LLPS-Hos-2472
TYRO3
▼ OVERVIEW
Status: | Reviewed |
Protein Name: | Tyrosine-protein kinase receptor TYRO3; Tyrosine-protein kinase BYK; Tyrosine-protein kinase DTK; Tyrosine-protein kinase RSE; Tyrosine-protein kinase SKY; Tyrosine-protein kinase TIF |
Gene Name: | TYRO3, BYK, DTK, RSE, SKY, TIF |
Ensembl Gene: | ENSG00000092445.11 |
Ensembl Protein: | ENSP00000455441.1 |
Organism: | Homo sapiens |
Taxa ID: | 9606 |
LLPS Type: | Others |
▼ Classification
Condensates:
Condensate | Description | Tissue/Cell | PMIDs |
---|---|---|---|
Nucleolus | "...Thus, we analyzed the orthologous groups of the remaining 2316 identified proteins to the human nucleolar proteins. We detected 361 orthologues in NoPDB from the 2316 A. thaliana proteins." | N/A | 26980300 |
▼ FUNCTION
Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to several ligands including TULP1 or GAS6. Regulates many physiological processes including cell survival, migration and differentiation. Ligand binding at the cell surface induces dimerization and autophosphorylation of TYRO3 on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with PIK3R1 and thereby enhances PI3-kinase activity. Activates the AKT survival pathway, including nuclear translocation of NF-kappa-B and up-regulation of transcription of NF-kappa-B-regulated genes. TYRO3 signaling plays a role in various processes such as neuron protection from excitotoxic injury, platelet aggregation and cytoskeleton reorganization. Plays also an important role in inhibition of Toll-like receptors (TLRs)-mediated innate immune response by activating STAT1, which selectively induces production of suppressors of cytokine signaling SOCS1 and SOCS3. |
▼ CROSS REFERENCE
Database | Nucleotide ID | Protein ID |
---|---|---|
Ensembl | ENST00000568343.1 | ENSP00000455441.1 |
Ensembl | ENST00000559851.1 | ENSP00000452995.1 |
Ensembl | ENST00000559066.5 | ENSP00000454050.1 |
Ensembl | ENST00000559815.1 | ENSP00000453835.1 |
Ensembl | ENST00000263798.7 | ENSP00000263798.3 |
UniProt | Q06418, TYRO3_HUMAN, O14953, Q86VR3 | |
GeneBank | BC051756, X72886, D17517, D50479, BC049368, U18934, U05682 | BAA04467.1, AAC50070.1, BAA21781.1, CAA51396.1, AAA19236.1, AAH49368.1, AAH51756.1 |
RefSeq | NM_001330264.1, NM_006293.3 | NP_001317193.1, NP_006284.2 |
Entrez | 7301 |
▼ SEQUENCE
Protein Sequence (FASTA) |
---|
1 MALRRSMGRP GLPPLPLPPP PRLGLLLAAL ASLLLPESAA AGLKLMGAPV KLTVSQGQPV 60 61 KLNCSVEGME EPDIQWVKDG AVVQNLDQLY IPVSEQHWIG FLSLKSVERS DAGRYWCQVE 120 121 DGGETEISQP VWLTVEGVPF FTVEPKDLAV PPNAPFQLSC EAVGPPEPVT IVWWRGTTKI 180 181 GGPAPSPSVL NVTGVTQSTM FSCEAHNLKG LASSRTATVH LQALPAAPFN ITVTKLSSSN 240 241 ASVAWMPGAD GRALLQSCTV QVTQAPGGWE VLAVVVPVPP FTCLLRDLVP ATNYSLRVRC 300 301 ANALGPSPYA DWVPFQTKGL APASAPQNLH AIRTDSGLIL EWEEVIPEAP LEGPLGPYKL 360 361 SWVQDNGTQD ELTVEGTRAN LTGWDPQKDL IVRVCVSNAV GCGPWSQPLV VSSHDRAGQQ 420 421 GPPHSRTSWV PVVLGVLTAL VTAAALALIL LRKRRKETRF GQAFDSVMAR GEPAVHFRAA 480 481 RSFNRERPER IEATLDSLGI SDELKEKLED VLIPEQQFTL GRMLGKGEFG SVREAQLKQE 540 541 DGSFVKVAVK MLKADIIASS DIEEFLREAA CMKEFDHPHV AKLVGVSLRS RAKGRLPIPM 600 601 VILPFMKHGD LHAFLLASRI GENPFNLPLQ TLIRFMVDIA CGMEYLSSRN FIHRDLAARN 660 661 CMLAEDMTVC VADFGLSRKI YSGDYYRQGC ASKLPVKWLA LESLADNLYT VQSDVWAFGV 720 721 TMWEIMTRGQ TPYAGIENAE IYNYLIGGNR LKQPPECMED VYDLMYQCWS ADPKQRPSFT 780 781 CLRMELENIL GQLSVLSASQ DPLYINIERA EEPTAGGSLE LPGRDQPYSG AGDGSGMGAV 840 841 GGTPSDCRYI LTPGGLAEQP GQAEHQPESP LNETQRLLLL QQGLLPHSSC 890 |
Nucleotide CDS Sequence (FASTA) |
1 ATGGCGCTGA GGCGGAGCAT GGGGCGGCCG GGGCTCCCGC CGCTGCCGCT GCCGCCGCCA 60 61 CCGCGGCTCG GGCTGCTGCT GGCGGCTCTG GCTTCTCTGC TGCTCCCGGA GTCCGCCGCC 120 121 GCAGGTCTGA AGCTCATGGG AGCCCCGGTG AAGCTGACAG TGTCTCAGGG GCAGCCGGTG 180 181 AAGCTCAACT GCAGTGTGGA GGGGATGGAG GAGCCTGACA TCCAGTGGGT GAAGGATGGG 240 241 GCTGTGGTCC AGAACTTGGA CCAGTTGTAC ATCCCAGTCA GCGAGCAGCA CTGGATCGGC 300 301 TTCCTCAGCC TGAAGTCAGT GGAGCGCTCT GACGCCGGCC GGTACTGGTG CCAGGTGGAG 360 361 GATGGGGGTG AAACCGAGAT CTCCCAGCCA GTGTGGCTCA CGGTAGAAGG TGTGCCATTT 420 421 TTCACAGTGG AGCCAAAAGA TCTGGCAGTG CCACCCAATG CCCCTTTCCA ACTGTCTTGT 480 481 GAGGCTGTGG GTCCCCCTGA ACCTGTTACC ATTGTCTGGT GGAGAGGAAC TACGAAGATC 540 541 GGGGGACCCG CTCCCTCTCC ATCTGTTTTA AATGTAACAG GGGTGACCCA GAGCACCATG 600 601 TTTTCCTGTG AAGCTCACAA CCTAAAAGGC CTGGCCTCTT CTCGCACAGC CACTGTTCAC 660 661 CTTCAAGCAC TGCCTGCAGC CCCCTTCAAC ATCACCGTGA CAAAGCTTTC CAGCAGCAAC 720 721 GCTAGTGTGG CCTGGATGCC AGGTGCTGAT GGCCGAGCTC TGCTACAGTC CTGTACAGTT 780 781 CAGGTGACAC AGGCCCCAGG AGGCTGGGAA GTCCTGGCTG TTGTGGTCCC TGTGCCCCCC 840 841 TTTACCTGCC TGCTCCGGGA CCTGGTGCCT GCCACCAACT ACAGCCTCAG GGTGCGCTGT 900 901 GCCAATGCCT TGGGGCCCTC TCCCTATGCT GACTGGGTGC CCTTTCAGAC CAAGGGTCTA 960 961 GCCCCAGCCA GCGCTCCCCA AAACCTCCAT GCCATCCGCA CAGATTCAGG CCTCATCTTG 1020 1021 GAGTGGGAAG AAGTGATCCC CGAGGCCCCT TTGGAAGGCC CCCTGGGACC CTACAAACTG 1080 1081 TCCTGGGTTC AAGACAATGG AACCCAGGAT GAGCTGACAG TGGAGGGGAC CAGGGCCAAT 1140 1141 TTGACAGGCT GGGATCCCCA AAAGGACCTG ATCGTACGTG TGTGCGTCTC CAATGCAGTT 1200 1201 GGCTGTGGAC CCTGGAGTCA GCCACTGGTG GTCTCTTCTC ATGACCGTGC AGGCCAGCAG 1260 1261 GGCCCTCCTC ACAGCCGCAC ATCCTGGGTA CCTGTGGTCC TTGGTGTGCT AACGGCCCTG 1320 1321 GTGACGGCTG CTGCCCTGGC CCTCATCCTG CTTCGAAAGA GACGGAAAGA GACGCGGTTT 1380 1381 GGGCAAGCCT TTGACAGTGT CATGGCCCGG GGAGAGCCAG CCGTTCACTT CCGGGCAGCC 1440 1441 CGGTCCTTCA ATCGAGAAAG GCCCGAGCGC ATCGAGGCCA CATTGGACAG CTTGGGCATC 1500 1501 AGCGATGAAC TAAAGGAAAA ACTGGAGGAT GTGCTCATCC CAGAGCAGCA GTTCACCCTG 1560 1561 GGCCGGATGT TGGGCAAAGG AGAGTTTGGT TCAGTGCGGG AGGCCCAGCT GAAGCAAGAG 1620 1621 GATGGCTCCT TTGTGAAAGT GGCTGTGAAG ATGCTGAAAG CTGACATCAT TGCCTCAAGC 1680 1681 GACATTGAAG AGTTCCTCAG GGAAGCAGCT TGCATGAAGG AGTTTGACCA TCCACACGTG 1740 1741 GCCAAACTTG TTGGGGTAAG CCTCCGGAGC AGGGCTAAAG GCCGTCTCCC CATCCCCATG 1800 1801 GTCATCTTGC CCTTCATGAA GCATGGGGAC CTGCATGCCT TCCTGCTCGC CTCCCGGATT 1860 1861 GGGGAGAACC CCTTTAACCT ACCCCTCCAG ACCCTGATCC GGTTCATGGT GGACATTGCC 1920 1921 TGCGGCATGG AGTACCTGAG CTCTCGGAAC TTCATCCACC GAGACCTGGC TGCTCGGAAT 1980 1981 TGCATGCTGG CAGAGGACAT GACAGTGTGT GTGGCTGACT TCGGACTCTC CCGGAAGATC 2040 2041 TACAGTGGGG ACTACTATCG TCAAGGCTGT GCCTCCAAAC TGCCTGTCAA GTGGCTGGCC 2100 2101 CTGGAGAGCC TGGCCGACAA CCTGTATACT GTGCAGAGTG ACGTGTGGGC GTTCGGGGTG 2160 2161 ACCATGTGGG AGATCATGAC ACGTGGGCAG ACGCCATATG CTGGCATCGA AAACGCTGAG 2220 2221 ATTTACAACT ACCTCATTGG CGGGAACCGC CTGAAACAGC CTCCGGAGTG TATGGAGGAC 2280 2281 GTGTATGATC TCATGTACCA GTGCTGGAGT GCTGACCCCA AGCAGCGCCC GAGCTTTACT 2340 2341 TGTCTGCGAA TGGAACTGGA GAACATCTTG GGCCAGCTGT CTGTGCTATC TGCCAGCCAG 2400 2401 GACCCCTTAT ACATCAACAT CGAGAGAGCT GAGGAGCCCA CTGCGGGAGG CAGCCTGGAG 2460 2461 CTACCTGGCA GGGATCAGCC CTACAGTGGG GCTGGGGATG GCAGTGGCAT GGGGGCAGTG 2520 2521 GGTGGCACTC CCAGTGACTG TCGGTACATA CTCACCCCCG GAGGGCTGGC TGAGCAGCCA 2580 2581 GGGCAGGCAG AGCACCAGCC AGAGAGTCCC CTCAATGAGA CACAGAGGCT TTTGCTGCTG 2640 2641 CAGCAAGGGC TACTGCCACA CAGTAGCTGT TAG 2673 |
▼ KEYWORD
ID | Family |
3D-structure | |
ATP-binding | |
Cell adhesion | |
Cell membrane | |
Complete proteome | |
Disulfide bond | |
Glycoprotein | |
Host cell receptor for virus entry | |
Host-virus interaction | |
Immunoglobulin domain | |
Kinase | |
Membrane | |
Nucleotide-binding | |
Phosphoprotein | |
Polymorphism | |
Receptor | |
Reference proteome | |
Repeat | |
Signal | |
Transferase | |
Transmembrane | |
Transmembrane helix | |
Tyrosine-protein kinase
|
▼ GENE ONTOLOGY
ID | Classification | Description |
Cellular Component | Cell surface | |
Cellular Component | Endoplasmic reticulum membrane | |
Cellular Component | Integral component of plasma membrane | |
Cellular Component | Nuclear envelope | |
Cellular Component | Nucleus | |
Cellular Component | Receptor complex | |
Molecular Function | ATP binding | |
Molecular Function | Phosphatidylinositol 3-kinase binding | |
Molecular Function | Protein heterodimerization activity | |
Molecular Function | Protein tyrosine kinase activity | |
Molecular Function | Transmembrane receptor protein tyrosine kinase activity | |
Molecular Function | Virus receptor activity | |
Molecular Function | Wnt-protein binding | |
Biological Process | Apoptotic cell clearance | |
Biological Process | Cell adhesion | |
Biological Process | Forebrain cell migration | |
Biological Process | Natural killer cell differentiation | |
Biological Process | Negative regulation of inflammatory response | |
Biological Process | Negative regulation of innate immune response | |
Biological Process | Negative regulation of lymphocyte activation | |
Biological Process | Negative regulation of neuron apoptotic process | |
Biological Process | Negative regulation of toll-like receptor signaling pathway | |
Biological Process | Neuron cellular homeostasis | |
Biological Process | Neuropeptide signaling pathway | |
Biological Process | Ovulation cycle | |
Biological Process | Phosphatidylinositol 3-kinase signaling | |
Biological Process | Platelet activation | |
Biological Process | Platelet aggregation | |
Biological Process | Protein autophosphorylation | |
Biological Process | Protein kinase B signaling | |
Biological Process | Secretion by cell | |
Biological Process | Signal transduction | |
Biological Process | Spermatogenesis | |
Biological Process | Substrate adhesion-dependent cell spreading | |
Biological Process | Transmembrane receptor protein tyrosine kinase signaling pathway | |
Biological Process | Vagina development | |
Biological Process | Wnt signaling pathway |
▼ ANNOTATION
Physicochemical | ||||
Compute pI/Mw | AAindex |
Localization | ||||
COMPARTMENTS |
Methylation | ||||
TCGA | ICGC | MethyCancer |
▼ ORTHOLOGY
DrLLPS ID | Organism | Identity | E-value | Score |
---|---|---|---|---|
LLPS-Pat-1744 | Pan troglodytes | 99.76 | 0.0 | 1613 |
LLPS-Pap-3492 | Pan paniscus | 99.53 | 0.0 | 1610 |
LLPS-Cea-4813 | Cercocebus atys | 99.06 | 0.0 | 1604 |
LLPS-Mam-4021 | Macaca mulatta | 99.05 | 0.0 | 1599 |
LLPS-Chs-3915 | Chlorocebus sabaeus | 98.82 | 0.0 | 1598 |
LLPS-Caj-4524 | Callithrix jacchus | 97.76 | 0.0 | 1580 |
LLPS-Man-1837 | Macaca nemestrina | 97.67 | 0.0 | 1595 |
LLPS-Maf-3159 | Macaca fascicularis | 97.67 | 0.0 | 1595 |
LLPS-Mal-4542 | Mandrillus leucophaeus | 97.67 | 0.0 | 1594 |
LLPS-Gog-3879 | Gorilla gorilla | 97.56 | 0.0 | 1592 |
LLPS-Paa-1903 | Papio anubis | 97.56 | 0.0 | 1594 |
LLPS-Aon-3142 | Aotus nancymaae | 97.52 | 0.0 | 1581 |
LLPS-Rhb-3561 | Rhinopithecus bieti | 97.21 | 0.0 | 1582 |
LLPS-Otg-2233 | Otolemur garnettii | 95.89 | 0.0 | 1550 |
LLPS-Fec-3692 | Felis catus | 94.69 | 0.0 | 1534 |
LLPS-Eqc-2995 | Equus caballus | 94.69 | 0.0 | 1512 |
LLPS-Ict-2843 | Ictidomys tridecemlineatus | 94.57 | 0.0 | 1529 |
LLPS-Caf-1849 | Canis familiaris | 94.45 | 0.0 | 1527 |
LLPS-Mup-1661 | Mustela putorius furo | 94.22 | 0.0 | 1518 |
LLPS-Sus-2251 | Sus scrofa | 94.21 | 0.0 | 1532 |
LLPS-Urm-3411 | Ursus maritimus | 94.2 | 0.0 | 1519 |
LLPS-Aim-3660 | Ailuropoda melanoleuca | 93.76 | 0.0 | 1521 |
LLPS-Bot-4706 | Bos taurus | 92.92 | 0.0 | 1525 |
LLPS-Myl-3422 | Myotis lucifugus | 92.11 | 0.0 | 1476 |
LLPS-Ova-1604 | Ovis aries | 91.38 | 0.0 | 1420 |
LLPS-Dio-0817 | Dipodomys ordii | 91.2 | 0.0 | 1470 |
LLPS-Cap-3986 | Cavia porcellus | 90.55 | 0.0 | 1466 |
LLPS-Fud-0229 | Fukomys damarensis | 90.28 | 0.0 | 1456 |
LLPS-Ran-4801 | Rattus norvegicus | 89.96 | 0.0 | 1471 |
LLPS-Mum-4371 | Mus musculus | 89.73 | 0.0 | 1462 |
LLPS-Mea-3718 | Mesocricetus auratus | 89.61 | 0.0 | 1461 |
LLPS-Orc-3017 | Oryctolagus cuniculus | 88.65 | 0.0 | 1380 |
LLPS-Poa-0963 | Pongo abelii | 87.76 | 0.0 | 1244 |
LLPS-Loa-3325 | Loxodonta africana | 87.53 | 0.0 | 1431 |
LLPS-Ora-3416 | Ornithorhynchus anatinus | 86.62 | 1e-165 | 490 |
LLPS-Sah-1269 | Sarcophilus harrisii | 86.29 | 0.0 | 1370 |
LLPS-Nol-3572 | Nomascus leucogenys | 86.19 | 0.0 | 1315 |
LLPS-Mod-2534 | Monodelphis domestica | 86.18 | 0.0 | 1380 |
LLPS-Pes-1312 | Pelodiscus sinensis | 69.53 | 0.0 | 1144 |
LLPS-Anp-2302 | Anas platyrhynchos | 69.38 | 0.0 | 1140 |
LLPS-Tag-3539 | Taeniopygia guttata | 69.38 | 0.0 | 1138 |
LLPS-Meg-1375 | Meleagris gallopavo | 69.29 | 0.0 | 1138 |
LLPS-Fia-1238 | Ficedula albicollis | 69.01 | 0.0 | 1133 |
LLPS-Gaga-3379 | Gallus gallus | 68.92 | 0.0 | 1135 |
LLPS-Anc-3477 | Anolis carolinensis | 67.55 | 0.0 | 1097 |
LLPS-Xet-3012 | Xenopus tropicalis | 61.37 | 0.0 | 1024 |
LLPS-Scm-1437 | Scophthalmus maximus | 53.35 | 0.0 | 769 |
LLPS-Asm-1261 | Astyanax mexicanus | 53.29 | 0.0 | 801 |
LLPS-Dar-0713 | Danio rerio | 52.93 | 0.0 | 783 |
LLPS-Orn-0667 | Oreochromis niloticus | 52.89 | 0.0 | 762 |
LLPS-Tar-1347 | Takifugu rubripes | 52.84 | 0.0 | 781 |
LLPS-Xim-2656 | Xiphophorus maculatus | 52.67 | 0.0 | 774 |
LLPS-Gaa-3034 | Gasterosteus aculeatus | 52.3 | 0.0 | 752 |
LLPS-Icp-0975 | Ictalurus punctatus | 51.87 | 0.0 | 780 |
LLPS-Pof-2616 | Poecilia formosa | 51.38 | 0.0 | 749 |
LLPS-Scf-1539 | Scleropages formosus | 50.96 | 0.0 | 795 |
LLPS-Orl-3300 | Oryzias latipes | 50.45 | 0.0 | 719 |
LLPS-Lac-3729 | Latimeria chalumnae | 42.49 | 2e-60 | 225 |
LLPS-Drm-1666 | Drosophila melanogaster | 41.9 | 3e-58 | 222 |
LLPS-Cas-1514 | Carlito syrichta | 41.55 | 2e-58 | 223 |
LLPS-Tut-2068 | Tursiops truncatus | 41.13 | 2e-57 | 219 |
LLPS-Leo-3233 | Lepisosteus oculatus | 41.03 | 1e-57 | 219 |
LLPS-Cii-0103 | Ciona intestinalis | 40.22 | 9e-57 | 206 |
LLPS-Ten-3402 | Tetraodon nigroviridis | 39.93 | 4e-56 | 213 |
LLPS-Cis-0445 | Ciona savignyi | 39.15 | 7e-56 | 205 |