAGCA  CTGGATCGGC  300
301   TTCCTCAGCC  TGAAGTCAGT  GGAGCGCTCT  GACGCCGGCC  GGTACTGGTG  CCAGGTGGAG  360
361   GATGGGGGTG  AAACCGAGAT  CTCCCAGCCA  GTGTGGCTCA  CGGTAGAAGG  TGTGCCATTT  420
421   TTCACAGTGG  AGCCAAAAGA  TCTGGCAGTG  CCACCCAATG  CCCCTTTCCA  ACTGTCTTGT  480
481   GAGGCTGTGG  GTCCCCCTGA  ACCTGTTACC  ATTGTCTGGT  GGAGAGGAAC  TACGAAGATC  540
541   GGGGGACCCG  CTCCCTCTCC  ATCTGTTTTA  AATGTAACAG  GGGTGACCCA  GAGCACCATG  600
601   TTTTCCTGTG  AAGCTCACAA  CCTAAAAGGC  CTGGCCTCTT  CTCGCACAGC  CACTGTTCAC  660
661   CTTCAAGCAC  TGCCTGCAGC  CCCCTTCAAC  ATCACCGTGA  CAAAGCTTTC  CAGCAGCAAC  720
721   GCTAGTGTGG  CCTGGATGCC  AGGTGCTGAT  GGCCGAGCTC  TGCTACAGTC  CTGTACAGTT  780
781   CAGGTGACAC  AGGCCCCAGG  AGGCTGGGAA  GTCCTGGCTG  TTGTGGTCCC  TGTGCCCCCC  840
841   TTTACCTGCC  TGCTCCGGGA  CCTGGTGCCT  GCCACCAACT  ACAGCCTCAG  GGTGCGCTGT  900
901   GCCAATGCCT  TGGGGCCCTC  TCCCTATGCT  GACTGGGTGC  CCTTTCAGAC  CAAGGGTCTA  960
961   GCCCCAGCCA  GCGCTCCCCA  AAACCTCCAT  GCCATCCGCA  CAGATTCAGG  CCTCATCTTG  1020
1021  GAGTGGGAAG  AAGTGATCCC  CGAGGCCCCT  TTGGAAGGCC  CCCTGGGACC  CTACAAACTG  1080
1081  TCCTGGGTTC  AAGACAATGG  AACCCAGGAT  GAGCTGACAG  TGGAGGGGAC  CAGGGCCAAT  1140
1141  TTGACAGGCT  GGGATCCCCA  AAAGGACCTG  ATCGTACGTG  TGTGCGTCTC  CAATGCAGTT  1200
1201  GGCTGTGGAC  CCTGGAGTCA  GCCACTGGTG  GTCTCTTCTC  ATGACCGTGC  AGGCCAGCAG  1260
1261  GGCCCTCCTC  ACAGCCGCAC  ATCCTGGGTA  CCTGTGGTCC  TTGGTGTGCT  AACGGCCCTG  1320
1321  GTGACGGCTG  CTGCCCTGGC  CCTCATCCTG  CTTCGAAAGA  GACGGAAAGA  GACGCGGTTT  1380
1381  GGGCAAGCCT  TTGACAGTGT  CATGGCCCGG  GGAGAGCCAG  CCGTTCACTT  CCGGGCAGCC  1440
1441  CGGTCCTTCA  ATCGAGAAAG  GCCCGAGCGC  ATCGAGGCCA  CATTGGACAG  CTTGGGCATC  1500
1501  AGCGATGAAC  TAAAGGAAAA  ACTGGAGGAT  GTGCTCATCC  CAGAGCAGCA  GTTCACCCTG  1560
1561  GGCCGGATGT  TGGGCAAAGG  AGAGTTTGGT  TCAGTGCGGG  AGGCCCAGCT  GAAGCAAGAG  1620
1621  GATGGCTCCT  TTGTGAAAGT  GGCTGTGAAG  ATGCTGAAAG  CTGACATCAT  TGCCTCAAGC  1680
1681  GACATTGAAG  AGTTCCTCAG  GGAAGCAGCT  TGCATGAAGG  AGTTTGACCA  TCCACACGTG  1740
1741  GCCAAACTTG  TTGGGGTAAG  CCTCCGGAGC  AGGGCTAAAG  GCCGTCTCCC  CATCCCCATG  1800
1801  GTCATCTTGC  CCTTCATGAA  GCATGGGGAC  CTGCATGCCT  TCCTGCTCGC  CTCCCGGATT  1860
1861  GGGGAGAACC  CCTTTAACCT  ACCCCTCCAG  ACCCTGATCC  GGTTCATGGT  GGACATTGCC  1920
1921  TGCGGCATGG  AGTACCTGAG  CTCTCGGAAC  TTCATCCACC  GAGACCTGGC  TGCTCGGAAT  1980
1981  TGCATGCTGG  CAGAGGACAT  GACAGTGTGT  GTGGCTGACT  TCGGACTCTC  CCGGAAGATC  2040
2041  TACAGTGGGG  ACTACTATCG  TCAAGGCTGT  GCCTCCAAAC  TGCCTGTCAA  GTGGCTGGCC  2100
2101  CTGGAGAGCC  TGGCCGACAA  CCTGTATACT  GTGCAGAGTG  ACGTGTGGGC  GTTCGGGGTG  2160
2161  ACCATGTGGG  AGATCATGAC  ACGTGGGCAG  ACGCCATATG  CTGGCATCGA  AAACGCTGAG  2220
2221  ATTTACAACT  ACCTCATTGG  CGGGAACCGC  CTGAAACAGC  CTCCGGAGTG  TATGGAGGAC  2280
2281  GTGTATGATC  TCATGTACCA  GTGCTGGAGT  GCTGACCCCA  AGCAGCGCCC  GAGCTTTACT  2340
2341  TGTCTGCGAA  TGGAACTGGA  GAACATCTTG  GGCCAGCTGT  CTGTGCTATC  TGCCAGCCAG  2400
2401  GACCCCTTAT  ACATCAACAT  CGAGAGAGCT  GAGGAGCCCA  CTGCGGGAGG  CAGCCTGGAG  2460
2461  CTACCTGGCA  GGGATCAGCC  CTACAGTGGG  GCTGGGGATG  GCAGTGGCAT  GGGGGCAGTG  2520
2521  GGTGGCACTC  CCAGTGACTG  TCGGTACATA  CTCACCCCCG  GAGGGCTGGC  TGAGCAGCCA  2580
2581  GGGCAGGCAG  AGCACCAGCC  AGAGAGTCCC  CTCAATGAGA  CACAGAGGCT  TTTGCTGCTG  2640
2641  CAGCAAGGGC  TACTGCCACA  CAGTAGCTGT  TAG  2673

▼ KEYWORD


ID
Family
3D-structure
ATP-binding
Cell adhesion
Cell membrane
Complete proteome
Disulfide bond
Glycoprotein
Host cell receptor for virus entry
Host-virus interaction
Immunoglobulin domain
Kinase
Membrane
Nucleotide-binding
Phosphoprotein
Polymorphism
Receptor
Reference proteome
Repeat
Signal
Transferase
Transmembrane
Transmembrane helix
Tyrosine-protein kinase

▼ GENE ONTOLOGY


ID
Classification
Description
Cellular Component
Cell surface
Cellular Component
Endoplasmic reticulum membrane
Cellular Component
Integral component of plasma membrane
Cellular Component
Nuclear envelope
Cellular Component
Nucleus
Cellular Component
Receptor complex
Molecular Function
ATP binding
Molecular Function
Phosphatidylinositol 3-kinase binding
Molecular Function
Protein heterodimerization activity
Molecular Function
Protein tyrosine kinase activity
Molecular Function
Transmembrane receptor protein tyrosine kinase activity
Molecular Function
Virus receptor activity
Molecular Function
Wnt-protein binding
Biological Process
Apoptotic cell clearance
Biological Process
Cell adhesion
Biological Process
Forebrain cell migration
Biological Process
Natural killer cell differentiation
Biological Process
Negative regulation of inflammatory response
Biological Process
Negative regulation of innate immune response
Biological Process
Negative regulation of lymphocyte activation
Biological Process
Negative regulation of neuron apoptotic process
Biological Process
Negative regulation of toll-like receptor signaling pathway
Biological Process
Neuron cellular homeostasis
Biological Process
Neuropeptide signaling pathway
Biological Process
Ovulation cycle
Biological Process
Phosphatidylinositol 3-kinase signaling
Biological Process
Platelet activation
Biological Process
Platelet aggregation
Biological Process
Protein autophosphorylation
Biological Process
Protein kinase B signaling
Biological Process
Secretion by cell
Biological Process
Signal transduction
Biological Process
Spermatogenesis
Biological Process
Substrate adhesion-dependent cell spreading
Biological Process
Transmembrane receptor protein tyrosine kinase signaling pathway
Biological Process
Vagina development
Biological Process
Wnt signaling pathway

▼ KEGG



▼ ORTHOLOGY


DrLLPS IDOrganismIdentityE-valueScore
LLPS-Pat-1744Pan troglodytes99.760.01613
LLPS-Pap-3492Pan paniscus99.530.01610
LLPS-Cea-4813Cercocebus atys99.060.01604
LLPS-Mam-4021Macaca mulatta99.050.01599
LLPS-Chs-3915Chlorocebus sabaeus98.820.01598
LLPS-Caj-4524Callithrix jacchus97.760.01580
LLPS-Man-1837Macaca nemestrina97.670.01595
LLPS-Maf-3159Macaca fascicularis97.670.01595
LLPS-Mal-4542Mandrillus leucophaeus97.670.01594
LLPS-Gog-3879Gorilla gorilla97.560.01592
LLPS-Paa-1903Papio anubis97.560.01594
LLPS-Aon-3142Aotus nancymaae97.520.01581
LLPS-Rhb-3561Rhinopithecus bieti97.210.01582
LLPS-Otg-2233Otolemur garnettii95.890.01550
LLPS-Fec-3692Felis catus94.690.01534
LLPS-Eqc-2995Equus caballus94.690.01512
LLPS-Ict-2843Ictidomys tridecemlineatus94.570.01529
LLPS-Caf-1849Canis familiaris94.450.01527
LLPS-Mup-1661Mustela putorius furo94.220.01518
LLPS-Sus-2251Sus scrofa94.210.01532
LLPS-Urm-3411Ursus maritimus94.20.01519
LLPS-Aim-3660Ailuropoda melanoleuca93.760.01521
LLPS-Bot-4706Bos taurus92.920.01525
LLPS-Myl-3422Myotis lucifugus92.110.01476
LLPS-Ova-1604Ovis aries91.380.01420
LLPS-Dio-0817Dipodomys ordii91.20.01470
LLPS-Cap-3986Cavia porcellus90.550.01466
LLPS-Fud-0229Fukomys damarensis90.280.01456
LLPS-Ran-4801Rattus norvegicus89.960.01471
LLPS-Mum-4371Mus musculus89.730.01462
LLPS-Mea-3718Mesocricetus auratus89.610.01461
LLPS-Orc-3017Oryctolagus cuniculus88.650.01380
LLPS-Poa-0963Pongo abelii87.760.01244
LLPS-Loa-3325Loxodonta africana87.530.01431
LLPS-Ora-3416Ornithorhynchus anatinus86.621e-165 490
LLPS-Sah-1269Sarcophilus harrisii86.290.01370
LLPS-Nol-3572Nomascus leucogenys86.190.01315
LLPS-Mod-2534Monodelphis domestica86.180.01380
LLPS-Pes-1312Pelodiscus sinensis69.530.01144
LLPS-Anp-2302Anas platyrhynchos69.380.01140
LLPS-Tag-3539Taeniopygia guttata69.380.01138
LLPS-Meg-1375Meleagris gallopavo69.290.01138
LLPS-Fia-1238Ficedula albicollis69.010.01133
LLPS-Gaga-3379Gallus gallus68.920.01135
LLPS-Anc-3477Anolis carolinensis67.550.01097
LLPS-Xet-3012Xenopus tropicalis61.370.01024
LLPS-Scm-1437Scophthalmus maximus53.350.0 769
LLPS-Asm-1261Astyanax mexicanus53.290.0 801
LLPS-Dar-0713Danio rerio52.930.0 783
LLPS-Orn-0667Oreochromis niloticus52.890.0 762
LLPS-Tar-1347Takifugu rubripes52.840.0 781
LLPS-Xim-2656Xiphophorus maculatus52.670.0 774
LLPS-Gaa-3034Gasterosteus aculeatus52.30.0 752
LLPS-Icp-0975Ictalurus punctatus51.870.0 780
LLPS-Pof-2616Poecilia formosa51.380.0 749
LLPS-Scf-1539Scleropages formosus50.960.0 795
LLPS-Orl-3300Oryzias latipes50.450.0 719
LLPS-Lac-3729Latimeria chalumnae42.492e-60 225
LLPS-Drm-1666Drosophila melanogaster41.93e-58 222
LLPS-Cas-1514Carlito syrichta41.552e-58 223
LLPS-Tut-2068Tursiops truncatus41.132e-57 219
LLPS-Leo-3233Lepisosteus oculatus41.031e-57 219
LLPS-Cii-0103Ciona intestinalis40.229e-57 206
LLPS-Ten-3402Tetraodon nigroviridis39.934e-56 213
LLPS-Cis-0445Ciona savignyi39.157e-56 205