LLPS-Hos-2338
SAMD4B
▼ OVERVIEW
| Status: | Reviewed |
| Protein Name: | Protein Smaug homolog 2 |
| Gene Name: | SAMD4B, SMAUG2 |
| Ensembl Gene: | ENSG00000179134.15 |
| Ensembl Protein: | ENSP00000469404.1 |
| Organism: | Homo sapiens |
| Taxa ID: | 9606 |
| LLPS Type: | Others |
▼ Classification
Condensates:
| Condensate | Description | Tissue/Cell | PMIDs |
|---|---|---|---|
| Stress granule | "...Together, our APEX and IF screening approaches identified 260 SG proteins, including ~150 candidates that had not previously been associated with SGs." | Neural progenitor cells | 29373831 |
| Stress granule | "...A list of candidate SG proteins identified by mass spectrometry in NPCs, including statistical analysis." | Neural progenitor cells | 29373831 |
▼ FUNCTION
| Has transcriptional repressor activity. Overexpression inhibits the transcriptional activities of AP-1, p53/TP53 and CDKN1A. |
▼ CROSS REFERENCE
| Database | Nucleotide ID | Protein ID |
|---|---|---|
| Ensembl | ENST00000602243.5 | ENSP00000469404.1 |
| Ensembl | ENST00000600018.1 | ENSP00000470821.1 |
| Ensembl | ENST00000599712.1 | ENSP00000469620.1 |
| Ensembl | ENST00000598913.5 | ENSP00000470237.1 |
| Ensembl | ENST00000596368.1 | ENSP00000471509.1 |
| Ensembl | ENST00000610417.4 | ENSP00000484229.1 |
| Ensembl | ENST00000598605.1 | ENSP00000468891.1 |
| Ensembl | ENST00000611159.4 | ENSP00000482861.1 |
| Ensembl | ENST00000314471.10 | ENSP00000317224.5 |
| UniProt | Q5PRF9, SMAG2_HUMAN, A5Z0M6, Q6P194 | |
| GeneBank | EF601121, CH471126, BC054518, BC065211 | EAW56877.1, AAH54518.1, AAH65211.1, ABQ85549.1 |
| RefSeq | NM_001303614.1, NM_018028.3, XM_011527063.2, XM_017026920.1, XM_017026921.1 | NP_001290543.1, NP_060498.2, XP_011525365.1, XP_016882409.1, XP_016882410.1 |
| Entrez | 55095 |
▼ SEQUENCE
| Protein Sequence (FASTA) |
|---|
1 MMFRDQVGIL AGWFKGWNEC EQTVALLSLL KRVTRTQARF LQLCLEHSLA DCNDIHLLES 60 61 EANSAAIVSQ WQQESKEKVV SLLLSHLPLL QPGNTEAKSE YMRLLQKVLA YSIESNAFIE 120 121 ESRQLLSYAL IHPATTLEDR NALALWLSHL EERLASGFRS RPEPSYHSRQ GSDEWGGPAE 180 181 LGPGEAGPGW QDKPPRENGH VPFHPSSSVP PAINSIGSNA NTGLPCQIHP SPLKRSMSLI 240 241 PTSPQVPGEW PSPEELGARA AFTTPDHAPL SPQSSVASSG SEQTEEQGSS RNTFQEDGSG 300 301 MKDVPSWLKS LRLHKYAALF SQMSYEEMMT LTEQHLESQN VTKGARHKIA LSIQKLRERQ 360 361 SVLKSLEKDV LEGGNLRNAL QELQQIIITP IKAYSVLQAT VAAATTTPTA KDGAPGEPPL 420 421 PGAEPPLAHP GTDKGTEAKD PPAVENYPPP PAPAPTDGSE PAPAPVADGD IPSQFTRVMG 480 481 KVCTQLLVSR PDEENITSYL QLIEKCLTHE AFTETQKKRL LSWKQQVLKL LRTFPRKAAL 540 541 EMQNYRQQKG WAFGSNSLPI AGSVGMGVAR RTQRQFPMPP RALPPGRMGL LSPSGIGGVS 600 601 PRHALTSPSL GGQGRQNLWF ANPGGSNSMP SQSRSSVQRT HSLPVHSSPQ AILMFPPDCP 660 661 VPGPDLEINP TLESLCLSMT EHALGDGTDK TSTI 694 |
| Nucleotide CDS Sequence (FASTA) |
1 ATGATGTTCC GAGACCAGGT GGGCATCCTC GCTGGCTGGT TCAAAGGCTG GAATGAGTGT 60 61 GAGCAGACAG TGGCCCTCCT GTCACTTCTG AAACGGGTCA CCCGTACCCA GGCCCGCTTC 120 121 CTGCAGCTCT GCCTGGAGCA CTCACTGGCG GACTGCAATG ACATCCACCT GCTGGAGTCG 180 181 GAGGCCAACA GTGCTGCCAT CGTCAGCCAG TGGCAGCAGG AGTCCAAAGA GAAGGTGGTG 240 241 TCCCTCCTGC TGTCCCACCT TCCCCTGCTT CAGCCAGGCA ACACAGAGGC CAAGTCGGAG 300 301 TACATGAGGC TACTGCAGAA AGTGCTGGCC TACTCAATCG AGAGCAATGC TTTCATCGAG 360 361 GAGAGTCGCC AGCTGCTTTC CTATGCCCTC ATCCACCCAG CCACCACACT GGAGGACCGC 420 421 AACGCACTGG CCCTCTGGCT GAGCCACCTG GAAGAGCGGT TGGCTAGTGG CTTCCGCTCC 480 481 CGGCCAGAGC CCTCCTACCA TTCACGTCAA GGCTCAGATG AGTGGGGGGG CCCTGCAGAG 540 541 CTAGGCCCTG GGGAGGCAGG GCCAGGCTGG CAGGACAAGC CACCCCGGGA AAATGGACAC 600 601 GTGCCCTTCC ACCCATCCAG CTCAGTGCCG CCAGCCATCA ACAGTATTGG GAGCAATGCA 660 661 AACACAGGTC TCCCCTGCCA AATCCACCCT AGCCCACTGA AGCGCTCCAT GTCACTCATC 720 721 CCTACAAGCC CCCAGGTCCC TGGTGAGTGG CCGAGTCCAG AGGAGCTTGG GGCCCGGGCT 780 781 GCTTTTACCA CGCCCGATCA CGCACCTCTC TCGCCCCAGA GCAGCGTGGC CTCCTCTGGC 840 841 AGTGAGCAGA CAGAGGAGCA GGGCTCCAGC CGGAACACCT TCCAGGAGGA TGGCAGTGGC 900 901 ATGAAAGATG TGCCCTCATG GCTCAAGAGC CTCCGTTTGC ACAAGTATGC AGCCCTCTTC 960 961 TCACAGATGA GCTACGAGGA GATGATGACA CTGACTGAGC AGCACCTGGA GTCTCAGAAC 1020 1021 GTCACCAAAG GTGCCCGCCA CAAGATAGCC CTGAGCATCC AGAAGCTGCG TGAGAGACAG 1080 1081 AGCGTCCTCA AGTCCCTAGA GAAGGATGTG CTGGAAGGCG GGAACCTACG AAACGCTCTG 1140 1141 CAGGAGCTGC AGCAGATCAT CATCACTCCC ATCAAGGCCT ACAGTGTCCT CCAGGCCACC 1200 1201 GTGGCTGCCG CCACCACCAC CCCTACTGCC AAGGATGGGG CCCCGGGGGA ACCACCGCTG 1260 1261 CCAGGTGCTG AGCCTCCCCT AGCCCACCCC GGCACAGACA AAGGCACCGA GGCCAAGGAC 1320 1321 CCTCCAGCTG TGGAGAACTA CCCACCTCCA CCAGCTCCAG CTCCCACTGA TGGCAGTGAG 1380 1381 CCTGCCCCGG CTCCCGTCGC CGACGGAGAC ATCCCCAGCC AGTTTACACG GGTGATGGGC 1440 1441 AAAGTGTGCA CCCAACTGCT GGTGTCCCGA CCAGACGAGG AGAACATCAC CAGTTACCTC 1500 1501 CAGCTCATCG AAAAGTGCCT GACTCATGAG GCTTTCACGG AGACGCAGAA GAAACGGCTG 1560 1561 CTATCCTGGA AACAGCAAGT GCTGAAGCTC CTCCGGACAT TCCCGCGCAA AGCCGCACTA 1620 1621 GAGATGCAGA ACTACCGGCA GCAGAAAGGC TGGGCATTCG GCTCCAACTC GCTCCCCATA 1680 1681 GCTGGCTCTG TGGGGATGGG AGTGGCCCGG CGTACCCAGC GGCAGTTCCC AATGCCTCCC 1740 1741 CGGGCCCTCC CACCCGGCCG GATGGGCCTC CTGAGCCCCT CGGGCATTGG GGGTGTCTCC 1800 1801 CCTCGACATG CCCTCACCAG CCCCAGCCTT GGAGGCCAGG GCCGACAGAA CCTGTGGTTT 1860 1861 GCCAACCCTG GAGGCAGCAA CAGCATGCCC AGTCAGAGCC GCAGCTCTGT GCAGCGCACC 1920 1921 CACTCGCTCC CGGTCCACTC GTCACCCCAG GCCATTCTCA TGTTCCCTCC AGACTGCCCG 1980 1981 GTTCCTGGGC CTGACCTGGA GATCAATCCC ACTCTGGAGT CTCTGTGTCT GAGCATGACA 2040 2041 GAACACGCCT TGGGTGATGG GACAGACAAA ACCTCCACCA TCTGA 2085 |
▼ KEYWORD
▼ GENE ONTOLOGY
ID | Classification | Description |
Cellular Component | Cytosol | |
Cellular Component | Nucleus | |
Cellular Component | P-body | |
Molecular Function | MRNA binding | |
Molecular Function | RNA binding | |
Molecular Function | Translation repressor activity | |
Biological Process | Negative regulation of translation | |
Biological Process | Nuclear-transcribed mRNA poly(A) tail shortening | |
Biological Process | Regulation of mRNA stability |
▼ ANNOTATION
| Disease | ||||
| TumorFusions | ActiveDriverDB | |||
| Drug | ||||
| CTD | ||||
| Physicochemical | ||||
| Compute pI/Mw | AAindex | |||
| Function | ||||
| ENPD | CellMarker | |||
| Localization | ||||
| COMPARTMENTS | NLSdb | |||
| Methylation | ||||
| TCGA | ICGC | MethyCancer | ||
▼ ORTHOLOGY
| DrLLPS ID | Organism | Identity | E-value | Score |
|---|---|---|---|---|
| LLPS-Pap-4364 | Pan paniscus | 100.0 | 0.0 | 1181 |
| LLPS-Pat-3320 | Pan troglodytes | 100.0 | 0.0 | 1181 |
| LLPS-Gog-3646 | Gorilla gorilla | 99.79 | 0.0 | 820 |
| LLPS-Man-2712 | Macaca nemestrina | 99.57 | 0.0 | 1182 |
| LLPS-Rhb-3469 | Rhinopithecus bieti | 99.57 | 0.0 | 1182 |
| LLPS-Mam-4271 | Macaca mulatta | 99.57 | 0.0 | 1182 |
| LLPS-Maf-2802 | Macaca fascicularis | 99.57 | 0.0 | 1182 |
| LLPS-Cea-3234 | Cercocebus atys | 99.42 | 0.0 | 1182 |
| LLPS-Chs-1995 | Chlorocebus sabaeus | 99.42 | 0.0 | 1182 |
| LLPS-Mal-3800 | Mandrillus leucophaeus | 99.42 | 0.0 | 1182 |
| LLPS-Paa-3704 | Papio anubis | 99.28 | 0.0 | 1180 |
| LLPS-Aon-4821 | Aotus nancymaae | 98.7 | 0.0 | 1176 |
| LLPS-Ict-2352 | Ictidomys tridecemlineatus | 98.41 | 0.0 | 1178 |
| LLPS-Cas-4091 | Carlito syrichta | 97.99 | 0.0 | 1172 |
| LLPS-Fec-4260 | Felis catus | 97.7 | 0.0 | 1170 |
| LLPS-Otg-2675 | Otolemur garnettii | 97.41 | 0.0 | 1157 |
| LLPS-Tut-0140 | Tursiops truncatus | 97.38 | 0.0 | 1147 |
| LLPS-Caf-2335 | Canis familiaris | 97.25 | 0.0 | 1152 |
| LLPS-Eqc-2715 | Equus caballus | 97.12 | 0.0 | 1166 |
| LLPS-Sus-4166 | Sus scrofa | 97.12 | 0.0 | 1165 |
| LLPS-Mup-1372 | Mustela putorius furo | 97.12 | 0.0 | 1170 |
| LLPS-Fud-1238 | Fukomys damarensis | 96.97 | 0.0 | 1162 |
| LLPS-Mum-3897 | Mus musculus | 96.54 | 0.0 | 1165 |
| LLPS-Ran-4578 | Rattus norvegicus | 96.54 | 0.0 | 1166 |
| LLPS-Orc-1812 | Oryctolagus cuniculus | 96.4 | 0.0 | 1169 |
| LLPS-Ova-4123 | Ovis aries | 96.26 | 0.0 | 1160 |
| LLPS-Dio-0512 | Dipodomys ordii | 96.2 | 0.0 | 1028 |
| LLPS-Mea-2191 | Mesocricetus auratus | 96.12 | 0.0 | 1154 |
| LLPS-Cap-4653 | Cavia porcellus | 96.11 | 0.0 | 1165 |
| LLPS-Nol-3041 | Nomascus leucogenys | 95.97 | 0.0 | 1109 |
| LLPS-Myl-4028 | Myotis lucifugus | 95.4 | 0.0 | 1164 |
| LLPS-Loa-3671 | Loxodonta africana | 94.82 | 0.0 | 1150 |
| LLPS-Urm-3003 | Ursus maritimus | 92.11 | 0.0 | 1108 |
| LLPS-Caj-3201 | Callithrix jacchus | 92.09 | 0.0 | 1152 |
| LLPS-Mod-2692 | Monodelphis domestica | 89.5 | 0.0 | 1095 |
| LLPS-Sah-0158 | Sarcophilus harrisii | 83.31 | 0.0 | 1044 |
| LLPS-Pes-3546 | Pelodiscus sinensis | 79.83 | 0.0 | 1025 |
| LLPS-Anc-1300 | Anolis carolinensis | 79.69 | 0.0 | 1004 |
| LLPS-Dar-3476 | Danio rerio | 77.5 | 5e-62 | 226 |
| LLPS-Xim-1818 | Xiphophorus maculatus | 73.72 | 8e-65 | 234 |
| LLPS-Lac-3071 | Latimeria chalumnae | 73.33 | 0.0 | 878 |
| LLPS-Scm-2875 | Scophthalmus maximus | 72.46 | 6e-65 | 235 |
| LLPS-Leo-3103 | Lepisosteus oculatus | 71.35 | 0.0 | 908 |
| LLPS-Scf-3504 | Scleropages formosus | 71.02 | 0.0 | 871 |
| LLPS-Orn-2030 | Oreochromis niloticus | 70.53 | 0.0 | 845 |
| LLPS-Xet-1971 | Xenopus tropicalis | 69.94 | 0.0 | 854 |
| LLPS-Tar-2949 | Takifugu rubripes | 68.67 | 0.0 | 841 |
| LLPS-Pof-0424 | Poecilia formosa | 68.52 | 0.0 | 857 |
| LLPS-Ora-1653 | Ornithorhynchus anatinus | 67.65 | 3e-06 | 53.1 |
| LLPS-Cii-0365 | Ciona intestinalis | 67.61 | 4e-26 | 116 |
| LLPS-Orl-0978 | Oryzias latipes | 67.53 | 0.0 | 815 |
| LLPS-Ten-2796 | Tetraodon nigroviridis | 67.38 | 0.0 | 836 |
| LLPS-Gaga-3259 | Gallus gallus | 65.38 | 0.0 | 643 |
| LLPS-Fia-3295 | Ficedula albicollis | 61.58 | 0.0 | 737 |
| LLPS-Tag-1619 | Taeniopygia guttata | 61.33 | 0.0 | 727 |
| LLPS-Anp-3284 | Anas platyrhynchos | 56.82 | 2e-143 | 434 |
| LLPS-Poa-4068 | Pongo abelii | 56.51 | 0.0 | 574 |
| LLPS-Meg-0487 | Meleagris gallopavo | 56.28 | 0.0 | 546 |
| LLPS-Dos-0958 | Dothistroma septosporum | 40.91 | 3e-06 | 54.7 |
| LLPS-Ast-0701 | Aspergillus terreus | 38.71 | 3e-06 | 55.1 |
| LLPS-Asc-0492 | Aspergillus clavatus | 38.71 | 3e-06 | 54.7 |
| LLPS-Asni-1424 | Aspergillus niger | 38.71 | 2e-06 | 55.1 |
| LLPS-Zyt-0736 | Zymoseptoria tritici | 38.71 | 2e-06 | 55.5 |
| LLPS-Abg-0643 | Absidia glauca | 30.1 | 1e-06 | 55.8 |
| LLPS-Scj-1422 | Schizosaccharomyces japonicus | 26.88 | 9e-07 | 56.6 |